Incidental Mutation 'R9339:Ubr2'
| ID |
707412 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr2
|
| Ensembl Gene |
ENSMUSG00000023977 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 2 |
| Synonyms |
ENSMUSG00000043296, E130209G04Rik, 9930021A08Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.872)
|
| Stock # |
R9339 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
47239221-47321482 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 47284865 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 551
(V551E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108961
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000113335]
[ENSMUST00000113337]
[ENSMUST00000225599]
|
| AlphaFold |
Q6WKZ8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113335
AA Change: V551E
PolyPhen 2
Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000108961
Gene: ENSMUSG00000023977
AA Change: V551E
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
221 |
302 |
2.4e-23 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000113337
AA Change: V551E
PolyPhen 2
Score 0.298 (Sensitivity: 0.91; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000108963
Gene: ENSMUSG00000023977
AA Change: V551E
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
222 |
301 |
6.2e-26 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225599
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
99% (77/78) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
A |
G |
16: 4,667,521 (GRCm39) |
E304G |
unknown |
Het |
| 4933436I01Rik |
T |
A |
X: 66,964,689 (GRCm39) |
K57* |
probably null |
Het |
| Aar2 |
T |
C |
2: 156,392,893 (GRCm39) |
V94A |
probably benign |
Het |
| Abcb9 |
T |
C |
5: 124,228,176 (GRCm39) |
T22A |
possibly damaging |
Het |
| Adam25 |
T |
C |
8: 41,206,911 (GRCm39) |
V59A |
probably damaging |
Het |
| Ampd2 |
T |
C |
3: 107,987,616 (GRCm39) |
D103G |
probably damaging |
Het |
| Ankrd12 |
A |
G |
17: 66,291,408 (GRCm39) |
S1342P |
probably benign |
Het |
| Atp13a2 |
A |
G |
4: 140,730,571 (GRCm39) |
T739A |
probably benign |
Het |
| Catsperg1 |
T |
A |
7: 28,894,885 (GRCm39) |
N571Y |
probably benign |
Het |
| Cela3b |
A |
G |
4: 137,152,355 (GRCm39) |
I74T |
probably damaging |
Het |
| Cfhr1 |
A |
G |
1: 139,485,293 (GRCm39) |
L51P |
probably benign |
Het |
| Cfhr4 |
T |
A |
1: 139,682,044 (GRCm39) |
Y184F |
probably benign |
Het |
| Ckap5 |
T |
A |
2: 91,396,100 (GRCm39) |
D534E |
probably benign |
Het |
| Cstf3 |
C |
T |
2: 104,493,778 (GRCm39) |
P594L |
probably damaging |
Het |
| Ctdp1 |
A |
G |
18: 80,492,689 (GRCm39) |
L602P |
probably damaging |
Het |
| Defa24 |
A |
G |
8: 22,224,559 (GRCm39) |
T3A |
probably damaging |
Het |
| Dmgdh |
A |
G |
13: 93,847,941 (GRCm39) |
H546R |
probably benign |
Het |
| Dscam |
A |
G |
16: 96,517,263 (GRCm39) |
V882A |
possibly damaging |
Het |
| Dydc2 |
A |
G |
14: 40,771,260 (GRCm39) |
*140Q |
probably null |
Het |
| Ehd4 |
T |
C |
2: 119,921,708 (GRCm39) |
D516G |
possibly damaging |
Het |
| En1 |
T |
C |
1: 120,534,893 (GRCm39) |
V394A |
unknown |
Het |
| Erich3 |
T |
G |
3: 154,468,872 (GRCm39) |
L1108R |
unknown |
Het |
| Erp27 |
A |
G |
6: 136,896,945 (GRCm39) |
S86P |
probably benign |
Het |
| Esr1 |
A |
C |
10: 4,696,798 (GRCm39) |
S216R |
probably damaging |
Het |
| Fbxo40 |
A |
T |
16: 36,789,286 (GRCm39) |
I608N |
probably damaging |
Het |
| Fcna |
G |
A |
2: 25,517,782 (GRCm39) |
Q23* |
probably null |
Het |
| Foxn4 |
C |
T |
5: 114,394,955 (GRCm39) |
R324Q |
probably benign |
Het |
| Gata6 |
A |
G |
18: 11,054,520 (GRCm39) |
T150A |
probably damaging |
Het |
| Gbp2b |
T |
A |
3: 142,317,178 (GRCm39) |
H511Q |
probably benign |
Het |
| Gpr171 |
C |
A |
3: 59,005,362 (GRCm39) |
V138L |
probably damaging |
Het |
| Grhl2 |
G |
A |
15: 37,344,904 (GRCm39) |
V509I |
probably benign |
Het |
| Gzmd |
G |
A |
14: 56,367,869 (GRCm39) |
P135S |
probably damaging |
Het |
| Hhatl |
C |
A |
9: 121,618,862 (GRCm39) |
C90F |
probably benign |
Het |
| Hspg2 |
A |
G |
4: 137,278,480 (GRCm39) |
K3050R |
probably benign |
Het |
| Kcnh3 |
T |
C |
15: 99,130,786 (GRCm39) |
Y468H |
probably damaging |
Het |
| Lhfpl6 |
A |
G |
3: 52,950,891 (GRCm39) |
H55R |
probably benign |
Het |
| Lpgat1 |
T |
C |
1: 191,451,488 (GRCm39) |
V38A |
probably benign |
Het |
| Lrrc49 |
A |
G |
9: 60,510,031 (GRCm39) |
I479T |
probably benign |
Het |
| Map1b |
A |
T |
13: 99,567,570 (GRCm39) |
I1717N |
unknown |
Het |
| Map3k20 |
G |
T |
2: 72,272,216 (GRCm39) |
R781S |
possibly damaging |
Het |
| Mcm3ap |
A |
G |
10: 76,306,358 (GRCm39) |
E157G |
probably benign |
Het |
| Mylk2 |
A |
G |
2: 152,755,370 (GRCm39) |
E178G |
probably damaging |
Het |
| Naaladl2 |
A |
G |
3: 24,057,146 (GRCm39) |
L605P |
probably damaging |
Het |
| Nox4 |
G |
A |
7: 87,025,448 (GRCm39) |
R525Q |
probably benign |
Het |
| Nt5el |
C |
T |
13: 105,246,114 (GRCm39) |
T225I |
probably benign |
Het |
| Or10h28 |
T |
C |
17: 33,488,631 (GRCm39) |
V311A |
probably benign |
Het |
| Or4a76 |
T |
C |
2: 89,460,555 (GRCm39) |
E229G |
probably damaging |
Het |
| Padi3 |
A |
T |
4: 140,522,928 (GRCm39) |
I348N |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,709,335 (GRCm39) |
D660G |
probably damaging |
Het |
| Pdgfra |
T |
A |
5: 75,355,635 (GRCm39) |
S1048R |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,452,949 (GRCm39) |
V3958A |
probably damaging |
Het |
| Ppargc1b |
C |
A |
18: 61,456,267 (GRCm39) |
C80F |
probably damaging |
Het |
| Rbm28 |
T |
C |
6: 29,128,674 (GRCm39) |
E590G |
probably benign |
Het |
| Rbm47 |
T |
C |
5: 66,183,826 (GRCm39) |
E259G |
possibly damaging |
Het |
| Rint1 |
A |
G |
5: 23,993,355 (GRCm39) |
*37W |
probably null |
Het |
| Sacs |
G |
A |
14: 61,443,309 (GRCm39) |
R1785Q |
probably benign |
Het |
| Samm50 |
T |
C |
15: 84,095,276 (GRCm39) |
C421R |
probably benign |
Het |
| Scnn1b |
G |
T |
7: 121,511,254 (GRCm39) |
A314S |
probably damaging |
Het |
| Sf3b3 |
C |
A |
8: 111,542,854 (GRCm39) |
V868L |
probably benign |
Het |
| Sirt5 |
G |
T |
13: 43,530,327 (GRCm39) |
V136L |
probably benign |
Het |
| Slc1a7 |
T |
C |
4: 107,850,237 (GRCm39) |
V116A |
probably damaging |
Het |
| Slc24a4 |
G |
A |
12: 102,230,638 (GRCm39) |
V510M |
probably damaging |
Het |
| Slc35f5 |
T |
C |
1: 125,517,628 (GRCm39) |
I116T |
probably benign |
Het |
| Spata4 |
T |
C |
8: 55,053,899 (GRCm39) |
S22P |
probably benign |
Het |
| Sqstm1 |
A |
G |
11: 50,091,725 (GRCm39) |
V324A |
probably benign |
Het |
| Stmnd1 |
G |
A |
13: 46,453,079 (GRCm39) |
A252T |
probably benign |
Het |
| Tbl1xr1 |
C |
A |
3: 22,258,150 (GRCm39) |
N470K |
possibly damaging |
Het |
| Thap12 |
T |
C |
7: 98,364,323 (GRCm39) |
S164P |
possibly damaging |
Het |
| Thsd1 |
A |
G |
8: 22,733,898 (GRCm39) |
Y315C |
probably damaging |
Het |
| Tnni2 |
C |
A |
7: 141,997,672 (GRCm39) |
D102E |
probably damaging |
Het |
| Trav7n-4 |
A |
C |
14: 53,328,849 (GRCm39) |
N16T |
probably benign |
Het |
| Trpm7 |
T |
C |
2: 126,665,906 (GRCm39) |
K900R |
probably benign |
Het |
| Tspoap1 |
T |
A |
11: 87,668,839 (GRCm39) |
C1371S |
probably benign |
Het |
| Tssk5 |
A |
G |
15: 76,257,156 (GRCm39) |
M242T |
possibly damaging |
Het |
| Ubn2 |
A |
G |
6: 38,460,079 (GRCm39) |
I607V |
probably benign |
Het |
| Vipr2 |
A |
G |
12: 116,058,344 (GRCm39) |
N87S |
probably damaging |
Het |
| Vmn2r18 |
T |
A |
5: 151,485,132 (GRCm39) |
K787N |
probably damaging |
Het |
| Wwc2 |
A |
T |
8: 48,353,859 (GRCm39) |
W92R |
probably damaging |
Het |
| Zfp141 |
A |
G |
7: 42,125,639 (GRCm39) |
Y278H |
probably damaging |
Het |
| Zfp827 |
T |
C |
8: 79,844,887 (GRCm39) |
S686P |
probably benign |
Het |
|
| Other mutations in Ubr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00324:Ubr2
|
APN |
17 |
47,296,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL00332:Ubr2
|
APN |
17 |
47,301,916 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00518:Ubr2
|
APN |
17 |
47,303,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00693:Ubr2
|
APN |
17 |
47,283,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00785:Ubr2
|
APN |
17 |
47,255,791 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01144:Ubr2
|
APN |
17 |
47,268,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01459:Ubr2
|
APN |
17 |
47,241,435 (GRCm39) |
splice site |
probably benign |
|
|
IGL01637:Ubr2
|
APN |
17 |
47,267,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01710:Ubr2
|
APN |
17 |
47,254,335 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01726:Ubr2
|
APN |
17 |
47,303,907 (GRCm39) |
splice site |
probably benign |
|
|
IGL01925:Ubr2
|
APN |
17 |
47,265,875 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01960:Ubr2
|
APN |
17 |
47,284,893 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02170:Ubr2
|
APN |
17 |
47,278,123 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02308:Ubr2
|
APN |
17 |
47,245,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02387:Ubr2
|
APN |
17 |
47,274,076 (GRCm39) |
missense |
probably benign |
|
|
IGL02696:Ubr2
|
APN |
17 |
47,274,691 (GRCm39) |
missense |
probably benign |
|
|
IGL02726:Ubr2
|
APN |
17 |
47,283,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02750:Ubr2
|
APN |
17 |
47,280,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Ubr2
|
APN |
17 |
47,268,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02959:Ubr2
|
APN |
17 |
47,286,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03018:Ubr2
|
APN |
17 |
47,264,972 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03343:Ubr2
|
APN |
17 |
47,262,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4280001:Ubr2
|
UTSW |
17 |
47,255,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0446:Ubr2
|
UTSW |
17 |
47,294,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0513:Ubr2
|
UTSW |
17 |
47,297,705 (GRCm39) |
nonsense |
probably null |
|
|
R0565:Ubr2
|
UTSW |
17 |
47,266,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0600:Ubr2
|
UTSW |
17 |
47,278,174 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Ubr2
|
UTSW |
17 |
47,249,579 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0710:Ubr2
|
UTSW |
17 |
47,249,607 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0761:Ubr2
|
UTSW |
17 |
47,294,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0798:Ubr2
|
UTSW |
17 |
47,280,102 (GRCm39) |
splice site |
probably benign |
|
|
R0862:Ubr2
|
UTSW |
17 |
47,278,009 (GRCm39) |
nonsense |
probably null |
|
|
R0947:Ubr2
|
UTSW |
17 |
47,252,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0972:Ubr2
|
UTSW |
17 |
47,245,187 (GRCm39) |
splice site |
probably null |
|
|
R1500:Ubr2
|
UTSW |
17 |
47,297,615 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1514:Ubr2
|
UTSW |
17 |
47,311,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Ubr2
|
UTSW |
17 |
47,278,173 (GRCm39) |
nonsense |
probably null |
|
|
R1554:Ubr2
|
UTSW |
17 |
47,283,877 (GRCm39) |
missense |
probably benign |
|
|
R1575:Ubr2
|
UTSW |
17 |
47,243,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1602:Ubr2
|
UTSW |
17 |
47,251,987 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1941:Ubr2
|
UTSW |
17 |
47,284,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1966:Ubr2
|
UTSW |
17 |
47,265,845 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2041:Ubr2
|
UTSW |
17 |
47,296,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2111:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2189:Ubr2
|
UTSW |
17 |
47,254,290 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2219:Ubr2
|
UTSW |
17 |
47,296,968 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2307:Ubr2
|
UTSW |
17 |
47,277,141 (GRCm39) |
nonsense |
probably null |
|
|
R3426:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3428:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3608:Ubr2
|
UTSW |
17 |
47,255,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Ubr2
|
UTSW |
17 |
47,299,648 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4330:Ubr2
|
UTSW |
17 |
47,278,204 (GRCm39) |
missense |
probably null |
1.00 |
|
R4383:Ubr2
|
UTSW |
17 |
47,250,313 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4460:Ubr2
|
UTSW |
17 |
47,255,971 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4794:Ubr2
|
UTSW |
17 |
47,241,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Ubr2
|
UTSW |
17 |
47,296,922 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4913:Ubr2
|
UTSW |
17 |
47,270,385 (GRCm39) |
splice site |
probably null |
|
|
R5092:Ubr2
|
UTSW |
17 |
47,280,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5209:Ubr2
|
UTSW |
17 |
47,279,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Ubr2
|
UTSW |
17 |
47,294,196 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5250:Ubr2
|
UTSW |
17 |
47,241,368 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5437:Ubr2
|
UTSW |
17 |
47,274,623 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5607:Ubr2
|
UTSW |
17 |
47,245,126 (GRCm39) |
nonsense |
probably null |
|
|
R5848:Ubr2
|
UTSW |
17 |
47,267,581 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6089:Ubr2
|
UTSW |
17 |
47,293,218 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6382:Ubr2
|
UTSW |
17 |
47,268,241 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6552:Ubr2
|
UTSW |
17 |
47,277,194 (GRCm39) |
splice site |
probably null |
|
|
R6630:Ubr2
|
UTSW |
17 |
47,262,910 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6892:Ubr2
|
UTSW |
17 |
47,245,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6936:Ubr2
|
UTSW |
17 |
47,283,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7039:Ubr2
|
UTSW |
17 |
47,321,139 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7050:Ubr2
|
UTSW |
17 |
47,272,528 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7078:Ubr2
|
UTSW |
17 |
47,266,779 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7126:Ubr2
|
UTSW |
17 |
47,284,982 (GRCm39) |
splice site |
probably null |
|
|
R7219:Ubr2
|
UTSW |
17 |
47,246,360 (GRCm39) |
nonsense |
probably null |
|
|
R7262:Ubr2
|
UTSW |
17 |
47,311,665 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7352:Ubr2
|
UTSW |
17 |
47,241,352 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7366:Ubr2
|
UTSW |
17 |
47,266,771 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7449:Ubr2
|
UTSW |
17 |
47,275,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7496:Ubr2
|
UTSW |
17 |
47,301,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7759:Ubr2
|
UTSW |
17 |
47,296,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7869:Ubr2
|
UTSW |
17 |
47,301,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Ubr2
|
UTSW |
17 |
47,279,308 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8236:Ubr2
|
UTSW |
17 |
47,262,835 (GRCm39) |
missense |
probably benign |
|
|
R8376:Ubr2
|
UTSW |
17 |
47,253,721 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9026:Ubr2
|
UTSW |
17 |
47,245,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Ubr2
|
UTSW |
17 |
47,292,285 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9558:Ubr2
|
UTSW |
17 |
47,262,843 (GRCm39) |
missense |
probably benign |
|
|
R9606:Ubr2
|
UTSW |
17 |
47,245,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Ubr2
|
UTSW |
17 |
47,266,706 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9731:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Ubr2
|
UTSW |
17 |
47,311,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0061:Ubr2
|
UTSW |
17 |
47,281,037 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,311,692 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,270,435 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Ubr2
|
UTSW |
17 |
47,321,069 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTAATGTCTGGGGAGGA -3'
(R):5'- CCCTTGACACTTCCTGTTTAAAA -3'
Sequencing Primer
(F):5'- GGGAGGATTTTAACCTTTGAACTC -3'
(R):5'- CTTACACATCAATCCTGAGGTTTC -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation