Mutagenetix > Incidental Mutation

Incidental Mutation 'R9342:Dock10'

707525

Institutional Source

Beutler Lab

Gene Symbol

Dock10

Ensembl Gene

ENSMUSG00000038608

Gene Name

dedicator of cytokinesis 10

Synonyms

Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.457) question?

Stock #

R9342 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

80478790-80736244 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 80570360 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 365 (F365L)

Ref Sequence

ENSEMBL: ENSMUSP00000140085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077946] [ENSMUST00000186087] [ENSMUST00000187774] [ENSMUST00000190595] [ENSMUST00000190983] [ENSMUST00000191449]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000077946
AA Change: F377L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: F377L

Domain	Start	End	E-Value	Type
low complexity region	25	42	N/A	INTRINSIC
Pfam:DUF3398	61	153	1.7e-36	PFAM
PH	182	292	8.5e-17	SMART
Blast:PH	350	458	7e-18	BLAST
Pfam:DOCK-C2	668	859	1e-50	PFAM
low complexity region	1269	1279	N/A	INTRINSIC
low complexity region	1284	1295	N/A	INTRINSIC
Pfam:DHR-2	1592	2143	1.3e-216	PFAM
low complexity region	2174	2187	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000186087
AA Change: F390L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000140102
Gene: ENSMUSG00000038608
AA Change: F390L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	71	166	1.5e-29	PFAM
PH	195	305	3.9e-19	SMART
Blast:PH	363	475	3e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000187774
AA Change: F365L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: F365L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	46	141	9e-29	PFAM
PH	170	280	3.9e-19	SMART
Blast:PH	338	446	7e-18	BLAST
Pfam:DOCK-C2	655	848	1.5e-54	PFAM
low complexity region	1257	1267	N/A	INTRINSIC
low complexity region	1272	1283	N/A	INTRINSIC
low complexity region	1870	1890	N/A	INTRINSIC
Pfam:Ded_cyto	1954	2131	3.4e-65	PFAM
low complexity region	2162	2175	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190595
AA Change: F30L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000139567
Gene: ENSMUSG00000038608
AA Change: F30L

Domain	Start	End	E-Value	Type
Blast:PH	3	111	5e-18	BLAST
Pfam:DOCK-C2	320	513	1.2e-54	PFAM
low complexity region	922	932	N/A	INTRINSIC
low complexity region	937	948	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
Pfam:Ded_cyto	1588	1765	2.7e-65	PFAM
low complexity region	1783	1795	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190983
AA Change: F364L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: F364L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	45	140	8.9e-29	PFAM
PH	169	279	3.9e-19	SMART
Blast:PH	337	445	7e-18	BLAST
Pfam:DOCK-C2	654	847	1.5e-54	PFAM
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1271	1282	N/A	INTRINSIC
low complexity region	1869	1889	N/A	INTRINSIC
Pfam:Ded_cyto	1953	2130	3.4e-65	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000191449
AA Change: F359L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000140513
Gene: ENSMUSG00000038608
AA Change: F359L

Domain	Start	End	E-Value	Type
Pfam:DUF3398	40	135	1.1e-32	PFAM
PH	164	274	8.5e-17	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A330070K13Rik	T	C	5: 130,407,876 (GRCm39)	I112V	unknown	Het
Aars2	A	G	17: 45,818,002 (GRCm39)	N75D	possibly damaging	Het
Abcf2	G	A	5: 24,778,475 (GRCm39)	R228C	probably benign	Het
Agfg2	A	G	5: 137,652,114 (GRCm39)	L415P	probably benign	Het
Alpi	A	G	1: 87,026,386 (GRCm39)	L535P	unknown	Het
Anxa9	T	G	3: 95,210,359 (GRCm39)	T69P	probably damaging	Het
Arrb2	T	A	11: 70,327,463 (GRCm39)	D79E	probably benign	Het
Bcat1	A	G	6: 144,994,332 (GRCm39)	V55A	probably benign	Het
Cacna1c	A	G	6: 119,034,335 (GRCm39)	L64P		Het
Cd247	A	T	1: 165,682,759 (GRCm39)	D28V	probably damaging	Het
Celsr2	T	A	3: 108,320,442 (GRCm39)	N790I	probably damaging	Het
Clrn1	C	T	3: 58,792,251 (GRCm39)	V71I	probably benign	Het
Cmtr2	T	C	8: 110,949,078 (GRCm39)	Y463H	possibly damaging	Het
Col6a6	T	C	9: 105,663,172 (GRCm39)	T122A	probably benign	Het
Cubn	T	A	2: 13,463,767 (GRCm39)	D646V	probably damaging	Het
Dab2ip	T	A	2: 35,613,105 (GRCm39)	L1062Q	possibly damaging	Het
Dnajb4	T	C	3: 151,892,272 (GRCm39)	N187S	probably benign	Het
Erich6	G	A	3: 58,534,101 (GRCm39)	Q309*	probably null	Het
Ext1	T	C	15: 53,208,524 (GRCm39)	H79R	probably benign	Het
Fam187b	T	A	7: 30,677,185 (GRCm39)	C231*	probably null	Het
Fbh1	T	C	2: 11,754,414 (GRCm39)	I775V	probably benign	Het
Fbxo15	T	A	18: 84,983,609 (GRCm39)	M319K	unknown	Het
Fbxo9	A	T	9: 78,002,520 (GRCm39)	M187K	possibly damaging	Het
Fer1l4	T	C	2: 155,877,196 (GRCm39)	D1113G	probably benign	Het
Fsip2	A	T	2: 82,818,747 (GRCm39)	T4827S	possibly damaging	Het
Gm49398	A	T	13: 61,435,478 (GRCm39)	L7Q	probably damaging	Het
H2-M10.4	A	T	17: 36,771,285 (GRCm39)	W298R	probably damaging	Het
Hoxd10	A	G	2: 74,522,982 (GRCm39)	E220G	probably benign	Het
Hrh2	T	G	13: 54,368,222 (GRCm39)	L66R	probably damaging	Het
Igf1r	A	G	7: 67,844,746 (GRCm39)	T840A	probably benign	Het
Iqca1	A	G	1: 90,072,688 (GRCm39)	V64A	probably damaging	Het
Klc2	A	G	19: 5,158,659 (GRCm39)	S612P	probably benign	Het
Klf15	A	G	6: 90,443,851 (GRCm39)	E142G	probably damaging	Het
Krt40	T	A	11: 99,429,579 (GRCm39)	T332S	probably damaging	Het
Lrrc9	T	C	12: 72,506,767 (GRCm39)	F348S	probably damaging	Het
Lrrn4	T	C	2: 132,712,290 (GRCm39)	D511G	probably benign	Het
Lrtm2	T	C	6: 119,297,934 (GRCm39)	I36V	probably benign	Het
Lsm10	T	C	4: 125,991,860 (GRCm39)	L72P	probably damaging	Het
Mab21l3	T	A	3: 101,742,519 (GRCm39)	S14C	possibly damaging	Het
Map2k4	T	C	11: 65,581,569 (GRCm39)	K381R	probably benign	Het
Mcidas	A	G	13: 113,130,915 (GRCm39)	D80G	probably damaging	Het
Med23	A	G	10: 24,750,469 (GRCm39)	M99V	probably benign	Het
Mga	A	G	2: 119,778,656 (GRCm39)	D2067G	probably benign	Het
Ms4a19	T	A	19: 11,119,775 (GRCm39)	T52S	possibly damaging	Het
Msc	G	T	1: 14,825,707 (GRCm39)	P89Q	probably benign	Het
Nalf1	C	A	8: 9,821,006 (GRCm39)	A5S	probably damaging	Het
Or14c44	A	G	7: 86,062,430 (GRCm39)	I287V	probably benign	Het
Or2d3c	A	T	7: 106,526,564 (GRCm39)	I34N	possibly damaging	Het
Or5t7	A	T	2: 86,507,494 (GRCm39)	L61Q	probably damaging	Het
Plekhg6	T	C	6: 125,340,023 (GRCm39)	D779G	probably damaging	Het
Pnpla2	C	A	7: 141,035,331 (GRCm39)	Y44*	probably null	Het
Ppp1r17	T	A	6: 56,003,524 (GRCm39)	D112E	probably damaging	Het
Prdm2	A	G	4: 142,861,478 (GRCm39)	I604T	probably damaging	Het
Prkce	A	G	17: 86,781,877 (GRCm39)	Y182C	probably damaging	Het
Prokr2	G	A	2: 132,182,790 (GRCm39)	S189F	possibly damaging	Het
Qser1	A	T	2: 104,618,164 (GRCm39)	S793T	probably benign	Het
Reck	T	C	4: 43,943,301 (GRCm39)	F951S	probably benign	Het
Rev3l	T	C	10: 39,697,458 (GRCm39)	S652P	probably benign	Het
Rtl1	A	C	12: 109,558,884 (GRCm39)	L985R	probably damaging	Het
Sardh	T	C	2: 27,120,869 (GRCm39)	E385G	possibly damaging	Het
Sfmbt1	G	T	14: 30,519,599 (GRCm39)	W440L	possibly damaging	Het
Slc4a7	T	A	14: 14,772,541 (GRCm38)	C683*	probably null	Het
Slc51a	A	G	16: 32,298,517 (GRCm39)	L80P	possibly damaging	Het
Slco3a1	C	A	7: 74,154,037 (GRCm39)	L178F	probably damaging	Het
Spata6	T	A	4: 111,636,389 (GRCm39)	C227S	possibly damaging	Het
Tbc1d30	A	T	10: 121,103,366 (GRCm39)	Y555*	probably null	Het
Tcf7l2	A	G	19: 55,731,517 (GRCm39)	Q90R	probably benign	Het
Tff3	A	C	17: 31,346,423 (GRCm39)	S50A	probably benign	Het
Tnrc6c	T	C	11: 117,630,720 (GRCm39)	M1027T	probably benign	Het
Ttc12	A	G	9: 49,351,680 (GRCm39)	F606L	probably benign	Het
Uqcc3	G	A	19: 8,858,090 (GRCm39)	Q34*	probably null	Het
Veph1	T	A	3: 66,151,959 (GRCm39)	I157F	probably damaging	Het
Vmn2r14	G	A	5: 109,368,428 (GRCm39)	T188I	probably damaging	Het
Vmn2r67	A	G	7: 84,785,788 (GRCm39)	I739T	probably benign	Het
Vmn2r68	A	G	7: 84,882,993 (GRCm39)	F253S	probably benign	Het
Vmn2r74	T	C	7: 85,606,624 (GRCm39)	I241V	probably benign	Het
Vmn2r97	A	G	17: 19,149,368 (GRCm39)	E252G	probably benign	Het
Vps13b	T	C	15: 35,455,200 (GRCm39)	V703A	possibly damaging	Het
Vps25	T	A	11: 101,149,623 (GRCm39)	L149Q	probably damaging	Het
Xirp1	T	C	9: 119,845,950 (GRCm39)	T978A	probably benign	Het
Xpnpep1	T	A	19: 52,993,248 (GRCm39)	I360F	probably benign	Het
Zfpm1	C	T	8: 123,061,308 (GRCm39)	T291M	probably benign	Het
Zkscan8	A	G	13: 21,710,702 (GRCm39)	V136A	probably benign	Het
Zscan18	A	G	7: 12,505,612 (GRCm39)	Y592H	probably damaging	Het

Other mutations in Dock10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00569:Dock10	APN	1	80,562,729 (GRCm39)	missense	probably damaging	1.00
IGL00783:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00784:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00858:Dock10	APN	1	80,545,720 (GRCm39)	missense	possibly damaging	0.48
IGL01298:Dock10	APN	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
IGL01351:Dock10	APN	1	80,570,876 (GRCm39)	missense	probably damaging	1.00
IGL01356:Dock10	APN	1	80,501,459 (GRCm39)	missense	probably damaging	1.00
IGL01584:Dock10	APN	1	80,511,567 (GRCm39)	missense	probably damaging	0.99
IGL01619:Dock10	APN	1	80,612,015 (GRCm39)	splice site	probably benign
IGL01678:Dock10	APN	1	80,521,069 (GRCm39)	missense	probably damaging	1.00
IGL01759:Dock10	APN	1	80,503,990 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dock10	APN	1	80,511,510 (GRCm39)	missense	probably damaging	0.99
IGL02352:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02359:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dock10	APN	1	80,562,711 (GRCm39)	critical splice donor site	probably null
IGL02433:Dock10	APN	1	80,507,905 (GRCm39)	missense	probably damaging	1.00
IGL02471:Dock10	APN	1	80,493,339 (GRCm39)	missense	probably damaging	0.99
IGL02645:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02646:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02648:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02649:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02650:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02652:Dock10	APN	1	80,570,561 (GRCm39)	splice site	probably null
IGL02718:Dock10	APN	1	80,501,535 (GRCm39)	missense	probably benign	0.00
IGL02998:Dock10	APN	1	80,551,259 (GRCm39)	missense	probably damaging	1.00
IGL03057:Dock10	APN	1	80,545,088 (GRCm39)	missense	probably damaging	1.00
IGL03066:Dock10	APN	1	80,562,758 (GRCm39)	missense	probably benign	0.00
IGL03106:Dock10	APN	1	80,546,551 (GRCm39)	missense	probably damaging	0.98
IGL03148:Dock10	APN	1	80,518,075 (GRCm39)	missense	probably benign	0.01
IGL03271:Dock10	APN	1	80,483,126 (GRCm39)	missense	probably damaging	1.00
IGL03352:Dock10	APN	1	80,584,013 (GRCm39)	splice site	probably benign
LCD18:Dock10	UTSW	1	80,716,623 (GRCm38)	intron	probably benign
PIT4366001:Dock10	UTSW	1	80,573,438 (GRCm39)	missense	probably benign	0.30
PIT4581001:Dock10	UTSW	1	80,483,163 (GRCm39)	missense	probably damaging	1.00
R0019:Dock10	UTSW	1	80,583,642 (GRCm39)	missense	probably damaging	1.00
R0081:Dock10	UTSW	1	80,584,295 (GRCm39)	missense	probably damaging	0.99
R0095:Dock10	UTSW	1	80,501,788 (GRCm39)	missense	probably benign	0.00
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0255:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R0267:Dock10	UTSW	1	80,490,171 (GRCm39)	missense	probably damaging	1.00
R0299:Dock10	UTSW	1	80,514,646 (GRCm39)	missense	probably damaging	0.99
R0365:Dock10	UTSW	1	80,573,400 (GRCm39)	missense	probably damaging	1.00
R0387:Dock10	UTSW	1	80,517,993 (GRCm39)	missense	probably damaging	1.00
R0403:Dock10	UTSW	1	80,501,787 (GRCm39)	missense	possibly damaging	0.94
R0408:Dock10	UTSW	1	80,518,193 (GRCm39)	missense	probably benign	0.03
R0414:Dock10	UTSW	1	80,513,650 (GRCm39)	missense	possibly damaging	0.93
R0591:Dock10	UTSW	1	80,518,936 (GRCm39)	splice site	probably benign
R0698:Dock10	UTSW	1	80,507,895 (GRCm39)	missense	probably damaging	1.00
R0711:Dock10	UTSW	1	80,501,692 (GRCm39)	missense	probably damaging	1.00
R0925:Dock10	UTSW	1	80,514,657 (GRCm39)	missense	probably benign	0.20
R1162:Dock10	UTSW	1	80,546,559 (GRCm39)	missense	possibly damaging	0.58
R1370:Dock10	UTSW	1	80,518,060 (GRCm39)	missense	probably damaging	1.00
R1440:Dock10	UTSW	1	80,526,853 (GRCm39)	missense	probably benign	0.03
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1525:Dock10	UTSW	1	80,583,881 (GRCm39)	critical splice donor site	probably null
R1544:Dock10	UTSW	1	80,570,352 (GRCm39)	missense	probably benign	0.00
R1601:Dock10	UTSW	1	80,527,519 (GRCm39)	missense	probably benign	0.00
R1757:Dock10	UTSW	1	80,511,586 (GRCm39)	missense	probably damaging	1.00
R1765:Dock10	UTSW	1	80,583,540 (GRCm39)	missense	probably damaging	1.00
R1783:Dock10	UTSW	1	80,551,897 (GRCm39)	missense	probably benign	0.17
R1823:Dock10	UTSW	1	80,520,814 (GRCm39)	splice site	probably null
R1827:Dock10	UTSW	1	80,508,009 (GRCm39)	missense	probably benign	0.07
R1844:Dock10	UTSW	1	80,520,918 (GRCm39)	missense	probably damaging	0.99
R1856:Dock10	UTSW	1	80,584,285 (GRCm39)	missense	possibly damaging	0.46
R1974:Dock10	UTSW	1	80,488,143 (GRCm39)	missense	possibly damaging	0.50
R2006:Dock10	UTSW	1	80,527,506 (GRCm39)	missense	possibly damaging	0.95
R2112:Dock10	UTSW	1	80,483,360 (GRCm39)	missense	probably damaging	0.99
R2112:Dock10	UTSW	1	80,483,359 (GRCm39)	missense	probably damaging	1.00
R2113:Dock10	UTSW	1	80,584,280 (GRCm39)	missense	probably damaging	1.00
R2439:Dock10	UTSW	1	80,510,149 (GRCm39)	missense	probably damaging	1.00
R2566:Dock10	UTSW	1	80,517,970 (GRCm39)	missense	possibly damaging	0.88
R3086:Dock10	UTSW	1	80,510,074 (GRCm39)	missense	possibly damaging	0.91
R3766:Dock10	UTSW	1	80,514,643 (GRCm39)	missense	probably damaging	0.99
R3768:Dock10	UTSW	1	80,510,085 (GRCm39)	missense	probably damaging	1.00
R4009:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R4016:Dock10	UTSW	1	80,584,286 (GRCm39)	missense	probably damaging	1.00
R4179:Dock10	UTSW	1	80,488,134 (GRCm39)	missense	probably benign	0.00
R4243:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4244:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4245:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4674:Dock10	UTSW	1	80,584,337 (GRCm39)	missense	possibly damaging	0.79
R4696:Dock10	UTSW	1	80,493,330 (GRCm39)	missense	possibly damaging	0.95
R4789:Dock10	UTSW	1	80,518,998 (GRCm39)	missense	probably damaging	1.00
R4851:Dock10	UTSW	1	80,526,874 (GRCm39)	missense	probably benign	0.33
R4911:Dock10	UTSW	1	80,583,953 (GRCm39)	missense	probably damaging	1.00
R4976:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5086:Dock10	UTSW	1	80,529,189 (GRCm39)	missense	possibly damaging	0.89
R5119:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5301:Dock10	UTSW	1	80,625,973 (GRCm39)	missense	probably benign	0.41
R5404:Dock10	UTSW	1	80,481,630 (GRCm39)	intron	probably benign
R5457:Dock10	UTSW	1	80,501,781 (GRCm39)	missense	probably damaging	1.00
R5790:Dock10	UTSW	1	80,482,887 (GRCm39)	missense	probably benign	0.00
R5845:Dock10	UTSW	1	80,483,459 (GRCm39)	intron	probably benign
R5871:Dock10	UTSW	1	80,519,057 (GRCm39)	critical splice acceptor site	probably null
R5873:Dock10	UTSW	1	80,551,855 (GRCm39)	missense	probably damaging	1.00
R5881:Dock10	UTSW	1	80,538,640 (GRCm39)	missense	probably benign	0.19
R5895:Dock10	UTSW	1	80,514,676 (GRCm39)	missense	probably benign
R5935:Dock10	UTSW	1	80,483,304 (GRCm39)	intron	probably benign
R5965:Dock10	UTSW	1	80,546,461 (GRCm39)	splice site	probably null
R5966:Dock10	UTSW	1	80,546,225 (GRCm39)	missense	possibly damaging	0.84
R6008:Dock10	UTSW	1	80,583,890 (GRCm39)	missense	probably damaging	0.98
R6029:Dock10	UTSW	1	80,514,663 (GRCm39)	missense	possibly damaging	0.68
R6083:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R6145:Dock10	UTSW	1	80,553,621 (GRCm39)	nonsense	probably null
R6257:Dock10	UTSW	1	80,481,413 (GRCm39)	intron	probably benign
R6274:Dock10	UTSW	1	80,516,540 (GRCm39)	missense	probably damaging	1.00
R6324:Dock10	UTSW	1	80,482,893 (GRCm39)	missense	probably benign	0.03
R6346:Dock10	UTSW	1	80,553,573 (GRCm39)	splice site	probably null
R6476:Dock10	UTSW	1	80,518,959 (GRCm39)	nonsense	probably null
R6516:Dock10	UTSW	1	80,518,178 (GRCm39)	missense	probably damaging	1.00
R6526:Dock10	UTSW	1	80,564,068 (GRCm39)	missense	probably damaging	0.97
R6534:Dock10	UTSW	1	80,481,388 (GRCm39)	missense	probably benign	0.01
R6620:Dock10	UTSW	1	80,570,355 (GRCm39)	missense	probably benign	0.01
R6640:Dock10	UTSW	1	80,511,555 (GRCm39)	nonsense	probably null
R6669:Dock10	UTSW	1	80,570,572 (GRCm39)	missense	probably damaging	1.00
R6672:Dock10	UTSW	1	80,490,248 (GRCm39)	missense	probably benign	0.00
R6679:Dock10	UTSW	1	80,544,514 (GRCm39)	missense	probably benign	0.11
R6682:Dock10	UTSW	1	80,490,338 (GRCm39)	missense	probably damaging	1.00
R6712:Dock10	UTSW	1	80,514,583 (GRCm39)	missense	probably benign	0.00
R6726:Dock10	UTSW	1	80,490,147 (GRCm39)	missense	probably damaging	1.00
R6788:Dock10	UTSW	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
R6805:Dock10	UTSW	1	80,564,407 (GRCm39)	missense	probably benign
R6815:Dock10	UTSW	1	80,516,576 (GRCm39)	missense	possibly damaging	0.94
R6818:Dock10	UTSW	1	80,593,082 (GRCm39)	missense	possibly damaging	0.95
R6867:Dock10	UTSW	1	80,508,976 (GRCm39)	missense	probably damaging	1.00
R6964:Dock10	UTSW	1	80,481,365 (GRCm39)	intron	probably benign
R7026:Dock10	UTSW	1	80,479,504 (GRCm39)	missense	probably benign	0.40
R7084:Dock10	UTSW	1	80,481,573 (GRCm39)	missense
R7087:Dock10	UTSW	1	80,570,543 (GRCm39)	missense	probably benign
R7158:Dock10	UTSW	1	80,564,589 (GRCm39)	critical splice acceptor site	probably null
R7191:Dock10	UTSW	1	80,518,048 (GRCm39)	missense	possibly damaging	0.93
R7214:Dock10	UTSW	1	80,546,246 (GRCm39)	missense	probably benign	0.01
R7255:Dock10	UTSW	1	80,520,816 (GRCm39)	critical splice donor site	probably null
R7320:Dock10	UTSW	1	80,527,421 (GRCm39)	critical splice donor site	probably null
R7359:Dock10	UTSW	1	80,687,065 (GRCm39)	missense	probably benign	0.01
R7423:Dock10	UTSW	1	80,501,497 (GRCm39)	missense	possibly damaging	0.67
R7464:Dock10	UTSW	1	80,518,032 (GRCm39)	missense	probably damaging	0.99
R7483:Dock10	UTSW	1	80,493,283 (GRCm39)	missense	probably benign	0.01
R7487:Dock10	UTSW	1	80,562,765 (GRCm39)	missense	probably benign	0.00
R7789:Dock10	UTSW	1	80,536,930 (GRCm39)	missense	possibly damaging	0.82
R7943:Dock10	UTSW	1	80,626,006 (GRCm39)	missense	probably damaging	0.98
R7962:Dock10	UTSW	1	80,564,085 (GRCm39)	missense	possibly damaging	0.88
R8079:Dock10	UTSW	1	80,556,421 (GRCm39)	missense	probably benign	0.00
R8086:Dock10	UTSW	1	80,481,707 (GRCm39)	missense	probably benign	0.17
R8184:Dock10	UTSW	1	80,530,469 (GRCm39)	missense	probably damaging	1.00
R8220:Dock10	UTSW	1	80,506,366 (GRCm39)	missense	probably null	1.00
R8225:Dock10	UTSW	1	80,481,447 (GRCm39)	nonsense	probably null
R8267:Dock10	UTSW	1	80,518,045 (GRCm39)	missense	probably benign	0.00
R8276:Dock10	UTSW	1	80,505,998 (GRCm39)	missense	probably benign
R8294:Dock10	UTSW	1	80,488,079 (GRCm39)	missense	possibly damaging	0.88
R8298:Dock10	UTSW	1	80,514,654 (GRCm39)	missense	probably benign	0.00
R8326:Dock10	UTSW	1	80,583,892 (GRCm39)	missense	possibly damaging	0.77
R8724:Dock10	UTSW	1	80,570,344 (GRCm39)	missense	probably benign	0.00
R8828:Dock10	UTSW	1	80,521,134 (GRCm39)	missense	probably damaging	1.00
R8846:Dock10	UTSW	1	80,545,786 (GRCm39)	missense	possibly damaging	0.93
R8919:Dock10	UTSW	1	80,483,147 (GRCm39)	missense	probably benign	0.00
R8950:Dock10	UTSW	1	80,519,016 (GRCm39)	missense	probably benign
R8993:Dock10	UTSW	1	80,551,888 (GRCm39)	missense	probably benign	0.21
R9028:Dock10	UTSW	1	80,584,012 (GRCm39)	splice site	probably benign
R9115:Dock10	UTSW	1	80,490,156 (GRCm39)	missense	probably damaging	1.00
R9327:Dock10	UTSW	1	80,510,184 (GRCm39)	missense	probably damaging	1.00
R9421:Dock10	UTSW	1	80,501,509 (GRCm39)	missense	probably damaging	1.00
R9431:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R9486:Dock10	UTSW	1	80,479,452 (GRCm39)	missense	unknown
R9521:Dock10	UTSW	1	80,501,763 (GRCm39)	missense	probably damaging	1.00
R9598:Dock10	UTSW	1	80,625,939 (GRCm39)	missense	probably benign	0.15
R9629:Dock10	UTSW	1	80,481,389 (GRCm39)	missense
R9703:Dock10	UTSW	1	80,517,540 (GRCm39)	missense	probably damaging	0.98
RF021:Dock10	UTSW	1	80,542,290 (GRCm39)	critical splice acceptor site	probably null
X0025:Dock10	UTSW	1	80,514,637 (GRCm39)	missense	probably damaging	0.98
X0065:Dock10	UTSW	1	80,518,977 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock10	UTSW	1	80,510,064 (GRCm39)	missense	probably damaging	1.00
Z1176:Dock10	UTSW	1	80,538,671 (GRCm39)	missense	probably benign
Z1177:Dock10	UTSW	1	80,536,917 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- TGCTAGATCCTGAGGTTAGCAAG -3'
(R):5'- CACGAAACATGGGCAGACTC -3'

Sequencing Primer
(F):5'- TCCTGAGGTTAGCAAGCATAG -3'
(R):5'- AGACTCAATCTGTTCTCCCTGGAC -3'

Posted On

2022-04-18