Mutagenetix > Incidental Mutation

Incidental Mutation 'R9382:Vmn1r238'

710122

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R9382 (G1)

Quality Score

205.009

Status

Not validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 3122676 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 246 (V246A)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably damaging
Transcript: ENSMUST00000165255
AA Change: V246A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: V246A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600015I10Rik	A	T	6: 48,930,364	K99N	probably benign	Het
Abca8b	G	A	11: 109,979,885	S147L	probably benign	Het
Abraxas1	A	G	5: 100,809,783	V190A	probably benign	Het
Aox1	T	A	1: 58,065,342	H559Q	possibly damaging	Het
Arhgap31	C	T	16: 38,602,626	G1026D	probably benign	Het
C1ra	T	C	6: 124,513,860	F71L	probably benign	Het
C530025M09Rik	T	C	2: 149,830,720	H165R	unknown	Het
Celf2	A	T	2: 6,721,593	M43K	probably damaging	Het
Celsr3	T	C	9: 108,829,762	V1148A	possibly damaging	Het
Cmya5	T	G	13: 93,093,376	K1735Q	probably benign	Het
Cntln	A	C	4: 85,050,081	M846L	probably benign	Het
Cntn5	T	C	9: 9,673,812	T762A	probably benign	Het
Col11a1	T	A	3: 114,105,397	L525Q	unknown	Het
Col12a1	T	C	9: 79,682,082	T1064A	probably benign	Het
Cyc1	T	C	15: 76,345,073	V211A	possibly damaging	Het
Ddx56	A	G	11: 6,265,516	S296P	probably damaging	Het
Deptor	A	T	15: 55,112,402		probably benign	Het
Ezh1	C	T	11: 101,203,439	R409H	possibly damaging	Het
Fam228b	T	A	12: 4,748,147	E190V	probably damaging	Het
Fkbp15	A	T	4: 62,318,973	L635H	probably damaging	Het
Frem1	G	A	4: 82,983,385	L969F	possibly damaging	Het
Gabrg2	T	C	11: 41,967,606	R232G	probably benign	Het
Gpr26	G	A	7: 131,967,234	D103N	probably damaging	Het
Grid2ip	T	G	5: 143,375,348		probably null	Het
Ints7	T	C	1: 191,619,681	V834A	probably damaging	Het
Kcnh7	T	A	2: 62,837,268	H309L	probably benign	Het
Mael	T	C	1: 166,225,713	E241G	probably damaging	Het
Neb	T	A	2: 52,232,265	E584V		Het
Nexn	C	T	3: 152,253,764	V23M	probably damaging	Het
Npas1	T	C	7: 16,456,306		probably null	Het
Olfr566	T	C	7: 102,856,807	I158M	probably benign	Het
Pcdh17	T	G	14: 84,448,082	V663G	probably damaging	Het
Pga5	C	T	19: 10,669,533	G303S	probably damaging	Het
Poln	T	A	5: 34,007,498	K844N	probably damaging	Het
Prkar1b	C	T	5: 139,050,687	D227N	probably damaging	Het
Proc	T	A	18: 32,123,283	I444F	probably damaging	Het
Ptprn	G	T	1: 75,252,491	H791N	probably benign	Het
Ror1	T	C	4: 100,334,512	S160P	probably benign	Het
Satb2	T	A	1: 56,831,638		probably null	Het
Slc43a3	C	T	2: 84,950,427	A332V	probably benign	Het
Sp100	G	A	1: 85,699,615	V410M	probably damaging	Het
Srgap2	T	C	1: 131,289,608	T989A	probably benign	Het
Ssc5d	T	C	7: 4,927,284		probably null	Het
Tll2	A	G	19: 41,128,558	Y273H	probably benign	Het
Tub	T	C	7: 109,027,004	V295A	possibly damaging	Het
Unc13b	T	A	4: 43,172,512	D1113E	unknown	Het
Usp9y	C	A	Y: 1,364,776	M1012I	probably benign	Het
Vmn2r88	T	G	14: 51,418,740	V802G		Het
Wnt7b	T	C	15: 85,558,974	Q76R	probably damaging	Het
Zan	T	C	5: 137,391,655	R4852G	unknown	Het
Zfp618	A	T	4: 63,133,021	T680S	probably damaging	Het
Zfp784	T	A	7: 5,038,339	D25V	unknown	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AAGAAGTTATCTCTTACCTAAGCAGGG -3'
(R):5'- TGCTTCTGACAGTGTAGCAAC -3'

Sequencing Primer
(F):5'- CCTAAGCAGGGTAAAAACAGATTG -3'
(R):5'- ATCTTTAGTGTGCTTCTCTGATGTC -3'

Posted On

2022-04-18