Incidental Mutation 'R9344:Vipr1'
ID 707693
Institutional Source Beutler Lab
Gene Symbol Vipr1
Ensembl Gene ENSMUSG00000032528
Gene Name vasoactive intestinal peptide receptor 1
Synonyms VIP-R1, VPAC1, VIP receptor subtype 1
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9344 (G1)
Quality Score 129.008
Status Validated
Chromosome 9
Chromosomal Location 121471782-121502020 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 121471993 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000035115 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035115] [ENSMUST00000077706] [ENSMUST00000120918] [ENSMUST00000125075] [ENSMUST00000213757] [ENSMUST00000214592]
AlphaFold P97751
Predicted Effect probably null
Transcript: ENSMUST00000035115
SMART Domains Protein: ENSMUSP00000035115
Gene: ENSMUSG00000032528

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
HormR 59 131 7.38e-26 SMART
Pfam:7tm_2 140 386 1.4e-95 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077706
SMART Domains Protein: ENSMUSP00000076887
Gene: ENSMUSG00000032530

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120918
SMART Domains Protein: ENSMUSP00000113034
Gene: ENSMUSG00000032530

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125075
SMART Domains Protein: ENSMUSP00000115284
Gene: ENSMUSG00000032530

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 91 6.48e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213757
Predicted Effect probably benign
Transcript: ENSMUST00000214592
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal lethality associated with severe neonatal growth failure, enlarged cecum, intestinal hemorrhage, and enterocyte hyperproliferation in addition to disorganized islets and impaired glucose homeostasisin surviving mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik A G 16: 64,591,135 (GRCm39) V31A possibly damaging Het
Adss2 A G 1: 177,597,527 (GRCm39) Y378H probably damaging Het
Aldh1a1 T A 19: 20,608,150 (GRCm39) V324D probably damaging Het
Ankrd33b A G 15: 31,297,903 (GRCm39) S285P probably damaging Het
Arel1 C T 12: 84,981,371 (GRCm39) G269S probably damaging Het
Arhgap44 A G 11: 65,053,463 (GRCm39) M1T probably null Het
Arpin C T 7: 79,577,983 (GRCm39) V149I probably benign Het
Arpp21 A G 9: 112,014,720 (GRCm39) L28P possibly damaging Het
Ccr8 G A 9: 119,923,133 (GRCm39) V83I probably damaging Het
Cnksr1 T C 4: 133,963,508 (GRCm39) E58G probably damaging Het
Dctn2 T A 10: 127,114,084 (GRCm39) H341Q probably damaging Het
Ddx21 C A 10: 62,428,825 (GRCm39) A362S possibly damaging Het
Dnajc1 C T 2: 18,289,586 (GRCm39) V274I probably benign Het
Dock3 A C 9: 106,870,763 (GRCm39) C550W probably damaging Het
Dst T C 1: 34,220,676 (GRCm39) L2160S probably damaging Het
Duox1 T A 2: 122,168,163 (GRCm39) M1096K probably benign Het
Dync2h1 A T 9: 7,148,659 (GRCm39) D928E probably benign Het
E030025P04Rik C T 11: 109,030,454 (GRCm39) probably null Het
Eid2b T C 7: 27,977,591 (GRCm39) M129T possibly damaging Het
Fnip2 G A 3: 79,407,717 (GRCm39) S288F possibly damaging Het
Grm4 G T 17: 27,653,737 (GRCm39) R738S probably benign Het
Gsto2 A G 19: 47,864,884 (GRCm39) D139G probably benign Het
Herc2 T A 7: 55,772,112 (GRCm39) V1097E probably benign Het
Impg1 G A 9: 80,312,040 (GRCm39) A181V probably benign Het
Irs2 G T 8: 11,057,289 (GRCm39) S381* probably null Het
Itprid1 C T 6: 55,955,470 (GRCm39) T1026I probably benign Het
Lrrd1 A C 5: 3,908,819 (GRCm39) D697A possibly damaging Het
Nat10 A G 2: 103,573,460 (GRCm39) S346P probably damaging Het
Ncapg2 G A 12: 116,388,273 (GRCm39) R319H probably damaging Het
Nid1 A G 13: 13,652,894 (GRCm39) Y568C probably damaging Het
Noc2l G A 4: 156,325,130 (GRCm39) C325Y probably damaging Het
Or12e9 A T 2: 87,202,161 (GRCm39) D95V possibly damaging Het
Or1e17 C A 11: 73,831,744 (GRCm39) S224Y possibly damaging Het
Pde2a G T 7: 101,144,891 (GRCm39) V169F possibly damaging Het
Pon3 T C 6: 5,221,586 (GRCm39) K348R probably benign Het
Ppp6c A G 2: 39,090,052 (GRCm39) probably null Het
Prrc2b G A 2: 32,103,600 (GRCm39) G1026D probably benign Het
Psg22 A T 7: 18,460,816 (GRCm39) T482S possibly damaging Het
Rdh19 G A 10: 127,692,740 (GRCm39) V136M probably damaging Het
Sbf2 T A 7: 109,940,535 (GRCm39) N1275I probably benign Het
Sema4c T C 1: 36,592,395 (GRCm39) N182D probably damaging Het
Slc7a12 T A 3: 14,570,491 (GRCm39) H414Q probably damaging Het
Slitrk5 A G 14: 111,916,702 (GRCm39) I109V probably damaging Het
Spag17 C T 3: 100,010,793 (GRCm39) P2096S probably benign Het
Steap1 T A 5: 5,786,459 (GRCm39) D326V probably damaging Het
Tacr1 C T 6: 82,380,847 (GRCm39) T86I probably damaging Het
Tenm4 C T 7: 96,545,352 (GRCm39) T2493I probably damaging Het
Tet2 A G 3: 133,175,115 (GRCm39) S1411P possibly damaging Het
Tom1 C T 8: 75,785,076 (GRCm39) R303C probably damaging Het
Trav7n-4 T A 14: 53,329,200 (GRCm39) I70N possibly damaging Het
Utrn A C 10: 12,560,275 (GRCm39) V1338G probably benign Het
Vmn1r122 A T 7: 20,867,271 (GRCm39) H261Q probably benign Het
Vmn1r40 G T 6: 89,691,235 (GRCm39) L17F probably benign Het
Vmn2r54 A G 7: 12,366,283 (GRCm39) V217A probably benign Het
Vmn2r55 C A 7: 12,385,782 (GRCm39) G733* probably null Het
Vmn2r98 A T 17: 19,286,777 (GRCm39) N425I probably benign Het
Vps51 C T 19: 6,126,345 (GRCm39) V136I unknown Het
Zfp184 T C 13: 22,144,411 (GRCm39) C706R probably damaging Het
Other mutations in Vipr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01456:Vipr1 APN 9 121,494,244 (GRCm39) missense probably damaging 0.99
IGL01779:Vipr1 APN 9 121,493,696 (GRCm39) missense probably damaging 1.00
IGL01809:Vipr1 APN 9 121,490,506 (GRCm39) missense possibly damaging 0.70
IGL02250:Vipr1 APN 9 121,494,255 (GRCm39) missense probably benign 0.10
IGL02677:Vipr1 APN 9 121,489,349 (GRCm39) splice site probably benign
bernalillo UTSW 9 121,493,684 (GRCm39) missense probably damaging 1.00
R0036:Vipr1 UTSW 9 121,490,049 (GRCm39) missense probably benign
R0514:Vipr1 UTSW 9 121,487,115 (GRCm39) missense probably damaging 1.00
R0629:Vipr1 UTSW 9 121,489,237 (GRCm39) nonsense probably null
R1470:Vipr1 UTSW 9 121,494,586 (GRCm39) missense possibly damaging 0.66
R1470:Vipr1 UTSW 9 121,494,586 (GRCm39) missense possibly damaging 0.66
R1766:Vipr1 UTSW 9 121,490,485 (GRCm39) missense possibly damaging 0.87
R1884:Vipr1 UTSW 9 121,494,930 (GRCm39) missense possibly damaging 0.56
R1945:Vipr1 UTSW 9 121,497,541 (GRCm39) missense probably damaging 1.00
R1945:Vipr1 UTSW 9 121,497,540 (GRCm39) missense probably damaging 1.00
R2366:Vipr1 UTSW 9 121,494,250 (GRCm39) missense probably benign 0.19
R4275:Vipr1 UTSW 9 121,493,684 (GRCm39) missense probably damaging 1.00
R4600:Vipr1 UTSW 9 121,494,202 (GRCm39) splice site probably null
R5012:Vipr1 UTSW 9 121,487,111 (GRCm39) critical splice acceptor site probably null
R6190:Vipr1 UTSW 9 121,493,719 (GRCm39) missense probably damaging 1.00
R6376:Vipr1 UTSW 9 121,493,640 (GRCm39) missense probably damaging 1.00
R6473:Vipr1 UTSW 9 121,497,621 (GRCm39) missense probably damaging 1.00
R6476:Vipr1 UTSW 9 121,498,489 (GRCm39) missense probably benign 0.28
R6641:Vipr1 UTSW 9 121,498,631 (GRCm39) makesense probably null
R6752:Vipr1 UTSW 9 121,482,959 (GRCm39) missense probably damaging 0.99
R7189:Vipr1 UTSW 9 121,493,620 (GRCm39) missense probably damaging 0.97
R7371:Vipr1 UTSW 9 121,497,621 (GRCm39) missense probably damaging 1.00
R7419:Vipr1 UTSW 9 121,490,539 (GRCm39) missense probably damaging 0.97
R7647:Vipr1 UTSW 9 121,482,905 (GRCm39) missense possibly damaging 0.79
R8123:Vipr1 UTSW 9 121,498,518 (GRCm39) missense probably damaging 1.00
R8225:Vipr1 UTSW 9 121,471,915 (GRCm39) start codon destroyed possibly damaging 0.59
R8675:Vipr1 UTSW 9 121,493,732 (GRCm39) missense probably damaging 1.00
R9256:Vipr1 UTSW 9 121,490,118 (GRCm39) missense probably benign 0.09
R9343:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9422:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9424:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9463:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9464:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9517:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9576:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
R9577:Vipr1 UTSW 9 121,471,993 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AAGACTGGAGGAGCTCACTG -3'
(R):5'- TGATTGGGATCACTTCGCGG -3'

Sequencing Primer
(F):5'- TGGAGCTGTGCCTCATAGC -3'
(R):5'- CGGTGAGCGCTCTAAGATG -3'
Posted On 2022-04-18