Incidental Mutation 'R9371:Vmn2r12'
| ID |
709303 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r12
|
| Ensembl Gene |
ENSMUSG00000090688 |
| Gene Name |
vomeronasal 2, receptor 12 |
| Synonyms |
Gm6769 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R9371 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109233715-109245730 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109234452 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 587
(M587L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093612
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095922]
|
| AlphaFold |
L7N217 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095922
AA Change: M587L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000093612
Gene: ENSMUSG00000090688
AA Change: M587L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.8e-30 |
PFAM |
|
Pfam:NCD3G
|
505 |
559 |
1.7e-18 |
PFAM |
|
Pfam:7tm_3
|
591 |
827 |
3.9e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (56/56) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810009J06Rik |
T |
C |
6: 40,943,663 (GRCm39) |
I109T |
probably damaging |
Het |
| 2200002D01Rik |
CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC |
7: 28,947,048 (GRCm39) |
|
probably benign |
Het |
| Abca8b |
T |
G |
11: 109,858,498 (GRCm39) |
Q568P |
probably damaging |
Het |
| Add3 |
A |
G |
19: 53,221,499 (GRCm39) |
T204A |
probably damaging |
Het |
| Afg3l2 |
C |
A |
18: 67,567,262 (GRCm39) |
R196L |
possibly damaging |
Het |
| Agps |
T |
A |
2: 75,742,024 (GRCm39) |
|
probably null |
Het |
| Akap9 |
A |
G |
5: 4,011,852 (GRCm39) |
S852G |
possibly damaging |
Het |
| Aoc1 |
A |
G |
6: 48,883,102 (GRCm39) |
D326G |
probably benign |
Het |
| Cecr2 |
A |
G |
6: 120,739,229 (GRCm39) |
T1319A |
probably benign |
Het |
| Cenpo |
C |
T |
12: 4,266,686 (GRCm39) |
V141I |
probably benign |
Het |
| Clca4b |
A |
G |
3: 144,631,845 (GRCm39) |
L220S |
possibly damaging |
Het |
| Dicer1 |
A |
G |
12: 104,670,991 (GRCm39) |
L1017P |
probably damaging |
Het |
| Ero1b |
T |
G |
13: 12,589,728 (GRCm39) |
C44G |
probably damaging |
Het |
| Ffar2 |
A |
T |
7: 30,518,929 (GRCm39) |
W204R |
probably benign |
Het |
| Fmo3 |
T |
A |
1: 162,796,281 (GRCm39) |
E97V |
probably benign |
Het |
| Gcnt4 |
G |
T |
13: 97,083,634 (GRCm39) |
R310L |
possibly damaging |
Het |
| Gm7298 |
A |
G |
6: 121,744,541 (GRCm39) |
I520V |
probably benign |
Het |
| Gmpr |
T |
C |
13: 45,699,471 (GRCm39) |
L327P |
probably damaging |
Het |
| Grid2 |
T |
A |
6: 64,677,506 (GRCm39) |
H108Q |
unknown |
Het |
| Hmcn2 |
G |
T |
2: 31,301,917 (GRCm39) |
L2935F |
probably damaging |
Het |
| Hnf1b |
T |
C |
11: 83,779,986 (GRCm39) |
S440P |
probably benign |
Het |
| Hsph1 |
A |
T |
5: 149,543,395 (GRCm39) |
Y644N |
probably damaging |
Het |
| Igf2r |
A |
G |
17: 12,924,646 (GRCm39) |
I1057T |
possibly damaging |
Het |
| Igfn1 |
T |
C |
1: 135,906,001 (GRCm39) |
E269G |
probably damaging |
Het |
| Igkv14-126 |
A |
G |
6: 67,873,352 (GRCm39) |
T27A |
possibly damaging |
Het |
| Inhca |
A |
T |
9: 103,158,252 (GRCm39) |
Y103N |
probably benign |
Het |
| Kcnj15 |
A |
G |
16: 95,097,556 (GRCm39) |
R393G |
unknown |
Het |
| Lamb1 |
A |
G |
12: 31,348,863 (GRCm39) |
T632A |
probably damaging |
Het |
| Lrrk2 |
T |
C |
15: 91,607,407 (GRCm39) |
L590P |
probably damaging |
Het |
| Mrm3 |
A |
G |
11: 76,138,286 (GRCm39) |
T225A |
possibly damaging |
Het |
| Mthfd1l |
A |
G |
10: 4,053,335 (GRCm39) |
T895A |
possibly damaging |
Het |
| Myh1 |
G |
A |
11: 67,110,631 (GRCm39) |
|
probably null |
Het |
| Naip2 |
T |
A |
13: 100,298,354 (GRCm39) |
K561* |
probably null |
Het |
| Necab2 |
C |
T |
8: 120,173,923 (GRCm39) |
P44S |
probably benign |
Het |
| Nrde2 |
T |
C |
12: 100,092,477 (GRCm39) |
S1126G |
probably benign |
Het |
| Nup210l |
C |
T |
3: 90,107,173 (GRCm39) |
P1570L |
probably benign |
Het |
| Or14j6 |
A |
G |
17: 38,214,962 (GRCm39) |
H175R |
probably benign |
Het |
| Or8c17 |
T |
A |
9: 38,179,926 (GRCm39) |
V31E |
possibly damaging |
Het |
| Pecam1 |
T |
G |
11: 106,581,947 (GRCm39) |
D333A |
probably benign |
Het |
| Prss27 |
T |
C |
17: 24,257,141 (GRCm39) |
|
probably benign |
Het |
| Rapgef2 |
T |
C |
3: 79,082,300 (GRCm39) |
E100G |
probably damaging |
Het |
| Rnft2 |
A |
G |
5: 118,340,982 (GRCm39) |
F299L |
probably damaging |
Het |
| Rptor |
A |
G |
11: 119,562,152 (GRCm39) |
N105S |
possibly damaging |
Het |
| S100a7l2 |
T |
C |
3: 90,997,698 (GRCm39) |
T6A |
unknown |
Het |
| Scgb2b3 |
T |
A |
7: 31,059,642 (GRCm39) |
H44L |
probably benign |
Het |
| Slc22a17 |
A |
T |
14: 55,147,139 (GRCm39) |
V53D |
possibly damaging |
Het |
| Slc39a14 |
G |
A |
14: 70,547,569 (GRCm39) |
T298M |
probably benign |
Het |
| Sorbs1 |
G |
A |
19: 40,315,324 (GRCm39) |
T496M |
probably damaging |
Het |
| Spata31e1 |
G |
C |
13: 49,939,052 (GRCm39) |
T886S |
unknown |
Het |
| Taar8a |
T |
C |
10: 23,952,753 (GRCm39) |
V119A |
probably benign |
Het |
| Tas1r3 |
T |
C |
4: 155,945,059 (GRCm39) |
T721A |
possibly damaging |
Het |
| Tm7sf3 |
C |
T |
6: 146,525,179 (GRCm39) |
D89N |
possibly damaging |
Het |
| Tmie |
A |
T |
9: 110,696,651 (GRCm39) |
C77S |
probably damaging |
Het |
| Tpp2 |
T |
A |
1: 43,999,369 (GRCm39) |
I381K |
probably damaging |
Het |
| Ttn |
G |
C |
2: 76,776,822 (GRCm39) |
A1526G |
unknown |
Het |
| Zeb2 |
G |
T |
2: 44,888,912 (GRCm39) |
H344Q |
probably damaging |
Het |
| Zfp292 |
A |
G |
4: 34,810,800 (GRCm39) |
I753T |
probably damaging |
Het |
| Zfp442 |
A |
T |
2: 150,250,676 (GRCm39) |
C409S |
unknown |
Het |
| Zfp677 |
C |
T |
17: 21,618,053 (GRCm39) |
T370M |
probably damaging |
Het |
| Zfp947 |
G |
A |
17: 22,364,384 (GRCm39) |
T430I |
possibly damaging |
Het |
|
| Other mutations in Vmn2r12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00948:Vmn2r12
|
APN |
5 |
109,245,541 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL01096:Vmn2r12
|
APN |
5 |
109,234,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Vmn2r12
|
APN |
5 |
109,239,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Vmn2r12
|
APN |
5 |
109,240,893 (GRCm39) |
nonsense |
probably null |
|
|
IGL01762:Vmn2r12
|
APN |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01860:Vmn2r12
|
APN |
5 |
109,240,025 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02269:Vmn2r12
|
APN |
5 |
109,234,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02530:Vmn2r12
|
APN |
5 |
109,233,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02887:Vmn2r12
|
APN |
5 |
109,238,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03265:Vmn2r12
|
APN |
5 |
109,239,936 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0396:Vmn2r12
|
UTSW |
5 |
109,240,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0497:Vmn2r12
|
UTSW |
5 |
109,239,755 (GRCm39) |
nonsense |
probably null |
|
|
R0529:Vmn2r12
|
UTSW |
5 |
109,240,714 (GRCm39) |
missense |
probably benign |
|
|
R0715:Vmn2r12
|
UTSW |
5 |
109,238,373 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0742:Vmn2r12
|
UTSW |
5 |
109,234,281 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0894:Vmn2r12
|
UTSW |
5 |
109,235,716 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1173:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1174:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1259:Vmn2r12
|
UTSW |
5 |
109,239,763 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1349:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1388:Vmn2r12
|
UTSW |
5 |
109,240,840 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1549:Vmn2r12
|
UTSW |
5 |
109,240,696 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1766:Vmn2r12
|
UTSW |
5 |
109,239,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Vmn2r12
|
UTSW |
5 |
109,239,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1885:Vmn2r12
|
UTSW |
5 |
109,239,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2159:Vmn2r12
|
UTSW |
5 |
109,239,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2420:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2421:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2422:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2937:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Vmn2r12
|
UTSW |
5 |
109,238,370 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4061:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4063:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4090:Vmn2r12
|
UTSW |
5 |
109,239,412 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4297:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4298:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4299:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4304:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4308:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4594:Vmn2r12
|
UTSW |
5 |
109,234,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4783:Vmn2r12
|
UTSW |
5 |
109,234,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Vmn2r12
|
UTSW |
5 |
109,240,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4929:Vmn2r12
|
UTSW |
5 |
109,239,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Vmn2r12
|
UTSW |
5 |
109,239,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5389:Vmn2r12
|
UTSW |
5 |
109,238,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5431:Vmn2r12
|
UTSW |
5 |
109,239,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5527:Vmn2r12
|
UTSW |
5 |
109,234,483 (GRCm39) |
nonsense |
probably null |
|
|
R5639:Vmn2r12
|
UTSW |
5 |
109,240,666 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5753:Vmn2r12
|
UTSW |
5 |
109,239,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5797:Vmn2r12
|
UTSW |
5 |
109,233,736 (GRCm39) |
nonsense |
probably null |
|
|
R6142:Vmn2r12
|
UTSW |
5 |
109,240,763 (GRCm39) |
missense |
probably benign |
|
|
R6162:Vmn2r12
|
UTSW |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6176:Vmn2r12
|
UTSW |
5 |
109,233,866 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6853:Vmn2r12
|
UTSW |
5 |
109,240,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Vmn2r12
|
UTSW |
5 |
109,245,655 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,239,811 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,234,113 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7383:Vmn2r12
|
UTSW |
5 |
109,240,684 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7740:Vmn2r12
|
UTSW |
5 |
109,239,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7749:Vmn2r12
|
UTSW |
5 |
109,233,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Vmn2r12
|
UTSW |
5 |
109,235,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7908:Vmn2r12
|
UTSW |
5 |
109,234,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r12
|
UTSW |
5 |
109,239,747 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8175:Vmn2r12
|
UTSW |
5 |
109,238,349 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8234:Vmn2r12
|
UTSW |
5 |
109,234,074 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8771:Vmn2r12
|
UTSW |
5 |
109,239,952 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8947:Vmn2r12
|
UTSW |
5 |
109,234,522 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8991:Vmn2r12
|
UTSW |
5 |
109,234,033 (GRCm39) |
nonsense |
probably null |
|
|
R9116:Vmn2r12
|
UTSW |
5 |
109,233,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9122:Vmn2r12
|
UTSW |
5 |
109,240,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9153:Vmn2r12
|
UTSW |
5 |
109,234,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r12
|
UTSW |
5 |
109,233,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9524:Vmn2r12
|
UTSW |
5 |
109,239,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9587:Vmn2r12
|
UTSW |
5 |
109,239,322 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r12
|
UTSW |
5 |
109,240,646 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r12
|
UTSW |
5 |
109,239,303 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCCAAATGTGGTCTGCTGC -3'
(R):5'- GGAATGGATTCTCGACATTTATCG -3'
Sequencing Primer
(F):5'- CAAATGTGGTCTGCTGCAGGATG -3'
(R):5'- TGTGAGGTGTCCAGATGA -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation