Mutagenetix > Incidental Mutation

Incidental Mutation 'R9389:Ovgp1'

710471

Institutional Source

Beutler Lab

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

Chit5, MOGP, muc9, mucin 9, OGP, oviductin

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9389 (G1)

Quality Score

217.468

Status

Validated

Chromosome

Chromosomal Location

105973711-105987423 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCATCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA to CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA at 105986525 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132424 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

AlphaFold

Q62010

Predicted Effect

probably benign
Transcript: ENSMUST00000000573

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000163626

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210010C04Rik	C	T	6: 41,033,145	G85D	probably benign	Het
4931440F15Rik	A	G	11: 29,825,107	S117P	probably damaging	Het
Abcb1b	G	A	5: 8,825,614	V596I	probably benign	Het
Agtpbp1	A	T	13: 59,466,070	M1019K	probably damaging	Het
Arfgef3	A	G	10: 18,603,523	V1448A	probably damaging	Het
Baz1a	T	A	12: 54,916,823	E828D	probably damaging	Het
Ces1f	A	T	8: 93,269,972		probably null	Het
Cfap53	T	A	18: 74,299,343		probably null	Het
Col6a4	T	C	9: 106,000,784	Y1998C	probably damaging	Het
Col9a2	A	G	4: 121,054,751	T675A	probably benign	Het
Dusp6	G	A	10: 99,263,977	V96M	possibly damaging	Het
Elmo1	T	G	13: 20,185,491	M22R	probably benign	Het
Gm19965	A	G	1: 116,821,836	N416D		Het
Gpr162	A	G	6: 124,861,394	Y98H	probably damaging	Het
Igfals	G	A	17: 24,881,626	V564I	probably benign	Het
Il4	C	T	11: 53,614,010	R76H	probably damaging	Het
Itgb1	T	A	8: 128,707,156	N50K	probably benign	Het
Itpr3	A	T	17: 27,095,925	Y682F	possibly damaging	Het
Jak3	C	T	8: 71,684,052	P668S	probably damaging	Het
Malrd1	A	T	2: 15,703,156	N932I	unknown	Het
Mast4	C	A	13: 103,333,930	R88L	probably benign	Het
Mfsd11	T	G	11: 116,873,335	S381A	probably benign	Het
Mrm3	A	G	11: 76,250,030	D288G	probably damaging	Het
Myg1	G	T	15: 102,336,937	V198F	probably damaging	Het
Naip5	T	A	13: 100,219,830	E1092D	probably benign	Het
Npy6r	T	C	18: 44,275,692	I60T	probably damaging	Het
Olfr1109	A	T	2: 87,093,046	M117K	possibly damaging	Het
Olfr1308	G	T	2: 111,960,527	P182H	probably damaging	Het
Olfr1341	A	T	4: 118,710,156	M250L	probably benign	Het
Olfr177	C	T	16: 58,872,613	C179Y	probably damaging	Het
Olfr530	T	C	7: 140,373,017	T198A	probably benign	Het
Olfr811	G	A	10: 129,801,671	P285S	probably damaging	Het
Oxtr	C	A	6: 112,489,349	R150L	probably damaging	Het
Pappa	A	T	4: 65,180,888	Y548F	probably damaging	Het
Pip4k2a	T	C	2: 18,908,079	K73R	probably damaging	Het
Pla2g4f	T	A	2: 120,302,300	D685V	probably damaging	Het
Ppp1r35	T	A	5: 137,779,315	L81Q	probably damaging	Het
Ptprf	C	A	4: 118,236,039	A469S	probably benign	Het
Ranbp3l	T	A	15: 9,057,223	N322K	probably damaging	Het
Rev3l	T	A	10: 39,822,971	Y1155N	possibly damaging	Het
Rfesd	T	C	13: 76,003,012	Y96C	probably damaging	Het
Runx1	C	T	16: 92,613,680	V283I	possibly damaging	Het
Sema5b	A	C	16: 35,645,722	Q125P	probably damaging	Het
Spef2	A	T	15: 9,725,221	M150K	probably damaging	Het
Srcap	T	G	7: 127,542,283	L1745W	probably damaging	Het
Srgap2	A	G	1: 131,355,627	Y239H	probably damaging	Het
Svil	T	A	18: 5,090,811	H1304Q	possibly damaging	Het
Syne1	T	C	10: 5,229,193	D4427G	possibly damaging	Het
Tg	T	A	15: 66,689,324	M1065K	probably benign	Het
Tgm2	T	C	2: 158,117,896	T656A	probably benign	Het
Ttc37	A	G	13: 76,127,039	D403G	probably benign	Het
Ubr4	A	G	4: 139,425,924	K809E		Het
Vmn1r88	T	C	7: 13,178,619	S301P	probably damaging	Het
Wdr27	A	G	17: 14,891,718	V671A	possibly damaging	Het
Zbtb17	G	A	4: 141,465,820	V550I	possibly damaging	Het
Zeb2	A	T	2: 44,997,908	I379N	probably damaging	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105981277	nonsense	probably null
IGL01152:Ovgp1	APN	3	105986172	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105974991	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105978349	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105981351	critical splice donor site	probably null
IGL02712:Ovgp1	APN	3	105986513	unclassified	probably benign
IGL03065:Ovgp1	APN	3	105986366	missense	probably benign	0.01
IGL03140:Ovgp1	APN	3	105979906	missense	probably damaging	1.00
IGL03272:Ovgp1	APN	3	105981325	missense	probably damaging	0.99
PIT4472001:Ovgp1	UTSW	3	105986990	missense	unknown
R0277:Ovgp1	UTSW	3	105979892	intron	probably benign
R0560:Ovgp1	UTSW	3	105986410	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105974830	splice site	probably benign
R0743:Ovgp1	UTSW	3	105974932	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105986575	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105986752	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105977798	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105985068	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105974935	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105986993	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105977717	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105986912	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105986452	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105980171	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105986315	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105977711	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105980323	splice site	probably null
R4738:Ovgp1	UTSW	3	105979918	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105979953	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105977783	missense	probably damaging	1.00
R6531:Ovgp1	UTSW	3	105987071	unclassified	probably benign
R6540:Ovgp1	UTSW	3	105986581	nonsense	probably null
R6562:Ovgp1	UTSW	3	105980273	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105986431	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105986873	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105987071	missense	unknown
R7430:Ovgp1	UTSW	3	105986302	missense	probably damaging	0.99
R7430:Ovgp1	UTSW	3	105986303	missense	possibly damaging	0.62
R7566:Ovgp1	UTSW	3	105974310	start gained	probably benign
R7684:Ovgp1	UTSW	3	105979956	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105986794	missense	unknown
R7820:Ovgp1	UTSW	3	105986521	unclassified	probably benign
R7919:Ovgp1	UTSW	3	105981285	missense	probably damaging	1.00
R8039:Ovgp1	UTSW	3	105976023	missense	probably benign	0.26
R8483:Ovgp1	UTSW	3	105986995	unclassified	probably benign
R9259:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9261:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9262:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9359:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9390:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9444:Ovgp1	UTSW	3	105986525	unclassified	probably benign
R9445:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R9466:Ovgp1	UTSW	3	105980168	missense
R9586:Ovgp1	UTSW	3	105973822	missense	probably damaging	0.96
Z1177:Ovgp1	UTSW	3	105986840	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ATAACACGATGGCTGCTGAGG -3'
(R):5'- GTGGTGGTCTGAGAAATGCC -3'

Sequencing Primer
(F):5'- ACTATGAGCACACTGGACTTC -3'
(R):5'- CCAGTGGTGGTCTTAGAAATGCC -3'

Posted On

2022-04-18