Incidental Mutation 'R9384:Igkv7-33'
ID 710202
Institutional Source Beutler Lab
Gene Symbol Igkv7-33
Ensembl Gene ENSMUSG00000076575
Gene Name immunoglobulin kappa chain variable 7-33
Synonyms U29423
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R9384 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 70035616-70036183 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 70036174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 4 (Q4K)
Ref Sequence ENSEMBL: ENSMUSP00000142396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103376] [ENSMUST00000197429]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000103376
AA Change: Q4K

PolyPhen 2 Score 0.673 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000100177
Gene: ENSMUSG00000076575
AA Change: Q4K

DomainStartEndE-ValueType
IGv 37 115 1.01e-17 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000197429
AA Change: Q4K

PolyPhen 2 Score 0.679 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000142396
Gene: ENSMUSG00000076575
AA Change: Q4K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IGv 38 116 4.1e-20 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 G A 4: 128,655,851 (GRCm39) C73Y probably damaging Het
Agrn C T 4: 156,257,106 (GRCm39) A1213T probably damaging Het
Arhgef10 T C 8: 15,041,067 (GRCm39) L1079P probably damaging Het
Cdcp3 T C 7: 130,904,404 (GRCm39) V2374A unknown Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Coro6 A G 11: 77,360,218 (GRCm39) E436G probably benign Het
D430041D05Rik A G 2: 104,087,920 (GRCm39) V352A probably benign Het
Dcbld2 C T 16: 58,285,926 (GRCm39) T695I probably damaging Het
Dclk1 A C 3: 55,154,936 (GRCm39) Q122P possibly damaging Het
Dsel C A 1: 111,787,863 (GRCm39) E891* probably null Het
Eral1 A T 11: 77,969,130 (GRCm39) N123K probably damaging Het
Fzd6 C A 15: 38,895,102 (GRCm39) L423M probably damaging Het
Fzd6 T G 15: 38,895,103 (GRCm39) L423R probably damaging Het
Galntl6 G T 8: 58,415,461 (GRCm39) L231I probably damaging Het
Gm7137 A G 10: 77,623,614 (GRCm39) S141P unknown Het
Grm5 T C 7: 87,723,518 (GRCm39) Y603H probably damaging Het
Hcar2 A T 5: 124,002,597 (GRCm39) F302Y probably benign Het
Hs3st1 T G 5: 39,771,962 (GRCm39) D227A possibly damaging Het
Itprid1 A T 6: 55,952,613 (GRCm39) Q852L probably damaging Het
Kcp C T 6: 29,496,618 (GRCm39) probably null Het
Lrrc23 T C 6: 124,755,189 (GRCm39) K116R possibly damaging Het
Lrriq1 T A 10: 103,006,458 (GRCm39) R1222S probably benign Het
Nav3 T A 10: 109,554,158 (GRCm39) I1735F probably damaging Het
Neto1 A T 18: 86,413,965 (GRCm39) probably benign Het
Nlrp9a T A 7: 26,258,158 (GRCm39) L592Q probably damaging Het
Or1e30 C A 11: 73,677,796 (GRCm39) Q11K probably benign Het
Or5t7 T A 2: 86,507,357 (GRCm39) T107S probably benign Het
Pcdhb20 T A 18: 37,638,024 (GRCm39) H183Q probably benign Het
Pde4b A G 4: 102,112,448 (GRCm39) T11A probably benign Het
Pou2af3 T C 9: 51,183,638 (GRCm39) N112S probably benign Het
Ptcd3 A G 6: 71,874,110 (GRCm39) S234P possibly damaging Het
Rtn4 T C 11: 29,658,471 (GRCm39) V875A probably benign Het
Slc12a8 T A 16: 33,466,947 (GRCm39) C485S probably benign Het
Smc1b A G 15: 84,950,455 (GRCm39) S1190P probably damaging Het
Sorbs2 A G 8: 46,258,864 (GRCm39) R1134G probably benign Het
Sugt1 T C 14: 79,866,388 (GRCm39) Y336H probably damaging Het
Tas2r134 A T 2: 51,518,034 (GRCm39) Y171F probably damaging Het
Tdrd6 A T 17: 43,937,783 (GRCm39) D1088E probably benign Het
Tgfbrap1 A T 1: 43,095,912 (GRCm39) W509R probably damaging Het
Tmem115 T C 9: 107,411,742 (GRCm39) V22A possibly damaging Het
Tmem260 A G 14: 48,724,276 (GRCm39) T223A probably benign Het
Tmprss6 G A 15: 78,328,302 (GRCm39) H565Y probably damaging Het
Ubr4 A G 4: 139,194,631 (GRCm39) S1175G unknown Het
Uspl1 T C 5: 149,151,349 (GRCm39) S850P probably benign Het
Vmn2r11 C A 5: 109,201,266 (GRCm39) A413S probably damaging Het
Vmn2r19 T G 6: 123,292,923 (GRCm39) S322A probably benign Het
Zfp606 T A 7: 12,227,935 (GRCm39) C685* probably null Het
Other mutations in Igkv7-33
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4434001:Igkv7-33 UTSW 6 70,035,797 (GRCm39) missense possibly damaging 0.63
R1520:Igkv7-33 UTSW 6 70,036,132 (GRCm39) splice site probably benign
R6936:Igkv7-33 UTSW 6 70,035,785 (GRCm39) missense possibly damaging 0.88
R7635:Igkv7-33 UTSW 6 70,036,138 (GRCm39) missense probably benign 0.43
R7866:Igkv7-33 UTSW 6 70,035,847 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATGTCTGCACAGGCACCTAC -3'
(R):5'- TTGACACCAGCCACACTTG -3'

Sequencing Primer
(F):5'- TGTACAAACACGGAATATAGCAGC -3'
(R):5'- GCACACACTGCTCAGGC -3'
Posted On 2022-04-18