Incidental Mutation 'R9393:Nrip1'
ID 710709
Institutional Source Beutler Lab
Gene Symbol Nrip1
Ensembl Gene ENSMUSG00000048490
Gene Name nuclear receptor interacting protein 1
Synonyms 8430438I05Rik, 6030458L20Rik, RIP140
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9393 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 76084288-76170715 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76091353 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 68 (V68A)
Ref Sequence ENSEMBL: ENSMUSP00000112959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054178] [ENSMUST00000121927] [ENSMUST00000140483] [ENSMUST00000231585]
AlphaFold Q8CBD1
Predicted Effect probably benign
Transcript: ENSMUST00000054178
AA Change: V68A

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000051726
Gene: ENSMUSG00000048490
AA Change: V68A

DomainStartEndE-ValueType
low complexity region 182 195 N/A INTRINSIC
low complexity region 252 261 N/A INTRINSIC
PDB:2GPP|D 368 392 2e-7 PDB
low complexity region 707 718 N/A INTRINSIC
low complexity region 719 731 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121927
AA Change: V68A

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000112959
Gene: ENSMUSG00000048490
AA Change: V68A

DomainStartEndE-ValueType
Pfam:NRIP1_repr_1 27 331 5.4e-141 PFAM
PDB:2GPP|D 368 392 2e-7 PDB
Pfam:NRIP1_repr_2 412 739 7.5e-122 PFAM
Pfam:NRIP1_repr_3 754 841 8.4e-45 PFAM
Pfam:NRIP1_repr_4 849 1161 1.7e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140483
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231304
Predicted Effect probably benign
Transcript: ENSMUST00000231585
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,616,270 (GRCm39) S133G possibly damaging Het
Agps A G 2: 75,735,256 (GRCm39) E567G possibly damaging Het
Ak9 T C 10: 41,285,068 (GRCm39) I1381T unknown Het
Apcdd1 C T 18: 63,055,731 (GRCm39) probably benign Het
Arrb1 T A 7: 99,238,891 (GRCm39) C150S probably damaging Het
Asz1 T C 6: 18,051,330 (GRCm39) I450V probably benign Het
Atp10b A G 11: 43,063,608 (GRCm39) N181S probably damaging Het
Bptf A C 11: 106,965,134 (GRCm39) D1353E probably benign Het
Cacna2d1 T C 5: 16,140,013 (GRCm39) M1T probably null Het
Ccdc106 T A 7: 5,059,200 (GRCm39) I6N possibly damaging Het
Celf6 A T 9: 59,510,525 (GRCm39) Q252L probably benign Het
Colgalt2 A T 1: 152,360,598 (GRCm39) K212* probably null Het
Cryba4 T C 5: 112,394,632 (GRCm39) S166G probably benign Het
Cyp2w1 A G 5: 139,342,035 (GRCm39) E123G probably benign Het
Cyp4a10 G C 4: 115,382,566 (GRCm39) K285N probably damaging Het
Cyth1 G T 11: 118,074,710 (GRCm39) T197K probably benign Het
Ddhd1 A G 14: 45,894,685 (GRCm39) W262R probably damaging Het
Dnah8 T A 17: 30,872,361 (GRCm39) V450D possibly damaging Het
Eml5 C T 12: 98,842,433 (GRCm39) V222I probably benign Het
Fbxw19 A G 9: 109,324,873 (GRCm39) S15P probably damaging Het
Fhip2b G A 14: 70,831,463 (GRCm39) Q24* probably null Het
Fignl2 C A 15: 100,951,466 (GRCm39) R272L unknown Het
Gm10842 A T 11: 105,037,885 (GRCm39) D56V unknown Het
Gmps T A 3: 63,900,640 (GRCm39) N305K probably benign Het
Gnai1 A T 5: 18,565,055 (GRCm39) L38Q Het
Golim4 A T 3: 75,785,464 (GRCm39) D642E probably benign Het
Gp1ba A T 11: 70,531,293 (GRCm39) Q353L unknown Het
Gpnmb T C 6: 49,024,996 (GRCm39) S343P possibly damaging Het
Hexb G A 13: 97,313,336 (GRCm39) R507* probably null Het
Ifitm10 A T 7: 141,924,704 (GRCm39) V45D probably damaging Het
Khsrp T C 17: 57,330,350 (GRCm39) Y585C probably damaging Het
Kif21a A T 15: 90,853,981 (GRCm39) D795E probably benign Het
Klkb1 A T 8: 45,729,392 (GRCm39) V309E probably benign Het
Krtap9-1 C A 11: 99,764,664 (GRCm39) C133* probably null Het
Krtcap2 T C 3: 89,153,578 (GRCm39) probably benign Het
Lilra5 T C 7: 4,240,758 (GRCm39) M1T probably null Het
Magi1 G A 6: 93,659,890 (GRCm39) T1019I probably benign Het
Mdn1 T A 4: 32,713,825 (GRCm39) H1967Q Het
Mgat4f A G 1: 134,318,596 (GRCm39) D456G probably benign Het
Mroh2b A T 15: 4,980,666 (GRCm39) T1412S probably benign Het
Myh13 A T 11: 67,242,894 (GRCm39) M936L probably benign Het
Nalf2 C T X: 98,889,097 (GRCm39) R321W probably damaging Het
Ncapd3 A G 9: 26,962,682 (GRCm39) T373A possibly damaging Het
Noc2l T C 4: 156,320,784 (GRCm39) probably null Het
Nrg4 C T 9: 55,149,420 (GRCm39) S59N probably benign Het
Or11g24 T C 14: 50,662,255 (GRCm39) V93A probably benign Het
Or9k2 T C 10: 129,999,016 (GRCm39) T60A probably benign Het
Pcdhga6 G T 18: 37,840,212 (GRCm39) probably benign Het
Phf20l1 A G 15: 66,475,955 (GRCm39) N196S probably damaging Het
Ppp4r4 T A 12: 103,571,296 (GRCm39) Y787* probably null Het
Psma8 G A 18: 14,839,298 (GRCm39) R4Q probably null Het
Reg4 A G 3: 98,137,168 (GRCm39) K46E probably benign Het
Rnf14 T A 18: 38,442,680 (GRCm39) M327K possibly damaging Het
Rtn1 A T 12: 72,263,586 (GRCm39) Y753* probably null Het
Slc26a11 A G 11: 119,259,627 (GRCm39) R275G probably benign Het
Stard9 A G 2: 120,518,656 (GRCm39) T527A possibly damaging Het
Stk26 C T X: 49,930,618 (GRCm39) probably benign Het
Tas1r1 C T 4: 152,116,413 (GRCm39) C407Y probably damaging Het
Tcstv1b A T 13: 120,634,958 (GRCm39) Y80F probably benign Het
Tenm3 A G 8: 49,127,559 (GRCm39) S40P probably damaging Het
Tespa1 T A 10: 130,183,066 (GRCm39) S4T probably damaging Het
Tlr11 A G 14: 50,599,547 (GRCm39) N511S probably benign Het
Tmprss15 A G 16: 78,754,211 (GRCm39) I1014T probably benign Het
Tpte T A 8: 22,774,990 (GRCm39) M20K probably benign Het
Ttn A G 2: 76,612,390 (GRCm39) V17199A possibly damaging Het
Tubgcp3 A G 8: 12,703,411 (GRCm39) Y305H probably damaging Het
Ubr4 T A 4: 139,212,613 (GRCm39) V5081E unknown Het
Unkl T C 17: 25,448,392 (GRCm39) S322P probably damaging Het
Uqcc6 A G 10: 82,458,475 (GRCm39) S59P unknown Het
Vav3 T A 3: 109,485,682 (GRCm39) probably null Het
Vmn1r76 A G 7: 11,664,765 (GRCm39) S150P probably benign Het
Xpot A G 10: 121,445,600 (GRCm39) probably null Het
Xylt1 A G 7: 117,242,906 (GRCm39) I650V probably benign Het
Zan C A 5: 137,403,682 (GRCm39) A3955S unknown Het
Other mutations in Nrip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00496:Nrip1 APN 16 76,090,591 (GRCm39) missense possibly damaging 0.48
IGL00732:Nrip1 APN 16 76,089,949 (GRCm39) missense probably benign 0.31
IGL02024:Nrip1 APN 16 76,088,563 (GRCm39) missense probably benign 0.05
IGL02172:Nrip1 APN 16 76,088,380 (GRCm39) missense probably damaging 0.99
IGL02432:Nrip1 APN 16 76,088,668 (GRCm39) missense probably benign 0.04
IGL03025:Nrip1 APN 16 76,091,353 (GRCm39) missense probably benign 0.06
IGL03410:Nrip1 APN 16 76,089,379 (GRCm39) missense probably benign
PIT4802001:Nrip1 UTSW 16 76,090,157 (GRCm39) missense probably damaging 0.97
R0064:Nrip1 UTSW 16 76,091,558 (GRCm39) utr 5 prime probably benign
R0304:Nrip1 UTSW 16 76,089,595 (GRCm39) missense possibly damaging 0.67
R0320:Nrip1 UTSW 16 76,089,251 (GRCm39) missense probably benign 0.00
R0368:Nrip1 UTSW 16 76,090,904 (GRCm39) missense probably damaging 0.99
R1730:Nrip1 UTSW 16 76,089,778 (GRCm39) missense probably benign 0.42
R1783:Nrip1 UTSW 16 76,089,778 (GRCm39) missense probably benign 0.42
R1850:Nrip1 UTSW 16 76,090,232 (GRCm39) missense probably damaging 1.00
R1900:Nrip1 UTSW 16 76,088,927 (GRCm39) missense probably benign
R2252:Nrip1 UTSW 16 76,088,173 (GRCm39) missense probably damaging 1.00
R3935:Nrip1 UTSW 16 76,091,323 (GRCm39) missense possibly damaging 0.67
R4290:Nrip1 UTSW 16 76,088,876 (GRCm39) missense probably benign 0.00
R4426:Nrip1 UTSW 16 76,088,293 (GRCm39) missense possibly damaging 0.87
R4598:Nrip1 UTSW 16 76,089,968 (GRCm39) missense probably damaging 1.00
R4607:Nrip1 UTSW 16 76,089,920 (GRCm39) missense probably benign 0.00
R4608:Nrip1 UTSW 16 76,089,920 (GRCm39) missense probably benign 0.00
R5893:Nrip1 UTSW 16 76,090,841 (GRCm39) missense probably damaging 1.00
R5939:Nrip1 UTSW 16 76,089,010 (GRCm39) missense probably damaging 0.99
R5966:Nrip1 UTSW 16 76,090,471 (GRCm39) missense possibly damaging 0.47
R6093:Nrip1 UTSW 16 76,091,652 (GRCm39) start gained probably benign
R6154:Nrip1 UTSW 16 76,090,718 (GRCm39) missense probably damaging 1.00
R6639:Nrip1 UTSW 16 76,090,883 (GRCm39) nonsense probably null
R6910:Nrip1 UTSW 16 76,091,305 (GRCm39) missense probably damaging 1.00
R6921:Nrip1 UTSW 16 76,089,476 (GRCm39) missense possibly damaging 0.88
R7314:Nrip1 UTSW 16 76,088,078 (GRCm39) missense probably benign 0.00
R7346:Nrip1 UTSW 16 76,090,244 (GRCm39) missense possibly damaging 0.81
R7386:Nrip1 UTSW 16 76,090,775 (GRCm39) missense probably damaging 1.00
R7485:Nrip1 UTSW 16 76,088,338 (GRCm39) missense probably damaging 1.00
R7506:Nrip1 UTSW 16 76,091,347 (GRCm39) missense probably damaging 1.00
R7517:Nrip1 UTSW 16 76,088,072 (GRCm39) makesense probably null
R7657:Nrip1 UTSW 16 76,091,587 (GRCm39) splice site probably null
R7878:Nrip1 UTSW 16 76,091,554 (GRCm39) start codon destroyed probably null 0.99
R8068:Nrip1 UTSW 16 76,089,841 (GRCm39) missense possibly damaging 0.62
R8254:Nrip1 UTSW 16 76,088,287 (GRCm39) missense probably benign 0.02
R8261:Nrip1 UTSW 16 76,088,949 (GRCm39) missense possibly damaging 0.69
R8294:Nrip1 UTSW 16 76,089,418 (GRCm39) missense probably damaging 1.00
R8723:Nrip1 UTSW 16 76,089,553 (GRCm39) missense probably damaging 0.98
R8739:Nrip1 UTSW 16 76,088,236 (GRCm39) missense possibly damaging 0.51
R8956:Nrip1 UTSW 16 76,089,193 (GRCm39) missense probably benign 0.07
R8988:Nrip1 UTSW 16 76,088,902 (GRCm39) missense probably damaging 1.00
R9024:Nrip1 UTSW 16 76,088,388 (GRCm39) nonsense probably null
R9206:Nrip1 UTSW 16 76,089,616 (GRCm39) missense possibly damaging 0.93
R9208:Nrip1 UTSW 16 76,089,616 (GRCm39) missense possibly damaging 0.93
R9476:Nrip1 UTSW 16 76,089,820 (GRCm39) missense probably benign 0.26
Z1177:Nrip1 UTSW 16 76,090,367 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCTAGAGCTGAATGACTGAAG -3'
(R):5'- GCTTGGCTCTGATGTGCATC -3'

Sequencing Primer
(F):5'- GCAATGTGCTATCCTGTTTGC -3'
(R):5'- GTGCATCAGGATTCTATTGTCTTAAC -3'
Posted On 2022-04-18