Incidental Mutation 'R9390:Gucy2g'
ID 710574
Institutional Source Beutler Lab
Gene Symbol Gucy2g
Ensembl Gene ENSMUSG00000055523
Gene Name guanylate cyclase 2g
Synonyms 2410077I05Rik, GC-G
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9390 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 55186531-55229668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55190607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 1009 (V1009A)
Ref Sequence ENSEMBL: ENSMUSP00000068253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069183]
AlphaFold Q6TL19
Predicted Effect probably null
Transcript: ENSMUST00000069183
AA Change: V1009A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: V1009A

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
Pfam:ANF_receptor 65 416 5.2e-36 PFAM
low complexity region 471 487 N/A INTRINSIC
Pfam:Pkinase 574 826 2e-26 PFAM
Pfam:Pkinase_Tyr 577 826 6e-35 PFAM
CYCc 865 1059 6.42e-96 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik A T 16: 90,853,096 (GRCm39) S13R probably benign Het
Amn1 A T 6: 149,084,983 (GRCm39) D32E probably damaging Het
Asph T C 4: 9,635,927 (GRCm39) D108G probably damaging Het
C1rb T C 6: 124,557,336 (GRCm39) L491P probably damaging Het
Cep120 G A 18: 53,839,984 (GRCm39) R759* probably null Het
Chmp6 C T 11: 119,806,288 (GRCm39) T38M possibly damaging Het
Comtd1 A G 14: 21,898,867 (GRCm39) F25S possibly damaging Het
Dthd1 G A 5: 62,975,904 (GRCm39) G193R possibly damaging Het
Dyrk1a T A 16: 94,474,330 (GRCm39) S362R probably damaging Het
Ecm2 A G 13: 49,683,792 (GRCm39) D590G probably benign Het
Exd1 A T 2: 119,354,180 (GRCm39) W293R probably damaging Het
Fam110a C T 2: 151,812,116 (GRCm39) R218Q probably benign Het
Fga A T 3: 82,940,610 (GRCm39) N755Y probably damaging Het
Fstl4 C A 11: 52,891,102 (GRCm39) T80K probably benign Het
Gbp5 A G 3: 142,208,783 (GRCm39) K109E probably benign Het
Herc6 C T 6: 57,602,955 (GRCm39) Q545* probably null Het
Hpd T A 5: 123,318,794 (GRCm39) probably null Het
Il4 C T 11: 53,504,837 (GRCm39) R76H probably damaging Het
Inpp4b T C 8: 82,497,522 (GRCm39) V114A probably damaging Het
Ints14 A G 9: 64,891,314 (GRCm39) T432A probably benign Het
Isoc1 G A 18: 58,804,350 (GRCm39) R126H probably damaging Het
Klb G T 5: 65,533,044 (GRCm39) R451L possibly damaging Het
Lrtm2 C T 6: 119,297,948 (GRCm39) C31Y probably benign Het
Mga C T 2: 119,794,332 (GRCm39) S2672F probably damaging Het
Mkrn3 T C 7: 62,069,288 (GRCm39) I168V probably benign Het
Mlph C T 1: 90,867,088 (GRCm39) T370I probably benign Het
Naaladl1 A T 19: 6,162,725 (GRCm39) I478F probably damaging Het
Neb A T 2: 52,065,157 (GRCm39) H6251Q probably benign Het
Nom1 C T 5: 29,639,766 (GRCm39) R31C probably benign Het
Nup153 A C 13: 46,840,642 (GRCm39) F989V probably damaging Het
Nup188 T C 2: 30,220,777 (GRCm39) probably null Het
Or4c12 T C 2: 89,773,569 (GRCm39) K297E probably benign Het
Or5aq6 A T 2: 86,923,390 (GRCm39) M117K possibly damaging Het
Or6c210 A G 10: 129,495,938 (GRCm39) T88A probably benign Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Pcare T C 17: 72,057,983 (GRCm39) T565A probably benign Het
Pcdhb4 T C 18: 37,442,781 (GRCm39) V697A possibly damaging Het
Pds5a G T 5: 65,823,600 (GRCm39) Q64K probably benign Het
Pmpcb T C 5: 21,953,810 (GRCm39) F353L probably damaging Het
Pus10 G A 11: 23,656,937 (GRCm39) C221Y probably damaging Het
Qrfp A G 2: 31,698,749 (GRCm39) V61A possibly damaging Het
Runx1t1 A G 4: 13,865,932 (GRCm39) I393M probably benign Het
Sh2d5 T G 4: 137,985,481 (GRCm39) S310A probably benign Het
Shisa9 A G 16: 12,085,408 (GRCm39) E339G possibly damaging Het
Slc26a10 C T 10: 127,009,239 (GRCm39) E641K probably benign Het
Slc5a6 A G 5: 31,197,803 (GRCm39) V302A possibly damaging Het
Tdrd7 T A 4: 46,005,416 (GRCm39) D407E probably damaging Het
Trp53 A T 11: 69,478,394 (GRCm39) Q101L probably benign Het
Tsc2 T A 17: 24,823,824 (GRCm39) N994Y probably damaging Het
Ttc16 T G 2: 32,657,195 (GRCm39) K577Q possibly damaging Het
Vmn1r195 A G 13: 22,462,535 (GRCm39) I2V probably benign Het
Vmn2r83 G T 10: 79,317,322 (GRCm39) E522* probably null Het
Wdr48 T A 9: 119,746,245 (GRCm39) F450L probably benign Het
Wnt9a G A 11: 59,218,592 (GRCm39) E100K possibly damaging Het
Zfp729b A T 13: 67,739,182 (GRCm39) S1028T probably benign Het
Zfp729b C T 13: 67,742,014 (GRCm39) V84I possibly damaging Het
Other mutations in Gucy2g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Gucy2g APN 19 55,221,535 (GRCm39) missense probably benign 0.01
IGL01954:Gucy2g APN 19 55,187,123 (GRCm39) missense probably benign 0.01
IGL01969:Gucy2g APN 19 55,215,870 (GRCm39) missense probably benign 0.00
IGL02164:Gucy2g APN 19 55,226,455 (GRCm39) missense probably benign
IGL02534:Gucy2g APN 19 55,229,500 (GRCm39) missense probably damaging 1.00
IGL02667:Gucy2g APN 19 55,194,609 (GRCm39) missense possibly damaging 0.64
IGL02755:Gucy2g APN 19 55,198,786 (GRCm39) missense probably benign 0.10
IGL03187:Gucy2g APN 19 55,219,484 (GRCm39) missense possibly damaging 0.91
IGL03354:Gucy2g APN 19 55,221,512 (GRCm39) missense possibly damaging 0.95
PIT4366001:Gucy2g UTSW 19 55,226,214 (GRCm39) missense probably null 0.51
R0040:Gucy2g UTSW 19 55,205,734 (GRCm39) missense possibly damaging 0.73
R0126:Gucy2g UTSW 19 55,229,598 (GRCm39) missense probably benign
R0318:Gucy2g UTSW 19 55,226,230 (GRCm39) missense probably benign 0.00
R0576:Gucy2g UTSW 19 55,187,202 (GRCm39) missense probably damaging 1.00
R0604:Gucy2g UTSW 19 55,191,519 (GRCm39) missense probably benign 0.00
R0962:Gucy2g UTSW 19 55,198,716 (GRCm39) nonsense probably null
R1348:Gucy2g UTSW 19 55,211,338 (GRCm39) missense possibly damaging 0.68
R1458:Gucy2g UTSW 19 55,203,468 (GRCm39) splice site probably benign
R1693:Gucy2g UTSW 19 55,211,358 (GRCm39) missense probably damaging 1.00
R1795:Gucy2g UTSW 19 55,187,973 (GRCm39) missense probably damaging 1.00
R1804:Gucy2g UTSW 19 55,198,741 (GRCm39) missense probably benign 0.34
R1830:Gucy2g UTSW 19 55,211,362 (GRCm39) missense possibly damaging 0.94
R1902:Gucy2g UTSW 19 55,198,669 (GRCm39) missense probably benign 0.20
R1927:Gucy2g UTSW 19 55,226,191 (GRCm39) missense probably benign 0.02
R1969:Gucy2g UTSW 19 55,221,485 (GRCm39) missense probably benign 0.42
R1969:Gucy2g UTSW 19 55,211,328 (GRCm39) missense possibly damaging 0.90
R2071:Gucy2g UTSW 19 55,210,772 (GRCm39) missense possibly damaging 0.72
R2842:Gucy2g UTSW 19 55,229,379 (GRCm39) missense probably damaging 1.00
R2971:Gucy2g UTSW 19 55,198,708 (GRCm39) missense probably damaging 1.00
R4202:Gucy2g UTSW 19 55,218,201 (GRCm39) missense possibly damaging 0.96
R4405:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4407:Gucy2g UTSW 19 55,226,269 (GRCm39) missense probably benign 0.08
R4614:Gucy2g UTSW 19 55,190,579 (GRCm39) nonsense probably null
R4671:Gucy2g UTSW 19 55,226,500 (GRCm39) missense probably damaging 1.00
R4684:Gucy2g UTSW 19 55,194,688 (GRCm39) missense probably damaging 1.00
R4837:Gucy2g UTSW 19 55,214,485 (GRCm39) missense probably benign
R4969:Gucy2g UTSW 19 55,214,445 (GRCm39) missense probably benign
R5050:Gucy2g UTSW 19 55,229,367 (GRCm39) missense probably benign 0.05
R5059:Gucy2g UTSW 19 55,214,503 (GRCm39) missense probably benign 0.00
R5070:Gucy2g UTSW 19 55,218,219 (GRCm39) missense probably damaging 0.98
R5288:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5384:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5386:Gucy2g UTSW 19 55,203,548 (GRCm39) missense probably damaging 1.00
R5497:Gucy2g UTSW 19 55,187,133 (GRCm39) missense probably benign 0.00
R5531:Gucy2g UTSW 19 55,229,572 (GRCm39) missense probably benign 0.24
R5536:Gucy2g UTSW 19 55,226,359 (GRCm39) missense probably benign 0.05
R5679:Gucy2g UTSW 19 55,219,511 (GRCm39) missense possibly damaging 0.87
R5715:Gucy2g UTSW 19 55,221,587 (GRCm39) missense possibly damaging 0.93
R5941:Gucy2g UTSW 19 55,203,563 (GRCm39) missense probably damaging 1.00
R6250:Gucy2g UTSW 19 55,205,856 (GRCm39) missense probably damaging 0.99
R6288:Gucy2g UTSW 19 55,215,945 (GRCm39) missense probably benign 0.01
R6378:Gucy2g UTSW 19 55,229,377 (GRCm39) missense probably benign 0.00
R6605:Gucy2g UTSW 19 55,229,460 (GRCm39) missense probably damaging 1.00
R7020:Gucy2g UTSW 19 55,221,482 (GRCm39) missense probably damaging 0.98
R7064:Gucy2g UTSW 19 55,198,764 (GRCm39) missense probably benign 0.01
R7078:Gucy2g UTSW 19 55,229,583 (GRCm39) missense probably damaging 1.00
R7402:Gucy2g UTSW 19 55,194,725 (GRCm39) missense probably damaging 1.00
R7539:Gucy2g UTSW 19 55,191,586 (GRCm39) missense probably damaging 0.99
R7561:Gucy2g UTSW 19 55,194,772 (GRCm39) missense probably benign 0.38
R7583:Gucy2g UTSW 19 55,224,047 (GRCm39) missense probably damaging 1.00
R7804:Gucy2g UTSW 19 55,216,584 (GRCm39) missense probably benign 0.02
R7880:Gucy2g UTSW 19 55,194,712 (GRCm39) missense probably damaging 1.00
R8442:Gucy2g UTSW 19 55,205,833 (GRCm39) missense probably benign 0.00
R8559:Gucy2g UTSW 19 55,198,786 (GRCm39) missense probably benign 0.10
R8970:Gucy2g UTSW 19 55,191,478 (GRCm39) missense possibly damaging 0.56
R8972:Gucy2g UTSW 19 55,226,406 (GRCm39) missense probably benign 0.17
R9085:Gucy2g UTSW 19 55,221,597 (GRCm39) nonsense probably null
R9462:Gucy2g UTSW 19 55,221,469 (GRCm39) critical splice donor site probably null
R9502:Gucy2g UTSW 19 55,198,816 (GRCm39) missense probably damaging 1.00
R9610:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9611:Gucy2g UTSW 19 55,194,605 (GRCm39) missense probably damaging 1.00
R9644:Gucy2g UTSW 19 55,219,537 (GRCm39) missense probably benign 0.05
Z1177:Gucy2g UTSW 19 55,198,809 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CAGGTTGACTCCTGTGAATAATG -3'
(R):5'- AAAGATGCTTTGCAGGCACTC -3'

Sequencing Primer
(F):5'- AGACAAAATGCAAATGAGTCCTC -3'
(R):5'- TTGCAGGCACTCGATGATC -3'
Posted On 2022-04-18