Incidental Mutation 'R9394:Stk26'
ID 710767
Institutional Source Beutler Lab
Gene Symbol Stk26
Ensembl Gene ENSMUSG00000031112
Gene Name serine/threonine kinase 26
Synonyms 2610018G03Rik, Mst4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.162) question?
Stock # R9394 (G1)
Quality Score 222.008
Status Not validated
Chromosome X
Chromosomal Location 49930052-49981980 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) C to T at 49930618 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110537 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033444] [ENSMUST00000114887]
AlphaFold Q99JT2
Predicted Effect probably benign
Transcript: ENSMUST00000033444
SMART Domains Protein: ENSMUSP00000033444
Gene: ENSMUSG00000031112

DomainStartEndE-ValueType
S_TKc 24 274 1.07e-96 SMART
low complexity region 300 318 N/A INTRINSIC
PDB:4GEH|D 325 413 2e-54 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000114887
SMART Domains Protein: ENSMUSP00000110537
Gene: ENSMUSG00000031112

DomainStartEndE-ValueType
S_TKc 24 274 1.07e-96 SMART
low complexity region 300 318 N/A INTRINSIC
PDB:4GEH|D 325 389 1e-31 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 A G 4: 86,135,225 (GRCm39) D78G Het
Adgrv1 A G 13: 81,624,767 (GRCm39) V3734A possibly damaging Het
Alpk1 T A 3: 127,466,187 (GRCm39) E1106D probably damaging Het
Apc2 A G 10: 80,145,006 (GRCm39) Y639C probably damaging Het
Apcdd1 C T 18: 63,055,731 (GRCm39) probably benign Het
Arfgef2 G A 2: 166,676,469 (GRCm39) V119I probably benign Het
Cacna2d1 T C 5: 16,140,013 (GRCm39) M1T probably null Het
Cfap52 A G 11: 67,815,921 (GRCm39) *621R probably null Het
Dis3l T C 9: 64,225,017 (GRCm39) I427V probably benign Het
Dscaml1 G A 9: 45,661,354 (GRCm39) V1751I possibly damaging Het
Eif3c A T 7: 126,156,550 (GRCm39) F432L probably benign Het
Iars1 A G 13: 49,883,536 (GRCm39) N1110S probably benign Het
Ifitm10 A T 7: 141,924,704 (GRCm39) V45D probably damaging Het
Igfbpl1 A T 4: 45,826,792 (GRCm39) M1K probably null Het
Igkv3-1 T A 6: 70,680,953 (GRCm39) Y51N probably benign Het
Kcnq2 A T 2: 180,724,217 (GRCm39) I600K probably benign Het
Madd G A 2: 91,000,199 (GRCm39) T569M probably benign Het
Mapk7 A T 11: 61,381,858 (GRCm39) H351Q probably damaging Het
Met A C 6: 17,513,395 (GRCm39) Y415S probably damaging Het
Mmd2 A T 5: 142,555,239 (GRCm39) V151D probably damaging Het
Nacad T C 11: 6,549,390 (GRCm39) D1267G probably damaging Het
Or10g1 A G 14: 52,647,570 (GRCm39) V253A probably damaging Het
Or2l13 A C 16: 19,306,421 (GRCm39) T278P possibly damaging Het
Or2m13 A G 16: 19,226,019 (GRCm39) V249A probably benign Het
Or5w12 T C 2: 87,502,094 (GRCm39) I206V probably benign Het
Osbpl8 C T 10: 111,127,375 (GRCm39) R820* probably null Het
Oxsr1 C A 9: 119,151,134 (GRCm39) E3* probably null Het
Plekhg3 A G 12: 76,623,862 (GRCm39) D1035G probably damaging Het
Prune2 C T 19: 16,981,053 (GRCm39) T70I probably damaging Het
Ranbp2 T C 10: 58,291,698 (GRCm39) L235S probably damaging Het
Rasal1 A C 5: 120,816,746 (GRCm39) S761R probably benign Het
Rigi T C 4: 40,213,831 (GRCm39) N609S probably damaging Het
Rims1 T C 1: 22,511,856 (GRCm39) S566G probably damaging Het
Rnf123 T C 9: 107,942,905 (GRCm39) H611R probably damaging Het
Rpl35rt T C 1: 156,193,793 (GRCm39) V49A probably benign Het
Scn5a T A 9: 119,324,682 (GRCm39) N1382I probably damaging Het
Sgcb T C 5: 73,801,653 (GRCm39) I71V probably benign Het
Slc6a20a C A 9: 123,507,805 (GRCm39) V23L probably damaging Het
Slc7a1 A G 5: 148,270,712 (GRCm39) W585R probably damaging Het
Tom1l2 T C 11: 60,132,715 (GRCm39) T403A probably benign Het
Trpm1 G T 7: 63,918,480 (GRCm39) A1491S probably benign Het
Ttn A C 2: 76,707,058 (GRCm39) D9044E unknown Het
Ube3a A T 7: 58,921,960 (GRCm39) K111* probably null Het
Wee2 A G 6: 40,433,878 (GRCm39) H264R probably damaging Het
Zdhhc23 T A 16: 43,791,826 (GRCm39) I316F probably damaging Het
Zfc3h1 A G 10: 115,254,600 (GRCm39) E1398G probably damaging Het
Zfp612 C A 8: 110,810,993 (GRCm39) P57T probably damaging Het
Other mutations in Stk26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02253:Stk26 APN X 49,975,565 (GRCm39) missense probably damaging 1.00
IGL03353:Stk26 APN X 49,959,275 (GRCm39) missense probably damaging 0.99
R0664:Stk26 UTSW X 49,976,803 (GRCm39) nonsense probably null
R4067:Stk26 UTSW X 49,977,910 (GRCm39) missense probably benign 0.27
R9393:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
R9579:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
R9580:Stk26 UTSW X 49,930,618 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- TAAACTGAGTCCGGGAGAGC -3'
(R):5'- GAGCTTTACTTCGGGGTCAC -3'

Sequencing Primer
(F):5'- GTCCGGGAGAGCAGCGG -3'
(R):5'- TCACCTGGTGAGAGATCCG -3'
Posted On 2022-04-18