Incidental Mutation 'R0742:Lyz1'
ID 70734
Institutional Source Beutler Lab
Gene Symbol Lyz1
Ensembl Gene ENSMUSG00000069515
Gene Name lysozyme 1
Synonyms Lzp-s, Lyz, renal amyloidosis
MMRRC Submission 038923-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0742 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 117123702-117128773 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 117125022 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000089800 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092162] [ENSMUST00000092162]
AlphaFold P17897
Predicted Effect probably null
Transcript: ENSMUST00000092162
SMART Domains Protein: ENSMUSP00000089800
Gene: ENSMUSG00000069515

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LYZ1 19 147 4.61e-97 SMART
Predicted Effect probably null
Transcript: ENSMUST00000092162
SMART Domains Protein: ENSMUSP00000089800
Gene: ENSMUSG00000069515

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LYZ1 19 147 4.61e-97 SMART
Meta Mutation Damage Score 0.9493 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: This locus controls heat stability of lysozyme P. The d allele determines low heat stability in C3H/He; the c allele determines high heat stability in CASA. Another variation, measured as electrophoretic mobility, is seen between BALB/c and M. spretus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg2 T A 6: 58,655,311 (GRCm39) D415E probably benign Het
Aff3 A G 1: 38,666,189 (GRCm39) W12R probably damaging Het
Aldh3b2 G A 19: 4,031,034 (GRCm39) G428S probably damaging Het
Arhgef10l A G 4: 140,264,156 (GRCm39) L736P probably damaging Het
Baz2a G T 10: 127,949,535 (GRCm39) E374* probably null Het
Casd1 T C 6: 4,635,888 (GRCm39) probably null Het
Cct2 A T 10: 116,891,151 (GRCm39) probably null Het
Cdc42bpg G A 19: 6,368,605 (GRCm39) probably null Het
Copg2 T C 6: 30,840,548 (GRCm39) probably null Het
Fbxw15 C T 9: 109,384,624 (GRCm39) probably null Het
Fyb1 A G 15: 6,664,297 (GRCm39) D460G probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mroh3 A T 1: 136,118,718 (GRCm39) I533N probably damaging Het
Otogl A G 10: 107,702,601 (GRCm39) V684A possibly damaging Het
Pcdh15 A G 10: 74,457,129 (GRCm39) D1302G probably damaging Het
Plec A T 15: 76,056,983 (GRCm39) I4183N probably damaging Het
Rpe C T 1: 66,754,300 (GRCm39) T124I probably benign Het
Rufy4 T C 1: 74,185,875 (GRCm39) I514T probably benign Het
Scap T A 9: 110,210,327 (GRCm39) L912Q probably damaging Het
Sec61a2 T C 2: 5,881,359 (GRCm39) D264G probably benign Het
Slc4a3 T A 1: 75,532,725 (GRCm39) I995K probably damaging Het
Sptbn2 T C 19: 4,769,011 (GRCm39) I48T possibly damaging Het
Steap3 C T 1: 120,169,313 (GRCm39) R328H possibly damaging Het
Thoc2l G A 5: 104,670,020 (GRCm39) S1514N probably benign Het
Tmprss13 T C 9: 45,243,765 (GRCm39) F167S probably damaging Het
Ttc3 G A 16: 94,260,739 (GRCm39) C1408Y probably benign Het
Twf1 A G 15: 94,483,411 (GRCm39) M99T probably damaging Het
Unc80 A G 1: 66,567,052 (GRCm39) N886S possibly damaging Het
Vmn2r12 T A 5: 109,234,281 (GRCm39) T644S possibly damaging Het
Vps13b A G 15: 35,794,507 (GRCm39) S2306G probably benign Het
Xpo1 T C 11: 23,244,682 (GRCm39) V1020A possibly damaging Het
Ylpm1 T A 12: 85,075,886 (GRCm39) N870K probably benign Het
Other mutations in Lyz1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01351:Lyz1 APN 10 117,127,093 (GRCm39) missense probably damaging 1.00
IGL02420:Lyz1 APN 10 117,124,535 (GRCm39) missense probably damaging 1.00
R0507:Lyz1 UTSW 10 117,125,022 (GRCm39) critical splice donor site probably null
R1183:Lyz1 UTSW 10 117,128,715 (GRCm39) missense probably damaging 1.00
R2092:Lyz1 UTSW 10 117,124,504 (GRCm39) missense probably benign 0.00
R4629:Lyz1 UTSW 10 117,127,041 (GRCm39) missense probably benign
R9090:Lyz1 UTSW 10 117,124,492 (GRCm39) missense possibly damaging 0.49
R9271:Lyz1 UTSW 10 117,124,492 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- ACAGGATGCTCAAGAGCAATGCC -3'
(R):5'- TCGCTGCTTACTGCCACAGAGAAC -3'

Sequencing Primer
(F):5'- GATGCTCAAGAGCAATGCCTTATC -3'
(R):5'- TGCCACAGAGAACGCTGG -3'
Posted On 2013-09-30