Incidental Mutation 'R9365:Vmn2r16'
| ID |
708892 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r16
|
| Ensembl Gene |
ENSMUSG00000092080 |
| Gene Name |
vomeronasal 2, receptor 16 |
| Synonyms |
EG384220 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R9365 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109478247-109512347 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109488064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 312
(D312E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127838
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165180]
|
| AlphaFold |
A0A3B2WCY4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165180
AA Change: D312E
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: D312E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
425 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
509 |
563 |
8.2e-19 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
3.5e-56 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (60/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
| Ahi1 |
G |
A |
10: 20,848,035 (GRCm39) |
R481Q |
probably damaging |
Het |
| Arhgef3 |
T |
C |
14: 27,101,555 (GRCm39) |
I77T |
probably damaging |
Het |
| Ash1l |
T |
A |
3: 88,889,207 (GRCm39) |
V362E |
possibly damaging |
Het |
| Bcat2 |
T |
A |
7: 45,225,294 (GRCm39) |
F57L |
probably damaging |
Het |
| Ccdc73 |
C |
T |
2: 104,738,011 (GRCm39) |
L36F |
probably damaging |
Het |
| Ccl19 |
C |
T |
4: 42,756,288 (GRCm39) |
V15I |
probably benign |
Het |
| Cenpe |
T |
A |
3: 134,954,207 (GRCm39) |
V1688E |
possibly damaging |
Het |
| Ces1a |
A |
T |
8: 93,774,727 (GRCm39) |
F4I |
probably benign |
Het |
| Chchd6 |
G |
A |
6: 89,551,413 (GRCm39) |
P83S |
probably benign |
Het |
| Cnr1 |
T |
C |
4: 33,943,798 (GRCm39) |
M62T |
probably benign |
Het |
| Colec12 |
T |
C |
18: 9,848,146 (GRCm39) |
L108P |
probably damaging |
Het |
| Cyb5a |
T |
C |
18: 84,894,979 (GRCm39) |
|
probably benign |
Het |
| Dhrs4 |
C |
T |
14: 55,724,776 (GRCm39) |
T181I |
probably benign |
Het |
| Disc1 |
T |
C |
8: 125,851,285 (GRCm39) |
S392P |
probably benign |
Het |
| Dnah3 |
A |
G |
7: 119,566,859 (GRCm39) |
F69L |
|
Het |
| Ehmt1 |
T |
C |
2: 24,728,722 (GRCm39) |
D726G |
probably damaging |
Het |
| Epg5 |
T |
A |
18: 77,997,957 (GRCm39) |
L462I |
probably damaging |
Het |
| Exoc2 |
A |
T |
13: 31,040,697 (GRCm39) |
S774T |
probably benign |
Het |
| Fam135b |
A |
G |
15: 71,334,813 (GRCm39) |
S794P |
probably benign |
Het |
| Frmd4a |
T |
C |
2: 4,606,973 (GRCm39) |
V646A |
probably benign |
Het |
| Gm3543 |
G |
T |
14: 41,804,093 (GRCm39) |
D57E |
possibly damaging |
Het |
| Golgb1 |
T |
A |
16: 36,736,124 (GRCm39) |
D1831E |
probably damaging |
Het |
| Hace1 |
T |
G |
10: 45,586,092 (GRCm39) |
|
probably null |
Het |
| Irgc |
T |
C |
7: 24,131,872 (GRCm39) |
E315G |
possibly damaging |
Het |
| Ism1 |
A |
G |
2: 139,582,321 (GRCm39) |
Y211C |
probably damaging |
Het |
| Kpna1 |
T |
G |
16: 35,833,287 (GRCm39) |
V121G |
probably damaging |
Het |
| Lifr |
T |
A |
15: 7,198,521 (GRCm39) |
F250L |
probably damaging |
Het |
| Llgl2 |
A |
G |
11: 115,740,407 (GRCm39) |
T368A |
probably benign |
Het |
| Lmln |
T |
A |
16: 32,925,169 (GRCm39) |
C467* |
probably null |
Het |
| Lrrtm3 |
T |
C |
10: 63,923,943 (GRCm39) |
E408G |
probably benign |
Het |
| Melk |
C |
T |
4: 44,340,693 (GRCm39) |
A330V |
probably null |
Het |
| Mmp13 |
T |
G |
9: 7,277,921 (GRCm39) |
D271E |
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,052,297 (GRCm39) |
T390A |
|
Het |
| Myh8 |
A |
G |
11: 67,174,632 (GRCm39) |
K249R |
probably benign |
Het |
| Nr1h4 |
T |
A |
10: 89,319,315 (GRCm39) |
M184L |
probably damaging |
Het |
| Obscn |
T |
A |
11: 58,885,337 (GRCm39) |
|
probably null |
Het |
| Otog |
T |
G |
7: 45,920,688 (GRCm39) |
C964G |
probably damaging |
Het |
| Oxct2b |
T |
C |
4: 123,010,589 (GRCm39) |
S170P |
probably benign |
Het |
| Pcdha4 |
T |
C |
18: 37,087,112 (GRCm39) |
S432P |
possibly damaging |
Het |
| Prb1a |
T |
A |
6: 132,184,201 (GRCm39) |
R477S |
unknown |
Het |
| Prh1 |
G |
A |
6: 132,549,108 (GRCm39) |
G205D |
unknown |
Het |
| Psg23 |
C |
T |
7: 18,344,393 (GRCm39) |
G354D |
probably damaging |
Het |
| Pura |
T |
G |
18: 36,420,913 (GRCm39) |
D233E |
possibly damaging |
Het |
| Rb1cc1 |
G |
T |
1: 6,315,117 (GRCm39) |
L423F |
probably damaging |
Het |
| Rimbp3 |
T |
C |
16: 17,026,620 (GRCm39) |
S15P |
possibly damaging |
Het |
| Scn1a |
A |
G |
2: 66,148,465 (GRCm39) |
F7L |
probably benign |
Het |
| Sftpb |
A |
T |
6: 72,284,189 (GRCm39) |
R203* |
probably null |
Het |
| Slc30a9 |
A |
G |
5: 67,507,142 (GRCm39) |
K478R |
probably damaging |
Het |
| Slc35f5 |
T |
A |
1: 125,496,333 (GRCm39) |
M156K |
probably benign |
Het |
| Slc41a3 |
A |
G |
6: 90,612,327 (GRCm39) |
I232V |
probably benign |
Het |
| Slit2 |
A |
G |
5: 48,461,534 (GRCm39) |
D1527G |
probably benign |
Het |
| Srfbp1 |
T |
G |
18: 52,623,540 (GRCm39) |
V389G |
possibly damaging |
Het |
| Sun2 |
C |
T |
15: 79,622,720 (GRCm39) |
|
probably null |
Het |
| Tep1 |
G |
T |
14: 51,064,597 (GRCm39) |
A2386D |
probably damaging |
Het |
| Tex15 |
T |
A |
8: 34,064,564 (GRCm39) |
S1331R |
possibly damaging |
Het |
| Tgm1 |
A |
T |
14: 55,942,349 (GRCm39) |
N667K |
probably damaging |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tsen54 |
T |
C |
11: 115,713,410 (GRCm39) |
F438L |
probably damaging |
Het |
| Ube4a |
T |
C |
9: 44,862,191 (GRCm39) |
H150R |
probably benign |
Het |
| Uty |
T |
C |
Y: 1,099,712 (GRCm39) |
N1161S |
possibly damaging |
Het |
| Wdr55 |
T |
G |
18: 36,893,354 (GRCm39) |
C5W |
probably damaging |
Het |
| Zbtb24 |
C |
A |
10: 41,332,540 (GRCm39) |
P405Q |
probably damaging |
Het |
| Zkscan2 |
T |
A |
7: 123,079,591 (GRCm39) |
I789F |
probably damaging |
Het |
|
| Other mutations in Vmn2r16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Vmn2r16
|
APN |
5 |
109,488,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Vmn2r16
|
APN |
5 |
109,478,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01391:Vmn2r16
|
APN |
5 |
109,511,627 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01419:Vmn2r16
|
APN |
5 |
109,510,267 (GRCm39) |
splice site |
probably benign |
|
|
IGL01634:Vmn2r16
|
APN |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01845:Vmn2r16
|
APN |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Vmn2r16
|
APN |
5 |
109,478,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01910:Vmn2r16
|
APN |
5 |
109,487,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02217:Vmn2r16
|
APN |
5 |
109,487,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02327:Vmn2r16
|
APN |
5 |
109,487,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02491:Vmn2r16
|
APN |
5 |
109,487,703 (GRCm39) |
nonsense |
probably null |
|
|
IGL02531:Vmn2r16
|
APN |
5 |
109,488,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02680:Vmn2r16
|
APN |
5 |
109,487,948 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02884:Vmn2r16
|
APN |
5 |
109,508,757 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03084:Vmn2r16
|
APN |
5 |
109,478,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Vmn2r16
|
APN |
5 |
109,487,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03355:Vmn2r16
|
APN |
5 |
109,511,580 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0280:Vmn2r16
|
UTSW |
5 |
109,488,005 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0594:Vmn2r16
|
UTSW |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Vmn2r16
|
UTSW |
5 |
109,487,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r16
|
UTSW |
5 |
109,487,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1248:Vmn2r16
|
UTSW |
5 |
109,508,643 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1626:Vmn2r16
|
UTSW |
5 |
109,511,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Vmn2r16
|
UTSW |
5 |
109,511,853 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1929:Vmn2r16
|
UTSW |
5 |
109,487,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1982:Vmn2r16
|
UTSW |
5 |
109,511,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3038:Vmn2r16
|
UTSW |
5 |
109,487,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3437:Vmn2r16
|
UTSW |
5 |
109,478,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3734:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3820:Vmn2r16
|
UTSW |
5 |
109,510,143 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3873:Vmn2r16
|
UTSW |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4165:Vmn2r16
|
UTSW |
5 |
109,478,427 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4373:Vmn2r16
|
UTSW |
5 |
109,511,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4578:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4637:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4696:Vmn2r16
|
UTSW |
5 |
109,487,168 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5026:Vmn2r16
|
UTSW |
5 |
109,508,722 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Vmn2r16
|
UTSW |
5 |
109,478,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5433:Vmn2r16
|
UTSW |
5 |
109,511,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5955:Vmn2r16
|
UTSW |
5 |
109,511,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5958:Vmn2r16
|
UTSW |
5 |
109,510,153 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6353:Vmn2r16
|
UTSW |
5 |
109,488,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6389:Vmn2r16
|
UTSW |
5 |
109,478,344 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6819:Vmn2r16
|
UTSW |
5 |
109,488,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6994:Vmn2r16
|
UTSW |
5 |
109,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Vmn2r16
|
UTSW |
5 |
109,511,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7063:Vmn2r16
|
UTSW |
5 |
109,511,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Vmn2r16
|
UTSW |
5 |
109,508,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7268:Vmn2r16
|
UTSW |
5 |
109,488,331 (GRCm39) |
nonsense |
probably null |
|
|
R7420:Vmn2r16
|
UTSW |
5 |
109,511,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7591:Vmn2r16
|
UTSW |
5 |
109,510,223 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r16
|
UTSW |
5 |
109,487,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Vmn2r16
|
UTSW |
5 |
109,487,705 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7977:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r16
|
UTSW |
5 |
109,488,272 (GRCm39) |
nonsense |
probably null |
|
|
R8427:Vmn2r16
|
UTSW |
5 |
109,488,138 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8436:Vmn2r16
|
UTSW |
5 |
109,511,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8475:Vmn2r16
|
UTSW |
5 |
109,487,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8554:Vmn2r16
|
UTSW |
5 |
109,511,997 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8771:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r16
|
UTSW |
5 |
109,487,019 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8865:Vmn2r16
|
UTSW |
5 |
109,487,910 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8900:Vmn2r16
|
UTSW |
5 |
109,511,619 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9683:Vmn2r16
|
UTSW |
5 |
109,511,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Vmn2r16
|
UTSW |
5 |
109,487,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,511,779 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,488,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Vmn2r16
|
UTSW |
5 |
109,487,864 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGATATACATGACAAGGGC -3'
(R):5'- TCAGGACCATGTCAATTTTGTG -3'
Sequencing Primer
(F):5'- GTCAGCTTTAGAAGATGGGG -3'
(R):5'- GTGTTGTTGAATATAAACTGTCCCG -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation