Mutagenetix > Incidental Mutation

Incidental Mutation 'R9389:Olfr811'

710494

Institutional Source

Beutler Lab

Gene Symbol

Olfr811

Ensembl Gene

ENSMUSG00000063173

Gene Name

olfactory receptor 811

Synonyms

MOR110-6, GA_x6K02T2PULF-11481207-11480248

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R9389 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129800615-129804396 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 129801671 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 285 (P285S)

Ref Sequence

ENSEMBL: ENSMUSP00000148915 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076437] [ENSMUST00000215058] [ENSMUST00000217571]

AlphaFold

Q8VFI1

Predicted Effect

probably damaging
Transcript: ENSMUST00000076437
AA Change: P285S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000075768
Gene: ENSMUSG00000063173
AA Change: P285S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	306	1.1e-51	PFAM
Pfam:7tm_1	39	288	1.5e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215058
AA Change: P285S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000217571
AA Change: P285S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210010C04Rik	C	T	6: 41,033,145	G85D	probably benign	Het
4931440F15Rik	A	G	11: 29,825,107	S117P	probably damaging	Het
Abcb1b	G	A	5: 8,825,614	V596I	probably benign	Het
Agtpbp1	A	T	13: 59,466,070	M1019K	probably damaging	Het
Arfgef3	A	G	10: 18,603,523	V1448A	probably damaging	Het
Baz1a	T	A	12: 54,916,823	E828D	probably damaging	Het
Ces1f	A	T	8: 93,269,972		probably null	Het
Cfap53	T	A	18: 74,299,343		probably null	Het
Col6a4	T	C	9: 106,000,784	Y1998C	probably damaging	Het
Col9a2	A	G	4: 121,054,751	T675A	probably benign	Het
Dusp6	G	A	10: 99,263,977	V96M	possibly damaging	Het
Elmo1	T	G	13: 20,185,491	M22R	probably benign	Het
Gm19965	A	G	1: 116,821,836	N416D		Het
Gpr162	A	G	6: 124,861,394	Y98H	probably damaging	Het
Igfals	G	A	17: 24,881,626	V564I	probably benign	Het
Il4	C	T	11: 53,614,010	R76H	probably damaging	Het
Itgb1	T	A	8: 128,707,156	N50K	probably benign	Het
Itpr3	A	T	17: 27,095,925	Y682F	possibly damaging	Het
Jak3	C	T	8: 71,684,052	P668S	probably damaging	Het
Malrd1	A	T	2: 15,703,156	N932I	unknown	Het
Mast4	C	A	13: 103,333,930	R88L	probably benign	Het
Mfsd11	T	G	11: 116,873,335	S381A	probably benign	Het
Mrm3	A	G	11: 76,250,030	D288G	probably damaging	Het
Myg1	G	T	15: 102,336,937	V198F	probably damaging	Het
Naip5	T	A	13: 100,219,830	E1092D	probably benign	Het
Npy6r	T	C	18: 44,275,692	I60T	probably damaging	Het
Olfr1109	A	T	2: 87,093,046	M117K	possibly damaging	Het
Olfr1308	G	T	2: 111,960,527	P182H	probably damaging	Het
Olfr1341	A	T	4: 118,710,156	M250L	probably benign	Het
Olfr177	C	T	16: 58,872,613	C179Y	probably damaging	Het
Olfr530	T	C	7: 140,373,017	T198A	probably benign	Het
Ovgp1	CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCATCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA	CCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGCATTTCTAAGACCACCACTGGGGTTTCTAAGATCACCACTGGTGTTTCTAAGACCACCACTGGCATTTCTAAGACCA	3: 105,986,525		probably benign	Het
Oxtr	C	A	6: 112,489,349	R150L	probably damaging	Het
Pappa	A	T	4: 65,180,888	Y548F	probably damaging	Het
Pip4k2a	T	C	2: 18,908,079	K73R	probably damaging	Het
Pla2g4f	T	A	2: 120,302,300	D685V	probably damaging	Het
Ppp1r35	T	A	5: 137,779,315	L81Q	probably damaging	Het
Ptprf	C	A	4: 118,236,039	A469S	probably benign	Het
Ranbp3l	T	A	15: 9,057,223	N322K	probably damaging	Het
Rev3l	T	A	10: 39,822,971	Y1155N	possibly damaging	Het
Rfesd	T	C	13: 76,003,012	Y96C	probably damaging	Het
Runx1	C	T	16: 92,613,680	V283I	possibly damaging	Het
Sema5b	A	C	16: 35,645,722	Q125P	probably damaging	Het
Spef2	A	T	15: 9,725,221	M150K	probably damaging	Het
Srcap	T	G	7: 127,542,283	L1745W	probably damaging	Het
Srgap2	A	G	1: 131,355,627	Y239H	probably damaging	Het
Svil	T	A	18: 5,090,811	H1304Q	possibly damaging	Het
Syne1	T	C	10: 5,229,193	D4427G	possibly damaging	Het
Tg	T	A	15: 66,689,324	M1065K	probably benign	Het
Tgm2	T	C	2: 158,117,896	T656A	probably benign	Het
Ttc37	A	G	13: 76,127,039	D403G	probably benign	Het
Ubr4	A	G	4: 139,425,924	K809E		Het
Vmn1r88	T	C	7: 13,178,619	S301P	probably damaging	Het
Wdr27	A	G	17: 14,891,718	V671A	possibly damaging	Het
Zbtb17	G	A	4: 141,465,820	V550I	possibly damaging	Het
Zeb2	A	T	2: 44,997,908	I379N	probably damaging	Het

Other mutations in Olfr811

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00945:Olfr811	APN	10	129801907	missense	possibly damaging	0.64
IGL01957:Olfr811	APN	10	129802250	missense	probably damaging	1.00
IGL02394:Olfr811	APN	10	129802313	missense	possibly damaging	0.90
IGL02451:Olfr811	APN	10	129801833	nonsense	probably null
IGL03111:Olfr811	APN	10	129802078	missense	probably benign	0.00
IGL03369:Olfr811	APN	10	129802471	missense	probably damaging	0.99
R0704:Olfr811	UTSW	10	129802303	missense	probably benign	0.01
R1393:Olfr811	UTSW	10	129801932	missense	probably benign	0.22
R1941:Olfr811	UTSW	10	129802412	missense	probably benign	0.00
R1994:Olfr811	UTSW	10	129801661	missense	probably damaging	1.00
R3427:Olfr811	UTSW	10	129801851	missense	possibly damaging	0.85
R4296:Olfr811	UTSW	10	129802300	missense	probably damaging	0.97
R4937:Olfr811	UTSW	10	129802063	missense	probably benign	0.31
R5016:Olfr811	UTSW	10	129801793	missense	probably benign	0.01
R5615:Olfr811	UTSW	10	129801767	missense	probably damaging	1.00
R5662:Olfr811	UTSW	10	129802307	missense	possibly damaging	0.83
R5750:Olfr811	UTSW	10	129801620	missense	probably benign	0.01
R6109:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6109:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6110:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6110:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6117:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6117:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6119:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6119:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6120:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6120:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6124:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6124:Olfr811	UTSW	10	129801821	missense	probably damaging	1.00
R6395:Olfr811	UTSW	10	129802144	missense	probably damaging	1.00
R6440:Olfr811	UTSW	10	129801968	missense	probably damaging	1.00
R6559:Olfr811	UTSW	10	129801664	missense	probably damaging	1.00
R6707:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6708:Olfr811	UTSW	10	129801820	missense	probably damaging	1.00
R6868:Olfr811	UTSW	10	129802168	missense	probably damaging	1.00
R8024:Olfr811	UTSW	10	129801943	missense	probably damaging	1.00
R8956:Olfr811	UTSW	10	129802353	missense	possibly damaging	0.90
R9012:Olfr811	UTSW	10	129801602	missense	probably benign
R9029:Olfr811	UTSW	10	129802057	missense	probably damaging	1.00
R9030:Olfr811	UTSW	10	129802057	missense	probably damaging	1.00
R9038:Olfr811	UTSW	10	129801695	missense	probably damaging	0.98
R9663:Olfr811	UTSW	10	129801628	missense	probably benign	0.03
Z1177:Olfr811	UTSW	10	129802309	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CTGGAGAGGACAACATTAATATGAC -3'
(R):5'- GTTCCCTTCAGCTCAACAACG -3'

Sequencing Primer
(F):5'- CCTCAGTAAATGAAATGGTTCACATC -3'
(R):5'- ACGGAGAAAGGCCTTTTCC -3'

Posted On

2022-04-18