Incidental Mutation 'R9382:Vmn2r88'
| ID |
710116 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r88
|
| Ensembl Gene |
ENSMUSG00000000606 |
| Gene Name |
vomeronasal 2, receptor 88 |
| Synonyms |
V2r13, V2r3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
R9382 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
51648458-51656984 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 51656197 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 802
(V802G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125126
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022438]
[ENSMUST00000159674]
[ENSMUST00000162998]
[ENSMUST00000228139]
|
| AlphaFold |
L7N1W8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022438
AA Change: V811G
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000022438
Gene: ENSMUSG00000000606
AA Change: V811G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
457 |
8.3e-27 |
PFAM |
|
Pfam:NCD3G
|
516 |
570 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
1.9e-55 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000125126
Gene: ENSMUSG00000000606
AA Change: V802G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
30 |
408 |
3.2e-30 |
PFAM |
|
Pfam:NCD3G
|
463 |
516 |
1.2e-19 |
PFAM |
|
Pfam:7tm_3
|
546 |
785 |
3.7e-81 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162998
|
| SMART Domains |
Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Takusan
|
35 |
115 |
2.2e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163019
|
| SMART Domains |
Protein: ENSMUSP00000124837
Gene: ENSMUSG00000000606
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
52 |
399 |
3.7e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228139
AA Change: V803G
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
A |
11: 109,870,711 (GRCm39) |
S147L |
probably benign |
Het |
| Abraxas1 |
A |
G |
5: 100,957,649 (GRCm39) |
V190A |
probably benign |
Het |
| Aoc1l2 |
A |
T |
6: 48,907,298 (GRCm39) |
K99N |
probably benign |
Het |
| Aox1 |
T |
A |
1: 58,104,501 (GRCm39) |
H559Q |
possibly damaging |
Het |
| Arhgap31 |
C |
T |
16: 38,422,988 (GRCm39) |
G1026D |
probably benign |
Het |
| C1ra |
T |
C |
6: 124,490,819 (GRCm39) |
F71L |
probably benign |
Het |
| C530025M09Rik |
T |
C |
2: 149,672,640 (GRCm39) |
H165R |
unknown |
Het |
| Celf2 |
A |
T |
2: 6,726,404 (GRCm39) |
M43K |
probably damaging |
Het |
| Celsr3 |
T |
C |
9: 108,706,961 (GRCm39) |
V1148A |
possibly damaging |
Het |
| Cmya5 |
T |
G |
13: 93,229,884 (GRCm39) |
K1735Q |
probably benign |
Het |
| Cntln |
A |
C |
4: 84,968,318 (GRCm39) |
M846L |
probably benign |
Het |
| Cntn5 |
T |
C |
9: 9,673,817 (GRCm39) |
T762A |
probably benign |
Het |
| Col11a1 |
T |
A |
3: 113,899,046 (GRCm39) |
L525Q |
unknown |
Het |
| Col12a1 |
T |
C |
9: 79,589,364 (GRCm39) |
T1064A |
probably benign |
Het |
| Cyc1 |
T |
C |
15: 76,229,273 (GRCm39) |
V211A |
possibly damaging |
Het |
| Ddx56 |
A |
G |
11: 6,215,516 (GRCm39) |
S296P |
probably damaging |
Het |
| Deptor |
A |
T |
15: 54,975,798 (GRCm39) |
|
probably benign |
Het |
| Ezh1 |
C |
T |
11: 101,094,265 (GRCm39) |
R409H |
possibly damaging |
Het |
| Fam228b |
T |
A |
12: 4,798,147 (GRCm39) |
E190V |
probably damaging |
Het |
| Fkbp15 |
A |
T |
4: 62,237,210 (GRCm39) |
L635H |
probably damaging |
Het |
| Frem1 |
G |
A |
4: 82,901,622 (GRCm39) |
L969F |
possibly damaging |
Het |
| Gabrg2 |
T |
C |
11: 41,858,433 (GRCm39) |
R232G |
probably benign |
Het |
| Gpr26 |
G |
A |
7: 131,568,963 (GRCm39) |
D103N |
probably damaging |
Het |
| Grid2ip |
T |
G |
5: 143,361,103 (GRCm39) |
|
probably null |
Het |
| Ints7 |
T |
C |
1: 191,351,793 (GRCm39) |
V834A |
probably damaging |
Het |
| Kcnh7 |
T |
A |
2: 62,667,612 (GRCm39) |
H309L |
probably benign |
Het |
| Mael |
T |
C |
1: 166,053,282 (GRCm39) |
E241G |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,122,277 (GRCm39) |
E584V |
|
Het |
| Nexn |
C |
T |
3: 151,959,401 (GRCm39) |
V23M |
probably damaging |
Het |
| Npas1 |
T |
C |
7: 16,190,231 (GRCm39) |
|
probably null |
Het |
| Or51f1 |
T |
C |
7: 102,506,014 (GRCm39) |
I158M |
probably benign |
Het |
| Pcdh17 |
T |
G |
14: 84,685,522 (GRCm39) |
V663G |
probably damaging |
Het |
| Pga5 |
C |
T |
19: 10,646,897 (GRCm39) |
G303S |
probably damaging |
Het |
| Poln |
T |
A |
5: 34,164,842 (GRCm39) |
K844N |
probably damaging |
Het |
| Prkar1b |
C |
T |
5: 139,036,442 (GRCm39) |
D227N |
probably damaging |
Het |
| Proc |
T |
A |
18: 32,256,336 (GRCm39) |
I444F |
probably damaging |
Het |
| Ptprn |
G |
T |
1: 75,229,135 (GRCm39) |
H791N |
probably benign |
Het |
| Ror1 |
T |
C |
4: 100,191,709 (GRCm39) |
S160P |
probably benign |
Het |
| Satb2 |
T |
A |
1: 56,870,797 (GRCm39) |
|
probably null |
Het |
| Slc43a3 |
C |
T |
2: 84,780,771 (GRCm39) |
A332V |
probably benign |
Het |
| Sp100 |
G |
A |
1: 85,627,336 (GRCm39) |
V410M |
probably damaging |
Het |
| Srgap2 |
T |
C |
1: 131,217,346 (GRCm39) |
T989A |
probably benign |
Het |
| Ssc5d |
T |
C |
7: 4,930,283 (GRCm39) |
|
probably null |
Het |
| Tll2 |
A |
G |
19: 41,116,997 (GRCm39) |
Y273H |
probably benign |
Het |
| Tub |
T |
C |
7: 108,626,211 (GRCm39) |
V295A |
possibly damaging |
Het |
| Unc13b |
T |
A |
4: 43,172,512 (GRCm39) |
D1113E |
unknown |
Het |
| Usp9y |
C |
A |
Y: 1,364,776 (GRCm39) |
M1012I |
probably benign |
Het |
| Vmn1r238 |
A |
G |
18: 3,122,676 (GRCm39) |
V246A |
probably damaging |
Het |
| Wnt7b |
T |
C |
15: 85,443,175 (GRCm39) |
Q76R |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,389,917 (GRCm39) |
R4852G |
unknown |
Het |
| Zfp618 |
A |
T |
4: 63,051,258 (GRCm39) |
T680S |
probably damaging |
Het |
| Zfp784 |
T |
A |
7: 5,041,338 (GRCm39) |
D25V |
unknown |
Het |
|
| Other mutations in Vmn2r88 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r88
|
APN |
14 |
51,650,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,650,517 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,650,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r88
|
APN |
14 |
51,654,259 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02308:Vmn2r88
|
APN |
14 |
51,655,437 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02481:Vmn2r88
|
APN |
14 |
51,651,611 (GRCm39) |
missense |
probably benign |
|
|
IGL02483:Vmn2r88
|
APN |
14 |
51,651,611 (GRCm39) |
missense |
probably benign |
|
|
IGL03241:Vmn2r88
|
APN |
14 |
51,655,830 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0052:Vmn2r88
|
UTSW |
14 |
51,656,157 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0070:Vmn2r88
|
UTSW |
14 |
51,651,597 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0799:Vmn2r88
|
UTSW |
14 |
51,651,959 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0906:Vmn2r88
|
UTSW |
14 |
51,655,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1322:Vmn2r88
|
UTSW |
14 |
51,651,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1352:Vmn2r88
|
UTSW |
14 |
51,656,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1639:Vmn2r88
|
UTSW |
14 |
51,654,244 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1780:Vmn2r88
|
UTSW |
14 |
51,656,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r88
|
UTSW |
14 |
51,650,487 (GRCm39) |
splice site |
probably benign |
|
|
R1911:Vmn2r88
|
UTSW |
14 |
51,655,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2113:Vmn2r88
|
UTSW |
14 |
51,655,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2120:Vmn2r88
|
UTSW |
14 |
51,650,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2126:Vmn2r88
|
UTSW |
14 |
51,651,264 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2348:Vmn2r88
|
UTSW |
14 |
51,651,461 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2881:Vmn2r88
|
UTSW |
14 |
51,656,146 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2884:Vmn2r88
|
UTSW |
14 |
51,651,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3081:Vmn2r88
|
UTSW |
14 |
51,656,089 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3933:Vmn2r88
|
UTSW |
14 |
51,651,435 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3967:Vmn2r88
|
UTSW |
14 |
51,650,647 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4091:Vmn2r88
|
UTSW |
14 |
51,652,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4378:Vmn2r88
|
UTSW |
14 |
51,650,746 (GRCm39) |
nonsense |
probably null |
|
|
R4397:Vmn2r88
|
UTSW |
14 |
51,655,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4418:Vmn2r88
|
UTSW |
14 |
51,655,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4609:Vmn2r88
|
UTSW |
14 |
51,655,531 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4647:Vmn2r88
|
UTSW |
14 |
51,656,250 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4672:Vmn2r88
|
UTSW |
14 |
51,655,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4684:Vmn2r88
|
UTSW |
14 |
51,650,791 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4686:Vmn2r88
|
UTSW |
14 |
51,650,796 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4720:Vmn2r88
|
UTSW |
14 |
51,650,702 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5046:Vmn2r88
|
UTSW |
14 |
51,650,638 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5063:Vmn2r88
|
UTSW |
14 |
51,648,603 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5619:Vmn2r88
|
UTSW |
14 |
51,651,367 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5652:Vmn2r88
|
UTSW |
14 |
51,656,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6020:Vmn2r88
|
UTSW |
14 |
51,655,606 (GRCm39) |
nonsense |
probably null |
|
|
R6103:Vmn2r88
|
UTSW |
14 |
51,652,826 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6674:Vmn2r88
|
UTSW |
14 |
51,651,795 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6799:Vmn2r88
|
UTSW |
14 |
51,651,426 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7089:Vmn2r88
|
UTSW |
14 |
51,656,100 (GRCm39) |
missense |
|
|
|
R7104:Vmn2r88
|
UTSW |
14 |
51,651,253 (GRCm39) |
missense |
|
|
|
R7265:Vmn2r88
|
UTSW |
14 |
51,655,776 (GRCm39) |
missense |
|
|
|
R7316:Vmn2r88
|
UTSW |
14 |
51,651,712 (GRCm39) |
missense |
|
|
|
R7552:Vmn2r88
|
UTSW |
14 |
51,648,315 (GRCm39) |
splice site |
probably null |
|
|
R7611:Vmn2r88
|
UTSW |
14 |
51,651,454 (GRCm39) |
missense |
|
|
|
R7667:Vmn2r88
|
UTSW |
14 |
51,655,446 (GRCm39) |
missense |
|
|
|
R7682:Vmn2r88
|
UTSW |
14 |
51,655,906 (GRCm39) |
missense |
|
|
|
R7755:Vmn2r88
|
UTSW |
14 |
51,650,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7811:Vmn2r88
|
UTSW |
14 |
51,656,160 (GRCm39) |
missense |
|
|
|
R7882:Vmn2r88
|
UTSW |
14 |
51,650,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7957:Vmn2r88
|
UTSW |
14 |
51,650,589 (GRCm39) |
missense |
|
|
|
R7998:Vmn2r88
|
UTSW |
14 |
51,651,565 (GRCm39) |
missense |
|
|
|
R8142:Vmn2r88
|
UTSW |
14 |
51,651,564 (GRCm39) |
missense |
|
|
|
R8186:Vmn2r88
|
UTSW |
14 |
51,656,157 (GRCm39) |
missense |
|
|
|
R8348:Vmn2r88
|
UTSW |
14 |
51,656,253 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8448:Vmn2r88
|
UTSW |
14 |
51,656,253 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8483:Vmn2r88
|
UTSW |
14 |
51,650,530 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8783:Vmn2r88
|
UTSW |
14 |
51,651,523 (GRCm39) |
missense |
|
|
|
R8859:Vmn2r88
|
UTSW |
14 |
51,656,263 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8916:Vmn2r88
|
UTSW |
14 |
51,648,593 (GRCm39) |
missense |
|
|
|
R8936:Vmn2r88
|
UTSW |
14 |
51,655,983 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9004:Vmn2r88
|
UTSW |
14 |
51,650,624 (GRCm39) |
missense |
|
|
|
R9038:Vmn2r88
|
UTSW |
14 |
51,651,490 (GRCm39) |
missense |
|
|
|
R9063:Vmn2r88
|
UTSW |
14 |
51,648,329 (GRCm39) |
start gained |
probably benign |
|
|
R9311:Vmn2r88
|
UTSW |
14 |
51,650,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9483:Vmn2r88
|
UTSW |
14 |
51,648,641 (GRCm39) |
missense |
|
|
|
R9602:Vmn2r88
|
UTSW |
14 |
51,651,189 (GRCm39) |
missense |
|
|
|
V5622:Vmn2r88
|
UTSW |
14 |
51,650,584 (GRCm39) |
missense |
probably benign |
|
|
X0024:Vmn2r88
|
UTSW |
14 |
51,651,289 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
X0025:Vmn2r88
|
UTSW |
14 |
51,654,259 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Vmn2r88
|
UTSW |
14 |
51,655,644 (GRCm39) |
missense |
|
|
|
Z1177:Vmn2r88
|
UTSW |
14 |
51,655,503 (GRCm39) |
frame shift |
probably null |
|
|
Z1190:Vmn2r88
|
UTSW |
14 |
51,650,658 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTTCCATGTTGTCCTGGGATACTTG -3'
(R):5'- AGACAGTTCTGTCCTGTTTGTAAG -3'
Sequencing Primer
(F):5'- TCCTGGGATACTTGGGCTCC -3'
(R):5'- CTGTCCTGTTTGTAAGTTCAAATTTG -3'
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| Posted On |
2022-04-18 |
Incidental Mutation