Incidental Mutation 'R9343:Dennd2d'
ID 707614
Institutional Source Beutler Lab
Gene Symbol Dennd2d
Ensembl Gene ENSMUSG00000027901
Gene Name DENN domain containing 2D
Synonyms 2010308M01Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R9343 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 106389745-106410346 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 106397730 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000138462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029508] [ENSMUST00000149225] [ENSMUST00000183271]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000029508
SMART Domains Protein: ENSMUSP00000029508
Gene: ENSMUSG00000027901

DomainStartEndE-ValueType
low complexity region 3 17 N/A INTRINSIC
uDENN 47 139 4.15e-27 SMART
DENN 146 330 8.1e-71 SMART
dDENN 368 435 3.38e-18 SMART
low complexity region 447 461 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000149225
Predicted Effect probably null
Transcript: ENSMUST00000183271
SMART Domains Protein: ENSMUSP00000138462
Gene: ENSMUSG00000027901

DomainStartEndE-ValueType
low complexity region 15 28 N/A INTRINSIC
uDENN 57 149 4.15e-27 SMART
DENN 156 340 8.1e-71 SMART
dDENN 378 445 3.38e-18 SMART
low complexity region 457 471 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat2 T C 17: 13,167,538 (GRCm39) N166S probably damaging Het
Atp8b2 A T 3: 89,855,811 (GRCm39) F446I possibly damaging Het
Cacna2d3 A T 14: 28,704,315 (GRCm39) M822K possibly damaging Het
Caskin1 A G 17: 24,723,447 (GRCm39) E745G probably damaging Het
Clec4a2 G T 6: 123,104,955 (GRCm39) A82S probably benign Het
Col5a3 T C 9: 20,704,909 (GRCm39) N749S unknown Het
Col9a2 T A 4: 120,911,483 (GRCm39) M608K probably benign Het
Cope T C 8: 70,761,228 (GRCm39) probably null Het
Dpys T C 15: 39,656,748 (GRCm39) T440A possibly damaging Het
Fam186b G A 15: 99,177,616 (GRCm39) A570V probably damaging Het
Fbln5 G A 12: 101,737,551 (GRCm39) T152I probably damaging Het
Gm16503 A T 4: 147,625,508 (GRCm39) M1L unknown Het
Gm9195 A G 14: 72,717,500 (GRCm39) S278P probably damaging Het
Hmcn2 A G 2: 31,279,359 (GRCm39) N1787S probably benign Het
Klhl33 A G 14: 51,133,903 (GRCm39) probably null Het
Lrrk2 A G 15: 91,584,618 (GRCm39) D345G probably benign Het
Man2b2 A G 5: 36,975,951 (GRCm39) L368P probably damaging Het
Med23 T A 10: 24,788,705 (GRCm39) S1371T probably benign Het
Mllt3 T A 4: 87,792,168 (GRCm39) E109D possibly damaging Het
Myom2 G A 8: 15,134,633 (GRCm39) D479N probably damaging Het
Or52r1c A T 7: 102,735,324 (GRCm39) R195* probably null Het
Pcdhga10 G T 18: 37,880,532 (GRCm39) A98S probably benign Het
Pde8a A T 7: 80,950,427 (GRCm39) Q221H probably benign Het
Pkd1l1 T C 11: 8,786,399 (GRCm39) H2335R Het
Pkd1l1 T A 11: 8,911,305 (GRCm39) D324V Het
Pou2f2 G A 7: 24,794,277 (GRCm39) T363I possibly damaging Het
Prlr A G 15: 10,328,988 (GRCm39) I488V probably benign Het
Psmd2 T C 16: 20,475,441 (GRCm39) probably null Het
Rbm7 T C 9: 48,400,969 (GRCm39) D253G probably damaging Het
Ros1 A G 10: 51,972,116 (GRCm39) probably null Het
S1pr3 G T 13: 51,573,553 (GRCm39) V245L probably damaging Het
Sacs A G 14: 61,446,219 (GRCm39) D2755G probably benign Het
Scgn T A 13: 24,173,829 (GRCm39) probably null Het
Sh3rf3 A G 10: 58,966,802 (GRCm39) K715E probably damaging Het
Sox18 T C 2: 181,312,231 (GRCm39) E300G probably damaging Het
Spata31f3 TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG 4: 42,871,823 (GRCm39) probably benign Het
Spef2 T A 15: 9,713,190 (GRCm39) N394I probably damaging Het
Strn4 T C 7: 16,573,827 (GRCm39) F759L probably damaging Het
Tas2r144 A T 6: 42,193,066 (GRCm39) I269F probably benign Het
Tpcn1 T C 5: 120,678,737 (GRCm39) D606G possibly damaging Het
Trh A G 6: 92,220,823 (GRCm39) I13T probably benign Het
Umodl1 T C 17: 31,217,701 (GRCm39) I1169T possibly damaging Het
Vwa3b G A 1: 37,153,615 (GRCm39) D486N probably damaging Het
Wars2 T C 3: 99,094,846 (GRCm39) L47P probably benign Het
Zbtb14 A G 17: 69,695,576 (GRCm39) S425G probably damaging Het
Zdhhc16 T C 19: 41,926,549 (GRCm39) S111P probably benign Het
Other mutations in Dennd2d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Dennd2d APN 3 106,407,861 (GRCm39) missense possibly damaging 0.45
IGL01397:Dennd2d APN 3 106,394,365 (GRCm39) critical splice donor site probably null 0.00
IGL01410:Dennd2d APN 3 106,398,542 (GRCm39) missense probably damaging 1.00
IGL02022:Dennd2d APN 3 106,407,220 (GRCm39) missense probably benign 0.00
IGL02032:Dennd2d APN 3 106,398,543 (GRCm39) missense probably damaging 1.00
IGL02309:Dennd2d APN 3 106,402,284 (GRCm39) missense probably benign
R0140:Dennd2d UTSW 3 106,399,799 (GRCm39) missense probably benign 0.08
R0648:Dennd2d UTSW 3 106,407,871 (GRCm39) missense probably damaging 0.97
R1519:Dennd2d UTSW 3 106,399,875 (GRCm39) missense probably damaging 1.00
R1539:Dennd2d UTSW 3 106,394,236 (GRCm39) missense probably benign 0.00
R1652:Dennd2d UTSW 3 106,394,317 (GRCm39) missense probably benign 0.00
R1674:Dennd2d UTSW 3 106,399,833 (GRCm39) missense probably benign 0.17
R2179:Dennd2d UTSW 3 106,399,776 (GRCm39) missense probably benign 0.00
R3731:Dennd2d UTSW 3 106,407,271 (GRCm39) missense probably damaging 1.00
R4077:Dennd2d UTSW 3 106,389,939 (GRCm39) unclassified probably benign
R4134:Dennd2d UTSW 3 106,389,977 (GRCm39) missense probably benign 0.34
R4135:Dennd2d UTSW 3 106,389,977 (GRCm39) missense probably benign 0.34
R5214:Dennd2d UTSW 3 106,393,637 (GRCm39) critical splice donor site probably null
R5767:Dennd2d UTSW 3 106,395,131 (GRCm39) intron probably benign
R6001:Dennd2d UTSW 3 106,399,776 (GRCm39) missense probably benign 0.00
R6239:Dennd2d UTSW 3 106,402,193 (GRCm39) missense probably damaging 1.00
R7312:Dennd2d UTSW 3 106,398,579 (GRCm39) missense probably benign 0.38
R7593:Dennd2d UTSW 3 106,407,244 (GRCm39) missense probably damaging 1.00
R8841:Dennd2d UTSW 3 106,393,580 (GRCm39) missense probably benign
R9103:Dennd2d UTSW 3 106,397,684 (GRCm39) missense
R9341:Dennd2d UTSW 3 106,397,730 (GRCm39) critical splice donor site probably null
R9388:Dennd2d UTSW 3 106,395,915 (GRCm39) missense possibly damaging 0.93
Z1088:Dennd2d UTSW 3 106,407,190 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGCTGTTCGTTTCATGAACTAATCC -3'
(R):5'- TCTTCAGGAGAAACAGCCTTC -3'

Sequencing Primer
(F):5'- GAACTAATCCCATTTGTAGCACTC -3'
(R):5'- GGAGAAACAGCCTTCTAGATTTCC -3'
Posted On 2022-04-18