Incidental Mutation 'R9339:Adam25'
ID 707381
Institutional Source Beutler Lab
Gene Symbol Adam25
Ensembl Gene ENSMUSG00000071937
Gene Name ADAM metallopeptidase domain 25
Synonyms testase 2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R9339 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 41205245-41209213 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41206911 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 59 (V59A)
Ref Sequence ENSEMBL: ENSMUSP00000094420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096663]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000096663
AA Change: V59A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000094420
Gene: ENSMUSG00000071937
AA Change: V59A

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 53 179 3.4e-21 PFAM
Pfam:Reprolysin_5 220 398 1.6e-16 PFAM
Pfam:Reprolysin_4 220 407 2.5e-13 PFAM
Pfam:Reprolysin 221 410 5.6e-46 PFAM
Pfam:Reprolysin_2 222 399 9.7e-14 PFAM
Pfam:Reprolysin_3 246 366 1e-18 PFAM
DISIN 428 503 3.33e-39 SMART
ACR 504 640 8.95e-74 SMART
transmembrane domain 706 728 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A G 16: 4,667,521 (GRCm39) E304G unknown Het
4933436I01Rik T A X: 66,964,689 (GRCm39) K57* probably null Het
Aar2 T C 2: 156,392,893 (GRCm39) V94A probably benign Het
Abcb9 T C 5: 124,228,176 (GRCm39) T22A possibly damaging Het
Ampd2 T C 3: 107,987,616 (GRCm39) D103G probably damaging Het
Ankrd12 A G 17: 66,291,408 (GRCm39) S1342P probably benign Het
Atp13a2 A G 4: 140,730,571 (GRCm39) T739A probably benign Het
Catsperg1 T A 7: 28,894,885 (GRCm39) N571Y probably benign Het
Cela3b A G 4: 137,152,355 (GRCm39) I74T probably damaging Het
Cfhr1 A G 1: 139,485,293 (GRCm39) L51P probably benign Het
Cfhr4 T A 1: 139,682,044 (GRCm39) Y184F probably benign Het
Ckap5 T A 2: 91,396,100 (GRCm39) D534E probably benign Het
Cstf3 C T 2: 104,493,778 (GRCm39) P594L probably damaging Het
Ctdp1 A G 18: 80,492,689 (GRCm39) L602P probably damaging Het
Defa24 A G 8: 22,224,559 (GRCm39) T3A probably damaging Het
Dmgdh A G 13: 93,847,941 (GRCm39) H546R probably benign Het
Dscam A G 16: 96,517,263 (GRCm39) V882A possibly damaging Het
Dydc2 A G 14: 40,771,260 (GRCm39) *140Q probably null Het
Ehd4 T C 2: 119,921,708 (GRCm39) D516G possibly damaging Het
En1 T C 1: 120,534,893 (GRCm39) V394A unknown Het
Erich3 T G 3: 154,468,872 (GRCm39) L1108R unknown Het
Erp27 A G 6: 136,896,945 (GRCm39) S86P probably benign Het
Esr1 A C 10: 4,696,798 (GRCm39) S216R probably damaging Het
Fbxo40 A T 16: 36,789,286 (GRCm39) I608N probably damaging Het
Fcna G A 2: 25,517,782 (GRCm39) Q23* probably null Het
Foxn4 C T 5: 114,394,955 (GRCm39) R324Q probably benign Het
Gata6 A G 18: 11,054,520 (GRCm39) T150A probably damaging Het
Gbp2b T A 3: 142,317,178 (GRCm39) H511Q probably benign Het
Gpr171 C A 3: 59,005,362 (GRCm39) V138L probably damaging Het
Grhl2 G A 15: 37,344,904 (GRCm39) V509I probably benign Het
Gzmd G A 14: 56,367,869 (GRCm39) P135S probably damaging Het
Hhatl C A 9: 121,618,862 (GRCm39) C90F probably benign Het
Hspg2 A G 4: 137,278,480 (GRCm39) K3050R probably benign Het
Kcnh3 T C 15: 99,130,786 (GRCm39) Y468H probably damaging Het
Lhfpl6 A G 3: 52,950,891 (GRCm39) H55R probably benign Het
Lpgat1 T C 1: 191,451,488 (GRCm39) V38A probably benign Het
Lrrc49 A G 9: 60,510,031 (GRCm39) I479T probably benign Het
Map1b A T 13: 99,567,570 (GRCm39) I1717N unknown Het
Map3k20 G T 2: 72,272,216 (GRCm39) R781S possibly damaging Het
Mcm3ap A G 10: 76,306,358 (GRCm39) E157G probably benign Het
Mylk2 A G 2: 152,755,370 (GRCm39) E178G probably damaging Het
Naaladl2 A G 3: 24,057,146 (GRCm39) L605P probably damaging Het
Nox4 G A 7: 87,025,448 (GRCm39) R525Q probably benign Het
Nt5el C T 13: 105,246,114 (GRCm39) T225I probably benign Het
Or10h28 T C 17: 33,488,631 (GRCm39) V311A probably benign Het
Or4a76 T C 2: 89,460,555 (GRCm39) E229G probably damaging Het
Padi3 A T 4: 140,522,928 (GRCm39) I348N probably benign Het
Pcdh18 T C 3: 49,709,335 (GRCm39) D660G probably damaging Het
Pdgfra T A 5: 75,355,635 (GRCm39) S1048R probably damaging Het
Pkhd1l1 T C 15: 44,452,949 (GRCm39) V3958A probably damaging Het
Ppargc1b C A 18: 61,456,267 (GRCm39) C80F probably damaging Het
Rbm28 T C 6: 29,128,674 (GRCm39) E590G probably benign Het
Rbm47 T C 5: 66,183,826 (GRCm39) E259G possibly damaging Het
Rint1 A G 5: 23,993,355 (GRCm39) *37W probably null Het
Sacs G A 14: 61,443,309 (GRCm39) R1785Q probably benign Het
Samm50 T C 15: 84,095,276 (GRCm39) C421R probably benign Het
Scnn1b G T 7: 121,511,254 (GRCm39) A314S probably damaging Het
Sf3b3 C A 8: 111,542,854 (GRCm39) V868L probably benign Het
Sirt5 G T 13: 43,530,327 (GRCm39) V136L probably benign Het
Slc1a7 T C 4: 107,850,237 (GRCm39) V116A probably damaging Het
Slc24a4 G A 12: 102,230,638 (GRCm39) V510M probably damaging Het
Slc35f5 T C 1: 125,517,628 (GRCm39) I116T probably benign Het
Spata4 T C 8: 55,053,899 (GRCm39) S22P probably benign Het
Sqstm1 A G 11: 50,091,725 (GRCm39) V324A probably benign Het
Stmnd1 G A 13: 46,453,079 (GRCm39) A252T probably benign Het
Tbl1xr1 C A 3: 22,258,150 (GRCm39) N470K possibly damaging Het
Thap12 T C 7: 98,364,323 (GRCm39) S164P possibly damaging Het
Thsd1 A G 8: 22,733,898 (GRCm39) Y315C probably damaging Het
Tnni2 C A 7: 141,997,672 (GRCm39) D102E probably damaging Het
Trav7n-4 A C 14: 53,328,849 (GRCm39) N16T probably benign Het
Trpm7 T C 2: 126,665,906 (GRCm39) K900R probably benign Het
Tspoap1 T A 11: 87,668,839 (GRCm39) C1371S probably benign Het
Tssk5 A G 15: 76,257,156 (GRCm39) M242T possibly damaging Het
Ubn2 A G 6: 38,460,079 (GRCm39) I607V probably benign Het
Ubr2 A T 17: 47,284,865 (GRCm39) V551E probably benign Het
Vipr2 A G 12: 116,058,344 (GRCm39) N87S probably damaging Het
Vmn2r18 T A 5: 151,485,132 (GRCm39) K787N probably damaging Het
Wwc2 A T 8: 48,353,859 (GRCm39) W92R probably damaging Het
Zfp141 A G 7: 42,125,639 (GRCm39) Y278H probably damaging Het
Zfp827 T C 8: 79,844,887 (GRCm39) S686P probably benign Het
Other mutations in Adam25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Adam25 APN 8 41,207,958 (GRCm39) missense probably benign
IGL01977:Adam25 APN 8 41,208,134 (GRCm39) missense probably benign 0.00
IGL02098:Adam25 APN 8 41,208,680 (GRCm39) missense probably benign 0.12
IGL02233:Adam25 APN 8 41,208,423 (GRCm39) missense probably damaging 1.00
IGL02458:Adam25 APN 8 41,206,844 (GRCm39) missense probably benign 0.01
IGL02527:Adam25 APN 8 41,206,785 (GRCm39) missense possibly damaging 0.78
IGL02632:Adam25 APN 8 41,208,237 (GRCm39) missense possibly damaging 0.90
IGL02995:Adam25 APN 8 41,206,760 (GRCm39) missense probably benign 0.00
H8786:Adam25 UTSW 8 41,207,261 (GRCm39) missense probably benign 0.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0189:Adam25 UTSW 8 41,208,467 (GRCm39) missense probably damaging 1.00
R0505:Adam25 UTSW 8 41,208,261 (GRCm39) missense probably damaging 1.00
R0532:Adam25 UTSW 8 41,208,987 (GRCm39) missense probably benign 0.00
R0699:Adam25 UTSW 8 41,209,011 (GRCm39) missense probably benign
R0972:Adam25 UTSW 8 41,208,168 (GRCm39) missense probably damaging 1.00
R1053:Adam25 UTSW 8 41,207,768 (GRCm39) missense probably benign 0.30
R1079:Adam25 UTSW 8 41,208,513 (GRCm39) missense possibly damaging 0.87
R1872:Adam25 UTSW 8 41,208,263 (GRCm39) nonsense probably null
R1933:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R1934:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R4061:Adam25 UTSW 8 41,206,819 (GRCm39) missense possibly damaging 0.67
R4702:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4703:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4705:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4859:Adam25 UTSW 8 41,207,580 (GRCm39) missense probably benign 0.01
R5015:Adam25 UTSW 8 41,207,671 (GRCm39) missense probably benign 0.22
R5249:Adam25 UTSW 8 41,208,991 (GRCm39) missense probably benign
R5628:Adam25 UTSW 8 41,208,747 (GRCm39) missense probably benign 0.00
R5791:Adam25 UTSW 8 41,207,257 (GRCm39) missense probably benign
R6439:Adam25 UTSW 8 41,207,627 (GRCm39) missense possibly damaging 0.92
R6693:Adam25 UTSW 8 41,207,568 (GRCm39) missense probably damaging 1.00
R7041:Adam25 UTSW 8 41,207,121 (GRCm39) missense probably benign 0.04
R7101:Adam25 UTSW 8 41,208,438 (GRCm39) missense probably benign 0.00
R7531:Adam25 UTSW 8 41,206,914 (GRCm39) missense probably damaging 0.99
R7600:Adam25 UTSW 8 41,208,854 (GRCm39) missense probably benign 0.01
R7634:Adam25 UTSW 8 41,207,883 (GRCm39) missense probably benign 0.00
R7964:Adam25 UTSW 8 41,208,576 (GRCm39) missense probably damaging 0.99
R8017:Adam25 UTSW 8 41,207,124 (GRCm39) missense possibly damaging 0.56
R8021:Adam25 UTSW 8 41,207,796 (GRCm39) missense probably damaging 1.00
R8499:Adam25 UTSW 8 41,208,189 (GRCm39) missense probably damaging 1.00
R8686:Adam25 UTSW 8 41,208,521 (GRCm39) missense probably benign 0.44
R8715:Adam25 UTSW 8 41,207,099 (GRCm39) missense probably benign 0.00
R8847:Adam25 UTSW 8 41,206,746 (GRCm39) missense probably benign
R8921:Adam25 UTSW 8 41,207,710 (GRCm39) nonsense probably null
R9120:Adam25 UTSW 8 41,209,141 (GRCm39) utr 3 prime probably benign
R9158:Adam25 UTSW 8 41,208,645 (GRCm39) missense probably damaging 1.00
R9348:Adam25 UTSW 8 41,208,953 (GRCm39) missense probably benign
R9454:Adam25 UTSW 8 41,207,486 (GRCm39) missense probably damaging 0.99
R9492:Adam25 UTSW 8 41,206,736 (GRCm39) start codon destroyed probably benign 0.12
R9680:Adam25 UTSW 8 41,208,239 (GRCm39) missense probably damaging 1.00
RF006:Adam25 UTSW 8 41,208,834 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CATTAAAAGCCAGCACTGCATG -3'
(R):5'- GGCCATGGTAGTAGCAATCATTC -3'

Sequencing Primer
(F):5'- CTGCATGCAGACAAGACAAAG -3'
(R):5'- ATCATTCTGGACATAAGGCTGGTCC -3'
Posted On 2022-04-18