Mutagenetix > Incidental Mutation

Incidental Mutation 'R9344:Vmn2r98'

707709

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R9344 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19066515 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 425 (N425I)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: N425I

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: N425I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (57/57)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930453N24Rik	A	G	16: 64,770,772	V31A	possibly damaging	Het
Adss	A	G	1: 177,769,961	Y378H	probably damaging	Het
Aldh1a1	T	A	19: 20,630,786	V324D	probably damaging	Het
Ankrd33b	A	G	15: 31,297,757	S285P	probably damaging	Het
Arel1	C	T	12: 84,934,597	G269S	probably damaging	Het
Arhgap44	A	G	11: 65,162,637	M1T	probably null	Het
Arpin	C	T	7: 79,928,235	V149I	probably benign	Het
Arpp21	A	G	9: 112,185,652	L28P	possibly damaging	Het
Ccdc129	C	T	6: 55,978,485	T1026I	probably benign	Het
Ccr8	G	A	9: 120,094,067	V83I	probably damaging	Het
Cnksr1	T	C	4: 134,236,197	E58G	probably damaging	Het
Dctn2	T	A	10: 127,278,215	H341Q	probably damaging	Het
Ddx21	C	A	10: 62,593,046	A362S	possibly damaging	Het
Dnajc1	C	T	2: 18,284,775	V274I	probably benign	Het
Dock3	A	C	9: 106,993,564	C550W	probably damaging	Het
Dst	T	C	1: 34,181,595	L2160S	probably damaging	Het
Duox1	T	A	2: 122,337,682	M1096K	probably benign	Het
Dync2h1	A	T	9: 7,148,659	D928E	probably benign	Het
E030025P04Rik	C	T	11: 109,139,628		probably null	Het
Eid2b	T	C	7: 28,278,166	M129T	possibly damaging	Het
Fnip2	G	A	3: 79,500,410	S288F	possibly damaging	Het
Grm4	G	T	17: 27,434,763	R738S	probably benign	Het
Gsto2	A	G	19: 47,876,445	D139G	probably benign	Het
Herc2	T	A	7: 56,122,364	V1097E	probably benign	Het
Impg1	G	A	9: 80,404,758	A181V	probably benign	Het
Irs2	G	T	8: 11,007,289	S381*	probably null	Het
Lrrd1	A	C	5: 3,858,819	D697A	possibly damaging	Het
Nat10	A	G	2: 103,743,115	S346P	probably damaging	Het
Ncapg2	G	A	12: 116,424,653	R319H	probably damaging	Het
Nid1	A	G	13: 13,478,309	Y568C	probably damaging	Het
Noc2l	G	A	4: 156,240,673	C325Y	probably damaging	Het
Olfr1121	A	T	2: 87,371,817	D95V	possibly damaging	Het
Olfr23	C	A	11: 73,940,918	S224Y	possibly damaging	Het
Pde2a	G	T	7: 101,495,684	V169F	possibly damaging	Het
Pon3	T	C	6: 5,221,586	K348R	probably benign	Het
Ppp6c	A	G	2: 39,200,040		probably null	Het
Prrc2b	G	A	2: 32,213,588	G1026D	probably benign	Het
Psg22	A	T	7: 18,726,891	T482S	possibly damaging	Het
Rdh19	G	A	10: 127,856,871	V136M	probably damaging	Het
Sbf2	T	A	7: 110,341,328	N1275I	probably benign	Het
Sema4c	T	C	1: 36,553,314	N182D	probably damaging	Het
Slc7a12	T	A	3: 14,505,431	H414Q	probably damaging	Het
Slitrk5	A	G	14: 111,679,270	I109V	probably damaging	Het
Spag17	C	T	3: 100,103,477	P2096S	probably benign	Het
Steap1	T	A	5: 5,736,459	D326V	probably damaging	Het
Tacr1	C	T	6: 82,403,866	T86I	probably damaging	Het
Tenm4	C	T	7: 96,896,145	T2493I	probably damaging	Het
Tet2	A	G	3: 133,469,354	S1411P	possibly damaging	Het
Tom1	C	T	8: 75,058,448	R303C	probably damaging	Het
Trav7n-4	T	A	14: 53,091,743	I70N	possibly damaging	Het
Utrn	A	C	10: 12,684,531	V1338G	probably benign	Het
Vipr1	G	A	9: 121,642,927		probably null	Het
Vmn1r122	A	T	7: 21,133,346	H261Q	probably benign	Het
Vmn1r40	G	T	6: 89,714,253	L17F	probably benign	Het
Vmn2r54	A	G	7: 12,632,356	V217A	probably benign	Het
Vmn2r55	C	A	7: 12,651,855	G733*	probably null	Het
Vps51	C	T	19: 6,076,315	V136I	unknown	Het
Zfp184	T	C	13: 21,960,241	C706R	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19066286	missense	probably benign
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19065851	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19080719	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19066074	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19081219	missense	probably damaging	1.00
R9467:Vmn2r98	UTSW	17	19067255	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19081234	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19065403	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AATTGTCATGTGTTGGGAAACTGTC -3'
(R):5'- TGCTCCTGGTATCTTGTACATG -3'

Sequencing Primer
(F):5'- CATGTGTTGGGAAACTGTCAAACC -3'
(R):5'- GCTCCTGGTATCTTGTACATGACTTC -3'

Posted On

2022-04-18