Incidental Mutation 'R9381:Strip2'
ID 710011
Institutional Source Beutler Lab
Gene Symbol Strip2
Ensembl Gene ENSMUSG00000039629
Gene Name striatin interacting protein 2
Synonyms Myoscape, D330017J20Rik, Fam40b
MMRRC Submission 068992-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R9381 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 29917011-29959680 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 29927333 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 192 (S192P)
Ref Sequence ENSEMBL: ENSMUSP00000036477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046028] [ENSMUST00000115224] [ENSMUST00000151738]
AlphaFold Q8C9H6
Predicted Effect probably benign
Transcript: ENSMUST00000046028
AA Change: S192P

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000036477
Gene: ENSMUSG00000039629
AA Change: S192P

DomainStartEndE-ValueType
low complexity region 2 40 N/A INTRINSIC
N1221 57 364 1.68e-132 SMART
low complexity region 376 394 N/A INTRINSIC
low complexity region 398 419 N/A INTRINSIC
DUF3402 466 822 4.98e-199 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000115224
AA Change: S192P

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000110879
Gene: ENSMUSG00000039629
AA Change: S192P

DomainStartEndE-ValueType
low complexity region 2 40 N/A INTRINSIC
N1221 57 364 1.68e-132 SMART
low complexity region 376 394 N/A INTRINSIC
low complexity region 398 419 N/A INTRINSIC
DUF3402 466 662 4.85e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151738
AA Change: S192P

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000119506
Gene: ENSMUSG00000039629
AA Change: S192P

DomainStartEndE-ValueType
low complexity region 2 40 N/A INTRINSIC
N1221 57 364 1.68e-132 SMART
low complexity region 376 394 N/A INTRINSIC
low complexity region 398 419 N/A INTRINSIC
DUF3402 466 794 1.72e-161 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002D01Rik CCTTCTCCTTCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC CCTTCTCCTTCTTCTCCTTCTTCTCCATCTTCTCCTTCTTC 7: 28,947,048 (GRCm39) probably benign Het
9930111J21Rik1 T A 11: 48,839,204 (GRCm39) K461M probably damaging Het
Abhd16b A G 2: 181,135,881 (GRCm39) Y261C probably damaging Het
Acadl T C 1: 66,893,805 (GRCm39) T117A probably benign Het
Adamts15 A G 9: 30,813,816 (GRCm39) V783A probably damaging Het
Aff1 A T 5: 103,981,733 (GRCm39) Q624L possibly damaging Het
Afg3l2 T G 18: 67,575,451 (GRCm39) E74A probably damaging Het
Aig1 T C 10: 13,523,417 (GRCm39) E238G probably benign Het
Ankrd17 C T 5: 90,416,508 (GRCm39) R1108Q probably damaging Het
Anks1 A T 17: 28,272,979 (GRCm39) Y958F probably damaging Het
Arhgef28 C A 13: 98,036,269 (GRCm39) Q1663H possibly damaging Het
Asb3 T C 11: 31,051,088 (GRCm39) L475P probably damaging Het
Atg9a T A 1: 75,162,726 (GRCm39) M430L probably benign Het
Bco1 T A 8: 117,837,631 (GRCm39) V164E probably benign Het
Bhlhe40 T C 6: 108,642,244 (GRCm39) L396P probably damaging Het
C5ar2 A T 7: 15,970,887 (GRCm39) S347T probably damaging Het
Cdc42bpa T C 1: 179,969,048 (GRCm39) S1212P probably damaging Het
Ceacam3 C G 7: 16,893,715 (GRCm39) Q409E Het
Ces3b T C 8: 105,811,670 (GRCm39) V62A probably benign Het
Dalrd3 A G 9: 108,448,242 (GRCm39) probably null Het
Ddhd2 G T 8: 26,239,849 (GRCm39) A288E probably benign Het
Dnah17 T A 11: 117,914,219 (GRCm39) M4435L probably benign Het
Dok1 T C 6: 83,009,972 (GRCm39) K46E probably damaging Het
E030025P04Rik A G 11: 109,030,384 (GRCm39) Y168H unknown Het
Elavl2 T C 4: 91,197,009 (GRCm39) N23S probably benign Het
Elfn1 T C 5: 139,959,462 (GRCm39) V822A probably damaging Het
Emb G T 13: 117,357,096 (GRCm39) probably benign Het
Exoc5 C T 14: 49,275,194 (GRCm39) S202N probably benign Het
Fryl T C 5: 73,240,637 (GRCm39) D1321G probably benign Het
Gm12258 C T 11: 58,750,007 (GRCm39) T394I unknown Het
Gm28363 T A 1: 117,654,615 (GRCm39) S85T probably damaging Het
H2-Q1 A G 17: 35,542,138 (GRCm39) T237A probably damaging Het
Hectd4 A T 5: 121,472,492 (GRCm39) I2743F possibly damaging Het
Hs3st3b1 C T 11: 63,812,692 (GRCm39) G8S probably benign Het
Ighv1-16 T C 12: 114,629,598 (GRCm39) N63S probably benign Het
Il20rb A G 9: 100,343,541 (GRCm39) F238L possibly damaging Het
Il31ra A T 13: 112,668,253 (GRCm39) F439I possibly damaging Het
Jup C T 11: 100,270,391 (GRCm39) C372Y probably damaging Het
Kat2a T C 11: 100,602,692 (GRCm39) Q132R possibly damaging Het
Kcnq2 A G 2: 180,751,562 (GRCm39) I278T probably damaging Het
Lama1 T C 17: 68,044,479 (GRCm39) V126A Het
Lama2 T A 10: 27,064,023 (GRCm39) R1285* probably null Het
Larp1 A G 11: 57,949,532 (GRCm39) T1054A probably benign Het
Lrp1 A T 10: 127,441,337 (GRCm39) M262K probably benign Het
Lrrd1 A G 5: 3,901,074 (GRCm39) I460V probably benign Het
Ltbp1 A T 17: 75,696,434 (GRCm39) N1606I probably damaging Het
Mdga2 T C 12: 66,597,304 (GRCm39) N730S possibly damaging Het
Mpzl1 T C 1: 165,429,323 (GRCm39) H236R probably damaging Het
Mrps31 G A 8: 22,904,752 (GRCm39) R47K probably damaging Het
Nae1 A T 8: 105,250,239 (GRCm39) I218K probably benign Het
Npy2r T C 3: 82,448,356 (GRCm39) T140A probably damaging Het
Nr2e1 T A 10: 42,439,468 (GRCm39) L350F probably damaging Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Or51d1 A T 7: 102,347,654 (GRCm39) M70L probably damaging Het
Or5b124 G T 19: 13,610,647 (GRCm39) M57I probably damaging Het
Or5p50 A C 7: 107,421,812 (GRCm39) L288W probably damaging Het
Pabpc1l G T 2: 163,867,423 (GRCm39) C8F probably benign Het
Pafah1b3 A C 7: 24,994,699 (GRCm39) F172V probably benign Het
Pcdhga6 A T 18: 37,841,371 (GRCm39) T364S probably damaging Het
Ppp3cc T A 14: 70,462,441 (GRCm39) M399L probably benign Het
Prpsap2 T C 11: 61,635,782 (GRCm39) I173V probably benign Het
Rabggtb A T 3: 153,613,817 (GRCm39) W252R probably damaging Het
Raph1 A G 1: 60,540,959 (GRCm39) F351L unknown Het
Rasd2 T C 8: 75,948,589 (GRCm39) S172P probably damaging Het
Rbm15 T C 3: 107,238,752 (GRCm39) T549A probably benign Het
Reln A G 5: 22,549,202 (GRCm39) Y69H possibly damaging Het
Samd3 T A 10: 26,147,643 (GRCm39) N439K probably benign Het
Scap C A 9: 110,207,839 (GRCm39) A516D probably damaging Het
Selplg T C 5: 113,957,917 (GRCm39) T130A probably benign Het
Slc12a7 A G 13: 73,949,063 (GRCm39) M697V probably benign Het
Slc22a29 A G 19: 8,195,841 (GRCm39) I66T probably benign Het
Slco1a7 T C 6: 141,711,490 (GRCm39) I74V probably benign Het
Snrnp48 A C 13: 38,404,667 (GRCm39) I241L probably damaging Het
Sptb C T 12: 76,634,292 (GRCm39) E2140K probably benign Het
Svil A T 18: 5,099,013 (GRCm39) R1643S probably benign Het
Tbc1d2b A G 9: 90,101,139 (GRCm39) V617A possibly damaging Het
Tmem102 T C 11: 69,695,141 (GRCm39) E277G probably benign Het
Tmtc4 T G 14: 123,163,441 (GRCm39) I648L probably benign Het
Togaram1 T C 12: 65,014,204 (GRCm39) V485A probably damaging Het
Trim43b T C 9: 88,969,642 (GRCm39) I269V probably benign Het
Trpm2 T A 10: 77,747,191 (GRCm39) I1436F possibly damaging Het
Ube2d3 A T 3: 135,168,722 (GRCm39) I106F possibly damaging Het
Vdr G A 15: 97,755,333 (GRCm39) R397C probably damaging Het
Vps50 T C 6: 3,592,433 (GRCm39) S689P probably benign Het
Wipf2 A G 11: 98,787,068 (GRCm39) T366A probably damaging Het
Zfp128 T C 7: 12,624,897 (GRCm39) Y422H possibly damaging Het
Zfyve28 G A 5: 34,373,932 (GRCm39) T694I probably benign Het
Other mutations in Strip2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Strip2 APN 6 29,931,213 (GRCm39) missense probably benign 0.04
IGL01357:Strip2 APN 6 29,939,166 (GRCm39) splice site probably benign
IGL01636:Strip2 APN 6 29,931,192 (GRCm39) missense probably benign 0.06
IGL01959:Strip2 APN 6 29,928,553 (GRCm39) missense probably damaging 0.99
IGL01961:Strip2 APN 6 29,928,426 (GRCm39) splice site probably benign
IGL02089:Strip2 APN 6 29,917,179 (GRCm39) unclassified probably benign
1mM(1):Strip2 UTSW 6 29,955,630 (GRCm39) missense probably damaging 1.00
R0079:Strip2 UTSW 6 29,920,532 (GRCm39) critical splice donor site probably null
R0331:Strip2 UTSW 6 29,926,559 (GRCm39) missense probably benign 0.44
R0367:Strip2 UTSW 6 29,937,650 (GRCm39) missense possibly damaging 0.90
R0592:Strip2 UTSW 6 29,931,209 (GRCm39) missense probably benign 0.28
R1087:Strip2 UTSW 6 29,927,633 (GRCm39) missense probably damaging 0.99
R1390:Strip2 UTSW 6 29,929,828 (GRCm39) missense probably damaging 1.00
R1758:Strip2 UTSW 6 29,941,940 (GRCm39) critical splice donor site probably null
R2213:Strip2 UTSW 6 29,931,147 (GRCm39) missense probably damaging 0.99
R2437:Strip2 UTSW 6 29,941,940 (GRCm39) critical splice donor site probably null
R2900:Strip2 UTSW 6 29,939,034 (GRCm39) critical splice acceptor site probably null
R3892:Strip2 UTSW 6 29,917,074 (GRCm39) unclassified probably benign
R4010:Strip2 UTSW 6 29,955,584 (GRCm39) missense possibly damaging 0.66
R4435:Strip2 UTSW 6 29,925,049 (GRCm39) missense probably benign 0.06
R4807:Strip2 UTSW 6 29,925,092 (GRCm39) nonsense probably null
R5015:Strip2 UTSW 6 29,931,265 (GRCm39) missense probably benign 0.03
R5080:Strip2 UTSW 6 29,945,592 (GRCm39) missense probably damaging 0.99
R5484:Strip2 UTSW 6 29,917,154 (GRCm39) unclassified probably benign
R5502:Strip2 UTSW 6 29,927,623 (GRCm39) missense probably benign 0.23
R5899:Strip2 UTSW 6 29,956,957 (GRCm39) utr 3 prime probably benign
R6004:Strip2 UTSW 6 29,926,570 (GRCm39) missense probably damaging 0.98
R6479:Strip2 UTSW 6 29,944,496 (GRCm39) splice site probably null
R6835:Strip2 UTSW 6 29,941,916 (GRCm39) missense probably damaging 1.00
R7068:Strip2 UTSW 6 29,932,207 (GRCm39) missense probably benign 0.03
R7073:Strip2 UTSW 6 29,941,911 (GRCm39) missense possibly damaging 0.95
R7088:Strip2 UTSW 6 29,920,532 (GRCm39) critical splice donor site probably null
R7231:Strip2 UTSW 6 29,944,486 (GRCm39) missense probably damaging 0.96
R7399:Strip2 UTSW 6 29,927,612 (GRCm39) missense possibly damaging 0.94
R7813:Strip2 UTSW 6 29,923,912 (GRCm39) critical splice acceptor site probably null
R7827:Strip2 UTSW 6 29,923,928 (GRCm39) missense probably benign 0.18
R8354:Strip2 UTSW 6 29,920,531 (GRCm39) critical splice donor site probably null
R8723:Strip2 UTSW 6 29,941,863 (GRCm39) missense probably damaging 1.00
R8750:Strip2 UTSW 6 29,931,815 (GRCm39) missense probably damaging 0.96
R8793:Strip2 UTSW 6 29,956,815 (GRCm39) missense probably benign 0.27
R8843:Strip2 UTSW 6 29,923,968 (GRCm39) missense probably benign 0.44
R9175:Strip2 UTSW 6 29,933,035 (GRCm39) missense probably benign 0.01
R9336:Strip2 UTSW 6 29,931,824 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCCTGTCTTCACCATACATGAG -3'
(R):5'- TCGTAAGAGATGCCCAAGGC -3'

Sequencing Primer
(F):5'- GAGGATTTCAAAGGTCTACAGGTTCC -3'
(R):5'- CCAGTAGTTCCAGACTTCAAGGATG -3'
Posted On 2022-04-18