Incidental Mutation 'R9388:Or2w1b'
ID 710448
Institutional Source Beutler Lab
Gene Symbol Or2w1b
Ensembl Gene ENSMUSG00000060404
Gene Name olfactory receptor family 2 subfamily W member 1B
Synonyms Olfr1369, MOR256-31, GA_x6K02T2QHY8-12126170-12125935
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.346) question?
Stock # R9388 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 21299764-21300871 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21300774 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 304 (L304P)
Ref Sequence ENSEMBL: ENSMUSP00000150565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079050] [ENSMUST00000213326] [ENSMUST00000213922] [ENSMUST00000215207] [ENSMUST00000215941]
AlphaFold A0A140T8K7
Predicted Effect probably damaging
Transcript: ENSMUST00000079050
AA Change: L304P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000078059
Gene: ENSMUSG00000060404
AA Change: L304P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-47 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213326
AA Change: L304P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000213922
AA Change: L304P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000215207
AA Change: L304P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000215941
AA Change: L304P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (53/53)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T A 5: 113,338,714 (GRCm39) T433S probably benign Het
Abca14 A G 7: 119,882,261 (GRCm39) D1141G probably benign Het
Abca17 A G 17: 24,483,273 (GRCm39) S1728P unknown Het
Adam29 A C 8: 56,325,285 (GRCm39) C390G probably damaging Het
Angptl4 G A 17: 33,996,158 (GRCm39) R273* probably null Het
Arfgef3 T C 10: 18,505,877 (GRCm39) N929S probably benign Het
Baiap3 A G 17: 25,466,109 (GRCm39) probably null Het
Btla T C 16: 45,059,454 (GRCm39) S53P probably damaging Het
Cand1 A G 10: 119,047,213 (GRCm39) F759S possibly damaging Het
Cbll1 T C 12: 31,541,567 (GRCm39) T104A probably benign Het
Chd7 A G 4: 8,865,756 (GRCm39) M2688V possibly damaging Het
Cnot3 C A 7: 3,661,367 (GRCm39) H625Q possibly damaging Het
Dbn1 T C 13: 55,624,088 (GRCm39) I381V probably benign Het
Dennd2d T A 3: 106,395,915 (GRCm39) N135K possibly damaging Het
Dnah7c T C 1: 46,779,886 (GRCm39) I3196T probably damaging Het
Dock2 C A 11: 34,212,460 (GRCm39) R1227L possibly damaging Het
Esr1 A G 10: 4,919,179 (GRCm39) E423G probably benign Het
Ganab A G 19: 8,892,302 (GRCm39) Q826R probably damaging Het
Herc4 T A 10: 63,143,522 (GRCm39) M684K probably benign Het
Hipk2 A G 6: 38,707,956 (GRCm39) L613P probably damaging Het
Hpf1 A T 8: 61,353,182 (GRCm39) I188L probably benign Het
Ifnar1 C T 16: 91,292,367 (GRCm39) P207L probably benign Het
Il4 C T 11: 53,504,837 (GRCm39) R76H probably damaging Het
Kif1a C A 1: 93,000,029 (GRCm39) probably null Het
Kng1 A T 16: 22,898,388 (GRCm39) Y596F possibly damaging Het
Lrrc8d T A 5: 105,961,862 (GRCm39) H757Q probably damaging Het
Med24 A T 11: 98,600,893 (GRCm39) I600N possibly damaging Het
Mmp10 G A 9: 7,504,170 (GRCm39) W203* probably null Het
Mnt C T 11: 74,727,450 (GRCm39) A112V probably benign Het
Myh7b A T 2: 155,472,983 (GRCm39) N1415Y probably benign Het
Nipal1 T A 5: 72,825,557 (GRCm39) *417R probably null Het
Nlrp4c C T 7: 6,069,874 (GRCm39) Q592* probably null Het
Obscn T C 11: 58,943,489 (GRCm39) E4220G probably damaging Het
Or10al7 C T 17: 38,366,148 (GRCm39) C103Y probably damaging Het
Or13a23-ps1 G T 7: 140,118,928 (GRCm39) C166F unknown Het
Or5aq6 A T 2: 86,923,390 (GRCm39) M117K possibly damaging Het
Pcdhb20 A T 18: 37,638,853 (GRCm39) I460F probably benign Het
Prb1b T C 6: 132,289,437 (GRCm39) Q129R unknown Het
Primpol G A 8: 47,034,605 (GRCm39) T441I possibly damaging Het
Ptprc A G 1: 138,011,380 (GRCm39) V583A possibly damaging Het
Rfx6 T C 10: 51,554,117 (GRCm39) V71A possibly damaging Het
Rgsl1 T C 1: 153,693,355 (GRCm39) I574V probably benign Het
Rims3 A G 4: 120,748,552 (GRCm39) I258V possibly damaging Het
Sec16b T C 1: 157,388,393 (GRCm39) Y776H probably benign Het
Skint6 C T 4: 113,049,838 (GRCm39) D276N possibly damaging Het
Slc45a1 T C 4: 150,727,067 (GRCm39) D184G probably damaging Het
St6galnac4 A T 2: 32,479,625 (GRCm39) S61C probably damaging Het
Stab1 C T 14: 30,876,312 (GRCm39) V926M probably damaging Het
Stat1 A T 1: 52,193,037 (GRCm39) K642N possibly damaging Het
Tmprss3 A G 17: 31,410,041 (GRCm39) F191S probably damaging Het
Ube2o T C 11: 116,430,210 (GRCm39) D1176G possibly damaging Het
Usp17ld G T 7: 102,900,145 (GRCm39) N262K probably benign Het
Xpnpep1 T C 19: 52,993,233 (GRCm39) K365E probably damaging Het
Other mutations in Or2w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01689:Or2w1b APN 13 21,300,243 (GRCm39) missense probably damaging 0.97
R0631:Or2w1b UTSW 13 21,300,078 (GRCm39) missense probably damaging 1.00
R0960:Or2w1b UTSW 13 21,300,435 (GRCm39) missense possibly damaging 0.94
R1499:Or2w1b UTSW 13 21,300,303 (GRCm39) missense probably benign 0.32
R1549:Or2w1b UTSW 13 21,300,288 (GRCm39) missense probably benign 0.01
R1698:Or2w1b UTSW 13 21,300,735 (GRCm39) missense probably benign 0.11
R1711:Or2w1b UTSW 13 21,300,476 (GRCm39) missense probably benign 0.01
R2404:Or2w1b UTSW 13 21,300,012 (GRCm39) missense probably damaging 1.00
R2471:Or2w1b UTSW 13 21,300,599 (GRCm39) missense probably damaging 1.00
R3844:Or2w1b UTSW 13 21,300,233 (GRCm39) missense possibly damaging 0.91
R3977:Or2w1b UTSW 13 21,300,031 (GRCm39) missense probably benign 0.03
R3979:Or2w1b UTSW 13 21,300,031 (GRCm39) missense probably benign 0.03
R4804:Or2w1b UTSW 13 21,300,175 (GRCm39) nonsense probably null
R4914:Or2w1b UTSW 13 21,300,567 (GRCm39) missense probably benign 0.12
R5210:Or2w1b UTSW 13 21,300,222 (GRCm39) missense probably damaging 0.99
R5359:Or2w1b UTSW 13 21,300,437 (GRCm39) missense probably damaging 1.00
R5700:Or2w1b UTSW 13 21,300,171 (GRCm39) missense probably damaging 1.00
R6218:Or2w1b UTSW 13 21,300,401 (GRCm39) missense probably damaging 1.00
R6767:Or2w1b UTSW 13 21,300,227 (GRCm39) missense probably benign 0.02
R7396:Or2w1b UTSW 13 21,300,477 (GRCm39) missense probably benign 0.02
R7476:Or2w1b UTSW 13 21,300,191 (GRCm39) missense probably benign 0.04
R7612:Or2w1b UTSW 13 21,300,217 (GRCm39) missense probably damaging 0.99
R8257:Or2w1b UTSW 13 21,300,543 (GRCm39) missense probably benign 0.11
R9697:Or2w1b UTSW 13 21,299,892 (GRCm39) missense probably benign 0.21
V8831:Or2w1b UTSW 13 21,300,173 (GRCm39) missense possibly damaging 0.93
Z1176:Or2w1b UTSW 13 21,300,771 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGATCCCATCTCACTGTGG -3'
(R):5'- CATGTCTTCTTGGAGAACATGCC -3'

Sequencing Primer
(F):5'- TCACTGTGGTCTCCATATTCTATG -3'
(R):5'- GTCTTCTTGGAGAACATGCCAATAG -3'
Posted On 2022-04-18