Incidental Mutation 'R9359:Mex3d'
ID 708585
Institutional Source Beutler Lab
Gene Symbol Mex3d
Ensembl Gene ENSMUSG00000048696
Gene Name mex3 RNA binding family member D
Synonyms Rkhd1
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.274) question?
Stock # R9359 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 80216189-80223485 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 80217581 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 545 (N545K)
Ref Sequence ENSEMBL: ENSMUSP00000100987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105350]
AlphaFold no structure available at present
Predicted Effect
SMART Domains Protein: ENSMUSP00000100987
Gene: ENSMUSG00000048696
AA Change: N545K

DomainStartEndE-ValueType
internal_repeat_2 3 25 3.12e-8 PROSPERO
internal_repeat_1 5 34 7.48e-13 PROSPERO
internal_repeat_1 41 70 7.48e-13 PROSPERO
internal_repeat_2 51 73 3.12e-8 PROSPERO
low complexity region 78 94 N/A INTRINSIC
KH 125 193 6.8e-10 SMART
KH 220 287 4.45e-14 SMART
low complexity region 356 388 N/A INTRINSIC
low complexity region 463 478 N/A INTRINSIC
low complexity region 499 524 N/A INTRINSIC
low complexity region 535 557 N/A INTRINSIC
RING 560 599 7.34e-3 SMART
Predicted Effect
SMART Domains Protein: ENSMUSP00000115410
Gene: ENSMUSG00000048696
AA Change: N80K

DomainStartEndE-ValueType
low complexity region 2 31 N/A INTRINSIC
low complexity region 106 121 N/A INTRINSIC
low complexity region 142 167 N/A INTRINSIC
low complexity region 178 200 N/A INTRINSIC
RING 203 242 7.34e-3 SMART
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (45/45)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angpt4 C T 2: 151,780,892 (GRCm39) T380M probably damaging Het
Ankrd50 A T 3: 38,537,172 (GRCm39) N60K probably damaging Het
Atp6v0a4 G A 6: 38,059,048 (GRCm39) T245I probably benign Het
Calcoco2 TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC TCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,862 (GRCm39) probably null Het
Cyp2j13 T C 4: 95,950,170 (GRCm39) D277G probably damaging Het
Def8 A T 8: 124,185,105 (GRCm39) I310F probably benign Het
Dmtf1 A G 5: 9,171,927 (GRCm39) L503S possibly damaging Het
Dock1 T C 7: 134,770,125 (GRCm39) V1795A probably benign Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Gabbr1 A G 17: 37,381,605 (GRCm39) T790A probably damaging Het
Glg1 C T 8: 111,914,425 (GRCm39) R453Q probably benign Het
Gm10549 C T 18: 33,597,375 (GRCm39) P54S unknown Het
Gpld1 G A 13: 25,163,712 (GRCm39) V502I probably benign Het
Ifnar1 C T 16: 91,292,367 (GRCm39) P207L probably benign Het
Inhba A G 13: 16,191,966 (GRCm39) H29R probably benign Het
Insr G C 8: 3,208,717 (GRCm39) P1248R probably damaging Het
Ipcef1 C T 10: 6,840,663 (GRCm39) D349N probably damaging Het
Itga4 T A 2: 79,156,004 (GRCm39) I990N possibly damaging Het
Malrd1 T C 2: 15,618,988 (GRCm39) V284A Het
Maml2 C T 9: 13,532,969 (GRCm39) Q728* probably null Het
Mios T A 6: 8,214,894 (GRCm39) V30E probably benign Het
Muc16 A G 9: 18,449,060 (GRCm39) probably null Het
Naxd A G 8: 11,562,968 (GRCm39) K303E possibly damaging Het
Or2w1 T C 13: 21,317,865 (GRCm39) F307L probably benign Het
Or4l1 T C 14: 50,166,906 (GRCm39) T32A probably benign Het
Or5a21 T A 19: 12,310,803 (GRCm39) H139L possibly damaging Het
Or9q2 C T 19: 13,772,200 (GRCm39) M258I probably damaging Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Pknox1 C T 17: 31,822,229 (GRCm39) T332M possibly damaging Het
Ptgdr A G 14: 45,090,715 (GRCm39) S348P Het
Ptpdc1 T A 13: 48,740,030 (GRCm39) E467V probably benign Het
Qsox1 A G 1: 155,658,343 (GRCm39) S409P probably damaging Het
Rfx4 A G 10: 84,740,921 (GRCm39) T680A probably benign Het
Slc30a5 T C 13: 100,949,970 (GRCm39) T371A probably damaging Het
Slc5a7 A T 17: 54,583,669 (GRCm39) N540K probably benign Het
Slco6c1 A T 1: 96,990,248 (GRCm39) S664R possibly damaging Het
Tbxa2r A G 10: 81,168,958 (GRCm39) S216G probably damaging Het
Tgm4 C A 9: 122,881,837 (GRCm39) S344R probably damaging Het
Thoc6 A G 17: 23,887,823 (GRCm39) V328A possibly damaging Het
Trim61 T A 8: 65,467,228 (GRCm39) Q11L probably damaging Het
Txndc2 G A 17: 65,944,992 (GRCm39) T395I probably damaging Het
Txndc9 T C 1: 38,034,859 (GRCm39) E15G probably benign Het
Unc93a2 G T 17: 7,641,842 (GRCm39) T202K probably damaging Het
Uspl1 G A 5: 149,146,481 (GRCm39) V411M probably damaging Het
Vcpip1 A G 1: 9,816,049 (GRCm39) I778T possibly damaging Het
Vps54 A G 11: 21,242,108 (GRCm39) T408A probably benign Het
Wscd1 T C 11: 71,650,799 (GRCm39) L42P possibly damaging Het
Other mutations in Mex3d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01554:Mex3d APN 10 80,217,869 (GRCm39) missense possibly damaging 0.49
R0316:Mex3d UTSW 10 80,217,505 (GRCm39) missense probably damaging 0.97
R0401:Mex3d UTSW 10 80,222,728 (GRCm39) missense probably benign 0.33
R0734:Mex3d UTSW 10 80,217,366 (GRCm39) missense possibly damaging 0.55
R0894:Mex3d UTSW 10 80,217,376 (GRCm39) missense probably benign 0.04
R1452:Mex3d UTSW 10 80,217,354 (GRCm39) missense probably damaging 0.99
R1764:Mex3d UTSW 10 80,222,770 (GRCm39) missense probably benign 0.15
R1795:Mex3d UTSW 10 80,217,376 (GRCm39) missense probably benign 0.04
R4801:Mex3d UTSW 10 80,222,788 (GRCm39) missense possibly damaging 0.77
R4802:Mex3d UTSW 10 80,222,788 (GRCm39) missense possibly damaging 0.77
R5632:Mex3d UTSW 10 80,218,428 (GRCm39) missense probably damaging 1.00
R5701:Mex3d UTSW 10 80,217,379 (GRCm39) missense probably benign 0.00
R5964:Mex3d UTSW 10 80,218,421 (GRCm39) missense probably damaging 1.00
R6133:Mex3d UTSW 10 80,222,620 (GRCm39) missense probably damaging 0.99
R6414:Mex3d UTSW 10 80,217,205 (GRCm39) missense unknown
R6938:Mex3d UTSW 10 80,218,074 (GRCm39) missense possibly damaging 0.61
R7154:Mex3d UTSW 10 80,222,584 (GRCm39) missense
R7241:Mex3d UTSW 10 80,223,091 (GRCm39) missense
R7463:Mex3d UTSW 10 80,217,532 (GRCm39) missense
R8858:Mex3d UTSW 10 80,217,217 (GRCm39) missense unknown
R9583:Mex3d UTSW 10 80,218,129 (GRCm39) missense
Z1176:Mex3d UTSW 10 80,222,547 (GRCm39) missense
Z1177:Mex3d UTSW 10 80,217,184 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CATGGCCTCACCTTCAGAAC -3'
(R):5'- AGACCTGTTAGGAGCTGCAG -3'

Sequencing Primer
(F):5'- CTTCCGAGGGGACAGTGTCTAG -3'
(R):5'- AGCCCTTCTATGTGGGCAG -3'
Posted On 2022-04-18