Mutagenetix > Incidental Mutation

Incidental Mutation 'R9348:Oog2'

707907

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9348 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

143917289-143923504 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 143921789 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 233 (L233P)

Ref Sequence

ENSEMBL: ENSMUSP00000079267 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably damaging
Transcript: ENSMUST00000080405
AA Change: L233P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030
AA Change: L233P

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	C	T	8: 41,208,953 (GRCm39)	P740S	probably benign	Het
Arfgef1	G	T	1: 10,283,419 (GRCm39)	H163Q	probably benign	Het
Arih2	C	G	9: 108,488,938 (GRCm39)	R260P	probably damaging	Het
Atp6v1h	T	A	1: 5,187,699 (GRCm39)	D222E	probably damaging	Het
Auts2	T	C	5: 131,490,155 (GRCm39)	T165A		Het
BC034090	A	G	1: 155,099,049 (GRCm39)	S579P	probably benign	Het
Bpifb9b	T	A	2: 154,160,766 (GRCm39)	S546T	probably benign	Het
C4b	C	T	17: 34,952,159 (GRCm39)	V1229I	probably benign	Het
Cadps2	T	C	6: 23,344,262 (GRCm39)	D895G	probably benign	Het
Cby2	A	G	14: 75,820,838 (GRCm39)	S296P	probably damaging	Het
Cep112	T	C	11: 108,328,076 (GRCm39)	S51P	probably damaging	Het
Cep164	T	C	9: 45,717,708 (GRCm39)	H545R	unknown	Het
Creb3l1	C	T	2: 91,822,231 (GRCm39)		probably null	Het
Crlf1	T	A	8: 70,951,316 (GRCm39)	I65K	probably benign	Het
Crybg3	T	C	16: 59,421,256 (GRCm39)	M1V	probably null	Het
Cyb5d1	T	A	11: 69,285,830 (GRCm39)	I69L	probably damaging	Het
D430041D05Rik	T	C	2: 104,088,337 (GRCm39)	D213G	probably benign	Het
Dennd5a	C	G	7: 109,498,930 (GRCm39)		probably null	Het
Dennd5a	T	A	7: 109,498,942 (GRCm39)	M998L	probably benign	Het
E2f1	T	A	2: 154,402,755 (GRCm39)	E382D	probably benign	Het
Enpep	T	A	3: 129,102,772 (GRCm39)	T395S	probably benign	Het
Gm20939	A	G	17: 95,182,977 (GRCm39)	E71G	probably damaging	Het
Hs1bp3	T	A	12: 8,386,273 (GRCm39)	V225E	probably benign	Het
Icam5	T	C	9: 20,943,427 (GRCm39)	M1T	probably null	Het
Ifi205	T	C	1: 173,844,997 (GRCm39)	I262V	probably benign	Het
Iqce	T	C	5: 140,677,380 (GRCm39)	Y147C	probably damaging	Het
Kcnh2	C	T	5: 24,538,003 (GRCm39)	G120E	probably damaging	Het
Kif3c	A	G	12: 3,417,505 (GRCm39)	T509A	probably benign	Het
Napepld	A	T	5: 21,875,490 (GRCm39)	N351K	probably benign	Het
Ndufaf3	C	A	9: 108,443,357 (GRCm39)		probably null	Het
Nlrp9b	C	T	7: 19,757,336 (GRCm39)	T191I	probably damaging	Het
Or1a1b	T	A	11: 74,097,289 (GRCm39)	Y251F	probably damaging	Het
Or2g1	T	C	17: 38,106,992 (GRCm39)	I219T	probably damaging	Het
Or2n1d	A	T	17: 38,646,320 (GRCm39)	T91S	possibly damaging	Het
Or2w1	T	A	13: 21,317,131 (GRCm39)	F62Y	possibly damaging	Het
Preb	A	G	5: 31,112,995 (GRCm39)	F416L	probably benign	Het
Prickle2	C	T	6: 92,397,243 (GRCm39)	V217I	probably benign	Het
Prss45	T	A	9: 110,668,278 (GRCm39)	I157N	probably damaging	Het
Ranbp17	T	C	11: 33,429,232 (GRCm39)	T338A	probably benign	Het
Snd1	T	C	6: 28,745,206 (GRCm39)	F517S	probably damaging	Het
Srpk2	A	T	5: 23,719,671 (GRCm39)	F578I	probably damaging	Het
Stx2	A	T	5: 129,076,601 (GRCm39)	D27E	probably benign	Het
Tgfbrap1	A	G	1: 43,093,695 (GRCm39)	I599T	probably benign	Het
Trim25	G	T	11: 88,900,167 (GRCm39)	E305*	probably null	Het
Ttll7	T	A	3: 146,673,768 (GRCm39)	I821N	probably benign	Het
Wdfy3	A	G	5: 102,089,358 (GRCm39)	L612P	probably damaging	Het
Zcchc9	T	A	13: 91,954,186 (GRCm39)	D23V		Het
Zfp141	C	A	7: 42,124,814 (GRCm39)	E553*	probably null	Het
Zfyve26	T	C	12: 79,315,231 (GRCm39)	D1415G	possibly damaging	Het
Zpbp2	C	T	11: 98,442,141 (GRCm39)		probably benign	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	143,921,742 (GRCm39)	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	143,921,837 (GRCm39)	missense	probably benign	0.16
IGL01697:Oog2	APN	4	143,921,754 (GRCm39)	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	143,923,016 (GRCm39)	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	143,921,618 (GRCm39)	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	143,921,799 (GRCm39)	missense	probably benign	0.02
IGL03284:Oog2	APN	4	143,923,177 (GRCm39)	unclassified	probably benign
IGL03394:Oog2	APN	4	143,920,576 (GRCm39)	missense	probably benign	0.17
R0538:Oog2	UTSW	4	143,922,654 (GRCm39)	nonsense	probably null
R0892:Oog2	UTSW	4	143,923,069 (GRCm39)	missense	probably benign	0.00
R1024:Oog2	UTSW	4	143,922,856 (GRCm39)	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	143,920,523 (GRCm39)	intron	probably benign
R4157:Oog2	UTSW	4	143,920,523 (GRCm39)	intron	probably benign
R4166:Oog2	UTSW	4	143,921,411 (GRCm39)	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	143,922,782 (GRCm39)	missense	probably benign	0.18
R4732:Oog2	UTSW	4	143,920,511 (GRCm39)	intron	probably benign
R4734:Oog2	UTSW	4	143,923,021 (GRCm39)	missense	probably benign	0.00
R4741:Oog2	UTSW	4	143,921,715 (GRCm39)	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	143,921,669 (GRCm39)	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	143,917,302 (GRCm39)	start gained	probably benign
R6437:Oog2	UTSW	4	143,921,678 (GRCm39)	splice site	probably null
R6487:Oog2	UTSW	4	143,923,055 (GRCm39)	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	143,923,034 (GRCm39)	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	143,921,897 (GRCm39)	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	143,921,745 (GRCm39)	missense	probably benign	0.04
R7303:Oog2	UTSW	4	143,921,912 (GRCm39)	missense	probably benign	0.04
R7399:Oog2	UTSW	4	143,921,851 (GRCm39)	missense	probably benign	0.01
R8004:Oog2	UTSW	4	143,920,821 (GRCm39)	missense	probably benign	0.00
R8141:Oog2	UTSW	4	143,920,777 (GRCm39)	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	143,920,743 (GRCm39)	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	143,920,685 (GRCm39)	missense	probably benign	0.00
R9290:Oog2	UTSW	4	143,923,015 (GRCm39)	missense	probably benign	0.02
R9614:Oog2	UTSW	4	143,922,707 (GRCm39)	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	143,921,855 (GRCm39)	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	143,920,585 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CCATTCATCTACACTGTAGAAAGC -3'
(R):5'- GTGACCAGACCATCATGGAC -3'

Sequencing Primer
(F):5'- CTGTAGAAAGCTGAAAATTTATGGC -3'
(R):5'- GAAAGAGAAGAGAGGTGTTTTCTC -3'

Posted On

2022-04-18