Incidental Mutation 'R0743:Ovgp1'
ID 70762
Institutional Source Beutler Lab
Gene Symbol Ovgp1
Ensembl Gene ENSMUSG00000074340
Gene Name oviductal glycoprotein 1
Synonyms oviductin, Chit5, OGP, muc9, MOGP, mucin 9
MMRRC Submission 038924-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0743 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 105881118-105894739 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 105882248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 37 (L37H)
Ref Sequence ENSEMBL: ENSMUSP00000132424 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000130994] [ENSMUST00000163626]
AlphaFold Q62010
Predicted Effect probably damaging
Transcript: ENSMUST00000000573
AA Change: L50H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: L50H

DomainStartEndE-ValueType
low complexity region 4 13 N/A INTRINSIC
Glyco_18 22 360 1.38e-134 SMART
low complexity region 486 515 N/A INTRINSIC
low complexity region 533 626 N/A INTRINSIC
low complexity region 637 648 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130994
SMART Domains Protein: ENSMUSP00000120517
Gene: ENSMUSG00000000561

DomainStartEndE-ValueType
PDB:4GQB|B 1 52 8e-18 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137168
Predicted Effect probably damaging
Transcript: ENSMUST00000163626
AA Change: L37H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340
AA Change: L37H

DomainStartEndE-ValueType
Glyco_18 9 226 8.52e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164055
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167642
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.7%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A T 14: 118,790,700 (GRCm39) I844N possibly damaging Het
Bend7 A T 2: 4,749,055 (GRCm39) K57N probably damaging Het
Cacna2d4 C T 6: 119,284,247 (GRCm39) R745W probably damaging Het
Cfap91 A G 16: 38,155,996 (GRCm39) F76L probably damaging Het
Csmd2 A T 4: 128,007,469 (GRCm39) T149S probably benign Het
Cyp2a12 T C 7: 26,731,967 (GRCm39) I236T probably benign Het
Dennd2b A G 7: 109,156,552 (GRCm39) L66P probably damaging Het
Dnase1l2 A G 17: 24,660,854 (GRCm39) V170A possibly damaging Het
Dnm2 T A 9: 21,411,561 (GRCm39) Y597N probably damaging Het
Epsti1 A T 14: 78,168,715 (GRCm39) R117S probably damaging Het
Gabarapl2 A T 8: 112,669,137 (GRCm39) I32F probably damaging Het
Glrb T A 3: 80,786,987 (GRCm39) I59F probably damaging Het
Gosr1 A G 11: 76,620,972 (GRCm39) I239T probably benign Het
Kif5b G T 18: 6,209,192 (GRCm39) R857S probably damaging Het
Kmt5a C A 5: 124,585,282 (GRCm39) N44K probably damaging Het
Ksr1 A T 11: 78,912,329 (GRCm39) H675Q possibly damaging Het
Mep1b A G 18: 21,213,515 (GRCm39) D68G possibly damaging Het
Nebl A C 2: 17,415,929 (GRCm39) S327A probably benign Het
Nfat5 G A 8: 108,094,698 (GRCm39) E962K probably damaging Het
Nfatc4 A C 14: 56,064,101 (GRCm39) D126A probably damaging Het
Nmt2 A T 2: 3,315,822 (GRCm39) R271* probably null Het
Nol7 G A 13: 43,554,091 (GRCm39) V133I probably benign Het
Npepps A G 11: 97,096,884 (GRCm39) probably benign Het
Nphp3 GCATCATCATCATCATC GCATCATCATCATC 9: 103,899,967 (GRCm39) probably benign Het
Or1e1c A T 11: 73,265,715 (GRCm39) I47F probably benign Het
Or51ag1 C T 7: 103,156,069 (GRCm39) W28* probably null Het
Or6c66 T A 10: 129,461,712 (GRCm39) T73S probably benign Het
Or8h10 G A 2: 86,808,843 (GRCm39) T99I probably benign Het
Padi3 G T 4: 140,513,740 (GRCm39) A646D probably benign Het
Pamr1 A G 2: 102,440,252 (GRCm39) E142G probably damaging Het
Papolg A T 11: 23,820,818 (GRCm39) probably null Het
Pate8 T C 9: 36,492,597 (GRCm39) S103G probably benign Het
Pfkl C T 10: 77,831,077 (GRCm39) probably null Het
Plrg1 T C 3: 82,967,224 (GRCm39) S132P probably benign Het
Pramel23 A T 4: 143,425,134 (GRCm39) I103N probably damaging Het
Prr14l C A 5: 32,988,538 (GRCm39) C319F possibly damaging Het
Prtn3 T A 10: 79,715,511 (GRCm39) M1K probably null Het
Ptpn22 T C 3: 103,809,487 (GRCm39) F700S probably damaging Het
Ptprz1 C T 6: 23,044,366 (GRCm39) Q1273* probably null Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Ryr2 T C 13: 11,569,415 (GRCm39) D4963G probably damaging Het
Sec16a G A 2: 26,309,734 (GRCm39) L2091F possibly damaging Het
Senp6 C T 9: 80,000,871 (GRCm39) R27C probably damaging Het
Shcbp1 T A 8: 4,814,906 (GRCm39) M191L probably benign Het
Sirt4 T C 5: 115,621,014 (GRCm39) K53E probably benign Het
Slc10a2 A G 8: 5,139,132 (GRCm39) S271P probably damaging Het
Slc35b2 T A 17: 45,877,751 (GRCm39) F293I probably damaging Het
Slc38a10 C T 11: 120,031,469 (GRCm39) V103M probably damaging Het
Stab2 T A 10: 86,723,759 (GRCm39) I1479F probably damaging Het
Synpo2 A G 3: 122,906,355 (GRCm39) V987A probably benign Het
Syt9 A G 7: 107,035,768 (GRCm39) I262V probably damaging Het
Taf2 GCTTCTTCTTCTTCTTCTT GCTTCTTCTTCTTCTT 15: 54,879,857 (GRCm39) probably benign Het
Tmem39a A T 16: 38,405,764 (GRCm39) I200F probably damaging Het
Ttn G A 2: 76,579,613 (GRCm39) T23760M probably damaging Het
Uqcrc1 C T 9: 108,773,773 (GRCm39) Q22* probably null Het
Wdtc1 A G 4: 133,027,972 (GRCm39) W377R probably damaging Het
Zfp454 A G 11: 50,764,764 (GRCm39) S223P probably benign Het
Other mutations in Ovgp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00973:Ovgp1 APN 3 105,888,593 (GRCm39) nonsense probably null
IGL01152:Ovgp1 APN 3 105,893,488 (GRCm39) missense possibly damaging 0.94
IGL01458:Ovgp1 APN 3 105,882,307 (GRCm39) missense probably benign 0.01
IGL01646:Ovgp1 APN 3 105,885,665 (GRCm39) missense probably damaging 1.00
IGL01768:Ovgp1 APN 3 105,888,667 (GRCm39) critical splice donor site probably null
IGL02712:Ovgp1 APN 3 105,893,829 (GRCm39) unclassified probably benign
IGL03065:Ovgp1 APN 3 105,893,682 (GRCm39) missense probably benign 0.01
IGL03140:Ovgp1 APN 3 105,887,222 (GRCm39) missense probably damaging 1.00
IGL03272:Ovgp1 APN 3 105,888,641 (GRCm39) missense probably damaging 0.99
PIT4472001:Ovgp1 UTSW 3 105,894,306 (GRCm39) missense unknown
R0277:Ovgp1 UTSW 3 105,887,208 (GRCm39) intron probably benign
R0560:Ovgp1 UTSW 3 105,893,726 (GRCm39) unclassified probably benign
R0718:Ovgp1 UTSW 3 105,882,146 (GRCm39) splice site probably benign
R1362:Ovgp1 UTSW 3 105,893,891 (GRCm39) unclassified probably benign
R1556:Ovgp1 UTSW 3 105,894,068 (GRCm39) unclassified probably benign
R1776:Ovgp1 UTSW 3 105,885,114 (GRCm39) missense possibly damaging 0.52
R1831:Ovgp1 UTSW 3 105,892,384 (GRCm39) missense probably benign 0.04
R1986:Ovgp1 UTSW 3 105,882,251 (GRCm39) missense probably damaging 1.00
R2004:Ovgp1 UTSW 3 105,894,309 (GRCm39) unclassified probably benign
R2156:Ovgp1 UTSW 3 105,885,033 (GRCm39) missense possibly damaging 0.49
R2254:Ovgp1 UTSW 3 105,894,228 (GRCm39) unclassified probably benign
R2860:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R2861:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R3117:Ovgp1 UTSW 3 105,893,768 (GRCm39) unclassified probably benign
R3793:Ovgp1 UTSW 3 105,887,487 (GRCm39) missense probably benign 0.03
R3835:Ovgp1 UTSW 3 105,893,631 (GRCm39) missense probably benign 0.00
R3894:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R3894:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R3895:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R4050:Ovgp1 UTSW 3 105,893,912 (GRCm39) unclassified probably benign
R4050:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R4467:Ovgp1 UTSW 3 105,885,027 (GRCm39) missense probably benign 0.04
R4611:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R4628:Ovgp1 UTSW 3 105,887,639 (GRCm39) splice site probably null
R4738:Ovgp1 UTSW 3 105,887,234 (GRCm39) missense probably damaging 1.00
R4944:Ovgp1 UTSW 3 105,887,269 (GRCm39) missense possibly damaging 0.66
R5110:Ovgp1 UTSW 3 105,885,099 (GRCm39) missense probably damaging 1.00
R6531:Ovgp1 UTSW 3 105,894,387 (GRCm39) unclassified probably benign
R6540:Ovgp1 UTSW 3 105,893,897 (GRCm39) nonsense probably null
R6562:Ovgp1 UTSW 3 105,887,589 (GRCm39) missense probably damaging 1.00
R6601:Ovgp1 UTSW 3 105,893,747 (GRCm39) unclassified probably benign
R6906:Ovgp1 UTSW 3 105,894,189 (GRCm39) unclassified probably benign
R7313:Ovgp1 UTSW 3 105,894,387 (GRCm39) missense unknown
R7430:Ovgp1 UTSW 3 105,893,619 (GRCm39) missense possibly damaging 0.62
R7430:Ovgp1 UTSW 3 105,893,618 (GRCm39) missense probably damaging 0.99
R7566:Ovgp1 UTSW 3 105,881,626 (GRCm39) start gained probably benign
R7684:Ovgp1 UTSW 3 105,887,272 (GRCm39) missense probably damaging 0.99
R7805:Ovgp1 UTSW 3 105,894,110 (GRCm39) missense unknown
R7820:Ovgp1 UTSW 3 105,893,837 (GRCm39) unclassified probably benign
R7919:Ovgp1 UTSW 3 105,888,601 (GRCm39) missense probably damaging 1.00
R8039:Ovgp1 UTSW 3 105,883,339 (GRCm39) missense probably benign 0.26
R8483:Ovgp1 UTSW 3 105,894,311 (GRCm39) unclassified probably benign
R9259:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9261:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9262:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9359:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9389:Ovgp1 UTSW 3 105,893,841 (GRCm39) unclassified probably benign
R9390:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9444:Ovgp1 UTSW 3 105,893,841 (GRCm39) unclassified probably benign
R9445:Ovgp1 UTSW 3 105,893,883 (GRCm39) unclassified probably benign
R9466:Ovgp1 UTSW 3 105,887,484 (GRCm39) missense
R9586:Ovgp1 UTSW 3 105,881,138 (GRCm39) missense probably damaging 0.96
Z1177:Ovgp1 UTSW 3 105,894,156 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GTCAAGAATCTGAGTTCCCTTCTTGCC -3'
(R):5'- TGAGCCAAAGTTTCCCAGGAGAAAG -3'

Sequencing Primer
(F):5'- CCCATGATCTCTGCTGATTAATAC -3'
(R):5'- TATGTCAGAGGTACTCAGATCCC -3'
Posted On 2013-09-30