Mutagenetix > Incidental Mutation

Incidental Mutation 'R9363:Vmn2r102'

708810

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9363 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19880661-19915010 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 19897614 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 210 (H210Y)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

probably benign
Transcript: ENSMUST00000171741
AA Change: H210Y

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: H210Y

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (40/40)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	T	A	16: 56,438,575 (GRCm39)		probably null	Het
Alkbh1	A	T	12: 87,487,080 (GRCm39)	Y96*	probably null	Het
Alkbh8	T	A	9: 3,385,576 (GRCm39)	C658S	probably damaging	Het
Bean1	CT	C	8: 104,908,664 (GRCm39)		probably null	Het
Blm	T	C	7: 80,108,663 (GRCm39)	Y1327C	probably damaging	Het
Ccdc28a	C	T	10: 18,094,050 (GRCm39)	D190N	unknown	Het
Chdh	A	G	14: 29,753,310 (GRCm39)	E73G	probably damaging	Het
Dab2	C	T	15: 6,460,481 (GRCm39)	P463L	probably benign	Het
Dcun1d2	A	G	8: 13,309,014 (GRCm39)	Y184H	probably benign	Het
Dst	T	C	1: 34,235,060 (GRCm39)	L3535P	probably damaging	Het
Egr3	A	G	14: 70,316,761 (GRCm39)	I153V	possibly damaging	Het
Fktn	G	A	4: 53,734,854 (GRCm39)	G125D	probably benign	Het
Hcfc2	C	T	10: 82,574,258 (GRCm39)	P144L	probably damaging	Het
Jkampl	T	A	6: 73,446,487 (GRCm39)	I21F	possibly damaging	Het
Mdc1	C	A	17: 36,162,019 (GRCm39)	Q942K	probably benign	Het
Med15	C	T	16: 17,489,414 (GRCm39)	V387I	unknown	Het
Muc4	C	T	16: 32,576,992 (GRCm39)	S94L		Het
Or5ak23	T	A	2: 85,244,993 (GRCm39)	I77F	probably damaging	Het
Otud3	G	T	4: 138,623,133 (GRCm39)	N369K	probably benign	Het
Parp14	C	T	16: 35,678,586 (GRCm39)	E461K	possibly damaging	Het
Paxbp1	T	A	16: 90,827,395 (GRCm39)	Q480L	probably damaging	Het
Polr3a	G	A	14: 24,500,831 (GRCm39)	A1319V	probably damaging	Het
Pramel39-ps	G	T	5: 94,451,001 (GRCm39)	P375H	probably damaging	Het
Prkg2	A	T	5: 99,172,257 (GRCm39)	S153T	probably benign	Het
Scara3	T	C	14: 66,168,720 (GRCm39)	D299G	probably benign	Het
Scube1	C	A	15: 83,499,080 (GRCm39)	E712*	probably null	Het
Setd4	T	A	16: 93,388,009 (GRCm39)	E159V	probably benign	Het
Slc15a2	T	A	16: 36,572,672 (GRCm39)	I670F	possibly damaging	Het
Slc4a11	C	T	2: 130,533,664 (GRCm39)	A100T	probably damaging	Het
Smok2b	G	A	17: 13,453,637 (GRCm39)		probably null	Het
Snx18	G	A	13: 113,754,732 (GRCm39)	P67L	probably benign	Het
St3gal5	A	T	6: 72,119,301 (GRCm39)	K165*	probably null	Het
Sun5	A	G	2: 153,700,365 (GRCm39)	I294T	probably benign	Het
Svil	A	G	18: 5,037,155 (GRCm39)	K37E	probably benign	Het
Tmem104	T	C	11: 115,134,691 (GRCm39)	I409T	probably benign	Het
Tnxb	T	C	17: 34,917,294 (GRCm39)	Y2230H	possibly damaging	Het
Trps1	A	G	15: 50,524,676 (GRCm39)	S1085P	probably damaging	Het
Ttn	A	T	2: 76,612,592 (GRCm39)	N17162K	probably damaging	Het
Ugt1a7c	T	A	1: 88,023,616 (GRCm39)	F258L	probably damaging	Het
Vmn2r75	A	T	7: 85,815,423 (GRCm39)	V147E	probably benign	Het
Zhx3	G	A	2: 160,621,785 (GRCm39)	A794V	probably benign	Het
Zscan2	A	G	7: 80,525,331 (GRCm39)	T351A	probably benign	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19,899,154 (GRCm39)	missense	probably damaging	1.00
IGL00974:Vmn2r102	APN	17	19,897,771 (GRCm39)	missense	possibly damaging	0.93
IGL00978:Vmn2r102	APN	17	19,899,185 (GRCm39)	splice site	probably null
IGL01589:Vmn2r102	APN	17	19,899,066 (GRCm39)	missense	probably benign
IGL01738:Vmn2r102	APN	17	19,898,020 (GRCm39)	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19,880,731 (GRCm39)	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19,914,191 (GRCm39)	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19,901,447 (GRCm39)	missense	probably benign
IGL02589:Vmn2r102	APN	17	19,901,480 (GRCm39)	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19,898,170 (GRCm39)	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19,914,328 (GRCm39)	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19,914,286 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19,896,958 (GRCm39)	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19,880,851 (GRCm39)	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19,899,025 (GRCm39)	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19,898,112 (GRCm39)	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19,914,630 (GRCm39)	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19,897,043 (GRCm39)	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19,898,277 (GRCm39)	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19,899,106 (GRCm39)	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19,914,454 (GRCm39)	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19,880,887 (GRCm39)	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19,914,843 (GRCm39)	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19,899,032 (GRCm39)	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19,897,770 (GRCm39)	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19,914,755 (GRCm39)	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19,897,881 (GRCm39)	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19,897,006 (GRCm39)	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19,896,949 (GRCm39)	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19,914,930 (GRCm39)	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19,899,093 (GRCm39)	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19,914,787 (GRCm39)	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19,898,088 (GRCm39)	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19,880,845 (GRCm39)	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19,901,475 (GRCm39)	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4535:Vmn2r102	UTSW	17	19,914,975 (GRCm39)	missense	probably benign
R4662:Vmn2r102	UTSW	17	19,901,424 (GRCm39)	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19,914,576 (GRCm39)	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19,897,795 (GRCm39)	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19,898,203 (GRCm39)	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19,880,661 (GRCm39)	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19,897,834 (GRCm39)	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19,897,003 (GRCm39)	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19,914,393 (GRCm39)	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19,914,415 (GRCm39)	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19,897,804 (GRCm39)	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19,914,943 (GRCm39)	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19,914,402 (GRCm39)	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19,899,007 (GRCm39)	missense	probably benign
R6432:Vmn2r102	UTSW	17	19,901,483 (GRCm39)	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19,898,169 (GRCm39)	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19,914,450 (GRCm39)	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19,880,694 (GRCm39)	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19,914,456 (GRCm39)	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19,914,670 (GRCm39)	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19,897,749 (GRCm39)	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19,896,886 (GRCm39)	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19,901,405 (GRCm39)	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19,914,363 (GRCm39)	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19,898,093 (GRCm39)	missense	probably benign
R8126:Vmn2r102	UTSW	17	19,880,712 (GRCm39)	missense	probably benign	0.02
R8385:Vmn2r102	UTSW	17	19,914,088 (GRCm39)	missense	possibly damaging	0.89
R8410:Vmn2r102	UTSW	17	19,898,196 (GRCm39)	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19,880,841 (GRCm39)	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19,896,928 (GRCm39)	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19,897,558 (GRCm39)	missense	probably damaging	1.00
R9524:Vmn2r102	UTSW	17	19,897,564 (GRCm39)	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19,898,129 (GRCm39)	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19,914,305 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AATGTAGTGACTGGAATGTCCC -3'
(R):5'- GTCTCATCCATATGTTCCCAGAATTTG -3'

Sequencing Primer
(F):5'- GTGACTGGAATGTCCCTTTAAAAC -3'
(R):5'- CCCAGAATTTGGCAAAATGTGAAGTC -3'

Posted On

2022-04-18