Mutagenetix > Incidental Mutation

Incidental Mutation 'R9378:Vmn2r17'

709771

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R9378 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

109420013-109453387 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109427866 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 201 (H201R)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171841
AA Change: H201R

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: H201R

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700007K13Rik	TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC	TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC	2: 28,466,110 (GRCm38)		probably benign	Het
2210408I21Rik	A	G	13: 77,323,616 (GRCm38)	K1047E	possibly damaging	Het
Abca14	A	T	7: 120,207,968 (GRCm38)	Y79F	possibly damaging	Het
Abca2	T	A	2: 25,439,082 (GRCm38)	M978K	probably benign	Het
Adamts3	A	T	5: 89,700,410 (GRCm38)	C684*	probably null	Het
Adnp2	T	C	18: 80,129,422 (GRCm38)	T591A	probably benign	Het
Aff4	A	T	11: 53,372,479 (GRCm38)	T109S	probably damaging	Het
Agmo	A	G	12: 37,243,721 (GRCm38)	I48V	probably benign	Het
Appl1	G	A	14: 26,927,827 (GRCm38)	R581*	probably null	Het
Armc9	A	T	1: 86,262,044 (GRCm38)	M714L	probably benign	Het
Atp6v0d2	T	A	4: 19,922,377 (GRCm38)	T41S	probably benign	Het
Bin1	A	T	18: 32,419,868 (GRCm38)	Q182L	probably damaging	Het
Bmp10	A	G	6: 87,433,702 (GRCm38)	D159G	probably benign	Het
Bsn	G	A	9: 108,107,655 (GRCm38)	P295S	possibly damaging	Het
C130079G13Rik	A	G	3: 59,931,689 (GRCm38)	T11A	possibly damaging	Het
Cbx6	A	G	15: 79,828,405 (GRCm38)	S274P	probably damaging	Het
Cdc20b	A	G	13: 113,056,097 (GRCm38)	K108R	probably benign	Het
Ces1d	T	A	8: 93,186,096 (GRCm38)	N238I	probably damaging	Het
Col7a1	C	T	9: 108,958,640 (GRCm38)	Q663*	probably null	Het
Cpsf3	T	C	12: 21,308,038 (GRCm38)	I517T	possibly damaging	Het
Cyp2a5	C	A	7: 26,840,454 (GRCm38)	T309N	probably damaging	Het
Cyp2d40	A	G	15: 82,761,601 (GRCm38)	F68L	possibly damaging	Het
Cyp7b1	A	T	3: 18,096,673 (GRCm38)	W301R	probably damaging	Het
Dnah6	T	A	6: 73,212,530 (GRCm38)	N45I	probably benign	Het
Dnah7a	A	T	1: 53,582,617 (GRCm38)	H1116Q	probably benign	Het
Dntt	A	G	19: 41,038,917 (GRCm38)	N141S	probably benign	Het
Fbxl13	T	C	5: 21,585,203 (GRCm38)	N281D	probably damaging	Het
Frem2	A	T	3: 53,651,989 (GRCm38)	L1699H	probably damaging	Het
Gabrr3	T	C	16: 59,461,674 (GRCm38)	V464A	possibly damaging	Het
Gdap1	T	A	1: 17,157,129 (GRCm38)	I160N	probably damaging	Het
Hnrnpll	C	A	17: 80,061,862 (GRCm38)	R44L	unknown	Het
Hsp90ab1	T	C	17: 45,570,754 (GRCm38)	E187G	probably damaging	Het
Ighm	T	A	12: 113,422,590 (GRCm38)	T47S		Het
Itgb7	A	C	15: 102,227,396 (GRCm38)		probably null	Het
Kif16b	A	T	2: 142,619,818 (GRCm38)	C1293*	probably null	Het
Klf11	C	T	12: 24,655,044 (GRCm38)	R166C	probably benign	Het
Lca5l	T	A	16: 96,176,012 (GRCm38)	Q198L	probably damaging	Het
Lnx2	A	T	5: 147,024,370 (GRCm38)	M584K	probably benign	Het
Lpp	A	T	16: 24,721,987 (GRCm38)	M1L	probably benign	Het
Lrig3	A	G	10: 125,997,084 (GRCm38)	T276A	probably damaging	Het
Ltbp2	G	A	12: 84,791,090 (GRCm38)	P1192L	probably benign	Het
Megf8	A	T	7: 25,340,415 (GRCm38)		probably null	Het
Myh1	A	C	11: 67,202,433 (GRCm38)	T117P	probably damaging	Het
Neb	C	A	2: 52,244,101 (GRCm38)	R3290L	possibly damaging	Het
Neb	A	C	2: 52,247,292 (GRCm38)	V220G		Het
Nktr	A	T	9: 121,748,198 (GRCm38)	K444I	probably damaging	Het
Nol11	A	T	11: 107,173,679 (GRCm38)	M483K	probably benign	Het
Npy1r	C	A	8: 66,704,209 (GRCm38)	P94T	probably damaging	Het
Nsmaf	T	C	4: 6,440,940 (GRCm38)	T37A	probably benign	Het
Olfr1137	C	A	2: 87,711,079 (GRCm38)	V276F	possibly damaging	Het
Olfr1224-ps1	T	C	2: 89,157,055 (GRCm38)	N40S	probably damaging	Het
Olfr131	G	A	17: 38,082,165 (GRCm38)	A271V	possibly damaging	Het
Olfr160	A	G	9: 37,712,177 (GRCm38)	I34T	probably damaging	Het
Olfr286	A	G	15: 98,227,039 (GRCm38)	L204P	possibly damaging	Het
Olfr624	A	T	7: 103,670,182 (GRCm38)	M283K	probably damaging	Het
Olfr884	G	A	9: 38,047,479 (GRCm38)	V86M	possibly damaging	Het
Palld	C	T	8: 61,516,657 (GRCm38)	R1211H	unknown	Het
Pcdha3	A	G	18: 36,947,231 (GRCm38)	D342G	probably damaging	Het
Pclo	G	A	5: 14,765,863 (GRCm38)	V1266I		Het
Pcnx4	T	C	12: 72,555,890 (GRCm38)	Y309H	probably damaging	Het
Pde8a	C	T	7: 81,332,871 (GRCm38)	T746I	probably damaging	Het
Pdzrn3	T	G	6: 101,150,811 (GRCm38)	K965Q	probably damaging	Het
Phldb1	G	A	9: 44,704,128 (GRCm38)	A225V	probably benign	Het
Plat	A	G	8: 22,775,583 (GRCm38)	Y214C	probably damaging	Het
Plppr1	T	A	4: 49,325,627 (GRCm38)	C274*	probably null	Het
Poglut1	A	G	16: 38,526,771 (GRCm38)	F345L	possibly damaging	Het
Ppara	A	T	15: 85,777,636 (GRCm38)	E26V	possibly damaging	Het
Ppcdc	A	T	9: 57,420,288 (GRCm38)	W79R	probably damaging	Het
Prdm1	C	T	10: 44,440,154 (GRCm38)	C662Y	probably damaging	Het
Sgms2	G	A	3: 131,342,362 (GRCm38)		probably benign	Het
Slc31a1	T	A	4: 62,388,606 (GRCm38)	M133K	probably damaging	Het
Smg1	G	A	7: 118,178,775 (GRCm38)	Q1309*	probably null	Het
Sos1	T	C	17: 80,453,810 (GRCm38)	I152M	probably damaging	Het
Stk4	A	T	2: 164,110,216 (GRCm38)		probably benign	Het
Syne1	T	G	10: 5,250,954 (GRCm38)	N3538T	probably damaging	Het
Tbc1d16	A	G	11: 119,208,840 (GRCm38)	F236S	probably damaging	Het
Tgs1	T	A	4: 3,595,475 (GRCm38)	M548K	probably benign	Het
Twf1	G	A	15: 94,585,455 (GRCm38)	T124I	probably damaging	Het
Tyro3	G	A	2: 119,812,167 (GRCm38)	G611R	probably damaging	Het
Unc13b	T	A	4: 43,173,282 (GRCm38)	I1370K	unknown	Het
Usp40	A	G	1: 87,957,310 (GRCm38)	W939R	probably damaging	Het
Vamp8	A	T	6: 72,385,571 (GRCm38)	V82E	probably damaging	Het
Whrn	T	C	4: 63,431,842 (GRCm38)	H546R	probably benign	Het
Yeats2	T	C	16: 20,214,478 (GRCm38)	V1036A	probably benign	Het
Zfp352	T	G	4: 90,224,338 (GRCm38)	N238K	probably benign	Het
Zfp36l3	TCCAGGGGCGAGGGCAGCCCCAGGAGCAAGGGCCGCCCTAGGAATGAGGGCCGCCCCAGG	TCCAGG	X: 53,774,554 (GRCm38)		probably benign	Het
Zfp462	T	A	4: 55,011,510 (GRCm38)	S1159T	probably benign	Het
Zscan4-ps1	A	T	7: 11,066,265 (GRCm38)	H232Q	probably benign	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109,427,992 (GRCm38)	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109,453,032 (GRCm38)	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109,453,140 (GRCm38)	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109,452,518 (GRCm38)	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109,429,498 (GRCm38)	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109,420,037 (GRCm38)	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109,427,050 (GRCm38)	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109,427,947 (GRCm38)	missense	probably damaging	0.97
IGL02009:Vmn2r17	APN	5	109,452,848 (GRCm38)	missense	possibly damaging	0.67
IGL02365:Vmn2r17	APN	5	109,453,309 (GRCm38)	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109,434,381 (GRCm38)	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109,453,146 (GRCm38)	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109,453,080 (GRCm38)	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109,420,211 (GRCm38)	missense	probably benign
IGL03213:Vmn2r17	APN	5	109,434,390 (GRCm38)	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109,452,890 (GRCm38)	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109,427,916 (GRCm38)	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109,429,372 (GRCm38)	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109,428,336 (GRCm38)	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109,452,881 (GRCm38)	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109,427,326 (GRCm38)	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109,427,956 (GRCm38)	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109,428,244 (GRCm38)	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109,428,511 (GRCm38)	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109,428,478 (GRCm38)	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109,452,486 (GRCm38)	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109,427,209 (GRCm38)	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109,434,278 (GRCm38)	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109,428,031 (GRCm38)	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109,427,238 (GRCm38)	missense	probably benign
R3612:Vmn2r17	UTSW	5	109,429,597 (GRCm38)	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109,428,396 (GRCm38)	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109,452,966 (GRCm38)	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109,428,469 (GRCm38)	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109,429,562 (GRCm38)	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109,427,183 (GRCm38)	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109,427,983 (GRCm38)	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109,452,849 (GRCm38)	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109,434,380 (GRCm38)	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109,434,380 (GRCm38)	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109,427,119 (GRCm38)	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109,453,354 (GRCm38)	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109,427,873 (GRCm38)	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109,428,351 (GRCm38)	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109,429,476 (GRCm38)	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109,427,908 (GRCm38)	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109,434,284 (GRCm38)	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109,420,106 (GRCm38)	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109,428,164 (GRCm38)	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109,429,564 (GRCm38)	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109,427,274 (GRCm38)	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109,452,850 (GRCm38)	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109,427,273 (GRCm38)	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109,428,381 (GRCm38)	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109,427,829 (GRCm38)	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109,429,465 (GRCm38)	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109,428,399 (GRCm38)	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109,452,667 (GRCm38)	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109,428,471 (GRCm38)	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109,427,829 (GRCm38)	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109,452,891 (GRCm38)	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109,452,965 (GRCm38)	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109,427,873 (GRCm38)	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109,420,197 (GRCm38)	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109,420,169 (GRCm38)	missense	probably benign
R7893:Vmn2r17	UTSW	5	109,428,078 (GRCm38)	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109,453,369 (GRCm38)	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109,428,521 (GRCm38)	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109,428,306 (GRCm38)	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109,452,825 (GRCm38)	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109,452,944 (GRCm38)	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109,427,997 (GRCm38)	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109,452,846 (GRCm38)	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109,452,639 (GRCm38)	missense	probably damaging	0.98
R9597:Vmn2r17	UTSW	5	109,427,803 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTCCTAACAAGCACATTACTTATGG -3'
(R):5'- TATGCCCATCTTCTAAAGCTGAC -3'

Sequencing Primer
(F):5'- CAAGCACATTACTTATGGGGATG -3'
(R):5'- ACAACCTTGGCTGATGATGTC -3'

Posted On

2022-04-18