|Institutional Source||Beutler Lab|
|Gene Name||SET domain, bifurcated 2|
|Is this an essential gene?||Possibly essential (E-score: 0.529)|
|Stock #||R9336 (G1)|
|Chromosomal Location||59402009-59440884 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 59423367 bp (GRCm38)|
|Amino Acid Change||Valine to Alanine at position 109 (V109A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000106884 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000095775] [ENSMUST00000111253] [ENSMUST00000161459]|
AA Change: V109A
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit altered response to infection and improved patology following superinfection of influenza virus-infected mice with S. pneumonia. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Setdb2||
(F):5'- TTACAGGATGATGTAGACACTGAGC -3'
(R):5'- TCCGTTTGGGCAGAATTTCTAG -3'
(F):5'- TGTAGACACTGAGCTGACACTG -3'
(R):5'- GGGCAGAATTTCTAGTCAGTGAG -3'