Incidental Mutation 'R9340:Obox6'
ID 707441
Institutional Source Beutler Lab
Gene Symbol Obox6
Ensembl Gene ENSMUSG00000041583
Gene Name oocyte specific homeobox 6
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R9340 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 15567175-15573604 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 15567722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 242 (S242T)
Ref Sequence ENSEMBL: ENSMUSP00000104153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108513]
AlphaFold G3X9U1
Predicted Effect possibly damaging
Transcript: ENSMUST00000108513
AA Change: S242T

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104153
Gene: ENSMUSG00000041583
AA Change: S242T

DomainStartEndE-ValueType
HOX 145 207 8.52e-21 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit no detectable abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik T A 13: 61,001,647 (GRCm39) M58L probably benign Het
Abca8b A G 11: 109,840,939 (GRCm39) V1078A probably benign Het
Acvr2b A G 9: 119,257,492 (GRCm39) D175G probably damaging Het
Adad2 A G 8: 120,339,769 (GRCm39) M84V probably benign Het
Ahnak A T 19: 8,994,411 (GRCm39) M5232L probably benign Het
Ahsa1 T C 12: 87,315,053 (GRCm39) S69P probably damaging Het
Aipl1 C T 11: 71,928,253 (GRCm39) G11D probably damaging Het
Antxr2 G T 5: 98,086,306 (GRCm39) P434T probably damaging Het
Arap1 T C 7: 101,037,382 (GRCm39) Y470H probably damaging Het
Baz1a A G 12: 54,963,372 (GRCm39) I907T probably damaging Het
Baz1b A T 5: 135,246,729 (GRCm39) Q726L probably benign Het
Bcar3 C T 3: 122,298,462 (GRCm39) probably benign Het
Bean1 C T 8: 104,908,739 (GRCm39) R39C probably damaging Het
Cass4 A T 2: 172,268,686 (GRCm39) N256I possibly damaging Het
Cnot10 T C 9: 114,460,897 (GRCm39) K91R probably benign Het
Col6a6 C T 9: 105,651,757 (GRCm39) V1085M probably damaging Het
Dpf3 A G 12: 83,534,449 (GRCm39) probably null Het
Dync1i2 T A 2: 71,093,019 (GRCm39) W605R probably damaging Het
Exoc5 A T 14: 49,286,297 (GRCm39) V110E probably damaging Het
Fgfr2 T A 7: 129,782,136 (GRCm39) H563L probably damaging Het
Fosl2 A G 5: 32,304,379 (GRCm39) T105A probably benign Het
Fsip2 A G 2: 82,818,604 (GRCm39) H4779R possibly damaging Het
Fuca2 A G 10: 13,382,518 (GRCm39) Y268C probably damaging Het
Galnt13 G A 2: 54,770,161 (GRCm39) E318K probably damaging Het
Hc G A 2: 34,876,294 (GRCm39) T1584I probably damaging Het
Helb T C 10: 119,928,556 (GRCm39) K762E probably damaging Het
Hspg2 T G 4: 137,296,827 (GRCm39) L4335R probably damaging Het
Ift88 A C 14: 57,718,920 (GRCm39) Q635P probably damaging Het
Inpp5a C A 7: 138,969,380 (GRCm39) D25E probably benign Het
Kcnu1 A G 8: 26,376,786 (GRCm39) T387A possibly damaging Het
Lamb1 G A 12: 31,374,223 (GRCm39) D1529N probably benign Het
Lamb1 A T 12: 31,374,224 (GRCm39) D1529V probably benign Het
Lnx1 T C 5: 74,758,584 (GRCm39) N476S probably benign Het
Mup17 T C 4: 61,512,633 (GRCm39) M87V probably benign Het
Naip6 G A 13: 100,452,494 (GRCm39) T189I probably damaging Het
Nf1 T A 11: 79,447,629 (GRCm39) Y462N possibly damaging Het
Nup133 T C 8: 124,664,881 (GRCm39) D270G probably benign Het
Obox2 T C 7: 15,130,789 (GRCm39) L7S probably damaging Het
Ogfr AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG AGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGAGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAAGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCAAAAGGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGGGGCCAGAG 2: 180,236,850 (GRCm39) probably benign Het
Pigyl C T 9: 22,069,130 (GRCm39) probably benign Het
Rasa1 A G 13: 85,369,649 (GRCm39) V891A probably damaging Het
Rxrg A G 1: 167,458,890 (GRCm39) D292G possibly damaging Het
Saal1 A G 7: 46,351,248 (GRCm39) F243L probably benign Het
Sec24c G A 14: 20,729,598 (GRCm39) V59M probably benign Het
Sema4f C A 6: 82,890,890 (GRCm39) G639V probably damaging Het
Serpinb1c A T 13: 33,066,172 (GRCm39) C258S probably benign Het
Snx21 CACCTGCAGGCAGTGCCAGAGCTACGCCAAGCTCCGGACCTGCAGG CACCTGCAGG 2: 164,633,849 (GRCm39) probably benign Het
Syndig1 T C 2: 149,845,175 (GRCm39) S233P probably damaging Het
Taf6l A T 19: 8,752,636 (GRCm39) L377M probably damaging Het
Tcl1 T C 12: 105,184,979 (GRCm39) Y77C probably damaging Het
Tekt2 C A 4: 126,216,952 (GRCm39) M272I probably benign Het
Trp53bp1 T C 2: 121,100,460 (GRCm39) E98G probably benign Het
Ubr4 T A 4: 139,182,763 (GRCm39) I383N unknown Het
Wdr89 G T 12: 75,679,937 (GRCm39) P106T probably benign Het
Zfp534 T C 4: 147,758,698 (GRCm39) E657G possibly damaging Het
Zfp69 T C 4: 120,788,013 (GRCm39) K434R probably damaging Het
Zfyve26 T A 12: 79,321,680 (GRCm39) K980* probably null Het
Other mutations in Obox6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00705:Obox6 APN 7 15,567,662 (GRCm39) missense probably damaging 0.97
IGL01981:Obox6 APN 7 15,568,846 (GRCm39) missense possibly damaging 0.94
IGL02066:Obox6 APN 7 15,568,628 (GRCm39) missense probably benign 0.03
IGL02070:Obox6 APN 7 15,568,804 (GRCm39) missense probably damaging 1.00
IGL02450:Obox6 APN 7 15,567,638 (GRCm39) missense probably damaging 0.99
R0091:Obox6 UTSW 7 15,568,364 (GRCm39) missense probably benign 0.38
R0512:Obox6 UTSW 7 15,567,874 (GRCm39) missense probably benign 0.42
R1686:Obox6 UTSW 7 15,567,750 (GRCm39) missense probably damaging 0.99
R1727:Obox6 UTSW 7 15,568,502 (GRCm39) missense probably benign 0.04
R1755:Obox6 UTSW 7 15,568,445 (GRCm39) missense probably damaging 0.98
R1813:Obox6 UTSW 7 15,568,770 (GRCm39) missense possibly damaging 0.65
R1896:Obox6 UTSW 7 15,568,770 (GRCm39) missense possibly damaging 0.65
R2086:Obox6 UTSW 7 15,567,532 (GRCm39) missense probably damaging 1.00
R4730:Obox6 UTSW 7 15,568,738 (GRCm39) missense possibly damaging 0.85
R4732:Obox6 UTSW 7 15,568,697 (GRCm39) missense possibly damaging 0.85
R4733:Obox6 UTSW 7 15,568,697 (GRCm39) missense possibly damaging 0.85
R4790:Obox6 UTSW 7 15,568,502 (GRCm39) missense possibly damaging 0.78
R5830:Obox6 UTSW 7 15,568,382 (GRCm39) missense possibly damaging 0.93
R6838:Obox6 UTSW 7 15,567,664 (GRCm39) missense possibly damaging 0.95
R7275:Obox6 UTSW 7 15,567,805 (GRCm39) missense probably benign 0.19
R7347:Obox6 UTSW 7 15,568,571 (GRCm39) missense possibly damaging 0.53
R7485:Obox6 UTSW 7 15,567,863 (GRCm39) missense probably damaging 1.00
R8326:Obox6 UTSW 7 15,567,481 (GRCm39) missense possibly damaging 0.95
R8438:Obox6 UTSW 7 15,567,853 (GRCm39) missense probably damaging 1.00
R8802:Obox6 UTSW 7 15,567,772 (GRCm39) missense probably damaging 0.99
R9274:Obox6 UTSW 7 15,567,766 (GRCm39) missense possibly damaging 0.83
R9566:Obox6 UTSW 7 15,568,352 (GRCm39) missense
R9641:Obox6 UTSW 7 15,568,742 (GRCm39) nonsense probably null
R9722:Obox6 UTSW 7 15,568,831 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAGCCAGTCTGGACTTCAACTG -3'
(R):5'- TCACCTAGTGACCAGTTGGG -3'

Sequencing Primer
(F):5'- GCTACTGATTGACCAGAGTTCCAAG -3'
(R):5'- GGAAAACAGGTATTCCTCTGACGTC -3'
Posted On 2022-04-18