Incidental Mutation 'R9344:Vmn2r98'
| ID |
707709 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
R9344 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19286777 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 425
(N425I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170424
AA Change: N425I
PolyPhen 2
Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: N425I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930453N24Rik |
A |
G |
16: 64,591,135 (GRCm39) |
V31A |
possibly damaging |
Het |
| Adss2 |
A |
G |
1: 177,597,527 (GRCm39) |
Y378H |
probably damaging |
Het |
| Aldh1a1 |
T |
A |
19: 20,608,150 (GRCm39) |
V324D |
probably damaging |
Het |
| Ankrd33b |
A |
G |
15: 31,297,903 (GRCm39) |
S285P |
probably damaging |
Het |
| Arel1 |
C |
T |
12: 84,981,371 (GRCm39) |
G269S |
probably damaging |
Het |
| Arhgap44 |
A |
G |
11: 65,053,463 (GRCm39) |
M1T |
probably null |
Het |
| Arpin |
C |
T |
7: 79,577,983 (GRCm39) |
V149I |
probably benign |
Het |
| Arpp21 |
A |
G |
9: 112,014,720 (GRCm39) |
L28P |
possibly damaging |
Het |
| Ccr8 |
G |
A |
9: 119,923,133 (GRCm39) |
V83I |
probably damaging |
Het |
| Cnksr1 |
T |
C |
4: 133,963,508 (GRCm39) |
E58G |
probably damaging |
Het |
| Dctn2 |
T |
A |
10: 127,114,084 (GRCm39) |
H341Q |
probably damaging |
Het |
| Ddx21 |
C |
A |
10: 62,428,825 (GRCm39) |
A362S |
possibly damaging |
Het |
| Dnajc1 |
C |
T |
2: 18,289,586 (GRCm39) |
V274I |
probably benign |
Het |
| Dock3 |
A |
C |
9: 106,870,763 (GRCm39) |
C550W |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,220,676 (GRCm39) |
L2160S |
probably damaging |
Het |
| Duox1 |
T |
A |
2: 122,168,163 (GRCm39) |
M1096K |
probably benign |
Het |
| Dync2h1 |
A |
T |
9: 7,148,659 (GRCm39) |
D928E |
probably benign |
Het |
| E030025P04Rik |
C |
T |
11: 109,030,454 (GRCm39) |
|
probably null |
Het |
| Eid2b |
T |
C |
7: 27,977,591 (GRCm39) |
M129T |
possibly damaging |
Het |
| Fnip2 |
G |
A |
3: 79,407,717 (GRCm39) |
S288F |
possibly damaging |
Het |
| Grm4 |
G |
T |
17: 27,653,737 (GRCm39) |
R738S |
probably benign |
Het |
| Gsto2 |
A |
G |
19: 47,864,884 (GRCm39) |
D139G |
probably benign |
Het |
| Herc2 |
T |
A |
7: 55,772,112 (GRCm39) |
V1097E |
probably benign |
Het |
| Impg1 |
G |
A |
9: 80,312,040 (GRCm39) |
A181V |
probably benign |
Het |
| Irs2 |
G |
T |
8: 11,057,289 (GRCm39) |
S381* |
probably null |
Het |
| Itprid1 |
C |
T |
6: 55,955,470 (GRCm39) |
T1026I |
probably benign |
Het |
| Lrrd1 |
A |
C |
5: 3,908,819 (GRCm39) |
D697A |
possibly damaging |
Het |
| Nat10 |
A |
G |
2: 103,573,460 (GRCm39) |
S346P |
probably damaging |
Het |
| Ncapg2 |
G |
A |
12: 116,388,273 (GRCm39) |
R319H |
probably damaging |
Het |
| Nid1 |
A |
G |
13: 13,652,894 (GRCm39) |
Y568C |
probably damaging |
Het |
| Noc2l |
G |
A |
4: 156,325,130 (GRCm39) |
C325Y |
probably damaging |
Het |
| Or12e9 |
A |
T |
2: 87,202,161 (GRCm39) |
D95V |
possibly damaging |
Het |
| Or1e17 |
C |
A |
11: 73,831,744 (GRCm39) |
S224Y |
possibly damaging |
Het |
| Pde2a |
G |
T |
7: 101,144,891 (GRCm39) |
V169F |
possibly damaging |
Het |
| Pon3 |
T |
C |
6: 5,221,586 (GRCm39) |
K348R |
probably benign |
Het |
| Ppp6c |
A |
G |
2: 39,090,052 (GRCm39) |
|
probably null |
Het |
| Prrc2b |
G |
A |
2: 32,103,600 (GRCm39) |
G1026D |
probably benign |
Het |
| Psg22 |
A |
T |
7: 18,460,816 (GRCm39) |
T482S |
possibly damaging |
Het |
| Rdh19 |
G |
A |
10: 127,692,740 (GRCm39) |
V136M |
probably damaging |
Het |
| Sbf2 |
T |
A |
7: 109,940,535 (GRCm39) |
N1275I |
probably benign |
Het |
| Sema4c |
T |
C |
1: 36,592,395 (GRCm39) |
N182D |
probably damaging |
Het |
| Slc7a12 |
T |
A |
3: 14,570,491 (GRCm39) |
H414Q |
probably damaging |
Het |
| Slitrk5 |
A |
G |
14: 111,916,702 (GRCm39) |
I109V |
probably damaging |
Het |
| Spag17 |
C |
T |
3: 100,010,793 (GRCm39) |
P2096S |
probably benign |
Het |
| Steap1 |
T |
A |
5: 5,786,459 (GRCm39) |
D326V |
probably damaging |
Het |
| Tacr1 |
C |
T |
6: 82,380,847 (GRCm39) |
T86I |
probably damaging |
Het |
| Tenm4 |
C |
T |
7: 96,545,352 (GRCm39) |
T2493I |
probably damaging |
Het |
| Tet2 |
A |
G |
3: 133,175,115 (GRCm39) |
S1411P |
possibly damaging |
Het |
| Tom1 |
C |
T |
8: 75,785,076 (GRCm39) |
R303C |
probably damaging |
Het |
| Trav7n-4 |
T |
A |
14: 53,329,200 (GRCm39) |
I70N |
possibly damaging |
Het |
| Utrn |
A |
C |
10: 12,560,275 (GRCm39) |
V1338G |
probably benign |
Het |
| Vipr1 |
G |
A |
9: 121,471,993 (GRCm39) |
|
probably null |
Het |
| Vmn1r122 |
A |
T |
7: 20,867,271 (GRCm39) |
H261Q |
probably benign |
Het |
| Vmn1r40 |
G |
T |
6: 89,691,235 (GRCm39) |
L17F |
probably benign |
Het |
| Vmn2r54 |
A |
G |
7: 12,366,283 (GRCm39) |
V217A |
probably benign |
Het |
| Vmn2r55 |
C |
A |
7: 12,385,782 (GRCm39) |
G733* |
probably null |
Het |
| Vps51 |
C |
T |
19: 6,126,345 (GRCm39) |
V136I |
unknown |
Het |
| Zfp184 |
T |
C |
13: 22,144,411 (GRCm39) |
C706R |
probably damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATTGTCATGTGTTGGGAAACTGTC -3'
(R):5'- TGCTCCTGGTATCTTGTACATG -3'
Sequencing Primer
(F):5'- CATGTGTTGGGAAACTGTCAAACC -3'
(R):5'- GCTCCTGGTATCTTGTACATGACTTC -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation