Incidental Mutation 'R9373:Agfg2'
ID 709434
Institutional Source Beutler Lab
Gene Symbol Agfg2
Ensembl Gene ENSMUSG00000029722
Gene Name ArfGAP with FG repeats 2
Synonyms A630095P14Rik, Hrbl
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9373 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 137648725-137682988 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 137662476 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000098112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031736] [ENSMUST00000100544] [ENSMUST00000151839] [ENSMUST00000198657]
AlphaFold Q80WC7
Predicted Effect probably benign
Transcript: ENSMUST00000031736
SMART Domains Protein: ENSMUSP00000031736
Gene: ENSMUSG00000029722

DomainStartEndE-ValueType
ArfGap 27 153 7.19e-35 SMART
low complexity region 194 219 N/A INTRINSIC
low complexity region 235 249 N/A INTRINSIC
low complexity region 269 283 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000100544
SMART Domains Protein: ENSMUSP00000098112
Gene: ENSMUSG00000029722

DomainStartEndE-ValueType
ArfGap 27 153 7.19e-35 SMART
low complexity region 194 219 N/A INTRINSIC
low complexity region 235 249 N/A INTRINSIC
low complexity region 269 283 N/A INTRINSIC
low complexity region 285 296 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151839
SMART Domains Protein: ENSMUSP00000117351
Gene: ENSMUSG00000029722

DomainStartEndE-ValueType
ArfGap 27 153 7.19e-35 SMART
low complexity region 194 219 N/A INTRINSIC
low complexity region 235 249 N/A INTRINSIC
low complexity region 268 282 N/A INTRINSIC
low complexity region 284 295 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000198657
SMART Domains Protein: ENSMUSP00000143273
Gene: ENSMUSG00000029722

DomainStartEndE-ValueType
low complexity region 24 51 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: This gene encodes a paralog of the HIV-1 Rev binding proteins that serve as cellular co-factors for HIV-1 Rev protein in shuttling viral pre-mRNAs from the nucleus to the cytoplasm. The encoded protein contains an ADP-ribosylation factor GTPase activating protein (Arf-GAP) zinc finger domain, several phenylalanine-glycine (FG) motifs and asparagine-proline-phenylalanine (NPF) motifs. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
2310003L06Rik A C 5: 88,120,668 (GRCm39) D475A probably benign Het
Aatk T C 11: 119,906,343 (GRCm39) M243V possibly damaging Het
Acox1 A T 11: 116,065,173 (GRCm39) N627K possibly damaging Het
Adal A G 2: 120,980,703 (GRCm39) Y142C probably benign Het
Ajap1 C T 4: 153,516,670 (GRCm39) A224T probably benign Het
Alg1 T C 16: 5,056,990 (GRCm39) F234L probably benign Het
Arhgap27 G T 11: 103,251,287 (GRCm39) A147E possibly damaging Het
C9orf72 A G 4: 35,196,985 (GRCm39) F360S Het
Cachd1 T C 4: 100,832,067 (GRCm39) V743A possibly damaging Het
Cc2d2b G A 19: 40,784,167 (GRCm39) V655I unknown Het
Cd72 T C 4: 43,450,141 (GRCm39) S256G possibly damaging Het
Celf2 G T 2: 6,551,915 (GRCm39) N521K probably benign Het
Clca4a T A 3: 144,672,133 (GRCm39) N270Y possibly damaging Het
Clvs2 A T 10: 33,404,382 (GRCm39) V278E probably benign Het
Cwf19l2 T C 9: 3,454,718 (GRCm39) F677S probably damaging Het
Dnaaf4 A G 9: 72,871,462 (GRCm39) T241A probably damaging Het
Dusp9 TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG X: 72,684,217 (GRCm39) probably benign Het
Epdr1 T C 13: 19,778,707 (GRCm39) N130D possibly damaging Het
Fam184a G A 10: 53,566,115 (GRCm39) R491W probably benign Het
Foxp2 A G 6: 15,377,969 (GRCm39) Q160R unknown Het
Fstl5 T A 3: 76,555,669 (GRCm39) Y515* probably null Het
Garin5b T C 7: 4,760,712 (GRCm39) M667V Het
Helz2 G T 2: 180,882,741 (GRCm39) N17K probably benign Het
Irag1 A G 7: 110,545,038 (GRCm39) probably null Het
Jmjd1c C T 10: 66,932,495 (GRCm39) probably benign Het
Jup C T 11: 100,270,391 (GRCm39) C372Y probably damaging Het
Lrrn1 A C 6: 107,545,465 (GRCm39) Q421P possibly damaging Het
Mapk1 A G 16: 16,836,154 (GRCm39) I101V probably benign Het
Me2 T C 18: 73,918,800 (GRCm39) E427G probably damaging Het
Mrc1 G A 2: 14,274,999 (GRCm39) M433I probably damaging Het
Nelfb G A 2: 25,095,218 (GRCm39) R324W probably damaging Het
Nlrp4b T A 7: 10,449,126 (GRCm39) I443K probably benign Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Or5b118 A G 19: 13,449,216 (GRCm39) E294G probably damaging Het
Or8b50 G A 9: 38,518,142 (GRCm39) C127Y possibly damaging Het
Or8b9 T A 9: 37,766,750 (GRCm39) V212D probably damaging Het
Or9g3 A T 2: 85,590,275 (GRCm39) Y148* probably null Het
Parvb C T 15: 84,188,100 (GRCm39) T281I probably damaging Het
Prune2 A G 19: 17,099,502 (GRCm39) T1669A probably benign Het
Runx3 A G 4: 134,848,456 (GRCm39) T14A probably benign Het
Scn9a A G 2: 66,314,261 (GRCm39) V1819A probably benign Het
Senp1 T C 15: 97,964,435 (GRCm39) T260A probably benign Het
Serpinb10 A G 1: 107,474,749 (GRCm39) R304G possibly damaging Het
Spem1 C T 11: 69,712,640 (GRCm39) C65Y probably benign Het
Tdrd6 A G 17: 43,939,053 (GRCm39) V665A possibly damaging Het
Tenm2 C T 11: 35,930,713 (GRCm39) A1772T probably damaging Het
Tenm3 C T 8: 48,752,690 (GRCm39) V891I probably damaging Het
Trank1 A G 9: 111,194,259 (GRCm39) D761G probably benign Het
Tut7 T C 13: 59,944,681 (GRCm39) S1053G probably damaging Het
Ubap2l A T 3: 89,915,587 (GRCm39) Y985N unknown Het
Vwc2l A T 1: 70,768,218 (GRCm39) H94L probably damaging Het
Wdr27 G A 17: 15,154,795 (GRCm39) H41Y probably benign Het
Zfp7 AGTGCGGGAAAGGTTTCCACCTG AG 15: 76,774,798 (GRCm39) probably benign Het
Zfp7 TGCGGGAAAGGTTTCCACCTGAGCG TGCG 15: 76,774,800 (GRCm39) probably benign Het
Other mutations in Agfg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0020:Agfg2 UTSW 5 137,652,064 (GRCm39) missense probably benign 0.22
R0020:Agfg2 UTSW 5 137,652,064 (GRCm39) missense probably benign 0.22
R0584:Agfg2 UTSW 5 137,665,992 (GRCm39) missense probably damaging 1.00
R1692:Agfg2 UTSW 5 137,662,633 (GRCm39) missense probably damaging 0.99
R1982:Agfg2 UTSW 5 137,662,515 (GRCm39) missense possibly damaging 0.87
R2140:Agfg2 UTSW 5 137,665,378 (GRCm39) missense probably damaging 1.00
R3816:Agfg2 UTSW 5 137,652,036 (GRCm39) missense probably benign 0.03
R4527:Agfg2 UTSW 5 137,682,798 (GRCm39) missense unknown
R4645:Agfg2 UTSW 5 137,682,854 (GRCm39) utr 5 prime probably benign
R4965:Agfg2 UTSW 5 137,665,439 (GRCm39) critical splice acceptor site probably null
R5022:Agfg2 UTSW 5 137,658,422 (GRCm39) critical splice donor site probably null
R5426:Agfg2 UTSW 5 137,666,020 (GRCm39) missense probably damaging 1.00
R6140:Agfg2 UTSW 5 137,665,347 (GRCm39) missense probably damaging 1.00
R7474:Agfg2 UTSW 5 137,652,130 (GRCm39) missense possibly damaging 0.96
R7752:Agfg2 UTSW 5 137,665,966 (GRCm39) missense probably damaging 0.96
R7901:Agfg2 UTSW 5 137,665,966 (GRCm39) missense probably damaging 0.96
R8172:Agfg2 UTSW 5 137,665,431 (GRCm39) missense probably damaging 0.99
R8190:Agfg2 UTSW 5 137,653,664 (GRCm39) missense probably benign 0.06
R9005:Agfg2 UTSW 5 137,650,744 (GRCm39) missense probably damaging 0.98
R9238:Agfg2 UTSW 5 137,653,622 (GRCm39) missense probably damaging 0.99
R9342:Agfg2 UTSW 5 137,652,114 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTCTGCCAGGGTCTAGGTATCC -3'
(R):5'- AAACATGGTCCAAGGTTCTCTC -3'

Sequencing Primer
(F):5'- CCAGGGTCTAGGTATCCAGATG -3'
(R):5'- AGCATAACTGTTCTTTTCCACAGG -3'
Posted On 2022-04-18