Mutagenetix > Incidental Mutation

Incidental Mutation 'R9370:Krt9'

709277

Institutional Source

Beutler Lab

Gene Symbol

Krt9

Ensembl Gene

ENSMUSG00000051617

Gene Name

keratin 9

Synonyms

K9, Krt1-9

MMRRC Submission

068964-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9370 (G1)

Quality Score

155.457

Status

Not validated

Chromosome

Chromosomal Location

100077607-100084072 bp(-) (GRCm39)

Type of Mutation

small deletion (8 aa in frame mutation)

DNA Base Change (assembly)

TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC to TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC at 100079903 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000055255 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059707]

AlphaFold

Q6RHW0

Predicted Effect

probably benign
Transcript: ENSMUST00000059707

SMART Domains

Protein: ENSMUSP00000055255
Gene: ENSMUSG00000051617

Domain	Start	End	E-Value	Type
low complexity region	6	125	N/A	INTRINSIC
Filament	130	442	2.96e-124	SMART
low complexity region	462	716	N/A	INTRINSIC
low complexity region	721	737	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1d1	T	A	6: 37,544,099 (GRCm39)	*326R	probably null	Het
Cntn5	T	A	9: 9,833,520 (GRCm39)	I344F	probably benign	Het
Cyp2t4	G	A	7: 26,854,717 (GRCm39)	V66M	possibly damaging	Het
Eln	C	T	5: 134,741,476 (GRCm39)	V563I	unknown	Het
Epb41l5	T	C	1: 119,561,312 (GRCm39)	Y83C	probably damaging	Het
Epha8	T	C	4: 136,673,511 (GRCm39)	D91G	possibly damaging	Het
Fscn3	T	C	6: 28,434,535 (GRCm39)	V370A	probably benign	Het
Gcc2	A	G	10: 58,131,940 (GRCm39)	N1550S	probably benign	Het
Gck	T	C	11: 5,852,244 (GRCm39)	D365G	possibly damaging	Het
Hhatl	C	T	9: 121,617,836 (GRCm39)	G251E	possibly damaging	Het
Hspa12a	A	G	19: 58,813,708 (GRCm39)	F139S	probably damaging	Het
Ikzf2	T	C	1: 69,578,018 (GRCm39)	D497G	probably damaging	Het
Ino80	A	G	2: 119,232,848 (GRCm39)	S1157P	probably damaging	Het
Jmjd6	A	G	11: 116,729,952 (GRCm39)	I315T	probably benign	Het
Jup	C	T	11: 100,270,391 (GRCm39)	C372Y	probably damaging	Het
Lyst	C	T	13: 13,935,333 (GRCm39)	H3601Y	probably damaging	Het
Mars2	T	C	1: 55,276,624 (GRCm39)	S76P	probably benign	Het
Mtmr10	A	G	7: 63,969,249 (GRCm39)	E337G	probably benign	Het
Myo5b	A	G	18: 74,760,246 (GRCm39)	D254G	possibly damaging	Het
Nell1	A	T	7: 49,770,292 (GRCm39)	E117V	probably damaging	Het
Pcdhgb7	T	C	18: 37,884,937 (GRCm39)	S36P	possibly damaging	Het
Rps6kc1	A	C	1: 190,531,222 (GRCm39)	L927V	probably damaging	Het
Sacs	T	A	14: 61,441,080 (GRCm39)	I1042N	probably damaging	Het
Skint2	A	G	4: 112,481,259 (GRCm39)	N41D	possibly damaging	Het
Slc5a11	A	G	7: 122,834,855 (GRCm39)	T5A	probably benign	Het
Tbc1d22a	C	T	15: 86,123,441 (GRCm39)	T194I	probably benign	Het
Tmem234	T	A	4: 129,500,922 (GRCm39)	V93D	probably damaging	Het
Trim43b	T	C	9: 88,971,559 (GRCm39)	E199G	probably benign	Het
Ttc24	A	T	3: 87,980,136 (GRCm39)	V148E	probably benign	Het
Utp15	A	G	13: 98,387,119 (GRCm39)	F434L	probably damaging	Het
Vmn2r81	A	G	10: 79,104,424 (GRCm39)	Y349C	probably damaging	Het
Xpo5	T	A	17: 46,546,844 (GRCm39)	V865E	probably damaging	Het
Zfhx3	C	T	8: 109,521,340 (GRCm39)	R821C	probably damaging	Het
Zfp90	A	G	8: 107,145,791 (GRCm39)	D41G	probably damaging	Het
Zzef1	T	A	11: 72,744,148 (GRCm39)	C835S	probably damaging	Het

Other mutations in Krt9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00725:Krt9	APN	11	100,080,832 (GRCm39)	missense	probably damaging	1.00
IGL01695:Krt9	APN	11	100,082,263 (GRCm39)	critical splice donor site	probably null
IGL02383:Krt9	APN	11	100,082,041 (GRCm39)	missense	probably damaging	1.00
IGL02529:Krt9	APN	11	100,080,792 (GRCm39)	missense	probably damaging	0.99
IGL02819:Krt9	APN	11	100,082,346 (GRCm39)	missense	probably damaging	1.00
droplet	UTSW	11	100,081,614 (GRCm39)	missense	probably damaging	1.00
R5944_Krt9_487	UTSW	11	100,079,265 (GRCm39)	missense	unknown
G1citation:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R1356:Krt9	UTSW	11	100,079,640 (GRCm39)	small insertion	probably benign
R1397:Krt9	UTSW	11	100,083,464 (GRCm39)	missense	probably damaging	1.00
R1498:Krt9	UTSW	11	100,079,195 (GRCm39)	nonsense	probably null
R1772:Krt9	UTSW	11	100,082,131 (GRCm39)	missense	probably damaging	0.99
R1871:Krt9	UTSW	11	100,081,614 (GRCm39)	missense	probably damaging	1.00
R1883:Krt9	UTSW	11	100,079,523 (GRCm39)	missense	unknown
R1985:Krt9	UTSW	11	100,080,817 (GRCm39)	missense	probably benign	0.02
R2056:Krt9	UTSW	11	100,082,321 (GRCm39)	missense	probably damaging	1.00
R2253:Krt9	UTSW	11	100,081,685 (GRCm39)	missense	possibly damaging	0.83
R2305:Krt9	UTSW	11	100,083,942 (GRCm39)	missense	unknown
R2875:Krt9	UTSW	11	100,080,031 (GRCm39)	nonsense	probably null
R3813:Krt9	UTSW	11	100,080,503 (GRCm39)	missense	probably damaging	1.00
R3874:Krt9	UTSW	11	100,081,675 (GRCm39)	missense	probably damaging	1.00
R4157:Krt9	UTSW	11	100,079,475 (GRCm39)	missense	unknown
R4762:Krt9	UTSW	11	100,081,675 (GRCm39)	missense	probably damaging	1.00
R4873:Krt9	UTSW	11	100,080,863 (GRCm39)	missense	probably benign	0.06
R4875:Krt9	UTSW	11	100,080,863 (GRCm39)	missense	probably benign	0.06
R4923:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R4973:Krt9	UTSW	11	100,079,538 (GRCm39)	missense	unknown
R5153:Krt9	UTSW	11	100,082,068 (GRCm39)	missense	probably damaging	0.99
R5658:Krt9	UTSW	11	100,081,593 (GRCm39)	missense	probably damaging	0.98
R5696:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R5944:Krt9	UTSW	11	100,079,265 (GRCm39)	missense	unknown
R6147:Krt9	UTSW	11	100,079,665 (GRCm39)	missense	unknown
R6403:Krt9	UTSW	11	100,080,485 (GRCm39)	missense	probably damaging	0.99
R6476:Krt9	UTSW	11	100,081,640 (GRCm39)	missense	probably damaging	1.00
R6822:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7159:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7174:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7203:Krt9	UTSW	11	100,081,617 (GRCm39)	missense	probably damaging	1.00
R7805:Krt9	UTSW	11	100,083,522 (GRCm39)	missense	possibly damaging	0.85
R7817:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7822:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7834:Krt9	UTSW	11	100,083,492 (GRCm39)	missense	probably benign	0.06
R7947:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R7977:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R8943:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9092:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9099:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9203:Krt9	UTSW	11	100,079,734 (GRCm39)	missense	unknown
R9313:Krt9	UTSW	11	100,079,547 (GRCm39)	missense	unknown
R9361:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9438:Krt9	UTSW	11	100,079,824 (GRCm39)	missense	unknown
R9448:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9455:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9620:Krt9	UTSW	11	100,079,186 (GRCm39)	missense	unknown
R9676:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign
R9719:Krt9	UTSW	11	100,079,903 (GRCm39)	small deletion	probably benign

Posted On

2022-04-18