Incidental Mutation 'R9384:Tmem260'
ID 710222
Institutional Source Beutler Lab
Gene Symbol Tmem260
Ensembl Gene ENSMUSG00000036339
Gene Name transmembrane protein 260
Synonyms 6720456H20Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9384 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 48683581-48761703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 48724276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 223 (T223A)
Ref Sequence ENSEMBL: ENSMUSP00000118376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111735] [ENSMUST00000124720] [ENSMUST00000153765] [ENSMUST00000226422] [ENSMUST00000227440] [ENSMUST00000228697]
AlphaFold Q8BMD6
Predicted Effect probably benign
Transcript: ENSMUST00000111735
AA Change: T375A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000107364
Gene: ENSMUSG00000036339
AA Change: T375A

DomainStartEndE-ValueType
transmembrane domain 21 40 N/A INTRINSIC
Pfam:DUF2723 48 211 1.9e-43 PFAM
transmembrane domain 316 338 N/A INTRINSIC
transmembrane domain 353 372 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124720
AA Change: T223A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000118376
Gene: ENSMUSG00000036339
AA Change: T223A

DomainStartEndE-ValueType
Pfam:DUF2723 1 61 4.6e-9 PFAM
transmembrane domain 65 87 N/A INTRINSIC
transmembrane domain 164 186 N/A INTRINSIC
transmembrane domain 201 220 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153765
SMART Domains Protein: ENSMUSP00000116155
Gene: ENSMUSG00000036339

DomainStartEndE-ValueType
transmembrane domain 21 40 N/A INTRINSIC
Pfam:DUF2723 48 111 8.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226422
AA Change: T375A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000227440
AA Change: T375A

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000228697
AA Change: T185A

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A3galt2 G A 4: 128,655,851 (GRCm39) C73Y probably damaging Het
Agrn C T 4: 156,257,106 (GRCm39) A1213T probably damaging Het
Arhgef10 T C 8: 15,041,067 (GRCm39) L1079P probably damaging Het
Cdcp3 T C 7: 130,904,404 (GRCm39) V2374A unknown Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Coro6 A G 11: 77,360,218 (GRCm39) E436G probably benign Het
D430041D05Rik A G 2: 104,087,920 (GRCm39) V352A probably benign Het
Dcbld2 C T 16: 58,285,926 (GRCm39) T695I probably damaging Het
Dclk1 A C 3: 55,154,936 (GRCm39) Q122P possibly damaging Het
Dsel C A 1: 111,787,863 (GRCm39) E891* probably null Het
Eral1 A T 11: 77,969,130 (GRCm39) N123K probably damaging Het
Fzd6 C A 15: 38,895,102 (GRCm39) L423M probably damaging Het
Fzd6 T G 15: 38,895,103 (GRCm39) L423R probably damaging Het
Galntl6 G T 8: 58,415,461 (GRCm39) L231I probably damaging Het
Gm7137 A G 10: 77,623,614 (GRCm39) S141P unknown Het
Grm5 T C 7: 87,723,518 (GRCm39) Y603H probably damaging Het
Hcar2 A T 5: 124,002,597 (GRCm39) F302Y probably benign Het
Hs3st1 T G 5: 39,771,962 (GRCm39) D227A possibly damaging Het
Igkv7-33 G T 6: 70,036,174 (GRCm39) Q4K possibly damaging Het
Itprid1 A T 6: 55,952,613 (GRCm39) Q852L probably damaging Het
Kcp C T 6: 29,496,618 (GRCm39) probably null Het
Lrrc23 T C 6: 124,755,189 (GRCm39) K116R possibly damaging Het
Lrriq1 T A 10: 103,006,458 (GRCm39) R1222S probably benign Het
Nav3 T A 10: 109,554,158 (GRCm39) I1735F probably damaging Het
Neto1 A T 18: 86,413,965 (GRCm39) probably benign Het
Nlrp9a T A 7: 26,258,158 (GRCm39) L592Q probably damaging Het
Or1e30 C A 11: 73,677,796 (GRCm39) Q11K probably benign Het
Or5t7 T A 2: 86,507,357 (GRCm39) T107S probably benign Het
Pcdhb20 T A 18: 37,638,024 (GRCm39) H183Q probably benign Het
Pde4b A G 4: 102,112,448 (GRCm39) T11A probably benign Het
Pou2af3 T C 9: 51,183,638 (GRCm39) N112S probably benign Het
Ptcd3 A G 6: 71,874,110 (GRCm39) S234P possibly damaging Het
Rtn4 T C 11: 29,658,471 (GRCm39) V875A probably benign Het
Slc12a8 T A 16: 33,466,947 (GRCm39) C485S probably benign Het
Smc1b A G 15: 84,950,455 (GRCm39) S1190P probably damaging Het
Sorbs2 A G 8: 46,258,864 (GRCm39) R1134G probably benign Het
Sugt1 T C 14: 79,866,388 (GRCm39) Y336H probably damaging Het
Tas2r134 A T 2: 51,518,034 (GRCm39) Y171F probably damaging Het
Tdrd6 A T 17: 43,937,783 (GRCm39) D1088E probably benign Het
Tgfbrap1 A T 1: 43,095,912 (GRCm39) W509R probably damaging Het
Tmem115 T C 9: 107,411,742 (GRCm39) V22A possibly damaging Het
Tmprss6 G A 15: 78,328,302 (GRCm39) H565Y probably damaging Het
Ubr4 A G 4: 139,194,631 (GRCm39) S1175G unknown Het
Uspl1 T C 5: 149,151,349 (GRCm39) S850P probably benign Het
Vmn2r11 C A 5: 109,201,266 (GRCm39) A413S probably damaging Het
Vmn2r19 T G 6: 123,292,923 (GRCm39) S322A probably benign Het
Zfp606 T A 7: 12,227,935 (GRCm39) C685* probably null Het
Other mutations in Tmem260
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Tmem260 APN 14 48,724,336 (GRCm39) missense probably benign 0.27
IGL00338:Tmem260 APN 14 48,715,093 (GRCm39) missense probably damaging 0.97
IGL00508:Tmem260 APN 14 48,746,578 (GRCm39) missense probably damaging 0.99
IGL01308:Tmem260 APN 14 48,749,415 (GRCm39) missense probably damaging 1.00
IGL01548:Tmem260 APN 14 48,717,782 (GRCm39) missense possibly damaging 0.60
IGL01952:Tmem260 APN 14 48,709,933 (GRCm39) missense probably damaging 1.00
IGL03068:Tmem260 APN 14 48,724,371 (GRCm39) splice site probably benign
IGL03081:Tmem260 APN 14 48,733,750 (GRCm39) missense probably benign 0.14
R0131:Tmem260 UTSW 14 48,720,779 (GRCm39) nonsense probably null
R0131:Tmem260 UTSW 14 48,720,779 (GRCm39) nonsense probably null
R0132:Tmem260 UTSW 14 48,720,779 (GRCm39) nonsense probably null
R0149:Tmem260 UTSW 14 48,689,504 (GRCm39) missense possibly damaging 0.88
R0361:Tmem260 UTSW 14 48,689,504 (GRCm39) missense possibly damaging 0.88
R0396:Tmem260 UTSW 14 48,724,324 (GRCm39) missense possibly damaging 0.83
R0524:Tmem260 UTSW 14 48,709,935 (GRCm39) missense probably benign 0.00
R1734:Tmem260 UTSW 14 48,746,550 (GRCm39) missense probably benign 0.00
R2152:Tmem260 UTSW 14 48,715,066 (GRCm39) missense possibly damaging 0.62
R2474:Tmem260 UTSW 14 48,733,781 (GRCm39) missense probably null 0.90
R2928:Tmem260 UTSW 14 48,724,207 (GRCm39) missense probably damaging 1.00
R2999:Tmem260 UTSW 14 48,722,446 (GRCm39) missense possibly damaging 0.92
R3030:Tmem260 UTSW 14 48,722,458 (GRCm39) missense probably damaging 1.00
R4273:Tmem260 UTSW 14 48,742,761 (GRCm39) missense probably benign 0.11
R4276:Tmem260 UTSW 14 48,715,093 (GRCm39) missense probably damaging 0.97
R4277:Tmem260 UTSW 14 48,715,093 (GRCm39) missense probably damaging 0.97
R4278:Tmem260 UTSW 14 48,715,093 (GRCm39) missense probably damaging 0.97
R4791:Tmem260 UTSW 14 48,749,451 (GRCm39) intron probably benign
R4792:Tmem260 UTSW 14 48,749,451 (GRCm39) intron probably benign
R4810:Tmem260 UTSW 14 48,709,930 (GRCm39) missense probably damaging 0.99
R5189:Tmem260 UTSW 14 48,746,573 (GRCm39) missense probably benign 0.01
R5280:Tmem260 UTSW 14 48,742,716 (GRCm39) missense probably benign 0.02
R5289:Tmem260 UTSW 14 48,724,267 (GRCm39) missense possibly damaging 0.79
R5322:Tmem260 UTSW 14 48,724,306 (GRCm39) missense probably damaging 0.99
R5491:Tmem260 UTSW 14 48,749,627 (GRCm39) splice site probably null
R5593:Tmem260 UTSW 14 48,711,501 (GRCm39) missense probably benign 0.38
R5606:Tmem260 UTSW 14 48,722,437 (GRCm39) missense probably damaging 1.00
R5824:Tmem260 UTSW 14 48,742,785 (GRCm39) missense probably damaging 1.00
R5947:Tmem260 UTSW 14 48,724,258 (GRCm39) missense possibly damaging 0.93
R6587:Tmem260 UTSW 14 48,733,913 (GRCm39) splice site probably null
R7234:Tmem260 UTSW 14 48,742,786 (GRCm39) nonsense probably null
R7236:Tmem260 UTSW 14 48,746,647 (GRCm39) splice site probably null
R7836:Tmem260 UTSW 14 48,746,519 (GRCm39) missense probably benign 0.04
R8795:Tmem260 UTSW 14 48,689,370 (GRCm39) missense probably damaging 1.00
R8895:Tmem260 UTSW 14 48,737,845 (GRCm39) unclassified probably benign
R9056:Tmem260 UTSW 14 48,717,774 (GRCm39) missense probably benign
R9096:Tmem260 UTSW 14 48,757,803 (GRCm39) missense unknown
R9634:Tmem260 UTSW 14 48,709,816 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2022-04-18