Incidental Mutation 'R9378:Adamts3'
| ID |
709770 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts3
|
| Ensembl Gene |
ENSMUSG00000043635 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 3 |
| Synonyms |
1100001H14Rik, 6330442E02Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9378 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
89824946-90031193 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 89848269 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 684
(C684*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132219
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061427]
[ENSMUST00000163159]
|
| AlphaFold |
E9Q287 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000061427
AA Change: C684*
|
| SMART Domains |
Protein: ENSMUSP00000058552
Gene: ENSMUSG00000043635
AA Change: C684*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
42 |
201 |
5.1e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
5.4e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
1.9e-10 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.6e-22 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
7.7e-13 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.5e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
827 |
3e-34 |
PFAM |
|
TSP1
|
848 |
905 |
4.35e-2 |
SMART |
|
TSP1
|
908 |
967 |
4.95e-2 |
SMART |
|
TSP1
|
969 |
1016 |
6.58e-5 |
SMART |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1157 |
1177 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000163159
AA Change: C684*
|
| SMART Domains |
Protein: ENSMUSP00000132219
Gene: ENSMUSG00000043635
AA Change: C684*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
43 |
201 |
1.5e-40 |
PFAM |
|
Pfam:Reprolysin_5
|
254 |
439 |
2.2e-15 |
PFAM |
|
Pfam:Reprolysin_4
|
256 |
454 |
7.7e-11 |
PFAM |
|
Pfam:Reprolysin
|
257 |
460 |
3.7e-21 |
PFAM |
|
Pfam:Reprolysin_2
|
274 |
451 |
4.3e-14 |
PFAM |
|
Pfam:Reprolysin_3
|
278 |
409 |
1.3e-12 |
PFAM |
|
TSP1
|
554 |
606 |
1.26e-15 |
SMART |
|
Pfam:ADAM_spacer1
|
713 |
828 |
3.6e-28 |
PFAM |
|
TSP1
|
849 |
906 |
4.35e-2 |
SMART |
|
TSP1
|
909 |
968 |
4.95e-2 |
SMART |
|
TSP1
|
970 |
1017 |
6.58e-5 |
SMART |
|
low complexity region
|
1115 |
1129 |
N/A |
INTRINSIC |
|
low complexity region
|
1158 |
1178 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
A |
G |
13: 77,471,735 (GRCm39) |
K1047E |
possibly damaging |
Het |
| Aadacl2fm1 |
A |
G |
3: 59,839,110 (GRCm39) |
T11A |
possibly damaging |
Het |
| Abca14 |
A |
T |
7: 119,807,191 (GRCm39) |
Y79F |
possibly damaging |
Het |
| Abca2 |
T |
A |
2: 25,329,094 (GRCm39) |
M978K |
probably benign |
Het |
| Adnp2 |
T |
C |
18: 80,172,637 (GRCm39) |
T591A |
probably benign |
Het |
| Aff4 |
A |
T |
11: 53,263,306 (GRCm39) |
T109S |
probably damaging |
Het |
| Agmo |
A |
G |
12: 37,293,720 (GRCm39) |
I48V |
probably benign |
Het |
| Appl1 |
G |
A |
14: 26,649,784 (GRCm39) |
R581* |
probably null |
Het |
| Armc9 |
A |
T |
1: 86,189,766 (GRCm39) |
M714L |
probably benign |
Het |
| Atp6v0d2 |
T |
A |
4: 19,922,377 (GRCm39) |
T41S |
probably benign |
Het |
| Bin1 |
A |
T |
18: 32,552,921 (GRCm39) |
Q182L |
probably damaging |
Het |
| Bmp10 |
A |
G |
6: 87,410,684 (GRCm39) |
D159G |
probably benign |
Het |
| Bsn |
G |
A |
9: 107,984,854 (GRCm39) |
P295S |
possibly damaging |
Het |
| Cbx6 |
A |
G |
15: 79,712,606 (GRCm39) |
S274P |
probably damaging |
Het |
| Cdc20b |
A |
G |
13: 113,192,631 (GRCm39) |
K108R |
probably benign |
Het |
| Ces1d |
T |
A |
8: 93,912,724 (GRCm39) |
N238I |
probably damaging |
Het |
| Col7a1 |
C |
T |
9: 108,787,708 (GRCm39) |
Q663* |
probably null |
Het |
| Cpsf3 |
T |
C |
12: 21,358,039 (GRCm39) |
I517T |
possibly damaging |
Het |
| Cyp2a5 |
C |
A |
7: 26,539,879 (GRCm39) |
T309N |
probably damaging |
Het |
| Cyp2d40 |
A |
G |
15: 82,645,802 (GRCm39) |
F68L |
possibly damaging |
Het |
| Cyp7b1 |
A |
T |
3: 18,150,837 (GRCm39) |
W301R |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,189,513 (GRCm39) |
N45I |
probably benign |
Het |
| Dnah7a |
A |
T |
1: 53,621,776 (GRCm39) |
H1116Q |
probably benign |
Het |
| Dntt |
A |
G |
19: 41,027,356 (GRCm39) |
N141S |
probably benign |
Het |
| Fbxl13 |
T |
C |
5: 21,790,201 (GRCm39) |
N281D |
probably damaging |
Het |
| Frem2 |
A |
T |
3: 53,559,410 (GRCm39) |
L1699H |
probably damaging |
Het |
| Gabrr3 |
T |
C |
16: 59,282,037 (GRCm39) |
V464A |
possibly damaging |
Het |
| Gdap1 |
T |
A |
1: 17,227,353 (GRCm39) |
I160N |
probably damaging |
Het |
| Hnrnpll |
C |
A |
17: 80,369,291 (GRCm39) |
R44L |
unknown |
Het |
| Hsp90ab1 |
T |
C |
17: 45,881,680 (GRCm39) |
E187G |
probably damaging |
Het |
| Ighm |
T |
A |
12: 113,386,210 (GRCm39) |
T47S |
|
Het |
| Itgb7 |
A |
C |
15: 102,135,831 (GRCm39) |
|
probably null |
Het |
| Kif16b |
A |
T |
2: 142,461,738 (GRCm39) |
C1293* |
probably null |
Het |
| Klf11 |
C |
T |
12: 24,705,043 (GRCm39) |
R166C |
probably benign |
Het |
| Lca5l |
T |
A |
16: 95,977,212 (GRCm39) |
Q198L |
probably damaging |
Het |
| Lnx2 |
A |
T |
5: 146,961,180 (GRCm39) |
M584K |
probably benign |
Het |
| Lpp |
A |
T |
16: 24,540,737 (GRCm39) |
M1L |
probably benign |
Het |
| Lrig3 |
A |
G |
10: 125,832,953 (GRCm39) |
T276A |
probably damaging |
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Megf8 |
A |
T |
7: 25,039,840 (GRCm39) |
|
probably null |
Het |
| Myh1 |
A |
C |
11: 67,093,259 (GRCm39) |
T117P |
probably damaging |
Het |
| Neb |
C |
A |
2: 52,134,113 (GRCm39) |
R3290L |
possibly damaging |
Het |
| Neb |
A |
C |
2: 52,137,304 (GRCm39) |
V220G |
|
Het |
| Nktr |
A |
T |
9: 121,577,264 (GRCm39) |
K444I |
probably damaging |
Het |
| Nol11 |
A |
T |
11: 107,064,505 (GRCm39) |
M483K |
probably benign |
Het |
| Npy1r |
C |
A |
8: 67,156,861 (GRCm39) |
P94T |
probably damaging |
Het |
| Nsmaf |
T |
C |
4: 6,440,940 (GRCm39) |
T37A |
probably benign |
Het |
| Or10ad1b |
A |
G |
15: 98,124,920 (GRCm39) |
L204P |
possibly damaging |
Het |
| Or2y3 |
G |
A |
17: 38,393,056 (GRCm39) |
A271V |
possibly damaging |
Het |
| Or4c119 |
T |
C |
2: 88,987,399 (GRCm39) |
N40S |
probably damaging |
Het |
| Or51v8 |
A |
T |
7: 103,319,389 (GRCm39) |
M283K |
probably damaging |
Het |
| Or5w14 |
C |
A |
2: 87,541,423 (GRCm39) |
V276F |
possibly damaging |
Het |
| Or8a1b |
A |
G |
9: 37,623,473 (GRCm39) |
I34T |
probably damaging |
Het |
| Or8b37 |
G |
A |
9: 37,958,775 (GRCm39) |
V86M |
possibly damaging |
Het |
| Palld |
C |
T |
8: 61,969,691 (GRCm39) |
R1211H |
unknown |
Het |
| Pcdha3 |
A |
G |
18: 37,080,284 (GRCm39) |
D342G |
probably damaging |
Het |
| Pclo |
G |
A |
5: 14,815,877 (GRCm39) |
V1266I |
|
Het |
| Pcnx4 |
T |
C |
12: 72,602,664 (GRCm39) |
Y309H |
probably damaging |
Het |
| Pde8a |
C |
T |
7: 80,982,619 (GRCm39) |
T746I |
probably damaging |
Het |
| Pdzrn3 |
T |
G |
6: 101,127,772 (GRCm39) |
K965Q |
probably damaging |
Het |
| Phldb1 |
G |
A |
9: 44,615,425 (GRCm39) |
A225V |
probably benign |
Het |
| Pierce1 |
TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC |
TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC |
2: 28,356,122 (GRCm39) |
|
probably benign |
Het |
| Plat |
A |
G |
8: 23,265,599 (GRCm39) |
Y214C |
probably damaging |
Het |
| Plppr1 |
T |
A |
4: 49,325,627 (GRCm39) |
C274* |
probably null |
Het |
| Poglut1 |
A |
G |
16: 38,347,133 (GRCm39) |
F345L |
possibly damaging |
Het |
| Ppara |
A |
T |
15: 85,661,837 (GRCm39) |
E26V |
possibly damaging |
Het |
| Ppcdc |
A |
T |
9: 57,327,571 (GRCm39) |
W79R |
probably damaging |
Het |
| Prdm1 |
C |
T |
10: 44,316,150 (GRCm39) |
C662Y |
probably damaging |
Het |
| Sgms2 |
G |
A |
3: 131,136,011 (GRCm39) |
|
probably benign |
Het |
| Slc31a1 |
T |
A |
4: 62,306,843 (GRCm39) |
M133K |
probably damaging |
Het |
| Smg1 |
G |
A |
7: 117,777,998 (GRCm39) |
Q1309* |
probably null |
Het |
| Sos1 |
T |
C |
17: 80,761,239 (GRCm39) |
I152M |
probably damaging |
Het |
| Stk4 |
A |
T |
2: 163,952,136 (GRCm39) |
|
probably benign |
Het |
| Syne1 |
T |
G |
10: 5,200,954 (GRCm39) |
N3538T |
probably damaging |
Het |
| Tbc1d16 |
A |
G |
11: 119,099,666 (GRCm39) |
F236S |
probably damaging |
Het |
| Tgs1 |
T |
A |
4: 3,595,475 (GRCm39) |
M548K |
probably benign |
Het |
| Twf1 |
G |
A |
15: 94,483,336 (GRCm39) |
T124I |
probably damaging |
Het |
| Tyro3 |
G |
A |
2: 119,642,648 (GRCm39) |
G611R |
probably damaging |
Het |
| Unc13b |
T |
A |
4: 43,173,282 (GRCm39) |
I1370K |
unknown |
Het |
| Usp40 |
A |
G |
1: 87,885,032 (GRCm39) |
W939R |
probably damaging |
Het |
| Vamp8 |
A |
T |
6: 72,362,554 (GRCm39) |
V82E |
probably damaging |
Het |
| Vmn2r17 |
A |
G |
5: 109,575,732 (GRCm39) |
H201R |
possibly damaging |
Het |
| Whrn |
T |
C |
4: 63,350,079 (GRCm39) |
H546R |
probably benign |
Het |
| Yeats2 |
T |
C |
16: 20,033,228 (GRCm39) |
V1036A |
probably benign |
Het |
| Zfp352 |
T |
G |
4: 90,112,575 (GRCm39) |
N238K |
probably benign |
Het |
| Zfp36l3 |
TCCAGGGGCGAGGGCAGCCCCAGGAGCAAGGGCCGCCCTAGGAATGAGGGCCGCCCCAGG |
TCCAGG |
X: 52,776,521 (GRCm39) |
|
probably benign |
Het |
| Zfp462 |
T |
A |
4: 55,011,510 (GRCm39) |
S1159T |
probably benign |
Het |
| Zscan4-ps1 |
A |
T |
7: 10,800,192 (GRCm39) |
H232Q |
probably benign |
Het |
|
| Other mutations in Adamts3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00160:Adamts3
|
APN |
5 |
90,009,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00340:Adamts3
|
APN |
5 |
89,849,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00923:Adamts3
|
APN |
5 |
89,832,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01420:Adamts3
|
APN |
5 |
89,850,916 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL01522:Adamts3
|
APN |
5 |
89,850,802 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01676:Adamts3
|
APN |
5 |
90,029,402 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01676:Adamts3
|
APN |
5 |
89,825,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01678:Adamts3
|
APN |
5 |
89,855,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Adamts3
|
APN |
5 |
90,009,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01956:Adamts3
|
APN |
5 |
89,825,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02342:Adamts3
|
APN |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
IGL02415:Adamts3
|
APN |
5 |
89,854,506 (GRCm39) |
splice site |
probably null |
|
|
IGL03261:Adamts3
|
APN |
5 |
90,030,756 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL03301:Adamts3
|
APN |
5 |
89,855,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Adamts3
|
UTSW |
5 |
89,832,326 (GRCm39) |
missense |
probably benign |
|
|
R0079:Adamts3
|
UTSW |
5 |
89,840,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Adamts3
|
UTSW |
5 |
89,849,576 (GRCm39) |
nonsense |
probably null |
|
|
R0477:Adamts3
|
UTSW |
5 |
89,832,366 (GRCm39) |
missense |
probably benign |
|
|
R0605:Adamts3
|
UTSW |
5 |
90,009,334 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1036:Adamts3
|
UTSW |
5 |
89,843,952 (GRCm39) |
splice site |
probably benign |
|
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1462:Adamts3
|
UTSW |
5 |
90,009,208 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1621:Adamts3
|
UTSW |
5 |
89,869,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1799:Adamts3
|
UTSW |
5 |
89,923,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2163:Adamts3
|
UTSW |
5 |
89,856,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2412:Adamts3
|
UTSW |
5 |
89,849,630 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2421:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2422:Adamts3
|
UTSW |
5 |
89,831,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2921:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2922:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2923:Adamts3
|
UTSW |
5 |
90,009,393 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3402:Adamts3
|
UTSW |
5 |
89,849,592 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3431:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3432:Adamts3
|
UTSW |
5 |
89,855,312 (GRCm39) |
splice site |
probably benign |
|
|
R3813:Adamts3
|
UTSW |
5 |
89,825,785 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3816:Adamts3
|
UTSW |
5 |
89,853,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3905:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3906:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3907:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3908:Adamts3
|
UTSW |
5 |
90,009,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adamts3
|
UTSW |
5 |
89,848,346 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4684:Adamts3
|
UTSW |
5 |
89,850,866 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4844:Adamts3
|
UTSW |
5 |
89,825,675 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4925:Adamts3
|
UTSW |
5 |
89,832,182 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5097:Adamts3
|
UTSW |
5 |
89,840,909 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5100:Adamts3
|
UTSW |
5 |
89,856,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Adamts3
|
UTSW |
5 |
89,923,236 (GRCm39) |
missense |
probably benign |
|
|
R5265:Adamts3
|
UTSW |
5 |
90,009,411 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5322:Adamts3
|
UTSW |
5 |
89,855,159 (GRCm39) |
splice site |
probably null |
|
|
R5413:Adamts3
|
UTSW |
5 |
89,856,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5459:Adamts3
|
UTSW |
5 |
89,839,332 (GRCm39) |
splice site |
probably null |
|
|
R5738:Adamts3
|
UTSW |
5 |
89,856,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Adamts3
|
UTSW |
5 |
90,009,528 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5992:Adamts3
|
UTSW |
5 |
89,839,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Adamts3
|
UTSW |
5 |
89,869,673 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6572:Adamts3
|
UTSW |
5 |
90,009,468 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7098:Adamts3
|
UTSW |
5 |
90,009,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7172:Adamts3
|
UTSW |
5 |
90,030,860 (GRCm39) |
start gained |
probably benign |
|
|
R7263:Adamts3
|
UTSW |
5 |
89,825,601 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7401:Adamts3
|
UTSW |
5 |
89,855,309 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7599:Adamts3
|
UTSW |
5 |
90,009,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7829:Adamts3
|
UTSW |
5 |
90,009,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Adamts3
|
UTSW |
5 |
89,848,299 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7892:Adamts3
|
UTSW |
5 |
90,009,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8021:Adamts3
|
UTSW |
5 |
89,831,043 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8289:Adamts3
|
UTSW |
5 |
89,923,282 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Adamts3
|
UTSW |
5 |
89,850,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8468:Adamts3
|
UTSW |
5 |
89,842,627 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8827:Adamts3
|
UTSW |
5 |
89,839,324 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8864:Adamts3
|
UTSW |
5 |
89,854,981 (GRCm39) |
intron |
probably benign |
|
|
R8906:Adamts3
|
UTSW |
5 |
89,825,575 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9000:Adamts3
|
UTSW |
5 |
89,854,570 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9005:Adamts3
|
UTSW |
5 |
89,825,693 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9505:Adamts3
|
UTSW |
5 |
89,855,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Adamts3
|
UTSW |
5 |
89,834,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Adamts3
|
UTSW |
5 |
89,850,901 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1088:Adamts3
|
UTSW |
5 |
89,832,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,923,210 (GRCm39) |
missense |
not run |
|
|
Z1177:Adamts3
|
UTSW |
5 |
89,855,723 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGGAATGCTAGGGGATGC -3'
(R):5'- AGTAAACTATGCTGGTCAAACATCC -3'
Sequencing Primer
(F):5'- ATGCTGGGGGATGCCAG -3'
(R):5'- AGACTGGGGATGTTGCTTA -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation