Mutagenetix > Incidental Mutation

Incidental Mutation 'R9387:Vmn1r226'

710402

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r226

Ensembl Gene

ENSMUSG00000042848

Gene Name

vomeronasal 1 receptor 226

Synonyms

V1re2

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R9387 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20907770-20908666 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20907831 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 21 (L21Q)

Ref Sequence

ENSEMBL: ENSMUSP00000058266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061756]

AlphaFold

Q8R2A8

Predicted Effect

probably damaging
Transcript: ENSMUST00000061756
AA Change: L21Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058266
Gene: ENSMUSG00000042848
AA Change: L21Q

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	286	5.2e-12	PFAM
Pfam:7tm_1	22	285	9.1e-7	PFAM
Pfam:V1R	33	292	8.7e-26	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.9%
20x: 99.6%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	T	C	17: 24,553,255 (GRCm39)	D152G	probably benign	Het
Abcb1b	G	A	5: 8,875,614 (GRCm39)	V596I	probably benign	Het
Acss3	A	G	10: 106,959,255 (GRCm39)	S64P	probably damaging	Het
Aggf1	T	C	13: 95,507,461 (GRCm39)	Y108C	probably damaging	Het
Arpc5l	T	C	2: 38,903,195 (GRCm39)	V73A	probably benign	Het
Atp5f1d	A	G	10: 79,981,134 (GRCm39)	D126G	probably damaging	Het
Carmil3	T	A	14: 55,731,869 (GRCm39)	L199*	probably null	Het
Cblb	A	G	16: 51,853,515 (GRCm39)	R44G	probably benign	Het
Cdcp3	A	G	7: 130,863,620 (GRCm39)	I1208V	unknown	Het
Chaf1b	T	G	16: 93,689,629 (GRCm39)	F225V	probably benign	Het
Creb3l2	A	T	6: 37,356,751 (GRCm39)	N105K	probably damaging	Het
Dagla	A	T	19: 10,248,465 (GRCm39)	I65N	probably damaging	Het
Dclre1c	T	G	2: 3,425,342 (GRCm39)	F30V	probably damaging	Het
Dicer1	A	G	12: 104,695,499 (GRCm39)	V144A	possibly damaging	Het
Dlg5	C	T	14: 24,197,168 (GRCm39)	G1593D	probably damaging	Het
Enpp3	A	T	10: 24,711,990 (GRCm39)	M1K	probably null	Het
Fmod	C	A	1: 133,968,514 (GRCm39)	H185N	probably benign	Het
Gon4l	A	G	3: 88,802,260 (GRCm39)	E957G	probably benign	Het
Hat1	A	G	2: 71,264,512 (GRCm39)	M310V	possibly damaging	Het
Klhl31	A	T	9: 77,557,826 (GRCm39)	T181S	probably benign	Het
Krt36	T	A	11: 99,994,906 (GRCm39)	E222V	probably damaging	Het
Lrrc27	A	T	7: 138,807,837 (GRCm39)	K315*	probably null	Het
Mak16	T	G	8: 31,650,794 (GRCm39)	D232A	probably damaging	Het
Mepce	A	G	5: 137,783,322 (GRCm39)	S335P	possibly damaging	Het
Mki67	T	A	7: 135,302,378 (GRCm39)	R885S	probably damaging	Het
Mmrn1	G	A	6: 60,935,176 (GRCm39)	W224*	probably null	Het
Mroh8	T	A	2: 157,098,386 (GRCm39)	Q254L	possibly damaging	Het
Mup18	A	T	4: 61,590,854 (GRCm39)	V101E	probably damaging	Het
Nbea	T	C	3: 55,898,460 (GRCm39)	K1508R	probably benign	Het
Or5aq6	A	T	2: 86,923,390 (GRCm39)	M117K	possibly damaging	Het
Or5g9	A	G	2: 85,551,806 (GRCm39)	Y19C	probably benign	Het
Pcdh15	A	T	10: 74,066,192 (GRCm39)	I286F	probably damaging	Het
Pcdhb8	A	T	18: 37,488,751 (GRCm39)	Q143L	probably benign	Het
Pibf1	T	C	14: 99,448,436 (GRCm39)	S632P	probably damaging	Het
Senp6	A	G	9: 79,999,646 (GRCm39)	K100R	probably damaging	Het
Slc5a9	A	G	4: 111,750,864 (GRCm39)	S81P	probably damaging	Het
Sox8	T	C	17: 25,786,338 (GRCm39)	Q455R	probably damaging	Het
Stard13	A	T	5: 151,113,483 (GRCm39)	M26K	probably benign	Het
Sulf1	T	A	1: 12,908,778 (GRCm39)	M597K	probably benign	Het
Ugt2a3	T	A	5: 87,484,832 (GRCm39)	D64V	probably benign	Het
Unc80	T	C	1: 66,589,097 (GRCm39)		probably null	Het
Vav3	A	T	3: 109,565,291 (GRCm39)	H729L	probably benign	Het
Wdtc1	A	G	4: 133,036,058 (GRCm39)		probably null	Het
Zfp984	A	G	4: 147,840,002 (GRCm39)	M283T	probably benign	Het
Zik1	A	G	7: 10,224,623 (GRCm39)	L158P	probably damaging	Het

Other mutations in Vmn1r226

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01081:Vmn1r226	APN	17	20,908,166 (GRCm39)	missense	probably damaging	1.00
IGL02103:Vmn1r226	APN	17	20,907,926 (GRCm39)	missense	probably damaging	0.98
IGL03394:Vmn1r226	APN	17	20,908,446 (GRCm39)	missense	probably benign	0.00
R0243:Vmn1r226	UTSW	17	20,907,839 (GRCm39)	missense	probably benign	0.00
R0605:Vmn1r226	UTSW	17	20,908,133 (GRCm39)	missense	probably benign	0.12
R1463:Vmn1r226	UTSW	17	20,907,994 (GRCm39)	missense	probably benign	0.00
R1571:Vmn1r226	UTSW	17	20,908,538 (GRCm39)	missense	probably damaging	0.97
R1677:Vmn1r226	UTSW	17	20,908,335 (GRCm39)	missense	probably damaging	1.00
R1917:Vmn1r226	UTSW	17	20,907,842 (GRCm39)	missense	probably damaging	0.99
R1918:Vmn1r226	UTSW	17	20,907,842 (GRCm39)	missense	probably damaging	0.99
R1919:Vmn1r226	UTSW	17	20,907,842 (GRCm39)	missense	probably damaging	0.99
R1980:Vmn1r226	UTSW	17	20,908,308 (GRCm39)	missense	possibly damaging	0.81
R2291:Vmn1r226	UTSW	17	20,908,475 (GRCm39)	missense	probably damaging	1.00
R2377:Vmn1r226	UTSW	17	20,907,992 (GRCm39)	missense	probably benign	0.05
R3878:Vmn1r226	UTSW	17	20,908,260 (GRCm39)	missense	possibly damaging	0.79
R5166:Vmn1r226	UTSW	17	20,908,125 (GRCm39)	missense	probably benign	0.43
R6510:Vmn1r226	UTSW	17	20,908,115 (GRCm39)	missense	probably benign	0.37
R6599:Vmn1r226	UTSW	17	20,908,551 (GRCm39)	missense	probably benign	0.01
R7304:Vmn1r226	UTSW	17	20,908,011 (GRCm39)	missense	probably damaging	1.00
R8836:Vmn1r226	UTSW	17	20,908,133 (GRCm39)	missense	probably benign	0.00
R8955:Vmn1r226	UTSW	17	20,908,287 (GRCm39)	missense	possibly damaging	0.79
X0066:Vmn1r226	UTSW	17	20,908,512 (GRCm39)	missense	probably damaging	0.99
Z1177:Vmn1r226	UTSW	17	20,908,479 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GATTCTTACACACAGTTCCCAATC -3'
(R):5'- ATGGACATACTCCTGGCTAGTC -3'

Sequencing Primer
(F):5'- CAAGAAACTTCAATATATGCAATGGC -3'
(R):5'- TAGTAAGTTTGCACCCAACATCACTG -3'

Posted On

2022-04-18