Mutagenetix > Incidental Mutation

Incidental Mutation 'R9378:Dnah6'

709774

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R9378 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 73212530 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 45 (N45I)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: N45I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: N45I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: N45I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: N45I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: N45I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: N45I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700007K13Rik	TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC	TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC	2: 28,466,110		probably benign	Het
2210408I21Rik	A	G	13: 77,323,616	K1047E	possibly damaging	Het
Abca14	A	T	7: 120,207,968	Y79F	possibly damaging	Het
Abca2	T	A	2: 25,439,082	M978K	probably benign	Het
Adamts3	A	T	5: 89,700,410	C684*	probably null	Het
Adnp2	T	C	18: 80,129,422	T591A	probably benign	Het
Aff4	A	T	11: 53,372,479	T109S	probably damaging	Het
Agmo	A	G	12: 37,243,721	I48V	probably benign	Het
Appl1	G	A	14: 26,927,827	R581*	probably null	Het
Armc9	A	T	1: 86,262,044	M714L	probably benign	Het
Atp6v0d2	T	A	4: 19,922,377	T41S	probably benign	Het
Bin1	A	T	18: 32,419,868	Q182L	probably damaging	Het
Bmp10	A	G	6: 87,433,702	D159G	probably benign	Het
Bsn	G	A	9: 108,107,655	P295S	possibly damaging	Het
C130079G13Rik	A	G	3: 59,931,689	T11A	possibly damaging	Het
Cbx6	A	G	15: 79,828,405	S274P	probably damaging	Het
Cdc20b	A	G	13: 113,056,097	K108R	probably benign	Het
Ces1d	T	A	8: 93,186,096	N238I	probably damaging	Het
Col7a1	C	T	9: 108,958,640	Q663*	probably null	Het
Cpsf3	T	C	12: 21,308,038	I517T	possibly damaging	Het
Cyp2a5	C	A	7: 26,840,454	T309N	probably damaging	Het
Cyp2d40	A	G	15: 82,761,601	F68L	possibly damaging	Het
Cyp7b1	A	T	3: 18,096,673	W301R	probably damaging	Het
Dnah7a	A	T	1: 53,582,617	H1116Q	probably benign	Het
Dntt	A	G	19: 41,038,917	N141S	probably benign	Het
Fbxl13	T	C	5: 21,585,203	N281D	probably damaging	Het
Frem2	A	T	3: 53,651,989	L1699H	probably damaging	Het
Gabrr3	T	C	16: 59,461,674	V464A	possibly damaging	Het
Gdap1	T	A	1: 17,157,129	I160N	probably damaging	Het
Hnrnpll	C	A	17: 80,061,862	R44L	unknown	Het
Hsp90ab1	T	C	17: 45,570,754	E187G	probably damaging	Het
Ighm	T	A	12: 113,422,590	T47S		Het
Itgb7	A	C	15: 102,227,396		probably null	Het
Kif16b	A	T	2: 142,619,818	C1293*	probably null	Het
Klf11	C	T	12: 24,655,044	R166C	probably benign	Het
Lca5l	T	A	16: 96,176,012	Q198L	probably damaging	Het
Lnx2	A	T	5: 147,024,370	M584K	probably benign	Het
Lpp	A	T	16: 24,721,987	M1L	probably benign	Het
Lrig3	A	G	10: 125,997,084	T276A	probably damaging	Het
Ltbp2	G	A	12: 84,791,090	P1192L	probably benign	Het
Megf8	A	T	7: 25,340,415		probably null	Het
Myh1	A	C	11: 67,202,433	T117P	probably damaging	Het
Neb	C	A	2: 52,244,101	R3290L	possibly damaging	Het
Neb	A	C	2: 52,247,292	V220G		Het
Nktr	A	T	9: 121,748,198	K444I	probably damaging	Het
Nol11	A	T	11: 107,173,679	M483K	probably benign	Het
Npy1r	C	A	8: 66,704,209	P94T	probably damaging	Het
Nsmaf	T	C	4: 6,440,940	T37A	probably benign	Het
Olfr1137	C	A	2: 87,711,079	V276F	possibly damaging	Het
Olfr1224-ps1	T	C	2: 89,157,055	N40S	probably damaging	Het
Olfr131	G	A	17: 38,082,165	A271V	possibly damaging	Het
Olfr160	A	G	9: 37,712,177	I34T	probably damaging	Het
Olfr286	A	G	15: 98,227,039	L204P	possibly damaging	Het
Olfr624	A	T	7: 103,670,182	M283K	probably damaging	Het
Olfr884	G	A	9: 38,047,479	V86M	possibly damaging	Het
Palld	C	T	8: 61,516,657	R1211H	unknown	Het
Pcdha3	A	G	18: 36,947,231	D342G	probably damaging	Het
Pclo	G	A	5: 14,765,863	V1266I		Het
Pcnx4	T	C	12: 72,555,890	Y309H	probably damaging	Het
Pde8a	C	T	7: 81,332,871	T746I	probably damaging	Het
Pdzrn3	T	G	6: 101,150,811	K965Q	probably damaging	Het
Phldb1	G	A	9: 44,704,128	A225V	probably benign	Het
Plat	A	G	8: 22,775,583	Y214C	probably damaging	Het
Plppr1	T	A	4: 49,325,627	C274*	probably null	Het
Poglut1	A	G	16: 38,526,771	F345L	possibly damaging	Het
Ppara	A	T	15: 85,777,636	E26V	possibly damaging	Het
Ppcdc	A	T	9: 57,420,288	W79R	probably damaging	Het
Prdm1	C	T	10: 44,440,154	C662Y	probably damaging	Het
Sgms2	G	A	3: 131,342,362		probably benign	Het
Slc31a1	T	A	4: 62,388,606	M133K	probably damaging	Het
Smg1	G	A	7: 118,178,775	Q1309*	probably null	Het
Sos1	T	C	17: 80,453,810	I152M	probably damaging	Het
Stk4	A	T	2: 164,110,216		probably benign	Het
Syne1	T	G	10: 5,250,954	N3538T	probably damaging	Het
Tbc1d16	A	G	11: 119,208,840	F236S	probably damaging	Het
Tgs1	T	A	4: 3,595,475	M548K	probably benign	Het
Twf1	G	A	15: 94,585,455	T124I	probably damaging	Het
Tyro3	G	A	2: 119,812,167	G611R	probably damaging	Het
Unc13b	T	A	4: 43,173,282	I1370K	unknown	Het
Usp40	A	G	1: 87,957,310	W939R	probably damaging	Het
Vamp8	A	T	6: 72,385,571	V82E	probably damaging	Het
Vmn2r17	A	G	5: 109,427,866	H201R	possibly damaging	Het
Whrn	T	C	4: 63,431,842	H546R	probably benign	Het
Yeats2	T	C	16: 20,214,478	V1036A	probably benign	Het
Zfp352	T	G	4: 90,224,338	N238K	probably benign	Het
Zfp36l3	TCCAGGGGCGAGGGCAGCCCCAGGAGCAAGGGCCGCCCTAGGAATGAGGGCCGCCCCAGG	TCCAGG	X: 53,774,554		probably benign	Het
Zfp462	T	A	4: 55,011,510	S1159T	probably benign	Het
Zscan4-ps1	A	T	7: 11,066,265	H232Q	probably benign	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,195,737 (GRCm38)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,086,207 (GRCm38)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,195,761 (GRCm38)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,212,434 (GRCm38)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,123,771 (GRCm38)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,156,350 (GRCm38)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,033,526 (GRCm38)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,083,157 (GRCm38)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,173,390 (GRCm38)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,074,781 (GRCm38)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,065,725 (GRCm38)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,173,456 (GRCm38)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,092,178 (GRCm38)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,074,748 (GRCm38)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,024,252 (GRCm38)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,075,802 (GRCm38)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,076,660 (GRCm38)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,188,377 (GRCm38)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,065,776 (GRCm38)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,135,801 (GRCm38)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,032,569 (GRCm38)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,060,143 (GRCm38)	missense	probably benign
IGL02126:Dnah6	APN	6	73,103,166 (GRCm38)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73,017,797 (GRCm38)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,133,650 (GRCm38)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,168,911 (GRCm38)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,101,898 (GRCm38)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,076,640 (GRCm38)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,027,448 (GRCm38)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73,021,227 (GRCm38)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,095,104 (GRCm38)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,121,823 (GRCm38)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,208,599 (GRCm38)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,138,715 (GRCm38)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,032,587 (GRCm38)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,149,140 (GRCm38)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,145,004 (GRCm38)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,041,054 (GRCm38)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,144,700 (GRCm38)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,053,647 (GRCm38)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,083,085 (GRCm38)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,075,850 (GRCm38)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,163,504 (GRCm38)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,065,755 (GRCm38)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,208,641 (GRCm38)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,101,880 (GRCm38)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,114,582 (GRCm38)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,060,260 (GRCm38)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,038,734 (GRCm38)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,188,535 (GRCm38)	splice site	probably benign
R0165:Dnah6	UTSW	6	73,021,323 (GRCm38)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,082,923 (GRCm38)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,159,115 (GRCm38)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,173,558 (GRCm38)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,069,399 (GRCm38)	splice site	probably benign
R0345:Dnah6	UTSW	6	73,021,257 (GRCm38)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,188,359 (GRCm38)	missense	probably benign
R0362:Dnah6	UTSW	6	73,208,609 (GRCm38)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,083,124 (GRCm38)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,044,774 (GRCm38)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	73,022,412 (GRCm38)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,123,811 (GRCm38)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,129,474 (GRCm38)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,212,622 (GRCm38)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,087,602 (GRCm38)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,035,293 (GRCm38)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,124,757 (GRCm38)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,159,193 (GRCm38)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,144,965 (GRCm38)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,159,135 (GRCm38)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,124,709 (GRCm38)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,208,545 (GRCm38)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,191,619 (GRCm38)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,027,442 (GRCm38)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,049,048 (GRCm38)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,151,553 (GRCm38)	missense	probably benign
R1557:Dnah6	UTSW	6	73,049,131 (GRCm38)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,076,600 (GRCm38)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,067,469 (GRCm38)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,144,963 (GRCm38)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,100,112 (GRCm38)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,044,752 (GRCm38)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,155,296 (GRCm38)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,205,732 (GRCm38)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,129,540 (GRCm38)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,044,761 (GRCm38)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,160,982 (GRCm38)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,024,958 (GRCm38)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,181,797 (GRCm38)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,100,088 (GRCm38)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,181,762 (GRCm38)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,084,721 (GRCm38)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,121,970 (GRCm38)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,095,044 (GRCm38)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,092,192 (GRCm38)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,067,466 (GRCm38)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,173,419 (GRCm38)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,027,422 (GRCm38)	missense	probably benign
R2041:Dnah6	UTSW	6	73,073,439 (GRCm38)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73,021,182 (GRCm38)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,144,035 (GRCm38)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,049,166 (GRCm38)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,089,746 (GRCm38)	splice site	probably null
R2193:Dnah6	UTSW	6	73,138,640 (GRCm38)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,100,085 (GRCm38)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,113,581 (GRCm38)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73,021,109 (GRCm38)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,156,421 (GRCm38)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,091,967 (GRCm38)	splice site	probably null
R2436:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,173,350 (GRCm38)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,032,633 (GRCm38)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,191,498 (GRCm38)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,127,927 (GRCm38)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,089,592 (GRCm38)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,129,448 (GRCm38)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,149,484 (GRCm38)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,118,026 (GRCm38)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,129,291 (GRCm38)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,191,479 (GRCm38)	missense	probably benign
R4486:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,178,416 (GRCm38)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,192,405 (GRCm38)	missense	probably benign
R4573:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,152,712 (GRCm38)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,129,660 (GRCm38)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,070,597 (GRCm38)	missense	probably benign
R4653:Dnah6	UTSW	6	73,073,457 (GRCm38)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,037,688 (GRCm38)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,192,422 (GRCm38)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,025,012 (GRCm38)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,129,530 (GRCm38)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,095,074 (GRCm38)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,089,668 (GRCm38)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73,022,424 (GRCm38)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,044,762 (GRCm38)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,121,788 (GRCm38)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,192,676 (GRCm38)	intron	probably benign
R4948:Dnah6	UTSW	6	73,053,689 (GRCm38)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,188,383 (GRCm38)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,144,815 (GRCm38)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,044,691 (GRCm38)	missense	probably benign
R5044:Dnah6	UTSW	6	73,037,622 (GRCm38)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,181,761 (GRCm38)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,195,634 (GRCm38)	missense	probably benign
R5186:Dnah6	UTSW	6	73,067,427 (GRCm38)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,195,732 (GRCm38)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,113,488 (GRCm38)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,127,861 (GRCm38)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,212,620 (GRCm38)	missense	probably benign
R5343:Dnah6	UTSW	6	73,212,616 (GRCm38)	missense	probably benign
R5375:Dnah6	UTSW	6	73,123,855 (GRCm38)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,037,615 (GRCm38)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,060,138 (GRCm38)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,075,734 (GRCm38)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,086,185 (GRCm38)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,092,157 (GRCm38)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,092,116 (GRCm38)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,190,419 (GRCm38)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,159,229 (GRCm38)	missense	probably benign
R5541:Dnah6	UTSW	6	73,192,988 (GRCm38)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,151,689 (GRCm38)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,149,525 (GRCm38)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73,021,227 (GRCm38)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,060,279 (GRCm38)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,181,722 (GRCm38)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,086,166 (GRCm38)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,114,697 (GRCm38)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,188,494 (GRCm38)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,086,217 (GRCm38)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,191,605 (GRCm38)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,155,418 (GRCm38)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,074,586 (GRCm38)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,074,704 (GRCm38)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,044,732 (GRCm38)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,173,533 (GRCm38)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,053,695 (GRCm38)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,035,280 (GRCm38)	splice site	probably null
R6640:Dnah6	UTSW	6	73,024,293 (GRCm38)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,138,760 (GRCm38)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,037,549 (GRCm38)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,133,608 (GRCm38)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,133,542 (GRCm38)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,212,522 (GRCm38)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,181,755 (GRCm38)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,044,773 (GRCm38)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73,021,178 (GRCm38)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,087,562 (GRCm38)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,135,680 (GRCm38)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,181,705 (GRCm38)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,173,545 (GRCm38)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,084,760 (GRCm38)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,144,722 (GRCm38)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,212,612 (GRCm38)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,192,317 (GRCm38)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,212,492 (GRCm38)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,127,904 (GRCm38)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,118,099 (GRCm38)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,027,440 (GRCm38)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,149,430 (GRCm38)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,092,168 (GRCm38)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,095,206 (GRCm38)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,124,759 (GRCm38)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,169,080 (GRCm38)	splice site	probably null
R7735:Dnah6	UTSW	6	73,069,429 (GRCm38)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,025,720 (GRCm38)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,127,919 (GRCm38)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,135,467 (GRCm38)	splice site	probably null
R8034:Dnah6	UTSW	6	73,129,225 (GRCm38)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,160,913 (GRCm38)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,025,786 (GRCm38)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,060,225 (GRCm38)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,037,566 (GRCm38)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,044,728 (GRCm38)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,168,827 (GRCm38)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,195,681 (GRCm38)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,076,599 (GRCm38)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,025,000 (GRCm38)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,074,651 (GRCm38)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,138,774 (GRCm38)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,178,457 (GRCm38)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,095,188 (GRCm38)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,168,867 (GRCm38)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,075,890 (GRCm38)	intron	probably benign
R8737:Dnah6	UTSW	6	73,067,445 (GRCm38)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,179,828 (GRCm38)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,065,773 (GRCm38)	missense	probably benign
R8809:Dnah6	UTSW	6	73,032,563 (GRCm38)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,127,954 (GRCm38)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,144,173 (GRCm38)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73,021,148 (GRCm38)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,178,498 (GRCm38)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,144,751 (GRCm38)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,142,292 (GRCm38)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,084,657 (GRCm38)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,144,046 (GRCm38)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,067,486 (GRCm38)	missense	probably benign
R9106:Dnah6	UTSW	6	73,144,769 (GRCm38)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,060,203 (GRCm38)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,121,899 (GRCm38)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,144,941 (GRCm38)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,144,705 (GRCm38)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,027,514 (GRCm38)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,083,057 (GRCm38)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	73,021,278 (GRCm38)	missense	probably benign	0.22
R9439:Dnah6	UTSW	6	73,035,347 (GRCm38)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,142,316 (GRCm38)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,138,767 (GRCm38)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,191,606 (GRCm38)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,101,889 (GRCm38)	missense	probably benign
RF020:Dnah6	UTSW	6	73,118,057 (GRCm38)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,178,518 (GRCm38)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,191,500 (GRCm38)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,037,673 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,133,559 (GRCm38)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,087,783 (GRCm38)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,032,526 (GRCm38)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73,021,237 (GRCm38)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,155,272 (GRCm38)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,041,138 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTGGTGGGCAACTTGAAGC -3'
(R):5'- TTGTAACGGCGAATGTGGGC -3'

Sequencing Primer
(F):5'- GGTCTGCATAGCAAGTTCCAGATC -3'
(R):5'- GCGGCTCCCAACACTGAC -3'

Posted On

2022-04-18