Incidental Mutation 'R9377:Vmn2r77'
| ID |
709694 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r77
|
| Ensembl Gene |
ENSMUSG00000090949 |
| Gene Name |
vomeronasal 2, receptor 77 |
| Synonyms |
EG546983 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R9377 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86444442 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 32
(I32V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
| AlphaFold |
L7N2B7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164996
AA Change: I32V
PolyPhen 2
Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: I32V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700122O11Rik |
T |
C |
17: 48,348,273 (GRCm39) |
T55A |
probably benign |
Het |
| 3110070M22Rik |
T |
A |
13: 119,624,822 (GRCm39) |
|
probably benign |
Het |
| Acot12 |
T |
A |
13: 91,918,221 (GRCm39) |
N171K |
probably benign |
Het |
| Adam18 |
G |
A |
8: 25,104,859 (GRCm39) |
Q652* |
probably null |
Het |
| Adgrv1 |
T |
C |
13: 81,705,277 (GRCm39) |
E791G |
probably damaging |
Het |
| Aff1 |
C |
T |
5: 103,981,685 (GRCm39) |
S608L |
probably damaging |
Het |
| Amfr |
A |
T |
8: 94,707,018 (GRCm39) |
F432L |
probably damaging |
Het |
| Ankfn1 |
G |
A |
11: 89,332,284 (GRCm39) |
L421F |
possibly damaging |
Het |
| Ankrd31 |
T |
C |
13: 97,014,733 (GRCm39) |
V1334A |
probably benign |
Het |
| Ascc3 |
C |
T |
10: 50,608,858 (GRCm39) |
H1534Y |
possibly damaging |
Het |
| Aste1 |
G |
A |
9: 105,273,880 (GRCm39) |
C40Y |
probably benign |
Het |
| Atf3 |
T |
C |
1: 190,909,510 (GRCm39) |
H53R |
probably benign |
Het |
| Bsn |
C |
A |
9: 107,990,800 (GRCm39) |
V1651F |
probably damaging |
Het |
| Bsn |
A |
T |
9: 107,993,361 (GRCm39) |
L797Q |
probably damaging |
Het |
| Bzw2 |
T |
C |
12: 36,180,131 (GRCm39) |
D32G |
probably damaging |
Het |
| Cacna1e |
A |
T |
1: 154,361,458 (GRCm39) |
M531K |
possibly damaging |
Het |
| Cep120 |
A |
G |
18: 53,851,592 (GRCm39) |
F567L |
possibly damaging |
Het |
| Cit |
T |
C |
5: 116,084,914 (GRCm39) |
I815T |
probably benign |
Het |
| Cnot6l |
G |
T |
5: 96,276,826 (GRCm39) |
Q121K |
probably benign |
Het |
| Col4a2 |
G |
A |
8: 11,483,725 (GRCm39) |
G882R |
probably damaging |
Het |
| Col6a3 |
A |
G |
1: 90,743,961 (GRCm39) |
F536L |
probably damaging |
Het |
| Copg2 |
T |
A |
6: 30,793,721 (GRCm39) |
H394L |
possibly damaging |
Het |
| Cst13 |
A |
G |
2: 148,670,165 (GRCm39) |
M112V |
possibly damaging |
Het |
| Cyp2j7 |
G |
T |
4: 96,124,786 (GRCm39) |
N37K |
probably benign |
Het |
| Cyp2u1 |
T |
A |
3: 131,091,449 (GRCm39) |
N357I |
possibly damaging |
Het |
| Dars1 |
T |
C |
1: 128,344,945 (GRCm39) |
T4A |
probably benign |
Het |
| Dclk1 |
G |
T |
3: 55,429,374 (GRCm39) |
C414F |
possibly damaging |
Het |
| Dmbt1 |
A |
T |
7: 130,694,832 (GRCm39) |
Y1009F |
unknown |
Het |
| Ebf4 |
T |
C |
2: 130,148,775 (GRCm39) |
Y117H |
probably damaging |
Het |
| Eif2b4 |
A |
G |
5: 31,348,500 (GRCm39) |
Y196H |
probably benign |
Het |
| Enpp2 |
C |
T |
15: 54,739,080 (GRCm39) |
R401H |
probably damaging |
Het |
| Epo |
T |
C |
5: 137,484,017 (GRCm39) |
|
probably benign |
Het |
| Gli1 |
T |
A |
10: 127,173,359 (GRCm39) |
T100S |
possibly damaging |
Het |
| Gml2 |
T |
A |
15: 74,695,957 (GRCm39) |
F117Y |
probably benign |
Het |
| Hivep1 |
T |
C |
13: 42,335,403 (GRCm39) |
V2314A |
probably benign |
Het |
| Hspb8 |
A |
G |
5: 116,547,487 (GRCm39) |
I165T |
probably damaging |
Het |
| Itgax |
A |
T |
7: 127,732,849 (GRCm39) |
T243S |
probably benign |
Het |
| Itih4 |
G |
T |
14: 30,608,533 (GRCm39) |
L16F |
probably damaging |
Het |
| Kmt5a |
C |
T |
5: 124,578,064 (GRCm39) |
|
probably benign |
Het |
| Lamc1 |
T |
C |
1: 153,115,009 (GRCm39) |
E1089G |
probably benign |
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Mcmbp |
A |
T |
7: 128,317,803 (GRCm39) |
N147K |
probably benign |
Het |
| Mical2 |
C |
T |
7: 111,981,246 (GRCm39) |
L407F |
probably benign |
Het |
| Mybpc2 |
A |
T |
7: 44,158,999 (GRCm39) |
V653D |
probably benign |
Het |
| Myo3b |
G |
A |
2: 70,069,242 (GRCm39) |
V522I |
possibly damaging |
Het |
| Nbr1 |
A |
G |
11: 101,456,590 (GRCm39) |
T156A |
possibly damaging |
Het |
| Neb |
T |
A |
2: 52,039,291 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
A |
2: 52,116,546 (GRCm39) |
Y964F |
|
Het |
| Nr2f2 |
T |
A |
7: 70,007,856 (GRCm39) |
I209F |
probably damaging |
Het |
| Nwd2 |
A |
G |
5: 63,957,740 (GRCm39) |
T357A |
probably damaging |
Het |
| Palld |
C |
T |
8: 61,969,691 (GRCm39) |
R1211H |
unknown |
Het |
| Pcdhb19 |
T |
A |
18: 37,632,299 (GRCm39) |
V698E |
probably damaging |
Het |
| Pcdhga6 |
C |
T |
18: 37,841,570 (GRCm39) |
P430L |
probably damaging |
Het |
| Piezo2 |
A |
G |
18: 63,162,156 (GRCm39) |
L2225S |
possibly damaging |
Het |
| Plekhf1 |
A |
T |
7: 37,921,203 (GRCm39) |
W122R |
probably damaging |
Het |
| Pold3 |
A |
G |
7: 99,732,993 (GRCm39) |
S418P |
possibly damaging |
Het |
| Poldip3 |
T |
C |
15: 83,019,589 (GRCm39) |
N180S |
probably benign |
Het |
| Ppp1r21 |
C |
T |
17: 88,852,815 (GRCm39) |
R65* |
probably null |
Het |
| Ppp1r3d |
A |
T |
2: 178,055,669 (GRCm39) |
V111E |
probably damaging |
Het |
| Prrg4 |
T |
C |
2: 104,669,728 (GRCm39) |
I130V |
probably benign |
Het |
| Psma5 |
A |
T |
3: 108,172,448 (GRCm39) |
T55S |
probably benign |
Het |
| Rbm5 |
C |
A |
9: 107,627,252 (GRCm39) |
A440S |
probably benign |
Het |
| Rdx |
A |
G |
9: 51,980,168 (GRCm39) |
K254E |
possibly damaging |
Het |
| Rere |
A |
C |
4: 150,593,342 (GRCm39) |
Q312P |
unknown |
Het |
| Rest |
T |
C |
5: 77,416,128 (GRCm39) |
V114A |
possibly damaging |
Het |
| Rufy4 |
G |
T |
1: 74,171,879 (GRCm39) |
V201L |
probably benign |
Het |
| Scyl1 |
T |
C |
19: 5,809,023 (GRCm39) |
E727G |
probably benign |
Het |
| Serpinb6b |
T |
A |
13: 33,152,494 (GRCm39) |
M1K |
probably null |
Het |
| Sgsm1 |
C |
A |
5: 113,436,741 (GRCm39) |
V30F |
probably damaging |
Het |
| Skap1 |
A |
G |
11: 96,644,921 (GRCm39) |
D344G |
possibly damaging |
Het |
| Slc26a7 |
T |
C |
4: 14,516,189 (GRCm39) |
T547A |
probably benign |
Het |
| Slc6a3 |
C |
A |
13: 73,692,966 (GRCm39) |
S195R |
probably benign |
Het |
| Sorbs1 |
T |
C |
19: 40,387,048 (GRCm39) |
D6G |
probably damaging |
Het |
| Spock3 |
A |
T |
8: 63,798,746 (GRCm39) |
M253L |
probably damaging |
Het |
| Ssh2 |
A |
G |
11: 77,298,974 (GRCm39) |
Y107C |
possibly damaging |
Het |
| Svil |
T |
C |
18: 5,057,294 (GRCm39) |
S581P |
probably benign |
Het |
| Tbc1d14 |
T |
C |
5: 36,662,472 (GRCm39) |
T553A |
probably benign |
Het |
| Tet3 |
T |
A |
6: 83,380,596 (GRCm39) |
Q524L |
possibly damaging |
Het |
| Uckl1 |
A |
T |
2: 181,211,532 (GRCm39) |
V456E |
probably damaging |
Het |
| Ucp2 |
T |
C |
7: 100,146,040 (GRCm39) |
F4S |
probably benign |
Het |
| Vmn2r89 |
T |
A |
14: 51,692,601 (GRCm39) |
Y135N |
probably benign |
Het |
| Vtn |
A |
G |
11: 78,390,587 (GRCm39) |
E82G |
probably benign |
Het |
| Zfp758 |
A |
G |
17: 22,593,925 (GRCm39) |
N137S |
probably benign |
Het |
| Zgpat |
T |
A |
2: 181,021,646 (GRCm39) |
C357* |
probably null |
Het |
|
| Other mutations in Vmn2r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTACTTCAGAATCCTCCAGAG -3'
(R):5'- TCCCTCACCATAATTGGAATGC -3'
Sequencing Primer
(F):5'- CAGTGAACTCAAAAGTAAATGCTGTG -3'
(R):5'- CACCATAATTGGAATGCTTAATGTGC -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation