Incidental Mutation 'R9336:Adamtsl1'
| ID |
707129 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamtsl1
|
| Ensembl Gene |
ENSMUSG00000066113 |
| Gene Name |
ADAMTS-like 1 |
| Synonyms |
punctin-1, 5930437A14Rik, 6720426B09Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.291)
|
| Stock # |
R9336 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
85432409-86346622 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86240264 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 675
(V675A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102796
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000107178]
[ENSMUST00000141889]
|
| AlphaFold |
Q8BLI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107178
AA Change: V675A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000102796
Gene: ENSMUSG00000066113
AA Change: V675A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
TSP1
|
36 |
82 |
8.95e-7 |
SMART |
|
TSP1
|
301 |
360 |
4.35e-2 |
SMART |
|
TSP1
|
362 |
421 |
2.05e-2 |
SMART |
|
TSP1
|
422 |
476 |
3.99e-4 |
SMART |
|
TSP1
|
508 |
567 |
6.39e-3 |
SMART |
|
TSP1
|
593 |
650 |
7.86e-3 |
SMART |
|
TSP1
|
652 |
712 |
3.78e-5 |
SMART |
|
TSP1
|
715 |
772 |
2.66e-2 |
SMART |
|
TSP1
|
774 |
833 |
1.62e-4 |
SMART |
|
IGc2
|
873 |
937 |
4.19e-6 |
SMART |
|
low complexity region
|
1123 |
1142 |
N/A |
INTRINSIC |
|
IGc2
|
1175 |
1240 |
1.31e-7 |
SMART |
|
IGc2
|
1282 |
1351 |
7.81e-15 |
SMART |
|
IGc2
|
1400 |
1467 |
2.39e-10 |
SMART |
|
TSP1
|
1481 |
1537 |
2.12e-1 |
SMART |
|
TSP1
|
1540 |
1599 |
1.74e-4 |
SMART |
|
TSP1
|
1600 |
1658 |
8.2e0 |
SMART |
|
TSP1
|
1660 |
1717 |
1.96e-1 |
SMART |
|
Pfam:PLAC
|
1721 |
1751 |
1.4e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141889
|
| SMART Domains |
Protein: ENSMUSP00000119278
Gene: ENSMUSG00000066113
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
TSP1
|
36 |
82 |
8.95e-7 |
SMART |
|
TSP1
|
301 |
360 |
4.35e-2 |
SMART |
|
TSP1
|
379 |
438 |
2.05e-2 |
SMART |
|
TSP1
|
439 |
493 |
3.99e-4 |
SMART |
|
TSP1
|
525 |
584 |
6.39e-3 |
SMART |
|
TSP1
|
610 |
667 |
7.86e-3 |
SMART |
|
TSP1
|
707 |
764 |
2.66e-2 |
SMART |
|
TSP1
|
766 |
825 |
1.62e-4 |
SMART |
|
IGc2
|
865 |
929 |
4.19e-6 |
SMART |
|
low complexity region
|
1115 |
1134 |
N/A |
INTRINSIC |
|
IGc2
|
1167 |
1232 |
1.31e-7 |
SMART |
|
IGc2
|
1274 |
1343 |
7.81e-15 |
SMART |
|
IGc2
|
1392 |
1459 |
2.39e-10 |
SMART |
|
TSP1
|
1473 |
1529 |
2.12e-1 |
SMART |
|
TSP1
|
1532 |
1591 |
1.74e-4 |
SMART |
|
TSP1
|
1592 |
1650 |
8.2e0 |
SMART |
|
TSP1
|
1652 |
1709 |
1.96e-1 |
SMART |
|
Pfam:PLAC
|
1712 |
1744 |
5.6e-12 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(3) : Gene trapped(3) |
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510039O18Rik |
C |
T |
4: 148,029,490 (GRCm39) |
R487C |
probably benign |
Het |
| 2900026A02Rik |
A |
T |
5: 113,240,966 (GRCm39) |
|
probably null |
Het |
| Adamts15 |
T |
A |
9: 30,816,085 (GRCm39) |
T625S |
probably damaging |
Het |
| Ank3 |
A |
T |
10: 69,809,578 (GRCm39) |
T1120S |
probably benign |
Het |
| Armh3 |
A |
T |
19: 45,945,120 (GRCm39) |
M277K |
probably damaging |
Het |
| Babam2 |
A |
T |
5: 31,859,194 (GRCm39) |
M1L |
possibly damaging |
Het |
| Cadm3 |
G |
A |
1: 173,168,786 (GRCm39) |
Q261* |
probably null |
Het |
| Cdc27 |
A |
T |
11: 104,396,496 (GRCm39) |
D802E |
probably benign |
Het |
| Cfap206 |
C |
T |
4: 34,716,494 (GRCm39) |
V324I |
probably benign |
Het |
| Cfap44 |
T |
C |
16: 44,242,807 (GRCm39) |
I737T |
probably damaging |
Het |
| Chrm3 |
A |
T |
13: 9,928,652 (GRCm39) |
I128N |
probably damaging |
Het |
| Cyfip1 |
T |
A |
7: 55,554,189 (GRCm39) |
S743T |
probably benign |
Het |
| Ddias |
A |
G |
7: 92,507,314 (GRCm39) |
V867A |
possibly damaging |
Het |
| Ddx20 |
G |
C |
3: 105,585,903 (GRCm39) |
T814R |
possibly damaging |
Het |
| Dgka |
A |
T |
10: 128,566,935 (GRCm39) |
|
probably null |
Het |
| Dnah9 |
A |
T |
11: 65,761,775 (GRCm39) |
V3905E |
probably damaging |
Het |
| Dsg3 |
C |
A |
18: 20,657,742 (GRCm39) |
Q271K |
probably benign |
Het |
| Dvl2 |
T |
A |
11: 69,897,180 (GRCm39) |
I294N |
probably damaging |
Het |
| E2f3 |
G |
A |
13: 30,095,239 (GRCm39) |
H350Y |
possibly damaging |
Het |
| Eif2b5 |
G |
A |
16: 20,324,027 (GRCm39) |
D457N |
probably damaging |
Het |
| Erbb3 |
T |
C |
10: 128,420,929 (GRCm39) |
T125A |
probably benign |
Het |
| Etv5 |
A |
C |
16: 22,254,627 (GRCm39) |
C78G |
probably benign |
Het |
| Frrs1 |
G |
A |
3: 116,684,582 (GRCm39) |
R263H |
probably benign |
Het |
| Grid1 |
G |
A |
14: 35,043,664 (GRCm39) |
D340N |
probably damaging |
Het |
| Hivep3 |
A |
T |
4: 119,952,400 (GRCm39) |
I239F |
possibly damaging |
Het |
| Ifi208 |
C |
T |
1: 173,510,394 (GRCm39) |
T183I |
probably damaging |
Het |
| Ifitm2 |
AG |
A |
7: 140,535,814 (GRCm39) |
|
probably null |
Het |
| Igkv1-88 |
T |
A |
6: 68,839,313 (GRCm39) |
I100F |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,614,165 (GRCm39) |
N185S |
probably benign |
Het |
| Kmt2d |
A |
C |
15: 98,743,697 (GRCm39) |
L3821R |
unknown |
Het |
| Krtap22-2 |
T |
G |
16: 88,807,478 (GRCm39) |
Y40S |
unknown |
Het |
| Lrrc1 |
A |
G |
9: 77,349,480 (GRCm39) |
V362A |
probably damaging |
Het |
| Malsu1 |
T |
A |
6: 49,061,449 (GRCm39) |
I171N |
probably damaging |
Het |
| Mark1 |
C |
T |
1: 184,648,345 (GRCm39) |
G314S |
possibly damaging |
Het |
| Mib2 |
T |
C |
4: 155,743,394 (GRCm39) |
N135S |
probably benign |
Het |
| Mos |
A |
T |
4: 3,870,886 (GRCm39) |
L310Q |
probably damaging |
Het |
| Muc4 |
C |
T |
16: 32,569,756 (GRCm39) |
T272I |
possibly damaging |
Het |
| Myo15b |
A |
G |
11: 115,771,064 (GRCm39) |
T1654A |
|
Het |
| Napsa |
G |
T |
7: 44,231,769 (GRCm39) |
G153W |
probably damaging |
Het |
| Nos3 |
A |
C |
5: 24,584,761 (GRCm39) |
I722L |
probably benign |
Het |
| Or10z1 |
A |
T |
1: 174,077,679 (GRCm39) |
D271E |
probably damaging |
Het |
| Or1p1c |
A |
T |
11: 74,160,743 (GRCm39) |
D176V |
probably damaging |
Het |
| Or51h1 |
A |
T |
7: 102,308,199 (GRCm39) |
H57L |
probably damaging |
Het |
| Or5b104 |
A |
T |
19: 13,072,513 (GRCm39) |
S166R |
probably benign |
Het |
| P4ha2 |
T |
A |
11: 54,002,390 (GRCm39) |
D109E |
possibly damaging |
Het |
| Pappa |
G |
T |
4: 65,042,918 (GRCm39) |
C47F |
unknown |
Het |
| Pbx3 |
T |
A |
2: 34,261,832 (GRCm39) |
H34L |
probably benign |
Het |
| Pcca |
A |
G |
14: 122,887,738 (GRCm39) |
T234A |
probably benign |
Het |
| Pcdha11 |
C |
T |
18: 37,144,514 (GRCm39) |
R202W |
probably damaging |
Het |
| Pcdhga1 |
T |
G |
18: 37,795,251 (GRCm39) |
V85G |
probably damaging |
Het |
| Pclo |
A |
G |
5: 14,726,562 (GRCm39) |
I1807V |
unknown |
Het |
| Pgm3 |
A |
T |
9: 86,437,413 (GRCm39) |
F528Y |
probably benign |
Het |
| Pigz |
T |
C |
16: 31,763,694 (GRCm39) |
Y251H |
probably damaging |
Het |
| Pik3c2g |
G |
T |
6: 139,821,161 (GRCm39) |
Q687H |
|
Het |
| Pja2 |
A |
T |
17: 64,590,432 (GRCm39) |
N700K |
unknown |
Het |
| Pkd2l2 |
T |
C |
18: 34,561,158 (GRCm39) |
F389L |
probably damaging |
Het |
| Plcz1 |
T |
A |
6: 139,985,446 (GRCm39) |
T32S |
possibly damaging |
Het |
| Pola2 |
A |
G |
19: 5,991,029 (GRCm39) |
V555A |
possibly damaging |
Het |
| Ppp4r3a |
A |
C |
12: 101,015,919 (GRCm39) |
C541G |
probably benign |
Het |
| Prr15l |
A |
T |
11: 96,825,599 (GRCm39) |
K76N |
probably damaging |
Het |
| Psg28 |
C |
A |
7: 18,156,905 (GRCm39) |
K443N |
possibly damaging |
Het |
| Ptch2 |
G |
T |
4: 116,954,197 (GRCm39) |
A76S |
probably damaging |
Het |
| Ptch2 |
A |
G |
4: 116,966,776 (GRCm39) |
D553G |
possibly damaging |
Het |
| Ptprz1 |
T |
C |
6: 23,000,855 (GRCm39) |
S982P |
probably benign |
Het |
| Rnd3 |
T |
C |
2: 51,038,844 (GRCm39) |
I15V |
probably benign |
Het |
| Rtn3 |
T |
C |
19: 7,460,328 (GRCm39) |
K41E |
unknown |
Het |
| Sap25 |
T |
C |
5: 137,639,985 (GRCm39) |
S30P |
probably benign |
Het |
| Scfd2 |
A |
T |
5: 74,692,006 (GRCm39) |
I92N |
probably damaging |
Het |
| Sdr16c5 |
T |
C |
4: 4,016,108 (GRCm39) |
Y106C |
probably damaging |
Het |
| Sell |
T |
C |
1: 163,893,177 (GRCm39) |
I131T |
probably damaging |
Het |
| Sesn3 |
T |
A |
9: 14,225,850 (GRCm39) |
V195D |
probably damaging |
Het |
| Setdb2 |
A |
G |
14: 59,660,816 (GRCm39) |
V109A |
unknown |
Het |
| Skint2 |
T |
C |
4: 112,483,054 (GRCm39) |
I153T |
probably benign |
Het |
| Slc22a1 |
A |
G |
17: 12,886,142 (GRCm39) |
S164P |
probably damaging |
Het |
| Sowahc |
G |
A |
10: 59,058,305 (GRCm39) |
G147D |
probably benign |
Het |
| Strip2 |
G |
C |
6: 29,931,824 (GRCm39) |
G456R |
probably benign |
Het |
| Synpo |
G |
T |
18: 60,735,472 (GRCm39) |
R825S |
probably damaging |
Het |
| Tango6 |
A |
G |
8: 107,415,701 (GRCm39) |
D174G |
probably benign |
Het |
| Tas1r2 |
T |
C |
4: 139,389,316 (GRCm39) |
F433S |
probably damaging |
Het |
| Tas2r126 |
T |
C |
6: 42,411,877 (GRCm39) |
S137P |
probably benign |
Het |
| Tbc1d15 |
A |
G |
10: 115,044,866 (GRCm39) |
F512S |
probably damaging |
Het |
| Tenm3 |
A |
T |
8: 48,870,115 (GRCm39) |
L226Q |
probably damaging |
Het |
| Tmod1 |
A |
G |
4: 46,078,368 (GRCm39) |
T59A |
probably damaging |
Het |
| Tmprss9 |
T |
A |
10: 80,730,787 (GRCm39) |
M771K |
probably benign |
Het |
| Trim29 |
T |
C |
9: 43,238,350 (GRCm39) |
Y485H |
possibly damaging |
Het |
| Ttc17 |
T |
C |
2: 94,189,198 (GRCm39) |
K144E |
probably benign |
Het |
| Ttc21b |
A |
G |
2: 66,057,287 (GRCm39) |
Y562H |
probably benign |
Het |
| Ugt2b5 |
T |
C |
5: 87,285,130 (GRCm39) |
H269R |
probably benign |
Het |
| Utp20 |
A |
G |
10: 88,649,798 (GRCm39) |
F471L |
probably damaging |
Het |
| Vmn2r120 |
T |
A |
17: 57,832,201 (GRCm39) |
D196V |
possibly damaging |
Het |
| Wdr72 |
T |
C |
9: 74,117,292 (GRCm39) |
V680A |
probably damaging |
Het |
| Wee1 |
G |
A |
7: 109,721,689 (GRCm39) |
G45S |
probably damaging |
Het |
| Zfp1006 |
A |
T |
8: 129,944,149 (GRCm39) |
D91E |
unknown |
Het |
| Zfp518a |
G |
A |
19: 40,901,225 (GRCm39) |
V385I |
probably benign |
Het |
|
| Other mutations in Adamtsl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Adamtsl1
|
APN |
4 |
86,303,877 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00741:Adamtsl1
|
APN |
4 |
86,195,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00770:Adamtsl1
|
APN |
4 |
86,306,776 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL00774:Adamtsl1
|
APN |
4 |
86,306,776 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL00826:Adamtsl1
|
APN |
4 |
86,075,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00938:Adamtsl1
|
APN |
4 |
86,260,515 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01012:Adamtsl1
|
APN |
4 |
86,260,426 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01728:Adamtsl1
|
APN |
4 |
86,029,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01801:Adamtsl1
|
APN |
4 |
86,117,559 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL01922:Adamtsl1
|
APN |
4 |
86,168,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02006:Adamtsl1
|
APN |
4 |
86,117,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02192:Adamtsl1
|
APN |
4 |
86,146,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02351:Adamtsl1
|
APN |
4 |
86,075,110 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02358:Adamtsl1
|
APN |
4 |
86,075,110 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02373:Adamtsl1
|
APN |
4 |
86,168,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02660:Adamtsl1
|
APN |
4 |
86,150,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02964:Adamtsl1
|
APN |
4 |
86,342,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03233:Adamtsl1
|
APN |
4 |
86,260,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Adamtsl1
|
APN |
4 |
86,341,663 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03326:Adamtsl1
|
APN |
4 |
86,170,985 (GRCm39) |
splice site |
probably benign |
|
|
PIT4378001:Adamtsl1
|
UTSW |
4 |
86,117,601 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4418001:Adamtsl1
|
UTSW |
4 |
86,161,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Adamtsl1
|
UTSW |
4 |
86,260,960 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0131:Adamtsl1
|
UTSW |
4 |
86,260,960 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0132:Adamtsl1
|
UTSW |
4 |
86,260,960 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0453:Adamtsl1
|
UTSW |
4 |
86,150,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0480:Adamtsl1
|
UTSW |
4 |
86,171,055 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0496:Adamtsl1
|
UTSW |
4 |
86,259,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Adamtsl1
|
UTSW |
4 |
86,261,358 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0547:Adamtsl1
|
UTSW |
4 |
86,274,592 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0567:Adamtsl1
|
UTSW |
4 |
86,146,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0568:Adamtsl1
|
UTSW |
4 |
86,336,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Adamtsl1
|
UTSW |
4 |
86,195,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0931:Adamtsl1
|
UTSW |
4 |
86,168,084 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1186:Adamtsl1
|
UTSW |
4 |
86,306,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1387:Adamtsl1
|
UTSW |
4 |
86,293,230 (GRCm39) |
splice site |
probably benign |
|
|
R1459:Adamtsl1
|
UTSW |
4 |
86,344,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1518:Adamtsl1
|
UTSW |
4 |
86,260,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1532:Adamtsl1
|
UTSW |
4 |
86,166,302 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1603:Adamtsl1
|
UTSW |
4 |
86,333,767 (GRCm39) |
missense |
probably benign |
|
|
R1931:Adamtsl1
|
UTSW |
4 |
86,260,648 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2086:Adamtsl1
|
UTSW |
4 |
86,146,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2221:Adamtsl1
|
UTSW |
4 |
86,306,762 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2223:Adamtsl1
|
UTSW |
4 |
86,306,762 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2396:Adamtsl1
|
UTSW |
4 |
86,261,356 (GRCm39) |
nonsense |
probably null |
|
|
R2397:Adamtsl1
|
UTSW |
4 |
86,117,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Adamtsl1
|
UTSW |
4 |
86,075,025 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3121:Adamtsl1
|
UTSW |
4 |
86,255,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3715:Adamtsl1
|
UTSW |
4 |
86,135,213 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3848:Adamtsl1
|
UTSW |
4 |
86,336,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3849:Adamtsl1
|
UTSW |
4 |
86,336,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3850:Adamtsl1
|
UTSW |
4 |
86,336,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4194:Adamtsl1
|
UTSW |
4 |
85,972,245 (GRCm39) |
intron |
probably benign |
|
|
R4354:Adamtsl1
|
UTSW |
4 |
86,074,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4795:Adamtsl1
|
UTSW |
4 |
86,162,006 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4830:Adamtsl1
|
UTSW |
4 |
86,274,619 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4874:Adamtsl1
|
UTSW |
4 |
86,260,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4939:Adamtsl1
|
UTSW |
4 |
86,161,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4942:Adamtsl1
|
UTSW |
4 |
86,259,451 (GRCm39) |
nonsense |
probably null |
|
|
R4947:Adamtsl1
|
UTSW |
4 |
85,683,037 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4960:Adamtsl1
|
UTSW |
4 |
86,342,410 (GRCm39) |
nonsense |
probably null |
|
|
R4971:Adamtsl1
|
UTSW |
4 |
86,255,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Adamtsl1
|
UTSW |
4 |
86,075,087 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5213:Adamtsl1
|
UTSW |
4 |
86,303,865 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5237:Adamtsl1
|
UTSW |
4 |
86,303,906 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5250:Adamtsl1
|
UTSW |
4 |
86,135,182 (GRCm39) |
nonsense |
probably null |
|
|
R5411:Adamtsl1
|
UTSW |
4 |
86,306,650 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5554:Adamtsl1
|
UTSW |
4 |
86,195,182 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5631:Adamtsl1
|
UTSW |
4 |
86,195,160 (GRCm39) |
nonsense |
probably null |
|
|
R5739:Adamtsl1
|
UTSW |
4 |
86,150,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5905:Adamtsl1
|
UTSW |
4 |
86,260,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6028:Adamtsl1
|
UTSW |
4 |
86,260,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6044:Adamtsl1
|
UTSW |
4 |
86,130,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6261:Adamtsl1
|
UTSW |
4 |
86,255,115 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6300:Adamtsl1
|
UTSW |
4 |
86,166,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Adamtsl1
|
UTSW |
4 |
86,135,248 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6560:Adamtsl1
|
UTSW |
4 |
86,255,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6693:Adamtsl1
|
UTSW |
4 |
86,261,123 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6736:Adamtsl1
|
UTSW |
4 |
86,260,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Adamtsl1
|
UTSW |
4 |
86,075,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Adamtsl1
|
UTSW |
4 |
86,260,278 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7434:Adamtsl1
|
UTSW |
4 |
86,344,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7477:Adamtsl1
|
UTSW |
4 |
86,333,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7545:Adamtsl1
|
UTSW |
4 |
85,683,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Adamtsl1
|
UTSW |
4 |
86,195,358 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7580:Adamtsl1
|
UTSW |
4 |
85,972,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7593:Adamtsl1
|
UTSW |
4 |
86,259,450 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7710:Adamtsl1
|
UTSW |
4 |
86,150,810 (GRCm39) |
missense |
|
|
|
R7908:Adamtsl1
|
UTSW |
4 |
86,274,676 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7934:Adamtsl1
|
UTSW |
4 |
86,161,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8056:Adamtsl1
|
UTSW |
4 |
86,260,269 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8109:Adamtsl1
|
UTSW |
4 |
86,166,306 (GRCm39) |
missense |
|
|
|
R8143:Adamtsl1
|
UTSW |
4 |
86,260,492 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8205:Adamtsl1
|
UTSW |
4 |
86,117,650 (GRCm39) |
makesense |
probably null |
|
|
R8215:Adamtsl1
|
UTSW |
4 |
86,261,382 (GRCm39) |
missense |
probably benign |
0.45 |
|
R8250:Adamtsl1
|
UTSW |
4 |
86,260,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8261:Adamtsl1
|
UTSW |
4 |
86,195,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8417:Adamtsl1
|
UTSW |
4 |
86,074,926 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8494:Adamtsl1
|
UTSW |
4 |
86,240,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Adamtsl1
|
UTSW |
4 |
86,260,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8525:Adamtsl1
|
UTSW |
4 |
86,195,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8688:Adamtsl1
|
UTSW |
4 |
86,166,263 (GRCm39) |
missense |
|
|
|
R8698:Adamtsl1
|
UTSW |
4 |
86,306,714 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8778:Adamtsl1
|
UTSW |
4 |
85,432,687 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9015:Adamtsl1
|
UTSW |
4 |
86,150,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9127:Adamtsl1
|
UTSW |
4 |
86,208,027 (GRCm39) |
missense |
probably benign |
|
|
R9326:Adamtsl1
|
UTSW |
4 |
86,150,804 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9394:Adamtsl1
|
UTSW |
4 |
86,135,225 (GRCm39) |
missense |
|
|
|
R9416:Adamtsl1
|
UTSW |
4 |
86,342,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Adamtsl1
|
UTSW |
4 |
86,117,543 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9627:Adamtsl1
|
UTSW |
4 |
86,306,762 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9675:Adamtsl1
|
UTSW |
4 |
86,161,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9798:Adamtsl1
|
UTSW |
4 |
86,074,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Adamtsl1
|
UTSW |
4 |
86,260,930 (GRCm39) |
missense |
probably benign |
0.30 |
|
Z1176:Adamtsl1
|
UTSW |
4 |
86,260,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGACAGTTGGGTTTGAAGC -3'
(R):5'- TACCAACGTAAACTGTAGTTGGAAG -3'
Sequencing Primer
(F):5'- ACAGTTGGGTTTGAAGCTTAAGAC -3'
(R):5'- AGTAACTTTGGGACTCACCAGCTG -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation