Mutagenetix > Incidental Mutation

Incidental Mutation 'R9338:Or6c202'

707315

Institutional Source

Beutler Lab

Gene Symbol

Or6c202

Ensembl Gene

ENSMUSG00000061367

Gene Name

olfactory receptor family 6 subfamily C member 202

Synonyms

GA_x6K02T2PULF-10846420-10845467, Olfr771, MOR114-8

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R9338 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

128995898-128996851 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 128996610 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 81 (N81S)

Ref Sequence

ENSEMBL: ENSMUSP00000151108 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078914] [ENSMUST00000214271]

AlphaFold

Q8VFH6

Predicted Effect

probably benign
Transcript: ENSMUST00000078914
AA Change: N81S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000077948
Gene: ENSMUSG00000061367
AA Change: N81S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	304	8.9e-48	PFAM
Pfam:7tm_1	38	287	3e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214271
AA Change: N81S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb9	T	C	5: 124,228,176 (GRCm39)	T22A	possibly damaging	Het
Adam30	G	A	3: 98,070,129 (GRCm39)	G654D	probably damaging	Het
Cct3	T	C	3: 88,225,706 (GRCm39)	V343A	probably benign	Het
Col11a2	A	G	17: 34,266,204 (GRCm39)	T358A	unknown	Het
Cox6a2	T	C	7: 127,804,914 (GRCm39)	Y94C	probably damaging	Het
Cubn	T	A	2: 13,386,703 (GRCm39)	I1521F	probably damaging	Het
Dclk3	C	A	9: 111,268,373 (GRCm39)	A14E	unknown	Het
Dlgap2	T	C	8: 14,229,683 (GRCm39)		probably null	Het
Dop1b	C	A	16: 93,600,448 (GRCm39)	Q2042K	probably damaging	Het
Ech1	A	G	7: 28,525,427 (GRCm39)	S61G	probably null	Het
Ext2	T	A	2: 93,526,603 (GRCm39)	N678Y	probably damaging	Het
Fgfr2	G	T	7: 129,863,561 (GRCm39)	C28*	probably null	Het
Gon4l	C	A	3: 88,809,019 (GRCm39)	D1754E	probably benign	Het
Hivep2	T	A	10: 14,004,693 (GRCm39)	C430*	probably null	Het
Htr7	C	T	19: 35,941,780 (GRCm39)		probably null	Het
Idh3b	A	T	2: 130,122,392 (GRCm39)	M331K	probably damaging	Het
Ighv2-7	A	T	12: 113,771,118 (GRCm39)	F56I	probably benign	Het
Inpp5k	C	T	11: 75,536,411 (GRCm39)	H330Y	probably damaging	Het
Kif26b	T	C	1: 178,744,058 (GRCm39)	Y1385H	probably damaging	Het
Mad1l1	A	G	5: 140,074,561 (GRCm39)	L543P	probably damaging	Het
Mdn1	A	T	4: 32,666,536 (GRCm39)	H158L	probably benign	Het
Mpp2	T	A	11: 101,951,249 (GRCm39)	T511S	probably benign	Het
Msantd5f6	T	C	4: 73,320,245 (GRCm39)	E178G	possibly damaging	Het
Msh4	T	C	3: 153,573,444 (GRCm39)	I737V	possibly damaging	Het
Myo15b	T	C	11: 115,762,238 (GRCm39)	L1186P		Het
Nckap1l	A	G	15: 103,379,991 (GRCm39)	T346A	probably benign	Het
Nox4	G	A	7: 87,025,448 (GRCm39)	R525Q	probably benign	Het
Npy5r	T	C	8: 67,134,658 (GRCm39)	N45S	probably benign	Het
Pde6a	G	A	18: 61,354,109 (GRCm39)	A145T	probably damaging	Het
Pfkp	A	C	13: 6,634,724 (GRCm39)	S678A	probably damaging	Het
Phxr2	A	G	10: 98,962,043 (GRCm39)		probably benign	Het
Pi4ka	C	A	16: 17,135,227 (GRCm39)	L942F		Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 110,350,827 (GRCm39)		probably benign	Het
Pla2g4e	T	A	2: 120,019,914 (GRCm39)	T179S	probably benign	Het
Popdc2	G	A	16: 38,194,509 (GRCm39)	C310Y	probably benign	Het
Ppip5k1	C	T	2: 121,153,827 (GRCm39)	R113Q		Het
Prmt7	C	T	8: 106,961,665 (GRCm39)	R193C	unknown	Het
Prph	G	C	15: 98,955,359 (GRCm39)	R442P	probably damaging	Het
Prrc2b	A	G	2: 32,098,779 (GRCm39)	Y697C	probably damaging	Het
Ptprm	T	A	17: 67,069,143 (GRCm39)	R962S	probably damaging	Het
Raph1	A	G	1: 60,529,300 (GRCm39)	S654P	unknown	Het
Reln	A	G	5: 22,202,937 (GRCm39)	F1288L	probably damaging	Het
Rhot1	T	A	11: 80,145,568 (GRCm39)	I553N	probably benign	Het
Rnf168	T	C	16: 32,110,801 (GRCm39)		probably null	Het
Slamf6	T	A	1: 171,747,157 (GRCm39)		probably benign	Het
Srgap1	CTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTC	CTACCTCCTCTTAGGGACCACGCCCACCCCCTCCCAGGGACCATGCTTACCTCCTC	10: 121,689,458 (GRCm39)		probably benign	Het
Taf4b	C	T	18: 14,954,555 (GRCm39)	P544S	probably benign	Het
Tbc1d24	A	G	17: 24,427,377 (GRCm39)	V195A	probably benign	Het
Tomm70a	A	G	16: 56,942,399 (GRCm39)	M59V	probably benign	Het
Trip12	A	G	1: 84,727,019 (GRCm39)	S1184P	probably damaging	Het
Trrap	A	G	5: 144,727,925 (GRCm39)	S549G	probably benign	Het
Unc5d	T	A	8: 29,709,471 (GRCm39)		probably benign	Het
Ush2a	G	A	1: 188,308,489 (GRCm39)		probably null	Het
Usp45	T	C	4: 21,784,755 (GRCm39)	V147A	probably damaging	Het
Vmn2r77	T	A	7: 86,460,994 (GRCm39)	N773K	probably damaging	Het
Vps13c	A	T	9: 67,858,977 (GRCm39)	N2809I	probably damaging	Het
Yeats2	T	A	16: 20,032,078 (GRCm39)	S984R	possibly damaging	Het
Yeats2	T	A	16: 20,041,533 (GRCm39)	L1141Q	probably damaging	Het
Zfp58	T	A	13: 67,639,394 (GRCm39)	T366S	probably benign	Het

Other mutations in Or6c202

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02341:Or6c202	APN	10	128,996,302 (GRCm39)	missense	probably benign	0.30
IGL02366:Or6c202	APN	10	128,996,494 (GRCm39)	missense	probably damaging	1.00
IGL02947:Or6c202	APN	10	128,996,439 (GRCm39)	missense	probably damaging	1.00
R0040:Or6c202	UTSW	10	128,996,608 (GRCm39)	missense	probably benign	0.10
R0081:Or6c202	UTSW	10	128,996,707 (GRCm39)	missense	possibly damaging	0.55
R1179:Or6c202	UTSW	10	128,995,927 (GRCm39)	missense	probably benign	0.00
R1328:Or6c202	UTSW	10	128,996,293 (GRCm39)	missense	possibly damaging	0.54
R1701:Or6c202	UTSW	10	128,995,974 (GRCm39)	missense	probably damaging	1.00
R4470:Or6c202	UTSW	10	128,996,383 (GRCm39)	missense	probably benign	0.16
R4814:Or6c202	UTSW	10	128,996,245 (GRCm39)	missense	possibly damaging	0.77
R5106:Or6c202	UTSW	10	128,996,106 (GRCm39)	missense	probably damaging	0.99
R5109:Or6c202	UTSW	10	128,996,106 (GRCm39)	missense	probably damaging	0.99
R5209:Or6c202	UTSW	10	128,996,801 (GRCm39)	missense	possibly damaging	0.74
R5646:Or6c202	UTSW	10	128,996,706 (GRCm39)	missense	possibly damaging	0.55
R6114:Or6c202	UTSW	10	128,996,202 (GRCm39)	missense	probably benign
R6133:Or6c202	UTSW	10	128,996,752 (GRCm39)	missense	possibly damaging	0.55
R6879:Or6c202	UTSW	10	128,996,848 (GRCm39)	missense	probably benign	0.04
R7358:Or6c202	UTSW	10	128,995,939 (GRCm39)	missense	probably benign
R7426:Or6c202	UTSW	10	128,996,620 (GRCm39)	missense	possibly damaging	0.67
R7699:Or6c202	UTSW	10	128,995,924 (GRCm39)	missense	probably benign
R7700:Or6c202	UTSW	10	128,995,924 (GRCm39)	missense	probably benign
R8232:Or6c202	UTSW	10	128,996,097 (GRCm39)	missense	probably damaging	1.00
R8695:Or6c202	UTSW	10	128,996,233 (GRCm39)	missense	probably damaging	0.99
R8885:Or6c202	UTSW	10	128,996,334 (GRCm39)	missense	probably benign	0.00
R8959:Or6c202	UTSW	10	128,996,484 (GRCm39)	missense	probably damaging	1.00
R9497:Or6c202	UTSW	10	128,996,464 (GRCm39)	missense	probably benign	0.01
Z1177:Or6c202	UTSW	10	128,996,271 (GRCm39)	missense	probably benign	0.07

Predicted Primers

PCR Primer
(F):5'- GCAGAGAACAAGCGTCTGAC -3'
(R):5'- GCTGGGACTAACAGATGATCC -3'

Sequencing Primer
(F):5'- AGCGTCTGACACACCTTG -3'
(R):5'- GGGACTAACAGATGATCCTCAACTTC -3'

Posted On

2022-04-18