Mutagenetix > Incidental Mutation

Incidental Mutation 'R9364:Vmn1r193'

708856

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r193

Ensembl Gene

ENSMUSG00000046932

Gene Name

vomeronasal 1 receptor 193

Synonyms

V1ri9

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R9364 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22213672-22223160 bp(-) (GRCm38)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 22219819 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000058480 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057516] [ENSMUST00000227457] [ENSMUST00000227562] [ENSMUST00000228303]

AlphaFold

Q8R258

Predicted Effect

probably null
Transcript: ENSMUST00000057516
AA Change: M1K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000058480
Gene: ENSMUSG00000046932
AA Change: M1K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	23	317	4.4e-8	PFAM
Pfam:V1R	52	315	5.1e-36	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000227457
AA Change: M1K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

Predicted Effect

probably null
Transcript: ENSMUST00000227562
AA Change: M1K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

Predicted Effect

probably null
Transcript: ENSMUST00000228303
AA Change: M1K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2200002D01Rik	CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	7: 29,247,623		probably benign	Het
Ankrd17	C	T	5: 90,268,649	R1108Q	probably damaging	Het
Ccdc136	C	T	6: 29,405,961	A102V	probably damaging	Het
Ccnyl1	A	G	1: 64,714,591	Y187C	probably damaging	Het
Copa	G	A	1: 172,117,264	V882I	probably benign	Het
Cyp17a1	C	T	19: 46,668,726	R361H	probably damaging	Het
Ddx49	T	C	8: 70,293,576	T459A	probably benign	Het
Depdc5	A	G	5: 32,964,732	N1133S	probably benign	Het
Dnajc18	T	C	18: 35,675,207	D329G	probably damaging	Het
Dusp16	G	A	6: 134,719,019	P283L	probably damaging	Het
Efcab12	A	G	6: 115,838,014	V40A	probably benign	Het
Emb	G	T	13: 117,220,560		probably benign	Het
Fam120b	G	A	17: 15,405,758	A458T	possibly damaging	Het
Fgd4	G	A	16: 16,490,489	T9I	probably benign	Het
Hivep1	G	A	13: 42,154,775	D164N	possibly damaging	Het
Klf13	T	A	7: 63,924,861		probably benign	Het
Lrrc47	T	C	4: 154,015,941	S325P	possibly damaging	Het
Mast3	C	T	8: 70,786,182	V493M	probably damaging	Het
Med22	T	C	2: 26,905,809	T200A	probably benign	Het
Mettl15	T	A	2: 109,131,615	Q216H	probably benign	Het
Mmel1	A	G	4: 154,892,510	D561G	probably null	Het
Ms4a4a	G	A	19: 11,390,344	M191I	probably benign	Het
Myh11	T	A	16: 14,200,716	N1922I		Het
Myo7b	T	C	18: 32,000,360	I371V	probably benign	Het
Myo9b	T	C	8: 71,355,839	S1697P	probably damaging	Het
Neurod4	T	C	10: 130,270,971	T145A	probably benign	Het
Nfx1	T	C	4: 41,023,756	V1055A	probably benign	Het
Ntng1	C	T	3: 110,135,364	A49T	probably damaging	Het
Oc90	G	A	15: 65,889,588	P194S	probably benign	Het
Olfr1087	A	T	2: 86,690,231	V248D	possibly damaging	Het
Olfr1375	T	A	11: 51,048,396	Y96*	probably null	Het
Olfr169	T	A	16: 19,565,972	I304F	possibly damaging	Het
Olfr446	T	A	6: 42,927,600	I123N	probably damaging	Het
Opcml	A	C	9: 28,903,328	N292T	probably damaging	Het
Oplah	A	G	15: 76,309,587	S57P	probably benign	Het
Pdzd8	A	T	19: 59,345,142	L149Q	probably damaging	Het
Pid1	A	G	1: 84,159,311	V33A	probably benign	Het
Prpsap1	A	G	11: 116,494,189		probably benign	Het
R3hdml	T	C	2: 163,492,615	W42R	probably benign	Het
Rnase6	A	T	14: 51,130,405	N85Y	possibly damaging	Het
Scn3a	T	A	2: 65,461,252	M1717L	possibly damaging	Het
Setbp1	C	T	18: 78,783,384	S1338N	probably benign	Het
Sh2b2	T	C	5: 136,224,152	T389A	probably benign	Het
Sh2d4a	G	A	8: 68,294,366	G82D	probably damaging	Het
Skint9	A	T	4: 112,391,718	M171K	probably benign	Het
Slc5a11	C	T	7: 123,269,101	R505W	probably damaging	Het
Slx4	C	A	16: 3,987,956	M577I	probably benign	Het
Soga3	G	A	10: 29,196,779	R689Q	probably damaging	Het
Tarbp1	C	T	8: 126,450,723	V737I	probably benign	Het
Tm7sf3	C	T	6: 146,623,681	D89N	possibly damaging	Het
Tmem100	A	T	11: 90,035,707	E120V	probably damaging	Het
Trim72	C	T	7: 128,010,001	T325M	possibly damaging	Het
Trpc2	G	A	7: 102,090,612	G581D	possibly damaging	Het
Tyw1	G	A	5: 130,269,224	R202Q	probably damaging	Het
Ubn1	T	C	16: 5,070,628	S154P	unknown	Het
Uchl1	T	A	5: 66,676,306	M6K	probably damaging	Het
Wisp1	G	A	15: 66,913,051	R191K	probably benign	Het
Zfp429	T	A	13: 67,390,412	K304N	probably benign	Het
Zfp618	A	G	4: 63,118,587	N375D	probably damaging	Het
Zfp7	TGCGGGAAAGGTTTCCACCTGAGCG	TGCG	15: 76,890,600		probably benign	Het
Zfp78	A	T	7: 6,379,355	D468V	probably benign	Het
Zfp809	A	C	9: 22,239,098	Y297S	probably damaging	Het

Other mutations in Vmn1r193

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01642:Vmn1r193	APN	13	22219624	missense	probably damaging	1.00
IGL01862:Vmn1r193	APN	13	22219814	missense	probably benign	0.00
IGL01939:Vmn1r193	APN	13	22219723	nonsense	probably null
IGL03394:Vmn1r193	APN	13	22219769	missense	probably benign	0.02
R0158:Vmn1r193	UTSW	13	22219628	missense	probably damaging	1.00
R1830:Vmn1r193	UTSW	13	22219391	missense	probably benign
R2035:Vmn1r193	UTSW	13	22219562	missense	probably benign	0.37
R4651:Vmn1r193	UTSW	13	22219525	missense	probably damaging	1.00
R4652:Vmn1r193	UTSW	13	22219525	missense	probably damaging	1.00
R5298:Vmn1r193	UTSW	13	22219555	missense	probably damaging	1.00
R5865:Vmn1r193	UTSW	13	22219225	missense	probably damaging	1.00
R6208:Vmn1r193	UTSW	13	22218968	missense	possibly damaging	0.57
R6958:Vmn1r193	UTSW	13	22219974	start gained	probably benign
R8095:Vmn1r193	UTSW	13	22219061	missense	possibly damaging	0.89
R8128:Vmn1r193	UTSW	13	22218943	missense	probably damaging	1.00
R8211:Vmn1r193	UTSW	13	22219116	nonsense	probably null
R8308:Vmn1r193	UTSW	13	22218976	missense	probably benign	0.00
R8889:Vmn1r193	UTSW	13	22219669	missense	probably benign	0.05
R8949:Vmn1r193	UTSW	13	22219750	missense	possibly damaging	0.89
R9138:Vmn1r193	UTSW	13	22219674	missense	probably damaging	0.99
R9554:Vmn1r193	UTSW	13	22219819	start codon destroyed	probably null	0.02
V1662:Vmn1r193	UTSW	13	22219075	missense	possibly damaging	0.94
Z1177:Vmn1r193	UTSW	13	22219456	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGTTTACAAAAGCCAAGTGGATG -3'
(R):5'- ACTACCTTCTGTGGAGGCATC -3'

Sequencing Primer
(F):5'- AATTTTGTTCTCAGGACCCATGATG -3'
(R):5'- CTGTGGAGGCATCAGCATG -3'

Posted On

2022-04-18