Incidental Mutation 'R9366:Bicral'
ID 709014
Institutional Source Beutler Lab
Gene Symbol Bicral
Ensembl Gene ENSMUSG00000036568
Gene Name BRD4 interacting chromatin remodeling complex associated protein like
Synonyms BC032203, Gltscr1l
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9366 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 47109046-47169408 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 47117558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 788 (M788K)
Ref Sequence ENSEMBL: ENSMUSP00000044833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040624]
AlphaFold Q8CHH5
Predicted Effect possibly damaging
Transcript: ENSMUST00000040624
AA Change: M788K

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000044833
Gene: ENSMUSG00000036568
AA Change: M788K

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 204 218 N/A INTRINSIC
low complexity region 406 417 N/A INTRINSIC
low complexity region 605 616 N/A INTRINSIC
Pfam:GLTSCR1 701 808 4.5e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele display abnormal embryo turning, embryonic growth retardation, cardiac hypertrophy, and complete embryonic lethality during organogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 C T 8: 71,914,328 (GRCm39) R100Q probably benign Het
Acp5 C T 9: 22,039,224 (GRCm39) C163Y probably damaging Het
Ankrd17 C T 5: 90,416,508 (GRCm39) R1108Q probably damaging Het
Atp2b4 C A 1: 133,642,920 (GRCm39) G1062C probably damaging Het
C1s2 C A 6: 124,602,694 (GRCm39) A506S probably benign Het
Capn9 C G 8: 125,332,280 (GRCm39) T417S probably benign Het
Cd109 T G 9: 78,622,275 (GRCm39) S1422A probably benign Het
Cd207 G T 6: 83,648,779 (GRCm39) N294K probably damaging Het
Cdc42bpa A G 1: 179,921,675 (GRCm39) E605G probably damaging Het
Cdhr1 C A 14: 36,811,463 (GRCm39) G216V possibly damaging Het
Ckap2 A T 8: 22,658,988 (GRCm39) M585K possibly damaging Het
Clp1 G T 2: 84,556,473 (GRCm39) S2R probably benign Het
Cngb3 G T 4: 19,395,983 (GRCm39) V342F probably benign Het
Col18a1 T C 10: 76,932,258 (GRCm39) D65G unknown Het
Col3a1 C T 1: 45,380,391 (GRCm39) P972S unknown Het
Cxcr5 C T 9: 44,424,730 (GRCm39) C309Y possibly damaging Het
Cyp2t4 G A 7: 26,854,717 (GRCm39) V66M possibly damaging Het
Dcc A T 18: 71,708,281 (GRCm39) N478K probably damaging Het
Emb G T 13: 117,357,096 (GRCm39) probably benign Het
Emsy A T 7: 98,290,860 (GRCm39) N101K probably benign Het
Epb41l5 A G 1: 119,548,448 (GRCm39) Y137H probably damaging Het
Etfdh C T 3: 79,519,271 (GRCm39) G354D probably benign Het
Fa2h A T 8: 112,076,006 (GRCm39) Y206N probably benign Het
Gabrr2 T C 4: 33,085,771 (GRCm39) V217A Het
Gimap4 A G 6: 48,668,037 (GRCm39) K264R probably benign Het
Gpr31b C A 17: 13,270,375 (GRCm39) D265Y probably damaging Het
Irx4 A G 13: 73,417,025 (GRCm39) T474A probably benign Het
Kif21a T C 15: 90,843,951 (GRCm39) E1096G probably damaging Het
Letm2 A T 8: 26,084,165 (GRCm39) V22E probably damaging Het
Lrrc45 A G 11: 120,611,552 (GRCm39) E642G probably damaging Het
Mark1 A T 1: 184,653,792 (GRCm39) V170E probably damaging Het
Mbd6 G A 10: 127,122,304 (GRCm39) Q175* probably null Het
Mrc1 T A 2: 14,321,709 (GRCm39) D1067E probably damaging Het
Muc5b A G 7: 141,417,041 (GRCm39) H3329R probably benign Het
Myh1 A T 11: 67,110,114 (GRCm39) D1434V probably damaging Het
Myo5a T A 9: 75,124,800 (GRCm39) L1785Q probably damaging Het
Myrfl A G 10: 116,670,358 (GRCm39) I295T possibly damaging Het
Nav3 C A 10: 109,659,364 (GRCm39) R751L probably damaging Het
Neb T C 2: 52,172,699 (GRCm39) K1536R probably benign Het
Nynrin T G 14: 56,100,587 (GRCm39) S126A probably damaging Het
Or13p3 A T 4: 118,566,831 (GRCm39) T76S probably damaging Het
Or5m8 A G 2: 85,822,731 (GRCm39) D190G possibly damaging Het
Or6c69c A T 10: 129,911,067 (GRCm39) K263* probably null Het
Parp14 A C 16: 35,659,630 (GRCm39) probably null Het
Phldb1 G T 9: 44,622,546 (GRCm39) L36M possibly damaging Het
Pin1 C A 9: 20,566,841 (GRCm39) T81N probably damaging Het
Pkhd1l1 T C 15: 44,410,308 (GRCm39) I2605T probably benign Het
Plcb3 A G 19: 6,937,658 (GRCm39) probably null Het
Proser3 G A 7: 30,248,478 (GRCm39) S72L probably damaging Het
Pum2 T A 12: 8,783,344 (GRCm39) S598T probably benign Het
Pwp1 T A 10: 85,717,870 (GRCm39) N269K probably damaging Het
Qsox1 A G 1: 155,665,162 (GRCm39) S260P probably benign Het
Ric3 A G 7: 108,653,644 (GRCm39) L149P probably damaging Het
Rif1 A G 2: 52,010,356 (GRCm39) T707A Het
Rnf213 A C 11: 119,327,057 (GRCm39) R1682S Het
Rpgrip1l G T 8: 91,996,809 (GRCm39) Y690* probably null Het
Slc29a2 A G 19: 5,074,609 (GRCm39) T34A probably damaging Het
Slc6a1 A G 6: 114,280,974 (GRCm39) N176S possibly damaging Het
Slco1b2 T A 6: 141,602,552 (GRCm39) Y168* probably null Het
Snca C A 6: 60,792,675 (GRCm39) A78S probably benign Het
Snrnp200 T A 2: 127,058,010 (GRCm39) D257E probably benign Het
Srebf2 T C 15: 82,083,837 (GRCm39) V959A probably benign Het
Stk3 A C 15: 35,072,634 (GRCm39) I209S probably damaging Het
Thsd7a A T 6: 12,555,480 (GRCm39) C135S Het
Tlnrd1 G T 7: 83,531,582 (GRCm39) A283E probably benign Het
Tomm70a A T 16: 56,970,259 (GRCm39) K546* probably null Het
Trak1 C T 9: 121,301,578 (GRCm39) T778I probably damaging Het
Trappc9 T C 15: 72,808,937 (GRCm39) I709V probably benign Het
Trgc3 A G 13: 19,446,825 (GRCm39) T115A probably benign Het
Trp53rkb T C 2: 166,637,700 (GRCm39) S219P possibly damaging Het
Ubqlnl G C 7: 103,798,592 (GRCm39) L302V possibly damaging Het
Uqcc1 C A 2: 155,771,995 (GRCm39) probably benign Het
Vps13a G A 19: 16,672,894 (GRCm39) R1293W probably damaging Het
Vps9d1 G T 8: 123,974,486 (GRCm39) S267* probably null Het
Vwa5b1 A T 4: 138,318,229 (GRCm39) I546N probably damaging Het
Zbtb8b A T 4: 129,326,151 (GRCm39) M338K probably benign Het
Zfp652 C T 11: 95,643,833 (GRCm39) R344* probably null Het
Other mutations in Bicral
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Bicral APN 17 47,136,278 (GRCm39) missense probably benign 0.01
IGL01068:Bicral APN 17 47,136,317 (GRCm39) missense probably damaging 1.00
IGL01899:Bicral APN 17 47,135,600 (GRCm39) missense probably benign 0.08
IGL02321:Bicral APN 17 47,122,873 (GRCm39) missense probably benign 0.01
IGL02425:Bicral APN 17 47,119,380 (GRCm39) missense probably benign 0.05
R0091:Bicral UTSW 17 47,136,233 (GRCm39) missense probably damaging 1.00
R0268:Bicral UTSW 17 47,124,978 (GRCm39) splice site probably benign
R0344:Bicral UTSW 17 47,124,978 (GRCm39) splice site probably benign
R0508:Bicral UTSW 17 47,136,327 (GRCm39) missense possibly damaging 0.61
R0589:Bicral UTSW 17 47,112,522 (GRCm39) missense probably benign 0.00
R1442:Bicral UTSW 17 47,112,650 (GRCm39) missense probably benign 0.05
R1468:Bicral UTSW 17 47,135,519 (GRCm39) missense probably benign 0.00
R1468:Bicral UTSW 17 47,135,519 (GRCm39) missense probably benign 0.00
R1874:Bicral UTSW 17 47,136,104 (GRCm39) missense probably benign 0.30
R2057:Bicral UTSW 17 47,135,814 (GRCm39) missense possibly damaging 0.69
R2120:Bicral UTSW 17 47,135,741 (GRCm39) missense probably benign 0.02
R2190:Bicral UTSW 17 47,136,049 (GRCm39) missense probably damaging 0.98
R3737:Bicral UTSW 17 47,136,836 (GRCm39) missense probably damaging 1.00
R3961:Bicral UTSW 17 47,135,751 (GRCm39) missense probably damaging 0.96
R3977:Bicral UTSW 17 47,141,917 (GRCm39) start codon destroyed unknown
R3979:Bicral UTSW 17 47,141,917 (GRCm39) start codon destroyed unknown
R4183:Bicral UTSW 17 47,124,955 (GRCm39) missense probably damaging 1.00
R4876:Bicral UTSW 17 47,136,502 (GRCm39) missense probably damaging 1.00
R5104:Bicral UTSW 17 47,112,182 (GRCm39) missense probably damaging 0.98
R5310:Bicral UTSW 17 47,124,909 (GRCm39) missense possibly damaging 0.89
R5493:Bicral UTSW 17 47,112,620 (GRCm39) missense possibly damaging 0.77
R5610:Bicral UTSW 17 47,119,418 (GRCm39) missense probably damaging 0.99
R5656:Bicral UTSW 17 47,119,295 (GRCm39) missense probably damaging 0.99
R5771:Bicral UTSW 17 47,136,284 (GRCm39) missense possibly damaging 0.59
R5891:Bicral UTSW 17 47,112,155 (GRCm39) missense probably benign
R6426:Bicral UTSW 17 47,141,005 (GRCm39) missense probably benign 0.36
R6497:Bicral UTSW 17 47,136,499 (GRCm39) missense probably damaging 1.00
R7025:Bicral UTSW 17 47,112,594 (GRCm39) missense probably benign
R7037:Bicral UTSW 17 47,135,560 (GRCm39) missense probably benign 0.08
R7440:Bicral UTSW 17 47,136,710 (GRCm39) missense probably damaging 1.00
R7997:Bicral UTSW 17 47,112,534 (GRCm39) missense probably benign 0.37
R8680:Bicral UTSW 17 47,141,873 (GRCm39) splice site probably benign
R8802:Bicral UTSW 17 47,135,626 (GRCm39) missense probably benign 0.28
R9683:Bicral UTSW 17 47,122,944 (GRCm39) missense possibly damaging 0.89
V3553:Bicral UTSW 17 47,141,021 (GRCm39) missense probably damaging 1.00
X0019:Bicral UTSW 17 47,136,747 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACCAGCCAGTCTTGGTATATCC -3'
(R):5'- AGCAAATGTGATAGCATCCTGTG -3'

Sequencing Primer
(F):5'- AGAATTCCCGATCTGCCTGCTG -3'
(R):5'- TGATAGCATCCTGTGTGTATAGC -3'
Posted On 2022-04-18