Incidental Mutation 'R9342:Tnrc6c'
| ID |
707586 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnrc6c
|
| Ensembl Gene |
ENSMUSG00000025571 |
| Gene Name |
trinucleotide repeat containing 6C |
| Synonyms |
9930033H14Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9342 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
117545115-117654265 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 117630720 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 1027
(M1027T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115221
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026658]
[ENSMUST00000106344]
[ENSMUST00000138299]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026658
AA Change: M1187T
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000026658
Gene: ENSMUSG00000025571
AA Change: M1187T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106344
AA Change: M1187T
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000101951
Gene: ENSMUSG00000025571
AA Change: M1187T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
110 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
394 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
440 |
457 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
472 |
573 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
594 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
632 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
639 |
704 |
5.49e-5 |
PROSPERO |
|
internal_repeat_1
|
799 |
902 |
2.14e-5 |
PROSPERO |
|
low complexity region
|
964 |
981 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
991 |
1051 |
5.49e-5 |
PROSPERO |
|
low complexity region
|
1063 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1125 |
N/A |
INTRINSIC |
|
UBA
|
1145 |
1182 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1232 |
1459 |
6.8e-77 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1468 |
1646 |
4.1e-75 |
PFAM |
|
Pfam:TNRC6-PABC_bdg
|
1643 |
1722 |
3.7e-33 |
PFAM |
|
RRM
|
1725 |
1792 |
1.81e-2 |
SMART |
|
low complexity region
|
1813 |
1823 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138299
AA Change: M1027T
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000115221
Gene: ENSMUSG00000025571
AA Change: M1027T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
88 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
138 |
158 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
297 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
413 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
434 |
454 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
472 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
639 |
742 |
9.45e-5 |
PROSPERO |
|
low complexity region
|
804 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
965 |
N/A |
INTRINSIC |
|
UBA
|
985 |
1022 |
3.68e-4 |
SMART |
|
Pfam:M_domain
|
1036 |
1293 |
1.7e-53 |
PFAM |
|
low complexity region
|
1397 |
1406 |
N/A |
INTRINSIC |
|
PDB:3KTP|B
|
1422 |
1443 |
7e-7 |
PDB |
|
low complexity region
|
1507 |
1518 |
N/A |
INTRINSIC |
|
low complexity region
|
1531 |
1552 |
N/A |
INTRINSIC |
|
RRM
|
1557 |
1624 |
1.81e-2 |
SMART |
|
low complexity region
|
1645 |
1655 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele exhibit complete neonatal lethality with cyanosis, respiratory distress and thickened mesenchyme in air sacs. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A330070K13Rik |
T |
C |
5: 130,407,876 (GRCm39) |
I112V |
unknown |
Het |
| Aars2 |
A |
G |
17: 45,818,002 (GRCm39) |
N75D |
possibly damaging |
Het |
| Abcf2 |
G |
A |
5: 24,778,475 (GRCm39) |
R228C |
probably benign |
Het |
| Agfg2 |
A |
G |
5: 137,652,114 (GRCm39) |
L415P |
probably benign |
Het |
| Alpi |
A |
G |
1: 87,026,386 (GRCm39) |
L535P |
unknown |
Het |
| Anxa9 |
T |
G |
3: 95,210,359 (GRCm39) |
T69P |
probably damaging |
Het |
| Arrb2 |
T |
A |
11: 70,327,463 (GRCm39) |
D79E |
probably benign |
Het |
| Bcat1 |
A |
G |
6: 144,994,332 (GRCm39) |
V55A |
probably benign |
Het |
| Cacna1c |
A |
G |
6: 119,034,335 (GRCm39) |
L64P |
|
Het |
| Cd247 |
A |
T |
1: 165,682,759 (GRCm39) |
D28V |
probably damaging |
Het |
| Celsr2 |
T |
A |
3: 108,320,442 (GRCm39) |
N790I |
probably damaging |
Het |
| Clrn1 |
C |
T |
3: 58,792,251 (GRCm39) |
V71I |
probably benign |
Het |
| Cmtr2 |
T |
C |
8: 110,949,078 (GRCm39) |
Y463H |
possibly damaging |
Het |
| Col6a6 |
T |
C |
9: 105,663,172 (GRCm39) |
T122A |
probably benign |
Het |
| Cubn |
T |
A |
2: 13,463,767 (GRCm39) |
D646V |
probably damaging |
Het |
| Dab2ip |
T |
A |
2: 35,613,105 (GRCm39) |
L1062Q |
possibly damaging |
Het |
| Dnajb4 |
T |
C |
3: 151,892,272 (GRCm39) |
N187S |
probably benign |
Het |
| Dock10 |
A |
T |
1: 80,570,360 (GRCm39) |
F365L |
probably benign |
Het |
| Erich6 |
G |
A |
3: 58,534,101 (GRCm39) |
Q309* |
probably null |
Het |
| Ext1 |
T |
C |
15: 53,208,524 (GRCm39) |
H79R |
probably benign |
Het |
| Fam187b |
T |
A |
7: 30,677,185 (GRCm39) |
C231* |
probably null |
Het |
| Fbh1 |
T |
C |
2: 11,754,414 (GRCm39) |
I775V |
probably benign |
Het |
| Fbxo15 |
T |
A |
18: 84,983,609 (GRCm39) |
M319K |
unknown |
Het |
| Fbxo9 |
A |
T |
9: 78,002,520 (GRCm39) |
M187K |
possibly damaging |
Het |
| Fer1l4 |
T |
C |
2: 155,877,196 (GRCm39) |
D1113G |
probably benign |
Het |
| Fsip2 |
A |
T |
2: 82,818,747 (GRCm39) |
T4827S |
possibly damaging |
Het |
| Gm49398 |
A |
T |
13: 61,435,478 (GRCm39) |
L7Q |
probably damaging |
Het |
| H2-M10.4 |
A |
T |
17: 36,771,285 (GRCm39) |
W298R |
probably damaging |
Het |
| Hoxd10 |
A |
G |
2: 74,522,982 (GRCm39) |
E220G |
probably benign |
Het |
| Hrh2 |
T |
G |
13: 54,368,222 (GRCm39) |
L66R |
probably damaging |
Het |
| Igf1r |
A |
G |
7: 67,844,746 (GRCm39) |
T840A |
probably benign |
Het |
| Iqca1 |
A |
G |
1: 90,072,688 (GRCm39) |
V64A |
probably damaging |
Het |
| Klc2 |
A |
G |
19: 5,158,659 (GRCm39) |
S612P |
probably benign |
Het |
| Klf15 |
A |
G |
6: 90,443,851 (GRCm39) |
E142G |
probably damaging |
Het |
| Krt40 |
T |
A |
11: 99,429,579 (GRCm39) |
T332S |
probably damaging |
Het |
| Lrrc9 |
T |
C |
12: 72,506,767 (GRCm39) |
F348S |
probably damaging |
Het |
| Lrrn4 |
T |
C |
2: 132,712,290 (GRCm39) |
D511G |
probably benign |
Het |
| Lrtm2 |
T |
C |
6: 119,297,934 (GRCm39) |
I36V |
probably benign |
Het |
| Lsm10 |
T |
C |
4: 125,991,860 (GRCm39) |
L72P |
probably damaging |
Het |
| Mab21l3 |
T |
A |
3: 101,742,519 (GRCm39) |
S14C |
possibly damaging |
Het |
| Map2k4 |
T |
C |
11: 65,581,569 (GRCm39) |
K381R |
probably benign |
Het |
| Mcidas |
A |
G |
13: 113,130,915 (GRCm39) |
D80G |
probably damaging |
Het |
| Med23 |
A |
G |
10: 24,750,469 (GRCm39) |
M99V |
probably benign |
Het |
| Mga |
A |
G |
2: 119,778,656 (GRCm39) |
D2067G |
probably benign |
Het |
| Ms4a19 |
T |
A |
19: 11,119,775 (GRCm39) |
T52S |
possibly damaging |
Het |
| Msc |
G |
T |
1: 14,825,707 (GRCm39) |
P89Q |
probably benign |
Het |
| Nalf1 |
C |
A |
8: 9,821,006 (GRCm39) |
A5S |
probably damaging |
Het |
| Or14c44 |
A |
G |
7: 86,062,430 (GRCm39) |
I287V |
probably benign |
Het |
| Or2d3c |
A |
T |
7: 106,526,564 (GRCm39) |
I34N |
possibly damaging |
Het |
| Or5t7 |
A |
T |
2: 86,507,494 (GRCm39) |
L61Q |
probably damaging |
Het |
| Plekhg6 |
T |
C |
6: 125,340,023 (GRCm39) |
D779G |
probably damaging |
Het |
| Pnpla2 |
C |
A |
7: 141,035,331 (GRCm39) |
Y44* |
probably null |
Het |
| Ppp1r17 |
T |
A |
6: 56,003,524 (GRCm39) |
D112E |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 142,861,478 (GRCm39) |
I604T |
probably damaging |
Het |
| Prkce |
A |
G |
17: 86,781,877 (GRCm39) |
Y182C |
probably damaging |
Het |
| Prokr2 |
G |
A |
2: 132,182,790 (GRCm39) |
S189F |
possibly damaging |
Het |
| Qser1 |
A |
T |
2: 104,618,164 (GRCm39) |
S793T |
probably benign |
Het |
| Reck |
T |
C |
4: 43,943,301 (GRCm39) |
F951S |
probably benign |
Het |
| Rev3l |
T |
C |
10: 39,697,458 (GRCm39) |
S652P |
probably benign |
Het |
| Rtl1 |
A |
C |
12: 109,558,884 (GRCm39) |
L985R |
probably damaging |
Het |
| Sardh |
T |
C |
2: 27,120,869 (GRCm39) |
E385G |
possibly damaging |
Het |
| Sfmbt1 |
G |
T |
14: 30,519,599 (GRCm39) |
W440L |
possibly damaging |
Het |
| Slc4a7 |
T |
A |
14: 14,772,541 (GRCm38) |
C683* |
probably null |
Het |
| Slc51a |
A |
G |
16: 32,298,517 (GRCm39) |
L80P |
possibly damaging |
Het |
| Slco3a1 |
C |
A |
7: 74,154,037 (GRCm39) |
L178F |
probably damaging |
Het |
| Spata6 |
T |
A |
4: 111,636,389 (GRCm39) |
C227S |
possibly damaging |
Het |
| Tbc1d30 |
A |
T |
10: 121,103,366 (GRCm39) |
Y555* |
probably null |
Het |
| Tcf7l2 |
A |
G |
19: 55,731,517 (GRCm39) |
Q90R |
probably benign |
Het |
| Tff3 |
A |
C |
17: 31,346,423 (GRCm39) |
S50A |
probably benign |
Het |
| Ttc12 |
A |
G |
9: 49,351,680 (GRCm39) |
F606L |
probably benign |
Het |
| Uqcc3 |
G |
A |
19: 8,858,090 (GRCm39) |
Q34* |
probably null |
Het |
| Veph1 |
T |
A |
3: 66,151,959 (GRCm39) |
I157F |
probably damaging |
Het |
| Vmn2r14 |
G |
A |
5: 109,368,428 (GRCm39) |
T188I |
probably damaging |
Het |
| Vmn2r67 |
A |
G |
7: 84,785,788 (GRCm39) |
I739T |
probably benign |
Het |
| Vmn2r68 |
A |
G |
7: 84,882,993 (GRCm39) |
F253S |
probably benign |
Het |
| Vmn2r74 |
T |
C |
7: 85,606,624 (GRCm39) |
I241V |
probably benign |
Het |
| Vmn2r97 |
A |
G |
17: 19,149,368 (GRCm39) |
E252G |
probably benign |
Het |
| Vps13b |
T |
C |
15: 35,455,200 (GRCm39) |
V703A |
possibly damaging |
Het |
| Vps25 |
T |
A |
11: 101,149,623 (GRCm39) |
L149Q |
probably damaging |
Het |
| Xirp1 |
T |
C |
9: 119,845,950 (GRCm39) |
T978A |
probably benign |
Het |
| Xpnpep1 |
T |
A |
19: 52,993,248 (GRCm39) |
I360F |
probably benign |
Het |
| Zfpm1 |
C |
T |
8: 123,061,308 (GRCm39) |
T291M |
probably benign |
Het |
| Zkscan8 |
A |
G |
13: 21,710,702 (GRCm39) |
V136A |
probably benign |
Het |
| Zscan18 |
A |
G |
7: 12,505,612 (GRCm39) |
Y592H |
probably damaging |
Het |
|
| Other mutations in Tnrc6c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00839:Tnrc6c
|
APN |
11 |
117,605,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01013:Tnrc6c
|
APN |
11 |
117,612,855 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01092:Tnrc6c
|
APN |
11 |
117,612,811 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01383:Tnrc6c
|
APN |
11 |
117,605,083 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL01395:Tnrc6c
|
APN |
11 |
117,613,939 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01726:Tnrc6c
|
APN |
11 |
117,640,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL01869:Tnrc6c
|
APN |
11 |
117,646,274 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02108:Tnrc6c
|
APN |
11 |
117,612,025 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02457:Tnrc6c
|
APN |
11 |
117,613,803 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02612:Tnrc6c
|
APN |
11 |
117,633,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02748:Tnrc6c
|
APN |
11 |
117,622,996 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03160:Tnrc6c
|
APN |
11 |
117,640,651 (GRCm39) |
splice site |
probably benign |
|
|
rodion
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
K3955:Tnrc6c
|
UTSW |
11 |
117,651,564 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0015:Tnrc6c
|
UTSW |
11 |
117,612,284 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0143:Tnrc6c
|
UTSW |
11 |
117,643,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0323:Tnrc6c
|
UTSW |
11 |
117,630,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0464:Tnrc6c
|
UTSW |
11 |
117,651,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Tnrc6c
|
UTSW |
11 |
117,613,447 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1015:Tnrc6c
|
UTSW |
11 |
117,612,748 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1201:Tnrc6c
|
UTSW |
11 |
117,612,500 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1297:Tnrc6c
|
UTSW |
11 |
117,624,529 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1560:Tnrc6c
|
UTSW |
11 |
117,650,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1596:Tnrc6c
|
UTSW |
11 |
117,648,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Tnrc6c
|
UTSW |
11 |
117,651,556 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1892:Tnrc6c
|
UTSW |
11 |
117,605,188 (GRCm39) |
missense |
probably benign |
|
|
R1901:Tnrc6c
|
UTSW |
11 |
117,613,831 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1936:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1937:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1940:Tnrc6c
|
UTSW |
11 |
117,646,849 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R3622:Tnrc6c
|
UTSW |
11 |
117,640,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3711:Tnrc6c
|
UTSW |
11 |
117,613,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3725:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3775:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3776:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3836:Tnrc6c
|
UTSW |
11 |
117,614,055 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3844:Tnrc6c
|
UTSW |
11 |
117,646,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3928:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3929:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3937:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3943:Tnrc6c
|
UTSW |
11 |
117,614,355 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4501:Tnrc6c
|
UTSW |
11 |
117,613,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Tnrc6c
|
UTSW |
11 |
117,633,784 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4511:Tnrc6c
|
UTSW |
11 |
117,633,784 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4654:Tnrc6c
|
UTSW |
11 |
117,611,797 (GRCm39) |
missense |
probably benign |
|
|
R4765:Tnrc6c
|
UTSW |
11 |
117,633,753 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4824:Tnrc6c
|
UTSW |
11 |
117,613,731 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5004:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5094:Tnrc6c
|
UTSW |
11 |
117,611,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5130:Tnrc6c
|
UTSW |
11 |
117,629,176 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5234:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5235:Tnrc6c
|
UTSW |
11 |
117,651,555 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5345:Tnrc6c
|
UTSW |
11 |
117,614,113 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5359:Tnrc6c
|
UTSW |
11 |
117,649,731 (GRCm39) |
splice site |
silent |
|
|
R5428:Tnrc6c
|
UTSW |
11 |
117,591,588 (GRCm39) |
start codon destroyed |
probably null |
|
|
R5548:Tnrc6c
|
UTSW |
11 |
117,651,669 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5587:Tnrc6c
|
UTSW |
11 |
117,640,097 (GRCm39) |
nonsense |
probably null |
|
|
R5875:Tnrc6c
|
UTSW |
11 |
117,650,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5947:Tnrc6c
|
UTSW |
11 |
117,613,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6135:Tnrc6c
|
UTSW |
11 |
117,626,831 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6354:Tnrc6c
|
UTSW |
11 |
117,640,440 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6389:Tnrc6c
|
UTSW |
11 |
117,613,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7027:Tnrc6c
|
UTSW |
11 |
117,624,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7048:Tnrc6c
|
UTSW |
11 |
117,612,800 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7098:Tnrc6c
|
UTSW |
11 |
117,604,952 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7315:Tnrc6c
|
UTSW |
11 |
117,614,354 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7378:Tnrc6c
|
UTSW |
11 |
117,632,606 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7386:Tnrc6c
|
UTSW |
11 |
117,612,780 (GRCm39) |
missense |
probably benign |
|
|
R7515:Tnrc6c
|
UTSW |
11 |
117,632,507 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7665:Tnrc6c
|
UTSW |
11 |
117,611,777 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7755:Tnrc6c
|
UTSW |
11 |
117,648,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8679:Tnrc6c
|
UTSW |
11 |
117,604,961 (GRCm39) |
missense |
probably benign |
|
|
R8824:Tnrc6c
|
UTSW |
11 |
117,630,680 (GRCm39) |
splice site |
probably benign |
|
|
R8971:Tnrc6c
|
UTSW |
11 |
117,640,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9261:Tnrc6c
|
UTSW |
11 |
117,605,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Tnrc6c
|
UTSW |
11 |
117,591,630 (GRCm39) |
missense |
unknown |
|
|
R9633:Tnrc6c
|
UTSW |
11 |
117,638,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Tnrc6c
|
UTSW |
11 |
117,623,136 (GRCm39) |
missense |
probably benign |
|
|
V7580:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7581:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7582:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7583:Tnrc6c
|
UTSW |
11 |
117,614,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnrc6c
|
UTSW |
11 |
117,623,003 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTTCCTAAGGGCTGGCAAG -3'
(R):5'- TTTCCATCTGACTTGCTTTAAGGAC -3'
Sequencing Primer
(F):5'- TAAGGGCTGGCAAGAGCGTG -3'
(R):5'- GACTTGCTTTAAGGACACAGCTCAG -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation