Incidental Mutation 'R9378:Megf8'
| ID |
709778 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf8
|
| Ensembl Gene |
ENSMUSG00000045039 |
| Gene Name |
multiple EGF-like-domains 8 |
| Synonyms |
m687Ddg, b2b1702Clo, Egfl4, b2b288Clo |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.947)
|
| Stock # |
R9378 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
25016589-25065342 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to T
at 25039840 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128119]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000128119
|
| SMART Domains |
Protein: ENSMUSP00000122192
Gene: ENSMUSG00000045039
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
CUB
|
33 |
140 |
1.24e-15 |
SMART |
|
EGF
|
141 |
170 |
4.26e0 |
SMART |
|
EGF
|
173 |
203 |
2.43e1 |
SMART |
|
Pfam:Kelch_4
|
227 |
277 |
1.3e-11 |
PFAM |
|
Pfam:Kelch_3
|
240 |
287 |
1.6e-7 |
PFAM |
|
low complexity region
|
320 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
531 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
PSI
|
847 |
899 |
1.37e0 |
SMART |
|
low complexity region
|
932 |
938 |
N/A |
INTRINSIC |
|
PSI
|
949 |
991 |
2.11e-2 |
SMART |
|
PSI
|
1005 |
1073 |
7.82e-1 |
SMART |
|
EGF_CA
|
1074 |
1115 |
2.62e-9 |
SMART |
|
EGF
|
1117 |
1160 |
5.4e-2 |
SMART |
|
EGF_like
|
1163 |
1208 |
4e-1 |
SMART |
|
EGF_Lam
|
1211 |
1259 |
1.03e-7 |
SMART |
|
Blast:CUB
|
1263 |
1401 |
1e-30 |
BLAST |
|
EGF_like
|
1406 |
1445 |
3.29e1 |
SMART |
|
Pfam:Kelch_4
|
1509 |
1564 |
6.5e-12 |
PFAM |
|
Pfam:Kelch_3
|
1520 |
1574 |
1.2e-10 |
PFAM |
|
PSI
|
1868 |
1923 |
2.75e-1 |
SMART |
|
PSI
|
2004 |
2062 |
1.6e0 |
SMART |
|
PSI
|
2064 |
2121 |
1.68e-5 |
SMART |
|
EGF
|
2125 |
2164 |
1.08e-1 |
SMART |
|
EGF
|
2166 |
2194 |
4.26e0 |
SMART |
|
EGF
|
2204 |
2244 |
2.2e1 |
SMART |
|
EGF_like
|
2248 |
2321 |
6.37e-1 |
SMART |
|
low complexity region
|
2493 |
2504 |
N/A |
INTRINSIC |
|
low complexity region
|
2530 |
2541 |
N/A |
INTRINSIC |
|
transmembrane domain
|
2592 |
2614 |
N/A |
INTRINSIC |
|
low complexity region
|
2649 |
2668 |
N/A |
INTRINSIC |
|
low complexity region
|
2674 |
2702 |
N/A |
INTRINSIC |
|
low complexity region
|
2759 |
2774 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
A |
G |
13: 77,471,735 (GRCm39) |
K1047E |
possibly damaging |
Het |
| Aadacl2fm1 |
A |
G |
3: 59,839,110 (GRCm39) |
T11A |
possibly damaging |
Het |
| Abca14 |
A |
T |
7: 119,807,191 (GRCm39) |
Y79F |
possibly damaging |
Het |
| Abca2 |
T |
A |
2: 25,329,094 (GRCm39) |
M978K |
probably benign |
Het |
| Adamts3 |
A |
T |
5: 89,848,269 (GRCm39) |
C684* |
probably null |
Het |
| Adnp2 |
T |
C |
18: 80,172,637 (GRCm39) |
T591A |
probably benign |
Het |
| Aff4 |
A |
T |
11: 53,263,306 (GRCm39) |
T109S |
probably damaging |
Het |
| Agmo |
A |
G |
12: 37,293,720 (GRCm39) |
I48V |
probably benign |
Het |
| Appl1 |
G |
A |
14: 26,649,784 (GRCm39) |
R581* |
probably null |
Het |
| Armc9 |
A |
T |
1: 86,189,766 (GRCm39) |
M714L |
probably benign |
Het |
| Atp6v0d2 |
T |
A |
4: 19,922,377 (GRCm39) |
T41S |
probably benign |
Het |
| Bin1 |
A |
T |
18: 32,552,921 (GRCm39) |
Q182L |
probably damaging |
Het |
| Bmp10 |
A |
G |
6: 87,410,684 (GRCm39) |
D159G |
probably benign |
Het |
| Bsn |
G |
A |
9: 107,984,854 (GRCm39) |
P295S |
possibly damaging |
Het |
| Cbx6 |
A |
G |
15: 79,712,606 (GRCm39) |
S274P |
probably damaging |
Het |
| Cdc20b |
A |
G |
13: 113,192,631 (GRCm39) |
K108R |
probably benign |
Het |
| Ces1d |
T |
A |
8: 93,912,724 (GRCm39) |
N238I |
probably damaging |
Het |
| Col7a1 |
C |
T |
9: 108,787,708 (GRCm39) |
Q663* |
probably null |
Het |
| Cpsf3 |
T |
C |
12: 21,358,039 (GRCm39) |
I517T |
possibly damaging |
Het |
| Cyp2a5 |
C |
A |
7: 26,539,879 (GRCm39) |
T309N |
probably damaging |
Het |
| Cyp2d40 |
A |
G |
15: 82,645,802 (GRCm39) |
F68L |
possibly damaging |
Het |
| Cyp7b1 |
A |
T |
3: 18,150,837 (GRCm39) |
W301R |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,189,513 (GRCm39) |
N45I |
probably benign |
Het |
| Dnah7a |
A |
T |
1: 53,621,776 (GRCm39) |
H1116Q |
probably benign |
Het |
| Dntt |
A |
G |
19: 41,027,356 (GRCm39) |
N141S |
probably benign |
Het |
| Fbxl13 |
T |
C |
5: 21,790,201 (GRCm39) |
N281D |
probably damaging |
Het |
| Frem2 |
A |
T |
3: 53,559,410 (GRCm39) |
L1699H |
probably damaging |
Het |
| Gabrr3 |
T |
C |
16: 59,282,037 (GRCm39) |
V464A |
possibly damaging |
Het |
| Gdap1 |
T |
A |
1: 17,227,353 (GRCm39) |
I160N |
probably damaging |
Het |
| Hnrnpll |
C |
A |
17: 80,369,291 (GRCm39) |
R44L |
unknown |
Het |
| Hsp90ab1 |
T |
C |
17: 45,881,680 (GRCm39) |
E187G |
probably damaging |
Het |
| Ighm |
T |
A |
12: 113,386,210 (GRCm39) |
T47S |
|
Het |
| Itgb7 |
A |
C |
15: 102,135,831 (GRCm39) |
|
probably null |
Het |
| Kif16b |
A |
T |
2: 142,461,738 (GRCm39) |
C1293* |
probably null |
Het |
| Klf11 |
C |
T |
12: 24,705,043 (GRCm39) |
R166C |
probably benign |
Het |
| Lca5l |
T |
A |
16: 95,977,212 (GRCm39) |
Q198L |
probably damaging |
Het |
| Lnx2 |
A |
T |
5: 146,961,180 (GRCm39) |
M584K |
probably benign |
Het |
| Lpp |
A |
T |
16: 24,540,737 (GRCm39) |
M1L |
probably benign |
Het |
| Lrig3 |
A |
G |
10: 125,832,953 (GRCm39) |
T276A |
probably damaging |
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Myh1 |
A |
C |
11: 67,093,259 (GRCm39) |
T117P |
probably damaging |
Het |
| Neb |
C |
A |
2: 52,134,113 (GRCm39) |
R3290L |
possibly damaging |
Het |
| Neb |
A |
C |
2: 52,137,304 (GRCm39) |
V220G |
|
Het |
| Nktr |
A |
T |
9: 121,577,264 (GRCm39) |
K444I |
probably damaging |
Het |
| Nol11 |
A |
T |
11: 107,064,505 (GRCm39) |
M483K |
probably benign |
Het |
| Npy1r |
C |
A |
8: 67,156,861 (GRCm39) |
P94T |
probably damaging |
Het |
| Nsmaf |
T |
C |
4: 6,440,940 (GRCm39) |
T37A |
probably benign |
Het |
| Or10ad1b |
A |
G |
15: 98,124,920 (GRCm39) |
L204P |
possibly damaging |
Het |
| Or2y3 |
G |
A |
17: 38,393,056 (GRCm39) |
A271V |
possibly damaging |
Het |
| Or4c119 |
T |
C |
2: 88,987,399 (GRCm39) |
N40S |
probably damaging |
Het |
| Or51v8 |
A |
T |
7: 103,319,389 (GRCm39) |
M283K |
probably damaging |
Het |
| Or5w14 |
C |
A |
2: 87,541,423 (GRCm39) |
V276F |
possibly damaging |
Het |
| Or8a1b |
A |
G |
9: 37,623,473 (GRCm39) |
I34T |
probably damaging |
Het |
| Or8b37 |
G |
A |
9: 37,958,775 (GRCm39) |
V86M |
possibly damaging |
Het |
| Palld |
C |
T |
8: 61,969,691 (GRCm39) |
R1211H |
unknown |
Het |
| Pcdha3 |
A |
G |
18: 37,080,284 (GRCm39) |
D342G |
probably damaging |
Het |
| Pclo |
G |
A |
5: 14,815,877 (GRCm39) |
V1266I |
|
Het |
| Pcnx4 |
T |
C |
12: 72,602,664 (GRCm39) |
Y309H |
probably damaging |
Het |
| Pde8a |
C |
T |
7: 80,982,619 (GRCm39) |
T746I |
probably damaging |
Het |
| Pdzrn3 |
T |
G |
6: 101,127,772 (GRCm39) |
K965Q |
probably damaging |
Het |
| Phldb1 |
G |
A |
9: 44,615,425 (GRCm39) |
A225V |
probably benign |
Het |
| Pierce1 |
TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC |
TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC |
2: 28,356,122 (GRCm39) |
|
probably benign |
Het |
| Plat |
A |
G |
8: 23,265,599 (GRCm39) |
Y214C |
probably damaging |
Het |
| Plppr1 |
T |
A |
4: 49,325,627 (GRCm39) |
C274* |
probably null |
Het |
| Poglut1 |
A |
G |
16: 38,347,133 (GRCm39) |
F345L |
possibly damaging |
Het |
| Ppara |
A |
T |
15: 85,661,837 (GRCm39) |
E26V |
possibly damaging |
Het |
| Ppcdc |
A |
T |
9: 57,327,571 (GRCm39) |
W79R |
probably damaging |
Het |
| Prdm1 |
C |
T |
10: 44,316,150 (GRCm39) |
C662Y |
probably damaging |
Het |
| Sgms2 |
G |
A |
3: 131,136,011 (GRCm39) |
|
probably benign |
Het |
| Slc31a1 |
T |
A |
4: 62,306,843 (GRCm39) |
M133K |
probably damaging |
Het |
| Smg1 |
G |
A |
7: 117,777,998 (GRCm39) |
Q1309* |
probably null |
Het |
| Sos1 |
T |
C |
17: 80,761,239 (GRCm39) |
I152M |
probably damaging |
Het |
| Stk4 |
A |
T |
2: 163,952,136 (GRCm39) |
|
probably benign |
Het |
| Syne1 |
T |
G |
10: 5,200,954 (GRCm39) |
N3538T |
probably damaging |
Het |
| Tbc1d16 |
A |
G |
11: 119,099,666 (GRCm39) |
F236S |
probably damaging |
Het |
| Tgs1 |
T |
A |
4: 3,595,475 (GRCm39) |
M548K |
probably benign |
Het |
| Twf1 |
G |
A |
15: 94,483,336 (GRCm39) |
T124I |
probably damaging |
Het |
| Tyro3 |
G |
A |
2: 119,642,648 (GRCm39) |
G611R |
probably damaging |
Het |
| Unc13b |
T |
A |
4: 43,173,282 (GRCm39) |
I1370K |
unknown |
Het |
| Usp40 |
A |
G |
1: 87,885,032 (GRCm39) |
W939R |
probably damaging |
Het |
| Vamp8 |
A |
T |
6: 72,362,554 (GRCm39) |
V82E |
probably damaging |
Het |
| Vmn2r17 |
A |
G |
5: 109,575,732 (GRCm39) |
H201R |
possibly damaging |
Het |
| Whrn |
T |
C |
4: 63,350,079 (GRCm39) |
H546R |
probably benign |
Het |
| Yeats2 |
T |
C |
16: 20,033,228 (GRCm39) |
V1036A |
probably benign |
Het |
| Zfp352 |
T |
G |
4: 90,112,575 (GRCm39) |
N238K |
probably benign |
Het |
| Zfp36l3 |
TCCAGGGGCGAGGGCAGCCCCAGGAGCAAGGGCCGCCCTAGGAATGAGGGCCGCCCCAGG |
TCCAGG |
X: 52,776,521 (GRCm39) |
|
probably benign |
Het |
| Zfp462 |
T |
A |
4: 55,011,510 (GRCm39) |
S1159T |
probably benign |
Het |
| Zscan4-ps1 |
A |
T |
7: 10,800,192 (GRCm39) |
H232Q |
probably benign |
Het |
|
| Other mutations in Megf8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Megf8
|
APN |
7 |
25,043,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL00696:Megf8
|
APN |
7 |
25,041,817 (GRCm39) |
missense |
probably benign |
|
|
IGL01021:Megf8
|
APN |
7 |
25,037,799 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01290:Megf8
|
APN |
7 |
25,049,083 (GRCm39) |
nonsense |
probably null |
|
|
IGL01392:Megf8
|
APN |
7 |
25,063,174 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01410:Megf8
|
APN |
7 |
25,059,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01634:Megf8
|
APN |
7 |
25,058,206 (GRCm39) |
splice site |
probably benign |
|
|
IGL01648:Megf8
|
APN |
7 |
25,026,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01930:Megf8
|
APN |
7 |
25,034,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Megf8
|
APN |
7 |
25,048,439 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02150:Megf8
|
APN |
7 |
25,045,842 (GRCm39) |
splice site |
probably null |
|
|
IGL02192:Megf8
|
APN |
7 |
25,053,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02250:Megf8
|
APN |
7 |
25,042,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02301:Megf8
|
APN |
7 |
25,037,325 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02317:Megf8
|
APN |
7 |
25,063,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02324:Megf8
|
APN |
7 |
25,039,873 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02503:Megf8
|
APN |
7 |
25,062,988 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02583:Megf8
|
APN |
7 |
25,055,218 (GRCm39) |
missense |
probably benign |
|
|
IGL02636:Megf8
|
APN |
7 |
25,057,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02704:Megf8
|
APN |
7 |
25,059,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02898:Megf8
|
APN |
7 |
25,045,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03082:Megf8
|
APN |
7 |
25,029,661 (GRCm39) |
missense |
probably benign |
|
|
IGL03182:Megf8
|
APN |
7 |
25,046,773 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
megatherium
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4810001:Megf8
|
UTSW |
7 |
25,041,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Megf8
|
UTSW |
7 |
25,053,383 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0217:Megf8
|
UTSW |
7 |
25,063,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0514:Megf8
|
UTSW |
7 |
25,063,728 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0561:Megf8
|
UTSW |
7 |
25,028,257 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0563:Megf8
|
UTSW |
7 |
25,041,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Megf8
|
UTSW |
7 |
25,027,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0879:Megf8
|
UTSW |
7 |
25,037,896 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1430:Megf8
|
UTSW |
7 |
25,063,768 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1445:Megf8
|
UTSW |
7 |
25,042,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Megf8
|
UTSW |
7 |
25,034,280 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1606:Megf8
|
UTSW |
7 |
25,058,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Megf8
|
UTSW |
7 |
25,046,172 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1654:Megf8
|
UTSW |
7 |
25,037,911 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1661:Megf8
|
UTSW |
7 |
25,063,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1880:Megf8
|
UTSW |
7 |
25,034,285 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1962:Megf8
|
UTSW |
7 |
25,062,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Megf8
|
UTSW |
7 |
25,053,163 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2127:Megf8
|
UTSW |
7 |
25,064,007 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2129:Megf8
|
UTSW |
7 |
25,030,140 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2199:Megf8
|
UTSW |
7 |
25,039,039 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2201:Megf8
|
UTSW |
7 |
25,040,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Megf8
|
UTSW |
7 |
25,041,173 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2207:Megf8
|
UTSW |
7 |
25,049,222 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2361:Megf8
|
UTSW |
7 |
25,048,379 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2680:Megf8
|
UTSW |
7 |
25,016,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3086:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Megf8
|
UTSW |
7 |
25,059,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3939:Megf8
|
UTSW |
7 |
25,058,627 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4022:Megf8
|
UTSW |
7 |
25,037,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Megf8
|
UTSW |
7 |
25,054,793 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4357:Megf8
|
UTSW |
7 |
25,055,174 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4521:Megf8
|
UTSW |
7 |
25,042,126 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4620:Megf8
|
UTSW |
7 |
25,054,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4700:Megf8
|
UTSW |
7 |
25,062,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4916:Megf8
|
UTSW |
7 |
25,039,089 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4940:Megf8
|
UTSW |
7 |
25,060,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Megf8
|
UTSW |
7 |
25,030,517 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5258:Megf8
|
UTSW |
7 |
25,047,751 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5271:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5390:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5391:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5708:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5752:Megf8
|
UTSW |
7 |
25,054,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5930:Megf8
|
UTSW |
7 |
25,025,866 (GRCm39) |
nonsense |
probably null |
|
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Megf8
|
UTSW |
7 |
25,046,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6210:Megf8
|
UTSW |
7 |
25,043,145 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6457:Megf8
|
UTSW |
7 |
25,049,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6659:Megf8
|
UTSW |
7 |
25,058,159 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6867:Megf8
|
UTSW |
7 |
25,030,460 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6896:Megf8
|
UTSW |
7 |
25,029,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6899:Megf8
|
UTSW |
7 |
25,060,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Megf8
|
UTSW |
7 |
25,037,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Megf8
|
UTSW |
7 |
25,045,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7172:Megf8
|
UTSW |
7 |
25,043,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7378:Megf8
|
UTSW |
7 |
25,048,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Megf8
|
UTSW |
7 |
25,037,796 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7492:Megf8
|
UTSW |
7 |
25,053,273 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7699:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7700:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7756:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7758:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7786:Megf8
|
UTSW |
7 |
25,017,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7797:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7881:Megf8
|
UTSW |
7 |
25,040,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8165:Megf8
|
UTSW |
7 |
25,053,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8258:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8259:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8328:Megf8
|
UTSW |
7 |
25,046,917 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8362:Megf8
|
UTSW |
7 |
25,039,943 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8680:Megf8
|
UTSW |
7 |
25,059,166 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9080:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9297:Megf8
|
UTSW |
7 |
25,030,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9314:Megf8
|
UTSW |
7 |
25,029,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9530:Megf8
|
UTSW |
7 |
25,030,124 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9557:Megf8
|
UTSW |
7 |
25,058,511 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9592:Megf8
|
UTSW |
7 |
25,028,228 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9612:Megf8
|
UTSW |
7 |
25,054,488 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9629:Megf8
|
UTSW |
7 |
25,043,194 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9643:Megf8
|
UTSW |
7 |
25,046,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Megf8
|
UTSW |
7 |
25,030,166 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9745:Megf8
|
UTSW |
7 |
25,058,133 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Z1088:Megf8
|
UTSW |
7 |
25,039,094 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Megf8
|
UTSW |
7 |
25,046,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf8
|
UTSW |
7 |
25,045,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTGAGTGGCATCAGAGC -3'
(R):5'- CAGAGTGATAAGTGCTGGGGTC -3'
Sequencing Primer
(F):5'- GAGTGGCATCAGAGCACCAAC -3'
(R):5'- GCACCCCCTAGCCAGGAAC -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation