Mutagenetix > Incidental Mutation

Incidental Mutation 'R9357:Vmn1r3'

708450

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r3

Ensembl Gene

ENSMUSG00000115466

Gene Name

vomeronasal 1 receptor 3

Synonyms

Gm11778

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.323) question?

Stock #

R9357 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

3184385-3185305 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 3185149 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 53 (T53P)

Ref Sequence

ENSEMBL: ENSMUSP00000100790 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105159]

AlphaFold

A2AMT7

Predicted Effect

probably damaging
Transcript: ENSMUST00000105159
AA Change: T53P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100790
Gene: ENSMUSG00000115466
AA Change: T53P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	6	302	1.7e-9	PFAM
Pfam:7tm_1	30	292	5.1e-7	PFAM
Pfam:V1R	34	298	1.2e-35	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	A	G	11: 119,901,696 (GRCm39)	V900A	probably benign	Het
Adam28	C	T	14: 68,879,479 (GRCm39)	A190T	probably benign	Het
Ager	T	C	17: 34,817,541 (GRCm39)	V116A	probably damaging	Het
Agt	G	T	8: 125,291,065 (GRCm39)	H81N	probably benign	Het
Apc2	T	C	10: 80,146,872 (GRCm39)	V642A	probably damaging	Het
Atg4b	C	T	1: 93,713,648 (GRCm39)	T325M	probably damaging	Het
Atp10b	A	G	11: 43,150,711 (GRCm39)	S1470G	probably benign	Het
Cacul1	A	G	19: 60,533,942 (GRCm39)	I220T	probably benign	Het
Ccdc7a	T	C	8: 129,671,136 (GRCm39)		probably null	Het
Cnnm1	A	C	19: 43,429,827 (GRCm39)	D315A	probably damaging	Het
Fbxo24	A	G	5: 137,611,096 (GRCm39)	F565L	probably damaging	Het
Fpr-rs4	T	A	17: 18,242,211 (GRCm39)	S73T	probably damaging	Het
Gbp7	T	C	3: 142,248,889 (GRCm39)	V384A	probably benign	Het
Gcnt2	A	T	13: 41,041,732 (GRCm39)	H297L	possibly damaging	Het
Glo1	T	C	17: 30,831,518 (GRCm39)	E3G	probably benign	Het
Gsdmc4	T	C	15: 63,772,196 (GRCm39)	D161G	probably benign	Het
Ifi213	T	A	1: 173,396,392 (GRCm39)	M561L	probably benign	Het
Ighv1-63	A	G	12: 115,459,478 (GRCm39)	S40P	probably damaging	Het
Itpr2	A	G	6: 146,260,814 (GRCm39)	L971P	probably damaging	Het
Lrp2	A	T	2: 69,336,917 (GRCm39)	I1285N	probably damaging	Het
Map1b	A	T	13: 99,566,708 (GRCm39)	Y2004*	probably null	Het
Mindy1	C	T	3: 95,202,590 (GRCm39)	L394F	probably benign	Het
Mug1	A	G	6: 121,852,450 (GRCm39)	D846G	probably benign	Het
Myh7b	A	G	2: 155,463,268 (GRCm39)	E500G	probably damaging	Het
Myo18a	C	T	11: 77,733,014 (GRCm39)	T1348M	probably damaging	Het
Myo7b	A	T	18: 32,093,129 (GRCm39)	I2027N	probably damaging	Het
Neb	T	C	2: 52,069,580 (GRCm39)		probably null	Het
Obscn	G	A	11: 58,929,592 (GRCm39)	R5208C	probably damaging	Het
Parg	G	A	14: 31,996,874 (GRCm39)	D827N	probably damaging	Het
Pcdha6	A	T	18: 37,102,226 (GRCm39)	H473L	probably benign	Het
Pde4dip	A	G	3: 97,625,645 (GRCm39)	S1318P	probably benign	Het
Ppan	T	C	9: 20,801,220 (GRCm39)	S166P	possibly damaging	Het
Ppargc1b	C	A	18: 61,448,939 (GRCm39)	A128S	probably damaging	Het
Rdh16f2	T	A	10: 127,712,915 (GRCm39)	D304E	possibly damaging	Het
Sh3pxd2a	A	T	19: 47,260,448 (GRCm39)	L435Q	probably damaging	Het
Slc35d1	A	T	4: 103,065,333 (GRCm39)	Y183N		Het
Sspo	T	C	6: 48,443,989 (GRCm39)	S2166P	possibly damaging	Het
Tent5a	A	T	9: 85,208,672 (GRCm39)	N50K	probably benign	Het
Twf2	T	C	9: 106,092,100 (GRCm39)	F319S	probably benign	Het
Ush2a	C	T	1: 188,607,147 (GRCm39)	T4014M	probably benign	Het
Vmn2r76	T	C	7: 85,880,428 (GRCm39)	E86G	probably benign	Het
Wdtc1	A	G	4: 133,023,782 (GRCm39)	Y530H	probably damaging	Het
Xdh	A	G	17: 74,214,711 (GRCm39)	F745L	probably damaging	Het
Xdh	A	C	17: 74,233,541 (GRCm39)		probably null	Het
Zfp358	T	C	8: 3,545,568 (GRCm39)	L50P	probably damaging	Het

Other mutations in Vmn1r3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03130:Vmn1r3	APN	4	3,185,214 (GRCm39)	missense	possibly damaging	0.89
PIT4131001:Vmn1r3	UTSW	4	3,184,774 (GRCm39)	missense	probably benign	0.02
PIT4131001:Vmn1r3	UTSW	4	3,184,691 (GRCm39)	missense	probably damaging	1.00
PIT4142001:Vmn1r3	UTSW	4	3,184,774 (GRCm39)	missense	probably benign	0.02
PIT4142001:Vmn1r3	UTSW	4	3,184,691 (GRCm39)	missense	probably damaging	1.00
R0972:Vmn1r3	UTSW	4	3,185,125 (GRCm39)	missense	probably damaging	1.00
R1423:Vmn1r3	UTSW	4	3,185,231 (GRCm39)	missense	probably damaging	1.00
R3902:Vmn1r3	UTSW	4	3,185,241 (GRCm39)	missense	probably benign	0.41
R4999:Vmn1r3	UTSW	4	3,185,009 (GRCm39)	nonsense	probably null
R6091:Vmn1r3	UTSW	4	3,184,684 (GRCm39)	missense	probably damaging	0.97
R6140:Vmn1r3	UTSW	4	3,185,031 (GRCm39)	missense	probably damaging	0.97
R6188:Vmn1r3	UTSW	4	3,185,017 (GRCm39)	missense	probably damaging	1.00
R6299:Vmn1r3	UTSW	4	3,185,098 (GRCm39)	missense	possibly damaging	0.95
R6303:Vmn1r3	UTSW	4	3,184,975 (GRCm39)	missense	probably damaging	1.00
R6304:Vmn1r3	UTSW	4	3,184,975 (GRCm39)	missense	probably damaging	1.00
R6317:Vmn1r3	UTSW	4	3,184,993 (GRCm39)	missense	probably benign	0.39
R6430:Vmn1r3	UTSW	4	3,184,971 (GRCm39)	missense	probably benign
R6633:Vmn1r3	UTSW	4	3,184,971 (GRCm39)	missense	probably benign
R8919:Vmn1r3	UTSW	4	3,184,863 (GRCm39)	missense	probably benign	0.03
R9320:Vmn1r3	UTSW	4	3,185,284 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn1r3	UTSW	4	3,185,304 (GRCm39)	start codon destroyed	probably null	0.60

Predicted Primers

PCR Primer
(F):5'- GCAGGAGGGACCAATGTACTTG -3'
(R):5'- ATTCAAGTTCAGGGATTTTGGACC -3'

Sequencing Primer
(F):5'- CCACCTGGAGTTATTGGGGC -3'
(R):5'- GCCAGATTACAGTGGGAAT -3'

Posted On

2022-04-18