Mutagenetix > Incidental Mutation

Incidental Mutation 'R9397:Vmn2r115'

710908

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

V2Rp4, EG638102

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R9397 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23562951-23579102 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 23564152 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 108 (W108*)

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

probably null
Transcript: ENSMUST00000168175
AA Change: W108*

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: W108*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930555G01Rik	T	G	14: 5,051,639 (GRCm38)	V66G	possibly damaging	Het
A630001G21Rik	G	T	1: 85,653,002 (GRCm39)	Y55*	probably null	Het
Abca8a	G	A	11: 109,921,173 (GRCm39)	T1474I	probably damaging	Het
Acaca	T	G	11: 84,259,551 (GRCm39)	I1962S	probably damaging	Het
Acap1	A	T	11: 69,775,672 (GRCm39)	S455T	probably damaging	Het
Acbd7	G	A	2: 3,337,259 (GRCm39)		probably null	Het
Adamts9	A	G	6: 92,878,444 (GRCm39)	L541P	probably damaging	Het
Ankrd49	T	C	9: 14,692,711 (GRCm39)	N151S	probably benign	Het
Apcdd1	C	T	18: 63,055,731 (GRCm39)		probably benign	Het
Arhgap27	T	C	11: 103,231,115 (GRCm39)	D58G	probably damaging	Het
Btbd18	G	T	2: 84,497,810 (GRCm39)	A483S	probably damaging	Het
C2	A	G	17: 35,094,965 (GRCm39)	S257P	probably damaging	Het
Catsper3	T	A	13: 55,946,725 (GRCm39)	Y141N	probably damaging	Het
Cfap54	G	A	10: 92,833,147 (GRCm39)	L1160F	probably damaging	Het
Chst13	G	A	6: 90,286,506 (GRCm39)	P152L	probably damaging	Het
Cyp4f14	C	T	17: 33,130,516 (GRCm39)	G141D	probably damaging	Het
Duox1	C	T	2: 122,150,783 (GRCm39)	T286I	possibly damaging	Het
Epc2	G	A	2: 49,378,822 (GRCm39)	G92E	probably damaging	Het
Fmnl3	C	T	15: 99,225,938 (GRCm39)		probably null	Het
Glyatl3	G	A	17: 41,223,565 (GRCm39)	R59*	probably null	Het
Gm3633	T	A	14: 42,460,400 (GRCm39)	Q181L		Het
Guca1b	C	T	17: 47,696,560 (GRCm39)	T49M	probably benign	Het
Hdac9	T	A	12: 34,353,275 (GRCm39)	H645L	probably damaging	Het
Hhip	T	C	8: 80,719,112 (GRCm39)	R472G	probably benign	Het
Ifi203	A	G	1: 173,765,547 (GRCm39)	V9A	probably damaging	Het
Igkv9-123	A	T	6: 67,931,443 (GRCm39)	V41D	probably damaging	Het
Il5ra	T	A	6: 106,721,258 (GRCm39)	T14S	probably benign	Het
Ints2	A	G	11: 86,135,311 (GRCm39)	S368P	probably benign	Het
Kat6b	T	A	14: 21,675,244 (GRCm39)	S470T	possibly damaging	Het
Kmt2d	A	G	15: 98,747,994 (GRCm39)	V3110A	unknown	Het
Lama2	T	C	10: 26,981,117 (GRCm39)	N1846D	probably benign	Het
Lrp1b	T	A	2: 40,640,922 (GRCm39)	E3507D		Het
Ly6g6c	A	G	17: 35,288,317 (GRCm39)	N63S	probably benign	Het
Naprt	C	T	15: 75,763,859 (GRCm39)	V354I	probably null	Het
Nars1	A	G	18: 64,642,327 (GRCm39)	S172P	probably benign	Het
Odr4	C	T	1: 150,238,616 (GRCm39)	A434T	probably damaging	Het
Or6c5b	A	G	10: 129,245,909 (GRCm39)	R225G	possibly damaging	Het
Or7e177	T	C	9: 20,211,748 (GRCm39)	I85T	possibly damaging	Het
Pcdhb6	A	G	18: 37,469,353 (GRCm39)	D758G	probably benign	Het
Pkp4	G	A	2: 59,148,856 (GRCm39)	W536*	probably null	Het
Polr3b	C	T	10: 84,467,653 (GRCm39)	L78F	possibly damaging	Het
Rasa4	T	A	5: 136,129,836 (GRCm39)	V272E	possibly damaging	Het
Syne2	A	G	12: 76,040,849 (GRCm39)	T3836A	possibly damaging	Het
Tbpl2	C	T	2: 23,966,070 (GRCm39)	V308I	possibly damaging	Het
Tcea1	T	A	1: 4,962,141 (GRCm39)	I176K	probably damaging	Het
Try5	A	T	6: 41,289,314 (GRCm39)	F87L	probably benign	Het
Ttc8	G	T	12: 98,942,692 (GRCm39)	G411*	probably null	Het
Zdhhc13	C	T	7: 48,476,628 (GRCm39)	T581I	probably benign	Het
Zfp777	G	T	6: 48,021,190 (GRCm39)	T144K	probably benign	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23,575,934 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,345 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,371 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,135 (GRCm39)	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23,565,252 (GRCm39)	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23,565,313 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,323 (GRCm39)	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23,565,150 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,180 (GRCm39)	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23,567,008 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,798 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,753 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,238 (GRCm39)	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23,565,346 (GRCm39)	missense	probably benign	0.30
IGL01073:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23,564,113 (GRCm39)	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23,578,257 (GRCm39)	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23,565,252 (GRCm39)	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23,564,196 (GRCm39)	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23,579,074 (GRCm39)	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23,565,238 (GRCm39)	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23,578,249 (GRCm39)	missense	probably benign
R0865:Vmn2r115	UTSW	17	23,565,382 (GRCm39)	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23,564,245 (GRCm39)	missense	probably benign	0.12
R1645:Vmn2r115	UTSW	17	23,565,192 (GRCm39)	missense	possibly damaging	0.69
R1646:Vmn2r115	UTSW	17	23,578,513 (GRCm39)	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23,566,795 (GRCm39)	missense	probably benign
R1846:Vmn2r115	UTSW	17	23,578,357 (GRCm39)	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23,565,007 (GRCm39)	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23,578,388 (GRCm39)	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23,566,927 (GRCm39)	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23,578,297 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23,575,998 (GRCm39)	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23,564,146 (GRCm39)	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23,578,948 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23,579,017 (GRCm39)	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23,564,077 (GRCm39)	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23,564,197 (GRCm39)	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23,564,854 (GRCm39)	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23,565,373 (GRCm39)	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23,578,825 (GRCm39)	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23,579,030 (GRCm39)	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R5821:Vmn2r115	UTSW	17	23,566,937 (GRCm39)	missense	probably damaging	0.99
R6120:Vmn2r115	UTSW	17	23,565,003 (GRCm39)	missense	probably damaging	1.00
R6193:Vmn2r115	UTSW	17	23,575,983 (GRCm39)	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6290:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23,566,877 (GRCm39)	missense	possibly damaging	0.70
R6495:Vmn2r115	UTSW	17	23,578,572 (GRCm39)	missense	probably benign	0.02
R6599:Vmn2r115	UTSW	17	23,565,006 (GRCm39)	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23,565,046 (GRCm39)	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23,564,989 (GRCm39)	missense	probably benign	0.23
R7023:Vmn2r115	UTSW	17	23,578,785 (GRCm39)	missense	probably damaging	1.00
R7236:Vmn2r115	UTSW	17	23,578,576 (GRCm39)	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23,564,887 (GRCm39)	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23,565,371 (GRCm39)	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23,564,772 (GRCm39)	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23,563,124 (GRCm39)	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23,578,530 (GRCm39)	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23,564,773 (GRCm39)	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23,578,497 (GRCm39)	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23,564,803 (GRCm39)	missense	probably benign
R9114:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R9189:Vmn2r115	UTSW	17	23,564,784 (GRCm39)	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23,578,482 (GRCm39)	missense	probably benign	0.05
R9410:Vmn2r115	UTSW	17	23,578,915 (GRCm39)	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23,578,184 (GRCm39)	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23,578,333 (GRCm39)	missense	probably benign
V5622:Vmn2r115	UTSW	17	23,565,201 (GRCm39)	missense	probably damaging	1.00
X0023:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- ATGCAATCCAGTGTAGAATTGTCC -3'
(R):5'- GACAGAATTCCCACTCTGCCTC -3'

Sequencing Primer
(F):5'- TCCAGTGTAGAATTGTCCTTTTATTG -3'
(R):5'- GAATTCCCACTCTGCCTCAATAAAC -3'

Posted On

2022-04-18