Incidental Mutation 'R9367:Trp53i11'
ID 709027
Institutional Source Beutler Lab
Gene Symbol Trp53i11
Ensembl Gene ENSMUSG00000068735
Gene Name transformation related protein 53 inducible protein 11
Synonyms Tp53i11
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R9367 (G1)
Quality Score 154.008
Status Not validated
Chromosome 2
Chromosomal Location 93017893-93032104 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 93029273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 91 (V91L)
Ref Sequence ENSEMBL: ENSMUSP00000088042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090554] [ENSMUST00000111265] [ENSMUST00000111266] [ENSMUST00000150462]
AlphaFold Q4QQM4
Predicted Effect probably benign
Transcript: ENSMUST00000090554
AA Change: V91L

PolyPhen 2 Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000088042
Gene: ENSMUSG00000068735
AA Change: V91L

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 188 8.5e-102 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111265
SMART Domains Protein: ENSMUSP00000106896
Gene: ENSMUSG00000027217

DomainStartEndE-ValueType
Pfam:Tetraspannin 8 247 3.3e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111266
AA Change: V91L

PolyPhen 2 Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000106897
Gene: ENSMUSG00000068735
AA Change: V91L

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 188 2.1e-89 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150462
SMART Domains Protein: ENSMUSP00000115918
Gene: ENSMUSG00000068735

DomainStartEndE-ValueType
Pfam:p53-inducible11 10 87 1.5e-48 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
4930568D16Rik A T 2: 35,244,939 (GRCm39) Y138N probably benign Het
Abca4 T C 3: 121,838,197 (GRCm39) M1T probably null Het
Acer3 A G 7: 97,908,621 (GRCm39) V104A probably damaging Het
Agpat4 A G 17: 12,435,597 (GRCm39) E287G probably benign Het
Akip1 C T 7: 109,308,156 (GRCm39) A146V unknown Het
Ank2 T C 3: 126,738,678 (GRCm39) N2402S unknown Het
Arhgdig A T 17: 26,418,451 (GRCm39) Y177* probably null Het
Arhgef38 T A 3: 132,847,998 (GRCm39) T355S unknown Het
Atp8a2 C A 14: 60,249,827 (GRCm39) probably null Het
Atp8b4 A G 2: 126,216,430 (GRCm39) I672T probably damaging Het
Baat T A 4: 49,503,008 (GRCm39) D38V probably damaging Het
Bcl9 T C 3: 97,117,861 (GRCm39) S278G probably benign Het
Ccdc150 C T 1: 54,324,760 (GRCm39) L350F probably damaging Het
Ceacam20 T G 7: 19,705,533 (GRCm39) S175A probably damaging Het
Chd6 A T 2: 160,871,784 (GRCm39) I217K possibly damaging Het
Cnppd1 T C 1: 75,117,617 (GRCm39) I35V probably benign Het
Col15a1 T C 4: 47,245,603 (GRCm39) I118T probably damaging Het
Csmd3 A T 15: 47,567,564 (GRCm39) Y1289N Het
Dio2 T C 12: 90,696,587 (GRCm39) T134A probably benign Het
Dnaaf9 A T 2: 130,581,380 (GRCm39) N678K probably benign Het
Dnah17 A G 11: 117,987,464 (GRCm39) V1282A possibly damaging Het
Dnah17 A G 11: 118,012,212 (GRCm39) S517P possibly damaging Het
Dync2h1 C T 9: 7,125,730 (GRCm39) probably null Het
Echdc2 C A 4: 108,036,111 (GRCm39) P274Q probably damaging Het
Fam117a T A 11: 95,271,570 (GRCm39) C381S probably damaging Het
Fbxl12 A G 9: 20,550,130 (GRCm39) F122S probably damaging Het
Gen1 G A 12: 11,291,309 (GRCm39) Q892* probably null Het
Gimap4 A G 6: 48,667,746 (GRCm39) Y167C probably damaging Het
Gle1 T A 2: 29,839,014 (GRCm39) F476L probably damaging Het
Gpr135 A T 12: 72,117,473 (GRCm39) V98E possibly damaging Het
Greb1l A T 18: 10,522,130 (GRCm39) H742L probably benign Het
Habp2 G T 19: 56,304,781 (GRCm39) C392F probably damaging Het
Hapln3 G T 7: 78,771,455 (GRCm39) R145S probably damaging Het
Ikbkb A G 8: 23,171,711 (GRCm39) C179R probably damaging Het
Kat6a A T 8: 23,400,156 (GRCm39) I306L possibly damaging Het
Lmo3 A T 6: 138,342,958 (GRCm39) Y140* probably null Het
Lrrc32 T A 7: 98,148,937 (GRCm39) N572K probably damaging Het
Lrrn1 T A 6: 107,545,093 (GRCm39) M297K probably damaging Het
Magi2 G A 5: 20,766,308 (GRCm39) V676I probably damaging Het
Mdga1 T C 17: 30,051,282 (GRCm39) *957W probably null Het
Mip G T 10: 128,063,029 (GRCm39) G158V probably damaging Het
Mmp14 T C 14: 54,677,960 (GRCm39) I527T probably benign Het
Mmp27 G A 9: 7,573,550 (GRCm39) G188D probably damaging Het
Mylk4 A T 13: 32,960,236 (GRCm39) C17S possibly damaging Het
Naa50 T G 16: 43,977,554 (GRCm39) I94R probably damaging Het
Nyap1 A T 5: 137,734,248 (GRCm39) Y262N probably damaging Het
Obsl1 A G 1: 75,466,177 (GRCm39) V1517A probably benign Het
P4htm T A 9: 108,459,147 (GRCm39) M262L probably benign Het
Pappa2 T C 1: 158,784,542 (GRCm39) E156G probably benign Het
Pcdhb15 A T 18: 37,607,971 (GRCm39) Y401F possibly damaging Het
Pde2a G A 7: 101,160,361 (GRCm39) R845H probably damaging Het
Peg10 CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG CCACATCAGGATCCACATCAGGATGCACATCAG 6: 4,756,398 (GRCm39) probably benign Het
Penk C T 4: 4,134,097 (GRCm39) M183I probably benign Het
Pole T C 5: 110,444,955 (GRCm39) V437A probably damaging Het
Ppp1r7 T C 1: 93,279,262 (GRCm39) I114T probably damaging Het
Prr27 C A 5: 87,990,994 (GRCm39) P202Q probably benign Het
Pwp2 G A 10: 78,014,827 (GRCm39) Q386* probably null Het
Rad17 A T 13: 100,769,720 (GRCm39) S280T possibly damaging Het
Rhebl1 C T 15: 98,776,414 (GRCm39) E128K possibly damaging Het
Sema3e G T 5: 14,291,084 (GRCm39) V615L probably benign Het
Slc22a2 A T 17: 12,824,837 (GRCm39) Y233F probably benign Het
Ssu2 A G 6: 112,357,975 (GRCm39) S123P probably damaging Het
Stk10 A G 11: 32,538,878 (GRCm39) E239G Het
Surf6 G T 2: 26,782,380 (GRCm39) Q316K probably damaging Het
Tcerg1 G A 18: 42,685,573 (GRCm39) D637N possibly damaging Het
Tm7sf3 C T 6: 146,525,179 (GRCm39) D89N possibly damaging Het
Tnxb C A 17: 34,931,993 (GRCm39) F2175L probably damaging Het
Tspan9 A G 6: 127,944,102 (GRCm39) V66A probably damaging Het
Usp16 C T 16: 87,261,669 (GRCm39) T95M probably benign Het
Usp9y A T Y: 1,324,982 (GRCm39) F1691Y probably damaging Het
Uty A T Y: 1,099,584 (GRCm39) L1204I possibly damaging Het
Vmn1r192 A T 13: 22,371,800 (GRCm39) V140D possibly damaging Het
Vps54 T C 11: 21,250,234 (GRCm39) V552A probably benign Het
Vps8 T C 16: 21,340,668 (GRCm39) V804A possibly damaging Het
Zfp869 A C 8: 70,161,057 (GRCm39) L33R probably damaging Het
Other mutations in Trp53i11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0011:Trp53i11 UTSW 2 93,029,698 (GRCm39) unclassified probably benign
R0011:Trp53i11 UTSW 2 93,029,698 (GRCm39) unclassified probably benign
R0137:Trp53i11 UTSW 2 93,029,696 (GRCm39) unclassified probably benign
R0148:Trp53i11 UTSW 2 93,028,080 (GRCm39) missense probably damaging 1.00
R0759:Trp53i11 UTSW 2 93,029,303 (GRCm39) missense possibly damaging 0.80
R4700:Trp53i11 UTSW 2 93,030,245 (GRCm39) missense probably damaging 1.00
R5451:Trp53i11 UTSW 2 93,030,200 (GRCm39) missense possibly damaging 0.85
R5466:Trp53i11 UTSW 2 93,029,728 (GRCm39) missense possibly damaging 0.51
R5626:Trp53i11 UTSW 2 93,029,723 (GRCm39) missense possibly damaging 0.95
R6709:Trp53i11 UTSW 2 93,030,163 (GRCm39) missense probably benign
R7889:Trp53i11 UTSW 2 93,029,244 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCTGAGGCCCATACTTCAG -3'
(R):5'- CAGGGCAGTGAACCAACTAC -3'

Sequencing Primer
(F):5'- TACTTCAGGGTCTAGGCCAAC -3'
(R):5'- GTGAACCAACTACATGCATTCTAG -3'
Posted On 2022-04-18