Mutagenetix > Incidental Mutation

Incidental Mutation 'R9368:Dnah6'

709122

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R9368 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 73021278 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 4054 (S4054T)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: S4054T

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: S4054T

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: S4002T

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: S4002T

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: S4054T

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: S4054T

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2200002D01Rik	CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC	7: 29,247,623 (GRCm38)		probably benign	Het
Abcc9	A	T	6: 142,694,525 (GRCm38)	L79H	probably damaging	Het
Alb	A	G	5: 90,475,284 (GRCm38)	T601A	probably benign	Het
Aldh1l2	A	T	10: 83,495,952 (GRCm38)	L776*	probably null	Het
Ank3	A	G	10: 69,987,499 (GRCm38)	K666R		Het
Ankrd17	T	C	5: 90,244,127 (GRCm38)	T1895A	possibly damaging	Het
Ankrd17	C	T	5: 90,268,649 (GRCm38)	R1108Q	probably damaging	Het
Ap2a2	T	C	7: 141,627,902 (GRCm38)	F738L	probably benign	Het
Ap4m1	T	A	5: 138,177,183 (GRCm38)	C319*	probably null	Het
Arsj	C	T	3: 126,439,096 (GRCm38)	T497M	probably damaging	Het
Begain	G	T	12: 109,033,992 (GRCm38)	S284R	probably damaging	Het
Bicc1	A	T	10: 70,950,087 (GRCm38)	N408K	probably benign	Het
Cacybp	T	C	1: 160,203,638 (GRCm38)	M207V	possibly damaging	Het
Cct8l1	A	G	5: 25,516,338 (GRCm38)	D17G	probably benign	Het
Cd1d1	C	A	3: 86,998,632 (GRCm38)		probably null	Het
Chd3	C	T	11: 69,360,374 (GRCm38)	C554Y	probably damaging	Het
Chsy1	A	G	7: 66,171,751 (GRCm38)	D578G	probably damaging	Het
Col6a6	T	C	9: 105,786,101 (GRCm38)	Q79R	possibly damaging	Het
Cpne4	A	T	9: 104,686,539 (GRCm38)	R38S	probably damaging	Het
Cyp3a57	A	G	5: 145,381,349 (GRCm38)	D380G	probably benign	Het
Emb	G	T	13: 117,220,560 (GRCm38)		probably benign	Het
Eml5	T	C	12: 98,796,578 (GRCm38)	R1648G	probably benign	Het
Fam117b	A	T	1: 59,981,581 (GRCm38)	M537L	probably benign	Het
Fcrls	C	T	3: 87,257,599 (GRCm38)	V207I	possibly damaging	Het
Ffar1	A	G	7: 30,861,032 (GRCm38)	S147P	probably benign	Het
Fgfr3	G	A	5: 33,727,872 (GRCm38)	R110Q	probably benign	Het
Frmd6	T	A	12: 70,887,091 (GRCm38)		probably null	Het
Fry	A	G	5: 150,477,938 (GRCm38)	R356G		Het
Fsip2	A	G	2: 82,980,695 (GRCm38)	R2453G	possibly damaging	Het
Glipr1l3	G	A	10: 112,148,018 (GRCm38)	T181I	probably benign	Het
Hoxc10	A	G	15: 102,970,947 (GRCm38)	I301V	possibly damaging	Het
Igf2bp2	T	A	16: 22,065,145 (GRCm38)	D463V	probably damaging	Het
Ints13	T	C	6: 146,565,631 (GRCm38)	D194G	probably null	Het
Kif5c	A	T	2: 49,732,780 (GRCm38)	E548V	probably damaging	Het
Lrp2	T	C	2: 69,527,635 (GRCm38)	D350G	probably damaging	Het
Lrrc61	T	C	6: 48,568,311 (GRCm38)	S23P	possibly damaging	Het
Mcpt4	T	C	14: 56,061,677 (GRCm38)	M35V	probably damaging	Het
Mical1	T	A	10: 41,481,306 (GRCm38)	M369K	possibly damaging	Het
Mre11a	T	A	9: 14,825,218 (GRCm38)	F548L	probably benign	Het
Muc20	C	T	16: 32,794,101 (GRCm38)	C302Y	possibly damaging	Het
Nlgn1	T	C	3: 25,434,458 (GRCm38)	D571G	probably damaging	Het
Nup88	T	C	11: 70,967,930 (GRCm38)	K131E	probably damaging	Het
Nwd2	A	G	5: 63,804,963 (GRCm38)	D630G	probably damaging	Het
Olfr187	C	T	16: 59,036,315 (GRCm38)	V141M	probably benign	Het
Olfr410	A	G	11: 74,334,367 (GRCm38)	L288P	probably damaging	Het
Olfr805	A	T	10: 129,723,012 (GRCm38)	C177*	probably null	Het
Pdzd8	A	T	19: 59,300,787 (GRCm38)	L727*	probably null	Het
Pi16	T	A	17: 29,327,878 (GRCm38)	N475K	probably benign	Het
Pikfyve	G	A	1: 65,268,742 (GRCm38)	A1826T	probably damaging	Het
Plxna1	A	T	6: 89,337,156 (GRCm38)	S768T	probably benign	Het
Plxnc1	T	A	10: 94,864,737 (GRCm38)	R656*	probably null	Het
Poglut1	A	G	16: 38,529,488 (GRCm38)	W308R	probably damaging	Het
Prmt9	T	G	8: 77,559,034 (GRCm38)	V165G	probably benign	Het
Ptch2	A	G	4: 117,104,772 (GRCm38)	E102G	probably damaging	Het
Rpn2	G	T	2: 157,299,580 (GRCm38)	A303S	possibly damaging	Het
Rttn	A	C	18: 89,060,452 (GRCm38)	H1334P	probably damaging	Het
Sept3	A	T	15: 82,279,538 (GRCm38)	D32V	probably damaging	Het
Sftpa1	G	T	14: 41,132,460 (GRCm38)	M1I	probably null	Het
Slc15a2	G	A	16: 36,753,718 (GRCm38)	T591I	probably benign	Het
Slc18a2	C	T	19: 59,274,359 (GRCm38)	T252I	probably benign	Het
Smchd1	A	G	17: 71,387,076 (GRCm38)	F1225L	probably damaging	Het
Sppl2c	G	A	11: 104,187,735 (GRCm38)	G454S	probably damaging	Het
Swt1	A	G	1: 151,411,016 (GRCm38)	S242P	possibly damaging	Het
Tcaim	C	A	9: 122,818,863 (GRCm38)	H148N	probably damaging	Het
Tgfbr3l	T	C	8: 4,249,640 (GRCm38)	V141A	probably damaging	Het
Ticrr	A	G	7: 79,680,987 (GRCm38)	D711G	probably damaging	Het
Trim45	A	T	3: 100,925,003 (GRCm38)	Q184L	possibly damaging	Het
Tyw1	G	A	5: 130,269,224 (GRCm38)	R202Q	probably damaging	Het
Usp25	G	A	16: 77,107,955 (GRCm38)	R803H	probably damaging	Het
Vmn2r71	T	A	7: 85,624,234 (GRCm38)	M752K	probably damaging	Het
Wdr35	G	A	12: 9,021,826 (GRCm38)	V893I	probably benign	Het
Zdhhc7	G	T	8: 120,087,755 (GRCm38)	P105Q	probably damaging	Het
Zfp316	A	G	5: 143,264,291 (GRCm38)		probably null	Het
Zfp454	G	C	11: 50,873,710 (GRCm38)	N298K	possibly damaging	Het
Zfp7	TGCGGGAAAGGTTTCCACCTGAGCG	TGCG	15: 76,890,600 (GRCm38)		probably benign	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,195,737 (GRCm38)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,086,207 (GRCm38)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,195,761 (GRCm38)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,212,434 (GRCm38)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,123,771 (GRCm38)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,156,350 (GRCm38)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,033,526 (GRCm38)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,083,157 (GRCm38)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,173,390 (GRCm38)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,074,781 (GRCm38)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,065,725 (GRCm38)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,173,456 (GRCm38)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,092,178 (GRCm38)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,074,748 (GRCm38)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,024,252 (GRCm38)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,075,802 (GRCm38)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,076,660 (GRCm38)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,188,377 (GRCm38)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,065,776 (GRCm38)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,135,801 (GRCm38)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,032,569 (GRCm38)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,060,143 (GRCm38)	missense	probably benign
IGL02126:Dnah6	APN	6	73,103,166 (GRCm38)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73,017,797 (GRCm38)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,133,650 (GRCm38)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,168,911 (GRCm38)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,101,898 (GRCm38)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,076,640 (GRCm38)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,027,448 (GRCm38)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73,021,227 (GRCm38)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,095,104 (GRCm38)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,121,823 (GRCm38)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,208,599 (GRCm38)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,138,715 (GRCm38)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,032,587 (GRCm38)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,149,140 (GRCm38)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,145,004 (GRCm38)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,041,054 (GRCm38)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,144,700 (GRCm38)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,053,647 (GRCm38)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,083,085 (GRCm38)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,075,850 (GRCm38)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,163,504 (GRCm38)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,065,755 (GRCm38)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,208,641 (GRCm38)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,101,880 (GRCm38)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,114,582 (GRCm38)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,060,260 (GRCm38)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,038,734 (GRCm38)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,188,535 (GRCm38)	splice site	probably benign
R0165:Dnah6	UTSW	6	73,021,323 (GRCm38)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,082,923 (GRCm38)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,159,115 (GRCm38)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,173,558 (GRCm38)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,069,399 (GRCm38)	splice site	probably benign
R0345:Dnah6	UTSW	6	73,021,257 (GRCm38)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,188,359 (GRCm38)	missense	probably benign
R0362:Dnah6	UTSW	6	73,208,609 (GRCm38)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,083,124 (GRCm38)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,044,774 (GRCm38)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	73,022,412 (GRCm38)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,123,811 (GRCm38)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,129,474 (GRCm38)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,212,622 (GRCm38)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,087,602 (GRCm38)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,035,293 (GRCm38)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,124,757 (GRCm38)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,159,193 (GRCm38)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,144,965 (GRCm38)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,159,135 (GRCm38)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,124,709 (GRCm38)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,208,545 (GRCm38)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,191,619 (GRCm38)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,027,442 (GRCm38)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,049,048 (GRCm38)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,151,553 (GRCm38)	missense	probably benign
R1557:Dnah6	UTSW	6	73,049,131 (GRCm38)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,076,600 (GRCm38)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,067,469 (GRCm38)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,144,963 (GRCm38)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,100,112 (GRCm38)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,044,752 (GRCm38)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,155,296 (GRCm38)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,205,732 (GRCm38)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,129,540 (GRCm38)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,044,761 (GRCm38)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,160,982 (GRCm38)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,024,958 (GRCm38)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,181,797 (GRCm38)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,100,088 (GRCm38)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,181,762 (GRCm38)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,084,721 (GRCm38)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,121,970 (GRCm38)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,095,044 (GRCm38)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,092,192 (GRCm38)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,067,466 (GRCm38)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,173,419 (GRCm38)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,027,422 (GRCm38)	missense	probably benign
R2041:Dnah6	UTSW	6	73,073,439 (GRCm38)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73,021,182 (GRCm38)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,144,035 (GRCm38)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,049,166 (GRCm38)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,089,746 (GRCm38)	splice site	probably null
R2193:Dnah6	UTSW	6	73,138,640 (GRCm38)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,100,085 (GRCm38)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,113,581 (GRCm38)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73,021,109 (GRCm38)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,156,421 (GRCm38)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,091,967 (GRCm38)	splice site	probably null
R2436:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,173,350 (GRCm38)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,032,633 (GRCm38)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,191,498 (GRCm38)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,127,927 (GRCm38)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,089,592 (GRCm38)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,129,448 (GRCm38)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,149,484 (GRCm38)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,118,026 (GRCm38)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,129,291 (GRCm38)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,191,479 (GRCm38)	missense	probably benign
R4486:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,178,416 (GRCm38)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,192,405 (GRCm38)	missense	probably benign
R4573:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,152,712 (GRCm38)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,129,660 (GRCm38)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,070,597 (GRCm38)	missense	probably benign
R4653:Dnah6	UTSW	6	73,073,457 (GRCm38)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,037,688 (GRCm38)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,192,422 (GRCm38)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,025,012 (GRCm38)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,129,530 (GRCm38)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,095,074 (GRCm38)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,089,668 (GRCm38)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73,022,424 (GRCm38)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,044,762 (GRCm38)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,121,788 (GRCm38)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,192,676 (GRCm38)	intron	probably benign
R4948:Dnah6	UTSW	6	73,053,689 (GRCm38)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,188,383 (GRCm38)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,144,815 (GRCm38)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,044,691 (GRCm38)	missense	probably benign
R5044:Dnah6	UTSW	6	73,037,622 (GRCm38)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,181,761 (GRCm38)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,195,634 (GRCm38)	missense	probably benign
R5186:Dnah6	UTSW	6	73,067,427 (GRCm38)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,195,732 (GRCm38)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,113,488 (GRCm38)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,127,861 (GRCm38)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,212,620 (GRCm38)	missense	probably benign
R5343:Dnah6	UTSW	6	73,212,616 (GRCm38)	missense	probably benign
R5375:Dnah6	UTSW	6	73,123,855 (GRCm38)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,037,615 (GRCm38)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,060,138 (GRCm38)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,075,734 (GRCm38)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,086,185 (GRCm38)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,092,157 (GRCm38)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,092,116 (GRCm38)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,190,419 (GRCm38)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,159,229 (GRCm38)	missense	probably benign
R5541:Dnah6	UTSW	6	73,192,988 (GRCm38)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,151,689 (GRCm38)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,149,525 (GRCm38)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73,021,227 (GRCm38)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,060,279 (GRCm38)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,181,722 (GRCm38)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,086,166 (GRCm38)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,114,697 (GRCm38)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,188,494 (GRCm38)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,086,217 (GRCm38)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,191,605 (GRCm38)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,155,418 (GRCm38)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,074,586 (GRCm38)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,074,704 (GRCm38)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,044,732 (GRCm38)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,173,533 (GRCm38)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,053,695 (GRCm38)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,035,280 (GRCm38)	splice site	probably null
R6640:Dnah6	UTSW	6	73,024,293 (GRCm38)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,138,760 (GRCm38)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,037,549 (GRCm38)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,133,608 (GRCm38)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,133,542 (GRCm38)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,212,522 (GRCm38)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,181,755 (GRCm38)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,044,773 (GRCm38)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73,021,178 (GRCm38)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,087,562 (GRCm38)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,135,680 (GRCm38)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,181,705 (GRCm38)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,173,545 (GRCm38)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,084,760 (GRCm38)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,144,722 (GRCm38)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,212,612 (GRCm38)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,192,317 (GRCm38)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,212,492 (GRCm38)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,127,904 (GRCm38)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,118,099 (GRCm38)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,027,440 (GRCm38)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,149,430 (GRCm38)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,092,168 (GRCm38)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,095,206 (GRCm38)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,124,759 (GRCm38)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,169,080 (GRCm38)	splice site	probably null
R7735:Dnah6	UTSW	6	73,069,429 (GRCm38)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,025,720 (GRCm38)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,127,919 (GRCm38)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,135,467 (GRCm38)	splice site	probably null
R8034:Dnah6	UTSW	6	73,129,225 (GRCm38)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,160,913 (GRCm38)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,025,786 (GRCm38)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,060,225 (GRCm38)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,037,566 (GRCm38)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,044,728 (GRCm38)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,168,827 (GRCm38)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,195,681 (GRCm38)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,076,599 (GRCm38)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,025,000 (GRCm38)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,074,651 (GRCm38)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,138,774 (GRCm38)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,178,457 (GRCm38)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,095,188 (GRCm38)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,168,867 (GRCm38)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,075,890 (GRCm38)	intron	probably benign
R8737:Dnah6	UTSW	6	73,067,445 (GRCm38)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,179,828 (GRCm38)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,065,773 (GRCm38)	missense	probably benign
R8809:Dnah6	UTSW	6	73,032,563 (GRCm38)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,127,954 (GRCm38)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,144,173 (GRCm38)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73,021,148 (GRCm38)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,178,498 (GRCm38)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,144,751 (GRCm38)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,142,292 (GRCm38)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,084,657 (GRCm38)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,144,046 (GRCm38)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,067,486 (GRCm38)	missense	probably benign
R9106:Dnah6	UTSW	6	73,144,769 (GRCm38)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,060,203 (GRCm38)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,121,899 (GRCm38)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,144,941 (GRCm38)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,144,705 (GRCm38)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,027,514 (GRCm38)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,083,057 (GRCm38)	missense	probably benign	0.02
R9378:Dnah6	UTSW	6	73,212,530 (GRCm38)	missense	probably benign
R9439:Dnah6	UTSW	6	73,035,347 (GRCm38)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,142,316 (GRCm38)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,138,767 (GRCm38)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,191,606 (GRCm38)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,101,889 (GRCm38)	missense	probably benign
RF020:Dnah6	UTSW	6	73,118,057 (GRCm38)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,178,518 (GRCm38)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,191,500 (GRCm38)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,037,673 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,133,559 (GRCm38)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,087,783 (GRCm38)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,032,526 (GRCm38)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73,021,237 (GRCm38)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,155,272 (GRCm38)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,041,138 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTTAAGAACACGCTCACCTGTGG -3'
(R):5'- AACTGAGCATGAGGGTAGCC -3'

Sequencing Primer
(F):5'- ACGCTCACCTGTGGTTGAAAG -3'
(R):5'- GGGTAGCCCATCCCTCAAATCTTTAG -3'

Posted On

2022-04-18