Incidental Mutation 'R9380:Nin'
| ID |
709964 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9380 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
70058209-70160491 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 70074805 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 1859
(L1859P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082422
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021468
AA Change: L1859P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: L1859P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: L1859P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000095666
AA Change: L1859P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: L1859P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169074
AA Change: L1859P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: L1859P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220689
AA Change: L1152P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221579
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000223257
AA Change: L1859P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsl3 |
T |
G |
1: 78,659,602 (GRCm39) |
C85G |
possibly damaging |
Het |
| Alox12e |
A |
T |
11: 70,206,994 (GRCm39) |
|
probably null |
Het |
| Aoc1l2 |
T |
C |
6: 48,910,064 (GRCm39) |
I667T |
probably damaging |
Het |
| Asb10 |
A |
C |
5: 24,739,103 (GRCm39) |
|
probably null |
Het |
| B3galt9 |
G |
A |
2: 34,729,029 (GRCm39) |
C276Y |
probably damaging |
Het |
| Bcl2a1d |
G |
A |
9: 88,613,935 (GRCm39) |
|
probably benign |
Het |
| Camsap3 |
A |
T |
8: 3,653,999 (GRCm39) |
K556N |
probably benign |
Het |
| Cd300lf |
T |
A |
11: 115,015,153 (GRCm39) |
T146S |
probably benign |
Het |
| Chuk |
C |
A |
19: 44,062,958 (GRCm39) |
A744S |
unknown |
Het |
| Clint1 |
A |
T |
11: 45,742,988 (GRCm39) |
M4L |
probably benign |
Het |
| Cnot4 |
T |
C |
6: 35,029,865 (GRCm39) |
I344M |
possibly damaging |
Het |
| Cpne1 |
T |
C |
2: 155,920,721 (GRCm39) |
D135G |
probably benign |
Het |
| Csgalnact2 |
C |
A |
6: 118,105,840 (GRCm39) |
L159F |
probably damaging |
Het |
| Dnai2 |
T |
C |
11: 114,635,989 (GRCm39) |
F325L |
probably benign |
Het |
| Dnal4 |
G |
A |
15: 79,647,790 (GRCm39) |
S25L |
possibly damaging |
Het |
| Ep300 |
T |
C |
15: 81,500,245 (GRCm39) |
M515T |
unknown |
Het |
| Ewsr1 |
T |
C |
11: 5,043,730 (GRCm39) |
Y18C |
possibly damaging |
Het |
| Fam25a |
T |
C |
14: 34,073,957 (GRCm39) |
T72A |
possibly damaging |
Het |
| Flii |
T |
C |
11: 60,606,297 (GRCm39) |
Y1131C |
probably benign |
Het |
| Foxj1 |
C |
T |
11: 116,222,547 (GRCm39) |
A419T |
possibly damaging |
Het |
| Fsd1l |
A |
G |
4: 53,693,991 (GRCm39) |
T323A |
possibly damaging |
Het |
| Furin |
T |
C |
7: 80,041,506 (GRCm39) |
I551V |
probably benign |
Het |
| Gbp11 |
A |
G |
5: 105,475,202 (GRCm39) |
V382A |
probably benign |
Het |
| Gfod1 |
A |
C |
13: 43,354,320 (GRCm39) |
D218E |
probably damaging |
Het |
| Glp2r |
A |
T |
11: 67,637,572 (GRCm39) |
I153N |
possibly damaging |
Het |
| Gm11214 |
G |
T |
4: 63,580,850 (GRCm39) |
P100T |
possibly damaging |
Het |
| Gne |
A |
T |
4: 44,066,807 (GRCm39) |
F69I |
probably benign |
Het |
| Hsd3b2 |
T |
C |
3: 98,619,453 (GRCm39) |
K164R |
probably damaging |
Het |
| Hspa1b |
T |
C |
17: 35,177,170 (GRCm39) |
R272G |
probably damaging |
Het |
| Hydin |
C |
A |
8: 111,290,504 (GRCm39) |
T3321N |
probably benign |
Het |
| Impg1 |
A |
T |
9: 80,289,077 (GRCm39) |
S327T |
probably benign |
Het |
| Izumo2 |
T |
C |
7: 44,364,812 (GRCm39) |
V159A |
probably benign |
Het |
| Kat6b |
T |
C |
14: 21,678,926 (GRCm39) |
S430P |
probably damaging |
Het |
| Kcnj9 |
T |
A |
1: 172,153,447 (GRCm39) |
T226S |
probably benign |
Het |
| Kl |
T |
A |
5: 150,912,342 (GRCm39) |
M697K |
possibly damaging |
Het |
| Krt1 |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC |
15: 101,758,813 (GRCm39) |
|
probably benign |
Het |
| Lrrk1 |
G |
A |
7: 65,928,331 (GRCm39) |
P1266S |
probably damaging |
Het |
| Med13 |
A |
T |
11: 86,177,598 (GRCm39) |
N1499K |
probably benign |
Het |
| Mybbp1a |
A |
G |
11: 72,333,668 (GRCm39) |
I182V |
probably benign |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nlrp4e |
C |
G |
7: 23,020,755 (GRCm39) |
A414G |
probably benign |
Het |
| Or2y10 |
A |
G |
11: 49,454,904 (GRCm39) |
D52G |
possibly damaging |
Het |
| Or4a67 |
A |
T |
2: 88,598,530 (GRCm39) |
I43N |
probably damaging |
Het |
| Or4k1 |
C |
A |
14: 50,377,770 (GRCm39) |
G109W |
probably damaging |
Het |
| Or8b50 |
A |
G |
9: 38,518,415 (GRCm39) |
Y218C |
probably damaging |
Het |
| Osbpl8 |
T |
A |
10: 111,108,980 (GRCm39) |
S421T |
probably damaging |
Het |
| Paqr7 |
A |
G |
4: 134,234,350 (GRCm39) |
N69S |
probably damaging |
Het |
| Pcare |
A |
T |
17: 72,056,351 (GRCm39) |
S1109T |
possibly damaging |
Het |
| Pdgfrb |
G |
A |
18: 61,197,920 (GRCm39) |
G231D |
probably damaging |
Het |
| Pip5k1b |
A |
G |
19: 24,356,417 (GRCm39) |
Y174H |
probably damaging |
Het |
| Pkd1 |
T |
A |
17: 24,769,262 (GRCm39) |
L9Q |
unknown |
Het |
| Psmg4 |
A |
T |
13: 34,350,080 (GRCm39) |
T71S |
probably benign |
Het |
| Ptpn23 |
A |
G |
9: 110,221,581 (GRCm39) |
I173T |
possibly damaging |
Het |
| Qser1 |
G |
A |
2: 104,619,691 (GRCm39) |
Q284* |
probably null |
Het |
| Rcc2 |
G |
T |
4: 140,429,702 (GRCm39) |
A79S |
probably benign |
Het |
| Rgl3 |
G |
T |
9: 21,888,123 (GRCm39) |
Q464K |
probably damaging |
Het |
| Rhov |
C |
A |
2: 119,100,604 (GRCm39) |
R211L |
probably benign |
Het |
| Rp1l1 |
A |
G |
14: 64,266,475 (GRCm39) |
D687G |
probably benign |
Het |
| Selenbp2 |
A |
G |
3: 94,609,654 (GRCm39) |
I291V |
probably benign |
Het |
| Sh3glb2 |
A |
T |
2: 30,238,625 (GRCm39) |
V189E |
probably damaging |
Het |
| Slc46a2 |
A |
G |
4: 59,913,867 (GRCm39) |
I352T |
probably damaging |
Het |
| Sucla2 |
T |
A |
14: 73,828,312 (GRCm39) |
N306K |
probably benign |
Het |
| Suco |
A |
G |
1: 161,646,074 (GRCm39) |
V1209A |
possibly damaging |
Het |
| Tacc2 |
T |
A |
7: 130,226,771 (GRCm39) |
L1152Q |
possibly damaging |
Het |
| Tanc1 |
A |
T |
2: 59,665,796 (GRCm39) |
K1185M |
probably damaging |
Het |
| Tas2r114 |
A |
G |
6: 131,666,381 (GRCm39) |
F216L |
probably benign |
Het |
| Tead1 |
A |
T |
7: 112,441,105 (GRCm39) |
H78L |
possibly damaging |
Het |
| Tex12 |
T |
C |
9: 50,469,586 (GRCm39) |
I64V |
possibly damaging |
Het |
| Thap1 |
CAGCATCTGCTCGGAGCA |
CAGCA |
8: 26,650,884 (GRCm39) |
|
probably null |
Het |
| Trank1 |
A |
G |
9: 111,221,738 (GRCm39) |
E2825G |
probably benign |
Het |
| Trappc13 |
T |
A |
13: 104,280,707 (GRCm39) |
Y399F |
probably damaging |
Het |
| Trim21 |
T |
C |
7: 102,212,992 (GRCm39) |
D102G |
probably damaging |
Het |
| Trim27 |
G |
T |
13: 21,364,680 (GRCm39) |
V6L |
probably benign |
Het |
| Trim55 |
A |
G |
3: 19,728,559 (GRCm39) |
T457A |
probably benign |
Het |
| Trrap |
A |
G |
5: 144,769,981 (GRCm39) |
E2716G |
probably benign |
Het |
| Usp10 |
T |
G |
8: 120,682,943 (GRCm39) |
L712R |
probably damaging |
Het |
| Vldlr |
T |
A |
19: 27,216,192 (GRCm39) |
C338S |
possibly damaging |
Het |
| Zfp946 |
A |
G |
17: 22,673,680 (GRCm39) |
I145V |
probably benign |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,076,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,073,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,061,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,103,532 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,078,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,092,188 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,089,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,090,439 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,109,473 (GRCm39) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,092,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,103,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,149,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,090,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,067,706 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,082,044 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,078,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,073,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,103,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,076,887 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,107,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,067,736 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,090,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,064,424 (GRCm39) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,090,958 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,061,547 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,101,253 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,085,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,078,512 (GRCm39) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,089,443 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,092,337 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,077,712 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,089,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,090,569 (GRCm39) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,077,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,072,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,076,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,089,192 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,092,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,108,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,101,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,109,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,085,456 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,089,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,125,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,097,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,097,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,061,712 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,089,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,089,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,085,375 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,090,581 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,137,325 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,090,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,089,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,124,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,092,375 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,077,692 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,092,298 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,066,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,090,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,061,631 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,092,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,091,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,101,308 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,102,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,107,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,077,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,149,573 (GRCm39) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,091,013 (GRCm39) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,090,508 (GRCm39) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,090,838 (GRCm39) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,102,803 (GRCm39) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,124,997 (GRCm39) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,109,480 (GRCm39) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,124,956 (GRCm39) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,090,004 (GRCm39) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,089,591 (GRCm39) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,089,672 (GRCm39) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,076,795 (GRCm39) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,077,787 (GRCm39) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,067,793 (GRCm39) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,077,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,124,932 (GRCm39) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,076,786 (GRCm39) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,137,349 (GRCm39) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,102,762 (GRCm39) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,067,618 (GRCm39) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,149,468 (GRCm39) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,089,899 (GRCm39) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,094,009 (GRCm39) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,095,938 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,101,200 (GRCm39) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,090,869 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGGCAGCTAAGCAATTTGAATG -3'
(R):5'- TCCAATTCTCTGTCCAGGACTG -3'
Sequencing Primer
(F):5'- ACCAGTTAGTAATTTAATATGAGGGC -3'
(R):5'- ACTGGGTCTCGGAAACAGCTC -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation