Incidental Mutation 'R9374:Or6k4'
ID 709476
Institutional Source Beutler Lab
Gene Symbol Or6k4
Ensembl Gene ENSMUSG00000051528
Gene Name olfactory receptor family 6 subfamily K member 4
Synonyms MOR105-2, GA_x6K02T2P20D-21025190-21024243, Olfr424
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.160) question?
Stock # R9374 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 173964312-173965259 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 173964885 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 192 (T192S)
Ref Sequence ENSEMBL: ENSMUSP00000150840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053941] [ENSMUST00000214751]
AlphaFold E9Q0Q2
Predicted Effect probably benign
Transcript: ENSMUST00000053941
AA Change: T192S

PolyPhen 2 Score 0.345 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000054305
Gene: ENSMUSG00000051528
AA Change: T192S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-63 PFAM
Pfam:7tm_1 41 289 1.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214751
AA Change: T192S

PolyPhen 2 Score 0.345 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap21 A T 2: 20,886,397 (GRCm39) V270E probably damaging Het
Blvrb A G 7: 27,158,786 (GRCm39) D62G probably benign Het
Ccdc68 T A 18: 70,089,113 (GRCm39) S219T probably damaging Het
Celf2 G A 2: 6,590,886 (GRCm39) T303I possibly damaging Het
Cep290 T C 10: 100,372,729 (GRCm39) S1176P probably damaging Het
Cpeb2 C A 5: 43,391,584 (GRCm39) S260* probably null Het
Dscam A T 16: 96,857,857 (GRCm39) I51N probably benign Het
Erbb4 G A 1: 68,779,642 (GRCm39) Q45* probably null Het
Fam124a T G 14: 62,843,988 (GRCm39) S499A possibly damaging Het
Hipk3 T C 2: 104,301,850 (GRCm39) N114S probably benign Het
Hnrnph3 T C 10: 62,853,957 (GRCm39) M54V probably benign Het
Map7d1 T C 4: 126,127,429 (GRCm39) E720G unknown Het
Mark2 G T 19: 7,263,263 (GRCm39) T201N possibly damaging Het
Mef2c A G 13: 83,810,461 (GRCm39) N371S probably benign Het
Mgst3 T C 1: 167,205,871 (GRCm39) Y36C probably damaging Het
Mtor C T 4: 148,599,397 (GRCm39) R1482C probably damaging Het
Ndst1 G T 18: 60,845,931 (GRCm39) T126K probably damaging Het
Nkain3 C A 4: 20,778,431 (GRCm39) probably benign Het
Obscn T C 11: 58,922,787 (GRCm39) I5850V possibly damaging Het
Or11g1 C T 14: 50,651,625 (GRCm39) S208F probably benign Het
Or5d14 C T 2: 87,880,509 (GRCm39) W153* probably null Het
Pbx1 T C 1: 168,258,910 (GRCm39) D55G possibly damaging Het
Pi4ka T C 16: 17,125,574 (GRCm39) E1187G Het
Pkn1 A T 8: 84,404,367 (GRCm39) N543K probably benign Het
Plin1 T C 7: 79,372,544 (GRCm39) N343D probably benign Het
Prpf4 T C 4: 62,336,131 (GRCm39) V286A probably benign Het
Pyroxd2 A G 19: 42,719,756 (GRCm39) probably null Het
Rbpms A G 8: 34,294,173 (GRCm39) F190S possibly damaging Het
Rpl10a T A 17: 28,548,006 (GRCm39) F49Y possibly damaging Het
Slc32a1 A G 2: 158,455,995 (GRCm39) T217A probably damaging Het
Slco6c1 T C 1: 97,055,827 (GRCm39) S25G probably benign Het
Slitrk5 C T 14: 111,916,496 (GRCm39) T40I probably benign Het
Smchd1 T C 17: 71,718,843 (GRCm39) N842S possibly damaging Het
Sorbs1 G A 19: 40,361,923 (GRCm39) R154* probably null Het
Stc2 A G 11: 31,310,332 (GRCm39) S235P probably benign Het
Tcaf2 C T 6: 42,619,728 (GRCm39) A100T probably benign Het
Tcerg1l T C 7: 137,995,998 (GRCm39) D170G possibly damaging Het
Tcf15 T C 2: 151,986,039 (GRCm39) L165P probably damaging Het
Tle5 T C 10: 81,399,988 (GRCm39) V62A probably damaging Het
Tmem200c G T 17: 69,148,682 (GRCm39) G422W probably damaging Het
Tnfsf13b A G 8: 10,085,391 (GRCm39) I294V possibly damaging Het
Tns3 T A 11: 8,442,606 (GRCm39) T586S probably damaging Het
Unc80 A T 1: 66,629,460 (GRCm39) E1319V possibly damaging Het
Vegfc A G 8: 54,622,180 (GRCm39) I221V possibly damaging Het
Vmn1r86 A T 7: 12,836,781 (GRCm39) Y32N possibly damaging Het
Vmn2r111 T A 17: 22,787,859 (GRCm39) L497F probably benign Het
Wdr49 T C 3: 75,230,931 (GRCm39) D577G probably benign Het
Xpo4 A G 14: 57,828,512 (GRCm39) F783L possibly damaging Het
Other mutations in Or6k4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01453:Or6k4 APN 1 173,964,679 (GRCm39) missense possibly damaging 0.46
IGL01651:Or6k4 APN 1 173,964,907 (GRCm39) missense probably damaging 0.96
R0194:Or6k4 UTSW 1 173,964,327 (GRCm39) missense probably benign 0.04
R0357:Or6k4 UTSW 1 173,964,865 (GRCm39) nonsense probably null
R0732:Or6k4 UTSW 1 173,964,981 (GRCm39) missense possibly damaging 0.85
R1103:Or6k4 UTSW 1 173,964,457 (GRCm39) missense probably benign 0.07
R1623:Or6k4 UTSW 1 173,964,883 (GRCm39) missense probably damaging 0.98
R1829:Or6k4 UTSW 1 173,964,760 (GRCm39) missense probably benign 0.12
R6617:Or6k4 UTSW 1 173,964,814 (GRCm39) missense probably damaging 1.00
R7060:Or6k4 UTSW 1 173,964,376 (GRCm39) missense probably benign 0.00
R7203:Or6k4 UTSW 1 173,964,680 (GRCm39) nonsense probably null
R7625:Or6k4 UTSW 1 173,964,733 (GRCm39) missense probably benign 0.13
R7994:Or6k4 UTSW 1 173,964,273 (GRCm39) start gained probably benign
R8035:Or6k4 UTSW 1 173,964,490 (GRCm39) missense probably damaging 1.00
R8127:Or6k4 UTSW 1 173,965,155 (GRCm39) missense probably damaging 1.00
R8802:Or6k4 UTSW 1 173,964,616 (GRCm39) missense probably damaging 1.00
R9102:Or6k4 UTSW 1 173,964,322 (GRCm39) missense
R9296:Or6k4 UTSW 1 173,964,835 (GRCm39) missense probably benign 0.02
R9551:Or6k4 UTSW 1 173,964,885 (GRCm39) missense probably benign 0.34
R9552:Or6k4 UTSW 1 173,964,885 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TGACAGGTATGTTGCCATCTG -3'
(R):5'- GGGAGACACTGCCATAGAAC -3'

Sequencing Primer
(F):5'- GACAGGTATGTTGCCATCTGTAATCC -3'
(R):5'- GGAGACACTGCCATAGAACATCAAG -3'
Posted On 2022-04-18