Mutagenetix > Incidental Mutation

Incidental Mutation 'R9348:Oog2'

707907

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9348 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 144195219 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 233 (L233P)

Ref Sequence

ENSEMBL: ENSMUSP00000079267 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably damaging
Transcript: ENSMUST00000080405
AA Change: L233P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030
AA Change: L233P

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	C	T	8: 40,755,916	P740S	probably benign	Het
Arfgef1	G	T	1: 10,213,194	H163Q	probably benign	Het
Arih2	C	G	9: 108,611,739	R260P	probably damaging	Het
Atp6v1h	T	A	1: 5,117,476	D222E	probably damaging	Het
Auts2	T	C	5: 131,461,317	T165A		Het
BC034090	A	G	1: 155,223,303	S579P	probably benign	Het
Bpifb9b	T	A	2: 154,318,846	S546T	probably benign	Het
C4b	C	T	17: 34,733,185	V1229I	probably benign	Het
Cadps2	T	C	6: 23,344,263	D895G	probably benign	Het
Cep112	T	C	11: 108,437,250	S51P	probably damaging	Het
Cep164	T	C	9: 45,806,410	H545R	unknown	Het
Creb3l1	C	T	2: 91,991,886		probably null	Het
Crlf1	T	A	8: 70,498,666	I65K	probably benign	Het
Crybg3	T	C	16: 59,600,893	M1V	probably null	Het
Cyb5d1	T	A	11: 69,395,004	I69L	probably damaging	Het
D430041D05Rik	T	C	2: 104,257,992	D213G	probably benign	Het
Dennd5a	C	G	7: 109,899,723		probably null	Het
Dennd5a	T	A	7: 109,899,735	M998L	probably benign	Het
E2f1	T	A	2: 154,560,835	E382D	probably benign	Het
Enpep	T	A	3: 129,309,123	T395S	probably benign	Het
Gm20939	A	G	17: 94,875,549	E71G	probably damaging	Het
Hs1bp3	T	A	12: 8,336,273	V225E	probably benign	Het
Icam5	T	C	9: 21,032,131	M1T	probably null	Het
Ifi205	T	C	1: 174,017,431	I262V	probably benign	Het
Iqce	T	C	5: 140,691,625	Y147C	probably damaging	Het
Kcnh2	C	T	5: 24,333,005	G120E	probably damaging	Het
Kif3c	A	G	12: 3,367,505	T509A	probably benign	Het
Napepld	A	T	5: 21,670,492	N351K	probably benign	Het
Ndufaf3	C	A	9: 108,566,158		probably null	Het
Nlrp9b	C	T	7: 20,023,411	T191I	probably damaging	Het
Olfr123	T	C	17: 37,796,101	I219T	probably damaging	Het
Olfr136	A	T	17: 38,335,429	T91S	possibly damaging	Het
Olfr263	T	A	13: 21,132,961	F62Y	possibly damaging	Het
Olfr43	T	A	11: 74,206,463	Y251F	probably damaging	Het
Preb	A	G	5: 30,955,651	F416L	probably benign	Het
Prickle2	C	T	6: 92,420,262	V217I	probably benign	Het
Prss45	T	A	9: 110,839,210	I157N	probably damaging	Het
Ranbp17	T	C	11: 33,479,232	T338A	probably benign	Het
Snd1	T	C	6: 28,745,207	F517S	probably damaging	Het
Spert	A	G	14: 75,583,398	S296P	probably damaging	Het
Srpk2	A	T	5: 23,514,673	F578I	probably damaging	Het
Stx2	A	T	5: 128,999,537	D27E	probably benign	Het
Tgfbrap1	A	G	1: 43,054,535	I599T	probably benign	Het
Trim25	G	T	11: 89,009,341	E305*	probably null	Het
Ttll7	T	A	3: 146,968,013	I821N	probably benign	Het
Wdfy3	A	G	5: 101,941,492	L612P	probably damaging	Het
Zcchc9	T	A	13: 91,806,067	D23V		Het
Zfp141	C	A	7: 42,475,390	E553*	probably null	Het
Zfyve26	T	C	12: 79,268,457	D1415G	possibly damaging	Het
Zpbp2	C	T	11: 98,551,315		probably benign	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
IGL03394:Oog2	APN	4	144194006	missense	probably benign	0.17
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4157:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	144196212	missense	probably benign	0.18
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4741:Oog2	UTSW	4	144195145	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R4954:Oog2	UTSW	4	144190732	start gained	probably benign
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CCATTCATCTACACTGTAGAAAGC -3'
(R):5'- GTGACCAGACCATCATGGAC -3'

Sequencing Primer
(F):5'- CTGTAGAAAGCTGAAAATTTATGGC -3'
(R):5'- GAAAGAGAAGAGAGGTGTTTTCTC -3'

Posted On

2022-04-18