Incidental Mutation 'R9359:Trim61'
ID 708578
Institutional Source Beutler Lab
Gene Symbol Trim61
Ensembl Gene ENSMUSG00000109718
Gene Name tripartite motif-containing 61
Synonyms Rnf35, E330039K03Rik, 2czf61
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R9359 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 65465639-65471175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 65467228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 11 (Q11L)
Ref Sequence ENSEMBL: ENSMUSP00000077513 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048565] [ENSMUST00000078409]
AlphaFold Q8JZK6
Predicted Effect probably benign
Transcript: ENSMUST00000048565
SMART Domains Protein: ENSMUSP00000040299
Gene: ENSMUSG00000053490

DomainStartEndE-ValueType
RING 15 55 1.48e-7 SMART
low complexity region 81 90 N/A INTRINSIC
BBOX 91 132 3.12e-6 SMART
PRY 289 341 4.11e-15 SMART
Pfam:SPRY 344 459 2e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000078409
AA Change: Q11L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077513
Gene: ENSMUSG00000109718
AA Change: Q11L

DomainStartEndE-ValueType
RING 16 56 4.66e-5 SMART
low complexity region 157 170 N/A INTRINSIC
coiled coil region 201 232 N/A INTRINSIC
PRY 280 331 1.35e-10 SMART
Pfam:SPRY 334 458 5.7e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000211310
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (45/45)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angpt4 C T 2: 151,780,892 (GRCm39) T380M probably damaging Het
Ankrd50 A T 3: 38,537,172 (GRCm39) N60K probably damaging Het
Atp6v0a4 G A 6: 38,059,048 (GRCm39) T245I probably benign Het
Calcoco2 TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,862 (GRCm39) probably null Het
Cyp2j13 T C 4: 95,950,170 (GRCm39) D277G probably damaging Het
Def8 A T 8: 124,185,105 (GRCm39) I310F probably benign Het
Dmtf1 A G 5: 9,171,927 (GRCm39) L503S possibly damaging Het
Dock1 T C 7: 134,770,125 (GRCm39) V1795A probably benign Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Gabbr1 A G 17: 37,381,605 (GRCm39) T790A probably damaging Het
Glg1 C T 8: 111,914,425 (GRCm39) R453Q probably benign Het
Gm10549 C T 18: 33,597,375 (GRCm39) P54S unknown Het
Gpld1 G A 13: 25,163,712 (GRCm39) V502I probably benign Het
Ifnar1 C T 16: 91,292,367 (GRCm39) P207L probably benign Het
Inhba A G 13: 16,191,966 (GRCm39) H29R probably benign Het
Insr G C 8: 3,208,717 (GRCm39) P1248R probably damaging Het
Ipcef1 C T 10: 6,840,663 (GRCm39) D349N probably damaging Het
Itga4 T A 2: 79,156,004 (GRCm39) I990N possibly damaging Het
Malrd1 T C 2: 15,618,988 (GRCm39) V284A Het
Maml2 C T 9: 13,532,969 (GRCm39) Q728* probably null Het
Mex3d A T 10: 80,217,581 (GRCm39) N545K Het
Mios T A 6: 8,214,894 (GRCm39) V30E probably benign Het
Muc16 A G 9: 18,449,060 (GRCm39) probably null Het
Naxd A G 8: 11,562,968 (GRCm39) K303E possibly damaging Het
Or2w1 T C 13: 21,317,865 (GRCm39) F307L probably benign Het
Or4l1 T C 14: 50,166,906 (GRCm39) T32A probably benign Het
Or5a21 T A 19: 12,310,803 (GRCm39) H139L possibly damaging Het
Or9q2 C T 19: 13,772,200 (GRCm39) M258I probably damaging Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Pknox1 C T 17: 31,822,229 (GRCm39) T332M possibly damaging Het
Ptgdr A G 14: 45,090,715 (GRCm39) S348P Het
Ptpdc1 T A 13: 48,740,030 (GRCm39) E467V probably benign Het
Qsox1 A G 1: 155,658,343 (GRCm39) S409P probably damaging Het
Rfx4 A G 10: 84,740,921 (GRCm39) T680A probably benign Het
Slc30a5 T C 13: 100,949,970 (GRCm39) T371A probably damaging Het
Slc5a7 A T 17: 54,583,669 (GRCm39) N540K probably benign Het
Slco6c1 A T 1: 96,990,248 (GRCm39) S664R possibly damaging Het
Tbxa2r A G 10: 81,168,958 (GRCm39) S216G probably damaging Het
Tgm4 C A 9: 122,881,837 (GRCm39) S344R probably damaging Het
Thoc6 A G 17: 23,887,823 (GRCm39) V328A possibly damaging Het
Txndc2 G A 17: 65,944,992 (GRCm39) T395I probably damaging Het
Txndc9 T C 1: 38,034,859 (GRCm39) E15G probably benign Het
Unc93a2 G T 17: 7,641,842 (GRCm39) T202K probably damaging Het
Uspl1 G A 5: 149,146,481 (GRCm39) V411M probably damaging Het
Vcpip1 A G 1: 9,816,049 (GRCm39) I778T possibly damaging Het
Vps54 A G 11: 21,242,108 (GRCm39) T408A probably benign Het
Wscd1 T C 11: 71,650,799 (GRCm39) L42P possibly damaging Het
Other mutations in Trim61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Trim61 APN 8 65,466,743 (GRCm39) missense possibly damaging 0.94
R0184:Trim61 UTSW 8 65,467,069 (GRCm39) missense probably benign 0.40
R1955:Trim61 UTSW 8 65,466,044 (GRCm39) missense possibly damaging 0.46
R3928:Trim61 UTSW 8 65,465,969 (GRCm39) missense probably benign 0.39
R3929:Trim61 UTSW 8 65,465,969 (GRCm39) missense probably benign 0.39
R4850:Trim61 UTSW 8 65,466,070 (GRCm39) missense probably damaging 1.00
R6249:Trim61 UTSW 8 65,467,108 (GRCm39) missense probably benign 0.25
R6390:Trim61 UTSW 8 65,466,842 (GRCm39) missense probably benign 0.24
R6406:Trim61 UTSW 8 65,466,377 (GRCm39) missense possibly damaging 0.61
R7159:Trim61 UTSW 8 65,466,526 (GRCm39) missense probably benign 0.19
R7182:Trim61 UTSW 8 65,466,266 (GRCm39) missense probably damaging 0.99
R9403:Trim61 UTSW 8 65,467,228 (GRCm39) missense probably damaging 1.00
X0022:Trim61 UTSW 8 65,465,965 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AACTCACCTGGTGGCTGATTAC -3'
(R):5'- TGGACTCTGCCATCTGACTC -3'

Sequencing Primer
(F):5'- CACCTGGTGGCTGATTACTCAAAAAG -3'
(R):5'- ATCTGACTCCGGTGCTAAGG -3'
Posted On 2022-04-18