Incidental Mutation 'R9398:Olfr569'
ID 710939
Institutional Source Beutler Lab
Gene Symbol Olfr569
Ensembl Gene ENSMUSG00000062142
Gene Name olfactory receptor 569
Synonyms MOR30-1, GA_x6K02T2PBJ9-5599295-5598351
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R9398 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102883709-102890882 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102887793 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 120 (M120T)
Ref Sequence ENSEMBL: ENSMUSP00000149088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078191] [ENSMUST00000217024]
AlphaFold Q8VGZ2
Predicted Effect probably damaging
Transcript: ENSMUST00000078191
AA Change: M120T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077321
Gene: ENSMUSG00000062142
AA Change: M120T

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 1.2e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 229 1.3e-9 PFAM
Pfam:7tm_1 43 294 1.9e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217024
AA Change: M120T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvrl1 A T 15: 101,137,043 K228* probably null Het
Adrb2 T C 18: 62,179,205 D183G probably benign Het
Ap1m2 A G 9: 21,305,639 Y134H probably damaging Het
Arid5a A G 1: 36,318,992 T217A probably benign Het
Cdnf C T 2: 3,521,038 T89I possibly damaging Het
Cntnap3 G A 13: 64,903,834 R3W probably benign Het
Col6a6 A G 9: 105,774,626 I1062T probably benign Het
Ctss T C 3: 95,546,947 F270S possibly damaging Het
Ddhd1 C T 14: 45,657,660 G118R possibly damaging Het
Ddx11 A G 17: 66,129,917 K69E probably benign Het
Dgkb G A 12: 38,139,658 G328D probably damaging Het
Dock1 C T 7: 135,172,499 T1852M probably damaging Het
Gm19410 T C 8: 35,805,202 Y1346H probably benign Het
Gm6614 A G 6: 141,994,785 S137P possibly damaging Het
Gprin1 G T 13: 54,739,570 T297N probably damaging Het
Gramd1c A G 16: 44,013,018 F187S probably damaging Het
Gse1 A G 8: 120,576,335 N1072D unknown Het
Gtf3c6 G A 10: 40,257,524 probably benign Het
Hipk3 T A 2: 104,433,217 T897S probably benign Het
Igsf21 T A 4: 140,246,451 probably benign Het
Itgb1 A G 8: 128,726,124 I757V probably damaging Het
Lamb2 C T 9: 108,487,167 R1102W possibly damaging Het
Lzts2 T G 19: 45,024,769 C374W unknown Het
Mapk10 A T 5: 102,913,286 S462T probably damaging Het
Mtcl1 A T 17: 66,448,467 D293E possibly damaging Het
Nf1 T G 11: 79,547,192 H109Q probably damaging Het
Nlrp9b T C 7: 20,049,510 L926P probably damaging Het
Notch2 G A 3: 98,102,352 D532N probably damaging Het
Olfm4 A T 14: 80,011,809 Y122F probably benign Het
Olfr1001-ps1 T C 2: 85,634,023 V198A probably benign Het
Olfr141 A G 2: 86,806,816 L61P possibly damaging Het
Olfr502 T C 7: 108,523,828 T41A probably damaging Het
Olfr603 T A 7: 103,383,280 T241S probably damaging Het
Olfr684 A T 7: 105,156,799 Y294* probably null Het
P2rx2 A T 5: 110,340,272 M472K probably benign Het
Pbxip1 A G 3: 89,447,634 K487E probably benign Het
Plxnb2 A G 15: 89,160,919 V1108A probably benign Het
Polq A G 16: 37,061,032 N1186S probably benign Het
Por T A 5: 135,725,743 W6R unknown Het
Prex2 G A 1: 11,136,804 V529I probably benign Het
Rgs6 T G 12: 82,651,841 S5A probably benign Het
Rp9 G T 9: 22,448,786 S171* probably null Het
Sec11c T A 18: 65,809,497 I47N possibly damaging Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,467,570 probably benign Het
Sh2b1 GACCAGCTCAGCCACGGG GACCAGCTCAGCCACGGGTACCAGCTCAGCCACGGG 7: 126,467,574 probably benign Het
Sh2b1 GCCACGGGGACCAGCTC GCCACGGGGACCAGCTCATCCACGGGGACCAGCTC 7: 126,467,584 probably benign Het
Sorcs1 A G 19: 50,225,213 M692T possibly damaging Het
Sult1d1 T A 5: 87,566,095 Q30L probably benign Het
Tcea2 A G 2: 181,680,450 D15G probably damaging Het
Tep1 T C 14: 50,828,972 S2344G possibly damaging Het
Ttc6 T A 12: 57,737,618 Y1824* probably null Het
Ubqln5 T C 7: 104,128,778 T280A probably benign Het
Ush1c T C 7: 46,220,510 R342G probably benign Het
Vmn1r185 T A 7: 26,611,631 I150F probably benign Het
Vmn1r43 G A 6: 89,869,895 T203M probably damaging Het
Vmn1r86 A G 7: 13,102,334 M205T probably damaging Het
Vps13d A T 4: 145,170,386 Y321* probably null Het
Other mutations in Olfr569
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01965:Olfr569 APN 7 102887607 missense probably damaging 1.00
IGL02505:Olfr569 APN 7 102887607 missense probably damaging 1.00
IGL02885:Olfr569 APN 7 102888036 missense possibly damaging 0.83
IGL03339:Olfr569 APN 7 102887782 missense probably benign 0.02
R0383:Olfr569 UTSW 7 102887251 missense possibly damaging 0.91
R1767:Olfr569 UTSW 7 102887626 missense probably damaging 1.00
R1793:Olfr569 UTSW 7 102888043 missense probably benign 0.44
R1812:Olfr569 UTSW 7 102888078 missense probably benign 0.32
R6061:Olfr569 UTSW 7 102887951 missense probably benign 0.31
R7855:Olfr569 UTSW 7 102887628 missense probably benign 0.01
R8155:Olfr569 UTSW 7 102887245 missense probably benign 0.00
R8890:Olfr569 UTSW 7 102887492 nonsense probably null
R9131:Olfr569 UTSW 7 102887979 missense probably benign 0.07
R9188:Olfr569 UTSW 7 102887389 missense possibly damaging 0.95
Z1177:Olfr569 UTSW 7 102887761 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAACTTGAGCACAGCCATG -3'
(R):5'- ATTGACCACACCCTGCATG -3'

Sequencing Primer
(F):5'- CCATGTGCTCACAGTAGGAC -3'
(R):5'- GAGCCCATGTACCTCTTCCTGG -3'
Posted On 2022-04-18