Mutagenetix > Incidental Mutation

Incidental Mutation 'R9361:Or2y10'

708712

Institutional Source

Beutler Lab

Gene Symbol

Or2y10

Ensembl Gene

ENSMUSG00000107645

Gene Name

olfactory receptor family 2 subfamily Y member 10

Synonyms

GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.209) question?

Stock #

R9361 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

49454750-49455685 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 49455303 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 185 (K185R)

Ref Sequence

ENSEMBL: ENSMUSP00000151039 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000204300] [ENSMUST00000215360]

AlphaFold

Q7TQT5

Predicted Effect

probably damaging
Transcript: ENSMUST00000204300
AA Change: K185R

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000145428
Gene: ENSMUSG00000107645
AA Change: K185R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	5.4e-47	PFAM
Pfam:7tm_1	41	289	9.6e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215360
AA Change: K185R

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1190005I06Rik	C	T	8: 121,361,060 (GRCm39)	A12T	unknown	Het
Aasdh	T	A	5: 77,030,225 (GRCm39)	T792S	probably benign	Het
Actl11	T	A	9: 107,805,824 (GRCm39)	L49Q	probably damaging	Het
Adcy3	G	T	12: 4,259,366 (GRCm39)	R881L	possibly damaging	Het
Alox15	T	G	11: 70,241,679 (GRCm39)	K67N	probably damaging	Het
Amotl1	C	T	9: 14,504,677 (GRCm39)	R177Q	probably benign	Het
Ankrd34c	T	A	9: 89,612,183 (GRCm39)	I53F	probably damaging	Het
Atp8b5	T	A	4: 43,369,658 (GRCm39)	F932Y	possibly damaging	Het
Bckdk	A	G	7: 127,506,515 (GRCm39)	M281V	probably benign	Het
Ccdc33	C	T	9: 58,024,908 (GRCm39)	C106Y	possibly damaging	Het
Celsr3	T	A	9: 108,726,521 (GRCm39)	I3250N	probably damaging	Het
Ces1g	A	T	8: 94,061,646 (GRCm39)		probably null	Het
Ces2b	G	A	8: 105,564,039 (GRCm39)		probably null	Het
Clspn	A	T	4: 126,479,654 (GRCm39)	D1033V	probably damaging	Het
Cntln	G	T	4: 84,968,151 (GRCm39)	R790I	probably benign	Het
Cspg4	T	C	9: 56,803,877 (GRCm39)	V1656A	probably damaging	Het
Dennd2b	A	G	7: 109,126,991 (GRCm39)	S907P	probably damaging	Het
Dlgap1	A	T	17: 71,068,259 (GRCm39)	D610V	probably damaging	Het
Efcab3	C	T	11: 104,896,524 (GRCm39)	T4291I	probably benign	Het
Eya4	C	A	10: 22,985,766 (GRCm39)	G579W	probably damaging	Het
Fam83b	T	C	9: 76,400,076 (GRCm39)	I342M	probably benign	Het
Fhdc1	A	C	3: 84,356,140 (GRCm39)	C435G	probably damaging	Het
Fktn	G	A	4: 53,734,854 (GRCm39)	G125D	probably benign	Het
Fras1	T	G	5: 96,924,557 (GRCm39)	L3666R	probably damaging	Het
Gm21560	T	A	14: 6,218,262 (GRCm38)	H72L	possibly damaging	Het
Gtsf2	C	T	15: 103,348,066 (GRCm39)	W148*	probably null	Het
Gucy2c	T	C	6: 136,714,429 (GRCm39)	K466E	possibly damaging	Het
Higd2a	T	A	13: 54,738,120 (GRCm39)	D14E	probably benign	Het
Hlcs	C	T	16: 93,939,799 (GRCm39)	V513M	probably benign	Het
Ido1	T	C	8: 25,079,601 (GRCm39)	T148A	probably benign	Het
Ighv1-5	T	A	12: 114,476,985 (GRCm39)	T106S	probably damaging	Het
Igkv4-92	T	C	6: 68,732,090 (GRCm39)	T95A	possibly damaging	Het
Krt9	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC	11: 100,079,903 (GRCm39)		probably benign	Het
Larp4b	T	G	13: 9,199,937 (GRCm39)	F278V	probably damaging	Het
Lrch4	G	A	5: 137,635,076 (GRCm39)	R225H	probably damaging	Het
Mapkbp1	T	C	2: 119,845,252 (GRCm39)	Y378H	probably benign	Het
Nme9	T	A	9: 99,341,775 (GRCm39)	C42S	probably damaging	Het
Pdlim2	T	G	14: 70,402,190 (GRCm39)	T309P	probably damaging	Het
Pramel39-ps	G	T	5: 94,451,001 (GRCm39)	P375H	probably damaging	Het
Prodh	C	T	16: 17,898,834 (GRCm39)	C207Y	probably benign	Het
Prom1	A	T	5: 44,213,229 (GRCm39)	L168Q	probably damaging	Het
Resf1	T	G	6: 149,228,132 (GRCm39)	S393A	possibly damaging	Het
Selplg	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT	5: 113,957,756 (GRCm39)		probably benign	Het
Shkbp1	T	C	7: 27,051,492 (GRCm39)	Q189R	probably benign	Het
Skint4	T	C	4: 112,001,021 (GRCm39)	L372S	probably damaging	Het
Slc4a11	C	T	2: 130,533,664 (GRCm39)	A100T	probably damaging	Het
Specc1	A	T	11: 62,037,144 (GRCm39)	E699D	probably benign	Het
Speer1m	C	T	5: 11,970,646 (GRCm39)	T105M		Het
Syt6	C	A	3: 103,482,679 (GRCm39)		probably benign	Het
Tent5b	G	T	4: 133,213,461 (GRCm39)	A111S	probably damaging	Het
Tg	A	G	15: 66,557,246 (GRCm39)	E969G	possibly damaging	Het
Tie1	A	C	4: 118,336,829 (GRCm39)	H632Q	probably benign	Het
Trappc12	A	G	12: 28,796,417 (GRCm39)	W372R	probably damaging	Het
Trav7d-4	T	C	14: 53,007,606 (GRCm39)	V33A	probably damaging	Het
Ugdh	A	T	5: 65,575,886 (GRCm39)	N324K	probably damaging	Het
Vmn2r79	G	T	7: 86,652,822 (GRCm39)		probably null	Het
Washc2	T	C	6: 116,239,433 (GRCm39)	*1335Q	probably null	Het
Yme1l1	C	T	2: 23,081,063 (GRCm39)	T445I	possibly damaging	Het
Zdhhc11	T	C	13: 74,122,737 (GRCm39)	C158R	probably damaging	Het
Zfp128	T	C	7: 12,624,364 (GRCm39)	L244P	probably damaging	Het
Zfp445	T	A	9: 122,690,887 (GRCm39)	I103F	probably damaging	Het
Zfp980	A	T	4: 145,427,999 (GRCm39)	T243S	probably benign	Het

Other mutations in Or2y10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Or2y10	APN	11	49,454,747 (GRCm39)	utr 5 prime	probably benign
IGL01354:Or2y10	APN	11	49,455,024 (GRCm39)	missense	probably damaging	0.99
R0183:Or2y10	UTSW	11	49,455,675 (GRCm39)	missense	probably benign	0.14
R0849:Or2y10	UTSW	11	49,455,129 (GRCm39)	missense	probably damaging	0.99
R3855:Or2y10	UTSW	11	49,454,918 (GRCm39)	missense	probably damaging	0.98
R3904:Or2y10	UTSW	11	49,455,585 (GRCm39)	missense	possibly damaging	0.50
R4598:Or2y10	UTSW	11	49,455,545 (GRCm39)	missense	probably damaging	1.00
R4599:Or2y10	UTSW	11	49,455,545 (GRCm39)	missense	probably damaging	1.00
R5089:Or2y10	UTSW	11	49,455,240 (GRCm39)	missense	possibly damaging	0.94
R6029:Or2y10	UTSW	11	49,455,428 (GRCm39)	missense	possibly damaging	0.94
R6551:Or2y10	UTSW	11	49,454,816 (GRCm39)	missense	probably benign
R6953:Or2y10	UTSW	11	49,455,117 (GRCm39)	missense	probably damaging	1.00
R7223:Or2y10	UTSW	11	49,454,925 (GRCm39)	missense	probably damaging	0.99
R7343:Or2y10	UTSW	11	49,455,329 (GRCm39)	missense	possibly damaging	0.91
R7725:Or2y10	UTSW	11	49,455,359 (GRCm39)	missense	probably benign	0.01
R7762:Or2y10	UTSW	11	49,455,588 (GRCm39)	missense	possibly damaging	0.76
R8881:Or2y10	UTSW	11	49,455,209 (GRCm39)	missense	probably benign	0.01
R9380:Or2y10	UTSW	11	49,454,904 (GRCm39)	missense	possibly damaging	0.91
R9421:Or2y10	UTSW	11	49,455,201 (GRCm39)	missense	probably benign	0.03
R9733:Or2y10	UTSW	11	49,454,961 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTCACTGGGAGGAACTGAG -3'
(R):5'- GCACATGTCCCAAAAGCCTTTC -3'

Sequencing Primer
(F):5'- CAATGGCTATAGATCGCTATGCTGC -3'
(R):5'- AAGCCTTTCTGCGACCAG -3'

Posted On

2022-04-18