Incidental Mutation 'R9368:Ints13'
ID 709125
Institutional Source Beutler Lab
Gene Symbol Ints13
Ensembl Gene ENSMUSG00000040250
Gene Name integrator complex subunit 13
Synonyms 4933424B01Rik, Asun, Spata30
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R9368 (G1)
Quality Score 161.009
Status Not validated
Chromosome 6
Chromosomal Location 146451130-146479333 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 146467129 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 194 (D194G)
Ref Sequence ENSEMBL: ENSMUSP00000032427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032427]
AlphaFold Q8QZV7
Predicted Effect probably null
Transcript: ENSMUST00000032427
AA Change: D194G

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000032427
Gene: ENSMUSG00000040250
AA Change: D194G

DomainStartEndE-ValueType
Pfam:DUF2151 4 692 8.2e-292 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000118000
Gene: ENSMUSG00000040250
AA Change: D133G

DomainStartEndE-ValueType
Pfam:DUF2151 1 394 7.2e-171 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
Abcc9 A T 6: 142,640,251 (GRCm39) L79H probably damaging Het
Alb A G 5: 90,623,143 (GRCm39) T601A probably benign Het
Aldh1l2 A T 10: 83,331,816 (GRCm39) L776* probably null Het
Ank3 A G 10: 69,823,329 (GRCm39) K666R Het
Ankrd17 T C 5: 90,391,986 (GRCm39) T1895A possibly damaging Het
Ankrd17 C T 5: 90,416,508 (GRCm39) R1108Q probably damaging Het
Ap2a2 T C 7: 141,207,815 (GRCm39) F738L probably benign Het
Ap4m1 T A 5: 138,175,445 (GRCm39) C319* probably null Het
Arsj C T 3: 126,232,745 (GRCm39) T497M probably damaging Het
Begain G T 12: 108,999,918 (GRCm39) S284R probably damaging Het
Bicc1 A T 10: 70,785,917 (GRCm39) N408K probably benign Het
Cacybp T C 1: 160,031,208 (GRCm39) M207V possibly damaging Het
Cct8l1 A G 5: 25,721,336 (GRCm39) D17G probably benign Het
Cd1d1 C A 3: 86,905,939 (GRCm39) probably null Het
Chd3 C T 11: 69,251,200 (GRCm39) C554Y probably damaging Het
Chsy1 A G 7: 65,821,499 (GRCm39) D578G probably damaging Het
Col6a6 T C 9: 105,663,300 (GRCm39) Q79R possibly damaging Het
Cpne4 A T 9: 104,563,738 (GRCm39) R38S probably damaging Het
Cyp3a57 A G 5: 145,318,159 (GRCm39) D380G probably benign Het
Dnah6 A T 6: 72,998,261 (GRCm39) S4054T probably benign Het
Emb G T 13: 117,357,096 (GRCm39) probably benign Het
Eml5 T C 12: 98,762,837 (GRCm39) R1648G probably benign Het
Fam117b A T 1: 60,020,740 (GRCm39) M537L probably benign Het
Fcrl2 C T 3: 87,164,906 (GRCm39) V207I possibly damaging Het
Ffar1 A G 7: 30,560,457 (GRCm39) S147P probably benign Het
Fgfr3 G A 5: 33,885,216 (GRCm39) R110Q probably benign Het
Frmd6 T A 12: 70,933,865 (GRCm39) probably null Het
Fry A G 5: 150,401,403 (GRCm39) R356G Het
Fsip2 A G 2: 82,811,039 (GRCm39) R2453G possibly damaging Het
Glipr1l3 G A 10: 111,983,923 (GRCm39) T181I probably benign Het
Hoxc10 A G 15: 102,879,382 (GRCm39) I301V possibly damaging Het
Igf2bp2 T A 16: 21,883,895 (GRCm39) D463V probably damaging Het
Kif5c A T 2: 49,622,792 (GRCm39) E548V probably damaging Het
Lrp2 T C 2: 69,357,979 (GRCm39) D350G probably damaging Het
Lrrc61 T C 6: 48,545,245 (GRCm39) S23P possibly damaging Het
Mcpt4 T C 14: 56,299,134 (GRCm39) M35V probably damaging Het
Mical1 T A 10: 41,357,302 (GRCm39) M369K possibly damaging Het
Mre11a T A 9: 14,736,514 (GRCm39) F548L probably benign Het
Muc20 C T 16: 32,614,471 (GRCm39) C302Y possibly damaging Het
Nlgn1 T C 3: 25,488,622 (GRCm39) D571G probably damaging Het
Nup88 T C 11: 70,858,756 (GRCm39) K131E probably damaging Het
Nwd2 A G 5: 63,962,306 (GRCm39) D630G probably damaging Het
Or3a1 A G 11: 74,225,193 (GRCm39) L288P probably damaging Het
Or5h19 C T 16: 58,856,678 (GRCm39) V141M probably benign Het
Or6c212 A T 10: 129,558,881 (GRCm39) C177* probably null Het
Pdzd8 A T 19: 59,289,219 (GRCm39) L727* probably null Het
Pi16 T A 17: 29,546,852 (GRCm39) N475K probably benign Het
Pikfyve G A 1: 65,307,901 (GRCm39) A1826T probably damaging Het
Plxna1 A T 6: 89,314,138 (GRCm39) S768T probably benign Het
Plxnc1 T A 10: 94,700,599 (GRCm39) R656* probably null Het
Poglut1 A G 16: 38,349,850 (GRCm39) W308R probably damaging Het
Prmt9 T G 8: 78,285,663 (GRCm39) V165G probably benign Het
Ptch2 A G 4: 116,961,969 (GRCm39) E102G probably damaging Het
Rpn2 G T 2: 157,141,500 (GRCm39) A303S possibly damaging Het
Rttn A C 18: 89,078,576 (GRCm39) H1334P probably damaging Het
Septin3 A T 15: 82,163,739 (GRCm39) D32V probably damaging Het
Sftpa1 G T 14: 40,854,417 (GRCm39) M1I probably null Het
Slc15a2 G A 16: 36,574,080 (GRCm39) T591I probably benign Het
Slc18a2 C T 19: 59,262,791 (GRCm39) T252I probably benign Het
Smchd1 A G 17: 71,694,071 (GRCm39) F1225L probably damaging Het
Sppl2c G A 11: 104,078,561 (GRCm39) G454S probably damaging Het
Swt1 A G 1: 151,286,767 (GRCm39) S242P possibly damaging Het
Tcaim C A 9: 122,647,928 (GRCm39) H148N probably damaging Het
Tgfbr3l T C 8: 4,299,640 (GRCm39) V141A probably damaging Het
Ticrr A G 7: 79,330,735 (GRCm39) D711G probably damaging Het
Trim45 A T 3: 100,832,319 (GRCm39) Q184L possibly damaging Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Usp25 G A 16: 76,904,843 (GRCm39) R803H probably damaging Het
Vmn2r71 T A 7: 85,273,442 (GRCm39) M752K probably damaging Het
Wdr35 G A 12: 9,071,826 (GRCm39) V893I probably benign Het
Zdhhc7 G T 8: 120,814,494 (GRCm39) P105Q probably damaging Het
Zfp316 A G 5: 143,250,046 (GRCm39) probably null Het
Zfp454 G C 11: 50,764,537 (GRCm39) N298K possibly damaging Het
Zfp7 TGCGGGAAAGGTTTCCACCTGAGCG TGCG 15: 76,774,800 (GRCm39) probably benign Het
Other mutations in Ints13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Ints13 APN 6 146,467,174 (GRCm39) missense probably damaging 1.00
IGL02085:Ints13 APN 6 146,451,437 (GRCm39) utr 3 prime probably benign
IGL02439:Ints13 APN 6 146,455,721 (GRCm39) splice site probably benign
IGL02512:Ints13 APN 6 146,477,855 (GRCm39) missense probably damaging 1.00
IGL02523:Ints13 APN 6 146,459,109 (GRCm39) missense probably benign 0.09
IGL02988:Ints13 APN 6 146,457,646 (GRCm39) missense possibly damaging 0.49
R0083:Ints13 UTSW 6 146,452,162 (GRCm39) missense probably benign 0.06
R0085:Ints13 UTSW 6 146,476,285 (GRCm39) splice site probably benign
R0184:Ints13 UTSW 6 146,456,542 (GRCm39) missense probably benign 0.26
R0656:Ints13 UTSW 6 146,453,959 (GRCm39) missense probably benign 0.19
R1808:Ints13 UTSW 6 146,455,695 (GRCm39) missense probably damaging 1.00
R1838:Ints13 UTSW 6 146,468,109 (GRCm39) missense possibly damaging 0.92
R1906:Ints13 UTSW 6 146,453,868 (GRCm39) critical splice donor site probably null
R2140:Ints13 UTSW 6 146,477,929 (GRCm39) missense probably damaging 1.00
R3082:Ints13 UTSW 6 146,476,205 (GRCm39) missense possibly damaging 0.92
R5568:Ints13 UTSW 6 146,477,855 (GRCm39) missense probably damaging 1.00
R5757:Ints13 UTSW 6 146,451,604 (GRCm39) missense probably benign 0.01
R5770:Ints13 UTSW 6 146,456,571 (GRCm39) missense probably damaging 0.98
R5809:Ints13 UTSW 6 146,477,847 (GRCm39) missense probably benign 0.06
R6273:Ints13 UTSW 6 146,467,179 (GRCm39) missense probably damaging 1.00
R6882:Ints13 UTSW 6 146,464,939 (GRCm39) missense probably null 0.18
R6908:Ints13 UTSW 6 146,456,531 (GRCm39) missense probably damaging 0.99
R7089:Ints13 UTSW 6 146,476,216 (GRCm39) missense probably damaging 1.00
R7425:Ints13 UTSW 6 146,476,198 (GRCm39) critical splice donor site probably null
R7660:Ints13 UTSW 6 146,458,836 (GRCm39) missense probably benign 0.24
R7957:Ints13 UTSW 6 146,452,264 (GRCm39) missense probably damaging 0.99
R8529:Ints13 UTSW 6 146,464,926 (GRCm39) missense probably damaging 0.98
R8847:Ints13 UTSW 6 146,457,631 (GRCm39) missense probably benign 0.01
R9703:Ints13 UTSW 6 146,459,063 (GRCm39) missense probably damaging 1.00
R9777:Ints13 UTSW 6 146,463,326 (GRCm39) missense probably damaging 0.99
RF011:Ints13 UTSW 6 146,457,738 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGGTATGATAATGACCTACTGAAAC -3'
(R):5'- AGTGTCAGCATGCTACAGC -3'

Sequencing Primer
(F):5'- TGAACCCCTTTCCTGTGAAAAG -3'
(R):5'- CTACAGCTGAATAGTGGCTTTAGC -3'
Posted On 2022-04-18