Incidental Mutation 'R9396:Dusp2'
ID 710814
Institutional Source Beutler Lab
Gene Symbol Dusp2
Ensembl Gene ENSMUSG00000027368
Gene Name dual specificity phosphatase 2
Synonyms PAC1
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9396 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 127178079-127180296 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 127179638 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 294 (R294C)
Ref Sequence ENSEMBL: ENSMUSP00000028846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028846] [ENSMUST00000059839] [ENSMUST00000089673] [ENSMUST00000156747] [ENSMUST00000179618]
AlphaFold Q05922
Predicted Effect probably damaging
Transcript: ENSMUST00000028846
AA Change: R294C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000028846
Gene: ENSMUSG00000027368
AA Change: R294C

DomainStartEndE-ValueType
RHOD 17 145 6.72e-10 SMART
DSPc 176 314 1.49e-61 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000059839
SMART Domains Protein: ENSMUSP00000054456
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
Blast:ZnMc 31 60 4e-8 BLAST
ZnMc 69 213 1.13e-39 SMART
low complexity region 292 308 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000089673
SMART Domains Protein: ENSMUSP00000087102
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Blast:ZnMc 52 81 5e-8 BLAST
ZnMc 90 234 1.13e-39 SMART
low complexity region 313 329 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156747
SMART Domains Protein: ENSMUSP00000116771
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
Blast:ZnMc 31 60 6e-9 BLAST
ZnMc 69 193 4.02e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179618
SMART Domains Protein: ENSMUSP00000135987
Gene: ENSMUSG00000050468

DomainStartEndE-ValueType
Blast:ZnMc 31 60 4e-8 BLAST
ZnMc 69 213 1.13e-39 SMART
low complexity region 292 308 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 T A 17: 85,000,282 (GRCm39) F281I probably damaging Het
Acad8 A G 9: 26,887,041 (GRCm39) M402T probably damaging Het
Apcdd1 C T 18: 63,055,731 (GRCm39) probably benign Het
Apol7a T C 15: 77,273,925 (GRCm39) E179G possibly damaging Het
Asmt A G X: 169,110,141 (GRCm39) T217A probably benign Het
Cadm2 T C 16: 66,544,102 (GRCm39) Y318C probably damaging Het
Cckar G A 5: 53,864,623 (GRCm39) T26M probably damaging Het
Cd300ld G A 11: 114,878,230 (GRCm39) T94I probably damaging Het
Cdk5rap2 A G 4: 70,172,903 (GRCm39) Y1390H possibly damaging Het
Cdk5rap2 C T 4: 70,182,895 (GRCm39) S1268N probably damaging Het
Csrnp3 C T 2: 65,832,841 (GRCm39) R127C probably damaging Het
Dsc2 T A 18: 20,174,773 (GRCm39) R501* probably null Het
Edrf1 A G 7: 133,261,838 (GRCm39) K878E possibly damaging Het
Evc T C 5: 37,476,434 (GRCm39) T372A possibly damaging Het
Fcgr1 T A 3: 96,194,390 (GRCm39) K166* probably null Het
Fstl4 C A 11: 52,664,778 (GRCm39) P36Q probably benign Het
Gas2l2 A T 11: 83,313,659 (GRCm39) I551N probably benign Het
Hc G T 2: 34,927,615 (GRCm39) S333* probably null Het
Ibsp A G 5: 104,458,297 (GRCm39) Y278C probably damaging Het
Ifitm10 A T 7: 141,924,704 (GRCm39) V45D probably damaging Het
Kcnc3 T C 7: 44,240,937 (GRCm39) S210P possibly damaging Het
Klhl3 T G 13: 58,161,662 (GRCm39) T531P probably damaging Het
Mapt C A 11: 104,189,555 (GRCm39) P191Q possibly damaging Het
Myh9 T C 15: 77,647,496 (GRCm39) T1840A probably benign Het
Myof A T 19: 37,923,294 (GRCm39) C1320S probably damaging Het
Myom3 G T 4: 135,513,199 (GRCm39) V626L probably benign Het
Nalf2 C T X: 98,889,097 (GRCm39) R321W probably damaging Het
Ndor1 A G 2: 25,138,921 (GRCm39) L321P probably benign Het
Nhsl1 T A 10: 18,399,749 (GRCm39) M291K probably damaging Het
Nubp2 C T 17: 25,103,476 (GRCm39) V134I probably benign Het
Nuf2 T C 1: 169,337,917 (GRCm39) I287V probably benign Het
Or1d2 T A 11: 74,256,089 (GRCm39) M198K probably benign Het
Or2n1 T A 17: 38,486,421 (GRCm39) W149R probably damaging Het
Or4k42 A G 2: 111,319,864 (GRCm39) L213P probably benign Het
Or51i2 A G 7: 103,689,720 (GRCm39) N239S probably benign Het
Or55b4 A C 7: 102,134,180 (GRCm39) V49G possibly damaging Het
Or5k3 G A 16: 58,969,302 (GRCm39) V30M probably damaging Het
Or8k28 A T 2: 86,285,845 (GRCm39) C257S probably benign Het
Pals1 G T 12: 78,871,521 (GRCm39) R367L possibly damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Ppp1r12a A G 10: 108,100,571 (GRCm39) E863G probably damaging Het
Pskh1 C T 8: 106,640,091 (GRCm39) T257M possibly damaging Het
Rasgef1b T C 5: 99,377,188 (GRCm39) I334V probably benign Het
Rnf180 T A 13: 105,318,027 (GRCm39) K462* probably null Het
Sin3a A G 9: 57,008,445 (GRCm39) D455G probably benign Het
Slc15a4 A G 5: 127,694,463 (GRCm39) probably benign Het
Slc2a13 T C 15: 91,227,915 (GRCm39) T426A probably benign Het
Smarca5 T C 8: 81,463,358 (GRCm39) K70R probably benign Het
Smg1 A G 7: 117,807,303 (GRCm39) V182A unknown Het
Stim1 G A 7: 102,064,592 (GRCm39) V221I possibly damaging Het
Tbx18 T C 9: 87,609,432 (GRCm39) D201G probably damaging Het
Tcf25 A G 8: 124,127,831 (GRCm39) E630G probably benign Het
Tm7sf3 T C 6: 146,523,472 (GRCm39) N135S possibly damaging Het
Togaram1 A G 12: 65,014,429 (GRCm39) N560S probably damaging Het
Unc13d A G 11: 115,966,529 (GRCm39) probably null Het
Zfp445 A C 9: 122,681,581 (GRCm39) S787A probably benign Het
Zfp949 T C 9: 88,449,260 (GRCm39) W22R probably damaging Het
Other mutations in Dusp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01545:Dusp2 APN 2 127,179,695 (GRCm39) missense probably benign 0.00
R4353:Dusp2 UTSW 2 127,179,256 (GRCm39) missense probably damaging 1.00
R5973:Dusp2 UTSW 2 127,179,208 (GRCm39) missense probably damaging 1.00
R7936:Dusp2 UTSW 2 127,178,812 (GRCm39) nonsense probably null
R9211:Dusp2 UTSW 2 127,179,311 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACAGGCACCTGATTCCTCTG -3'
(R):5'- GCCGTCATCCTGGATTTCCTAG -3'

Sequencing Primer
(F):5'- GGCACCTGATTCCTCTGTCCAC -3'
(R):5'- GATTTCCTAGCACCCCAGTGG -3'
Posted On 2022-04-18